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The map label for this gene is fabG [H]

Identifier: 75908116

GI number: 75908116

Start: 2354372

End: 2355067

Strand: Direct

Name: fabG [H]

Synonym: Ava_1895

Alternate gene names: 75908116

Gene position: 2354372-2355067 (Clockwise)

Preceding gene: 75908106

Following gene: 75908119

Centisome position: 36.99

GC content: 45.83

Gene sequence:

>696_bases
ATGAAAGGTAGACAAGTTCTACTTACAGGCGGTACTGGTGGACTAGGTGTAGGTGTCACACCAGTCGTCCTCGCCCAAGG
TGCAAATCTGACCATTACTTACCGCAATCTCAAGGAAGTTGAACGCCTCAAGGAAGTTCTCCCGCCGGCGGATTTTGCCA
GAGTTACTTTTCTTCCCGCTAACTTGGAAGAAGAATCTTCTGTTGATAATCTCATTACCCGCATCGGTAGGGTAGATGTA
TTAATTCATCTTGTGGGTGGCTTTTCGATGGGCAAAATCCATGAATACAGTTATTACAGTTGGAAACGAGAATTTGATAT
CAATTTAAATACAACCTTTCTGGTATGCAAATATAGCCTCAAAAGTATGTTAGACCACGGCTACGGACGCATTATCACCA
TAGGTTCTAAGGCTGCTGTGGAACCATCAGGAGGATTAGCCGCCTATTCTGCGGCGAAGGCGGGTGTGGTAGCTTTCACA
AAAGCGATCGCTGATGAAACTAAAGGTACGAACATCACCGCTAATGTCATCCTCCCCACAATTATTGATACCCCCGCTAA
CCGTCAAGCGATGGGTACAGAGAACGCCGACAAATGGGTAAAGCCTGAGTCTATTGGCGAATTGATCTGCTTTTTAGCTT
CAGAAAAAGCCAAAGATATTCGCGGCGCTGCTATTCCGATATATGGAGGGGTGTAG

Upstream 100 bases:

>100_bases
AAAATTTCTCTCACAAGGTATAGAAGGGTTTTCATTCTATCCGCAAGCGATACGCCTACGCGTTATCTTGAATCATGAAG
CTCTCTGGAATTCATAAATC

Downstream 100 bases:

>100_bases
GGGTGTAGGGGTGTAGGAGAACAATTTTTTACTCCTCACTCCCTACTTCCTACTCCCTACTATTGCCTAATAGGTGTACC
ACAGGGATAAGTAGCAACTT

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: NA

Alternate protein names: BDH; 3-hydroxybutyrate dehydrogenase; 3-HBDH [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MKGRQVLLTGGTGGLGVGVTPVVLAQGANLTITYRNLKEVERLKEVLPPADFARVTFLPANLEEESSVDNLITRIGRVDV
LIHLVGGFSMGKIHEYSYYSWKREFDINLNTTFLVCKYSLKSMLDHGYGRIITIGSKAAVEPSGGLAAYSAAKAGVVAFT
KAIADETKGTNITANVILPTIIDTPANRQAMGTENADKWVKPESIGELICFLASEKAKDIRGAAIPIYGGV

Sequences:

>Translated_231_residues
MKGRQVLLTGGTGGLGVGVTPVVLAQGANLTITYRNLKEVERLKEVLPPADFARVTFLPANLEEESSVDNLITRIGRVDV
LIHLVGGFSMGKIHEYSYYSWKREFDINLNTTFLVCKYSLKSMLDHGYGRIITIGSKAAVEPSGGLAAYSAAKAGVVAFT
KAIADETKGTNITANVILPTIIDTPANRQAMGTENADKWVKPESIGELICFLASEKAKDIRGAAIPIYGGV
>Mature_231_residues
MKGRQVLLTGGTGGLGVGVTPVVLAQGANLTITYRNLKEVERLKEVLPPADFARVTFLPANLEEESSVDNLITRIGRVDV
LIHLVGGFSMGKIHEYSYYSWKREFDINLNTTFLVCKYSLKSMLDHGYGRIITIGSKAAVEPSGGLAAYSAAKAGVVAFT
KAIADETKGTNITANVILPTIIDTPANRQAMGTENADKWVKPESIGELICFLASEKAKDIRGAAIPIYGGV

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI19923817, Length=258, Percent_Identity=27.906976744186, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI32483357, Length=239, Percent_Identity=25.1046025104602, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI40254992, Length=200, Percent_Identity=25, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI66933014, Length=245, Percent_Identity=24.4897959183673, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4503817, Length=234, Percent_Identity=26.4957264957265, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI15277342, Length=147, Percent_Identity=30.6122448979592, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI4758504, Length=202, Percent_Identity=29.2079207920792, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=27.6859504132231, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788459, Length=243, Percent_Identity=27.9835390946502, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=25.2, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082160, Length=244, Percent_Identity=26.6393442622951, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI87082100, Length=253, Percent_Identity=28.8537549407115, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789208, Length=249, Percent_Identity=24.8995983935743, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI2367365, Length=236, Percent_Identity=27.1186440677966, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1789378, Length=249, Percent_Identity=22.8915662650602, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787820, Length=178, Percent_Identity=26.4044943820225, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=249, Percent_Identity=26.9076305220884, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=249, Percent_Identity=24.0963855421687, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538182, Length=206, Percent_Identity=28.6407766990291, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=206, Percent_Identity=27.6699029126214, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=242, Percent_Identity=24.7933884297521, Blast_Score=68, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17563726, Length=241, Percent_Identity=27.8008298755187, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=240, Percent_Identity=30.4166666666667, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=25.6, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI23397609, Length=244, Percent_Identity=24.5901639344262, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639444, Length=243, Percent_Identity=27.1604938271605, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI28571526, Length=248, Percent_Identity=24.5967741935484, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24644339, Length=248, Percent_Identity=22.9838709677419, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355319, Length=246, Percent_Identity=23.5772357723577, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21358495, Length=234, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24643142, Length=212, Percent_Identity=25, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI18859837, Length=154, Percent_Identity=27.2727272727273, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011294
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.30 [H]

Molecular weight: Translated: 24774; Mature: 24774

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGRQVLLTGGTGGLGVGVTPVVLAQGANLTITYRNLKEVERLKEVLPPADFARVTFLPA
CCCCEEEEECCCCCCCCCCCCEEEECCCCEEEEECCHHHHHHHHHHCCCCCCEEEEEEEC
NLEEESSVDNLITRIGRVDVLIHLVGGFSMGKIHEYSYYSWKREFDINLNTTFLVCKYSL
CCCCCCHHHHHHHHHHHHHHEEHHHCCCCCCCEEECCEECEEEEEECCCCCEEEEEEHHH
KSMLDHGYGRIITIGSKAAVEPSGGLAAYSAAKAGVVAFTKAIADETKGTNITANVILPT
HHHHHCCCCEEEEECCCCEECCCCCEEEHHHHHCCHHHHHHHHHHCCCCCEEEEEEEEEE
IIDTPANRQAMGTENADKWVKPESIGELICFLASEKAKDIRGAAIPIYGGV
EECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHCCCCEEEECCCC
>Mature Secondary Structure
MKGRQVLLTGGTGGLGVGVTPVVLAQGANLTITYRNLKEVERLKEVLPPADFARVTFLPA
CCCCEEEEECCCCCCCCCCCCEEEECCCCEEEEECCHHHHHHHHHHCCCCCCEEEEEEEC
NLEEESSVDNLITRIGRVDVLIHLVGGFSMGKIHEYSYYSWKREFDINLNTTFLVCKYSL
CCCCCCHHHHHHHHHHHHHHEEHHHCCCCCCCEEECCEECEEEEEECCCCCEEEEEEHHH
KSMLDHGYGRIITIGSKAAVEPSGGLAAYSAAKAGVVAFTKAIADETKGTNITANVILPT
HHHHHCCCCEEEEECCCCEECCCCCEEEHHHHHCCHHHHHHHHHHCCCCCEEEEEEEEEE
IIDTPANRQAMGTENADKWVKPESIGELICFLASEKAKDIRGAAIPIYGGV
EECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA