Click here to switch to the map view.

The map label for this gene is serS

Identifier: 75907945

GI number: 75907945

Start: 2162078

End: 2163358

Strand: Direct

Name: serS

Synonym: Ava_1724

Alternate gene names: 75907945

Gene position: 2162078-2163358 (Clockwise)

Preceding gene: 75907944

Following gene: 75907946

Centisome position: 33.96

GC content: 43.09

Gene sequence:

>1281_bases
GTGCTGGATATTAAGCAAATAAGGGAAAATCCCCAACTAATTCAGGAAAGGTTGAATAGCCGCAGTGGTACCTATGACAT
TCAACCTATATTACAGTTAGATAAGCAACAACGGGAGTTGGAAGCGACCCGCAGTCAAATCCAAGCCCGGAGTAACGAAA
TTGGTAAAATTGTCGGACAAAAGATTAAATCGGGTATTAATCCTCAAGACCCGGAAATCCAAGCTTTGCGGGATGAGGGA
AACTCCATTAAAGCCCAATTGAGTGAACTAGAACCAAGAGAAAAAGAACTCAAGGCGGAAATTGAGCAACTTATACTCGC
ACTCCCTAATTTACCCAGTGACTCTACACCGATAGGTAAAAGTGAGGAAGAAAATGTAGAGGTAAGGCGTTGGGGTGATG
AATATCTACCCCAGAACCCGAATATTATCCCCCATTGGGAAATCGGCGAAAAGCTGGGTATCCTCAATTTTGAGCGTGCT
GTCAAAGTTGCCCAAAGTCGCTTTGTCAACTTGATAGGGGCTGGTGCGGCGTTGGAGCGGGCATTAATTAACTTTATGCT
GAAAACGCAAACCGTAGCTGGCTATGTAGAAGTTAGTCCACCCTTGTTAGTCAATACTGATTCTTTAACAGGAACAGGTC
AATTACCGAAGTTTGCGGAAGAAAGCTTTAAGTGTGCTGATGATGAATTGTGGTTAATTCCCACAGCAGAAGTTCCTGTT
ACTAACCTTTATCGGGGTGAAATTCTGGCGGCGGAAAATTTACCCATTTATCACTGTGCTTATACTCCCTGTTTTCGTCG
GGAAGCAGGAAGTTATGGAAGAGATATGCGGGGTTTAATTCGCCTGCATCAATTCAATAAAGTAGAGTTGGTGAAAGTTG
TTCATCCCAGCACTTCTTTTGATGAATTAGAAAAATTGGTGGGGAATGCCGAAGCAATTTTACAGGCTTTAAAATTACCT
TACCGGGTGATTAATCTTTGTACTGGTGATTTAGGTTTTGGGGCAACGAAAACCTATGATTTAGAAGTATGGCTACCATC
TTCTGGTAAGTATCGAGAGATTTCTAGTTGTTCTAATTGCTTTGATTTCCAAGCGCGGCGAGCCGATATTCGCTTTAAGG
AAGCGGGTAAAAAAGGGACGCAGTTCGTCCATACCCTCAACGGTTCTGGCTTGGCTGTGGGGCGAACTATGGCAGCTATT
TTGGAGAATTATCAGCAACCAGATGGGACAATTTTGATACCGGAGGTTTTGCAGGTTTATTTGGGTAGGGAAGTTTTGTA
A

Upstream 100 bases:

>100_bases
ACAAGATTTTAGTATTTGCCTTTCCTGTCATGGCAAGACAAAATCGGTATATGCTGATGTGTTGGCAAGAAGATACTAGG
CGAAAGATTGAGAAAAATTT

Downstream 100 bases:

>100_bases
TACGGATACAAAGCACTCTCAGGTTTTCAGATTTGGCGTAATTTTTTACGAATAACCTCCATATAATCACTTCAAGAGAG
ATTATATGGAGATATTGATA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MLDIKQIRENPQLIQERLNSRSGTYDIQPILQLDKQQRELEATRSQIQARSNEIGKIVGQKIKSGINPQDPEIQALRDEG
NSIKAQLSELEPREKELKAEIEQLILALPNLPSDSTPIGKSEEENVEVRRWGDEYLPQNPNIIPHWEIGEKLGILNFERA
VKVAQSRFVNLIGAGAALERALINFMLKTQTVAGYVEVSPPLLVNTDSLTGTGQLPKFAEESFKCADDELWLIPTAEVPV
TNLYRGEILAAENLPIYHCAYTPCFRREAGSYGRDMRGLIRLHQFNKVELVKVVHPSTSFDELEKLVGNAEAILQALKLP
YRVINLCTGDLGFGATKTYDLEVWLPSSGKYREISSCSNCFDFQARRADIRFKEAGKKGTQFVHTLNGSGLAVGRTMAAI
LENYQQPDGTILIPEVLQVYLGREVL

Sequences:

>Translated_426_residues
MLDIKQIRENPQLIQERLNSRSGTYDIQPILQLDKQQRELEATRSQIQARSNEIGKIVGQKIKSGINPQDPEIQALRDEG
NSIKAQLSELEPREKELKAEIEQLILALPNLPSDSTPIGKSEEENVEVRRWGDEYLPQNPNIIPHWEIGEKLGILNFERA
VKVAQSRFVNLIGAGAALERALINFMLKTQTVAGYVEVSPPLLVNTDSLTGTGQLPKFAEESFKCADDELWLIPTAEVPV
TNLYRGEILAAENLPIYHCAYTPCFRREAGSYGRDMRGLIRLHQFNKVELVKVVHPSTSFDELEKLVGNAEAILQALKLP
YRVINLCTGDLGFGATKTYDLEVWLPSSGKYREISSCSNCFDFQARRADIRFKEAGKKGTQFVHTLNGSGLAVGRTMAAI
LENYQQPDGTILIPEVLQVYLGREVL
>Mature_426_residues
MLDIKQIRENPQLIQERLNSRSGTYDIQPILQLDKQQRELEATRSQIQARSNEIGKIVGQKIKSGINPQDPEIQALRDEG
NSIKAQLSELEPREKELKAEIEQLILALPNLPSDSTPIGKSEEENVEVRRWGDEYLPQNPNIIPHWEIGEKLGILNFERA
VKVAQSRFVNLIGAGAALERALINFMLKTQTVAGYVEVSPPLLVNTDSLTGTGQLPKFAEESFKCADDELWLIPTAEVPV
TNLYRGEILAAENLPIYHCAYTPCFRREAGSYGRDMRGLIRLHQFNKVELVKVVHPSTSFDELEKLVGNAEAILQALKLP
YRVINLCTGDLGFGATKTYDLEVWLPSSGKYREISSCSNCFDFQARRADIRFKEAGKKGTQFVHTLNGSGLAVGRTMAAI
LENYQQPDGTILIPEVLQVYLGREVL

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=342, Percent_Identity=36.8421052631579, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI8923421, Length=442, Percent_Identity=33.4841628959276, Blast_Score=211, Evalue=8e-55,
Organism=Homo sapiens, GI225579074, Length=445, Percent_Identity=31.685393258427, Blast_Score=187, Evalue=2e-47,
Organism=Escherichia coli, GI1787120, Length=433, Percent_Identity=49.4226327944573, Blast_Score=394, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17539260, Length=471, Percent_Identity=31.2101910828025, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI17542084, Length=322, Percent_Identity=29.1925465838509, Blast_Score=141, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=443, Percent_Identity=33.8600451467269, Blast_Score=255, Evalue=8e-69,
Organism=Saccharomyces cerevisiae, GI6321799, Length=405, Percent_Identity=29.6296296296296, Blast_Score=185, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24581334, Length=464, Percent_Identity=31.25, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI17737985, Length=333, Percent_Identity=28.8288288288288, Blast_Score=141, Evalue=8e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_ANAVT (Q3MCE0)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_322241.1
- HSSP:   Q9N0F3
- ProteinModelPortal:   Q3MCE0
- SMR:   Q3MCE0
- STRING:   Q3MCE0
- GeneID:   3682145
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_1724
- NMPDR:   fig|240292.3.peg.2804
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   Q3MCE0
- ProtClustDB:   PRK05431
- BioCyc:   AVAR240292:AVA_1724-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47740; Mature: 47740

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 289-289 BINDING 389-389

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKQIRENPQLIQERLNSRSGTYDIQPILQLDKQQRELEATRSQIQARSNEIGKIVGQ
CCCHHHHHCCHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIKSGINPQDPEIQALRDEGNSIKAQLSELEPREKELKAEIEQLILALPNLPSDSTPIGK
HHHCCCCCCCCCHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SEEENVEVRRWGDEYLPQNPNIIPHWEIGEKLGILNFERAVKVAQSRFVNLIGAGAALER
CCCCCCHHEECCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
ALINFMLKTQTVAGYVEVSPPLLVNTDSLTGTGQLPKFAEESFKCADDELWLIPTAEVPV
HHHHHHHHHHHHEEEEEECCCEEEECCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCC
TNLYRGEILAAENLPIYHCAYTPCFRREAGSYGRDMRGLIRLHQFNKVELVKVVHPSTSF
CCCCCCCEEEECCCCEEEECCCCHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCH
DELEKLVGNAEAILQALKLPYRVINLCTGDLGFGATKTYDLEVWLPSSGKYREISSCSNC
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHH
FDFQARRADIRFKEAGKKGTQFVHTLNGSGLAVGRTMAAILENYQQPDGTILIPEVLQVY
HHHHHHHHCCCHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
LGREVL
HCCCCC
>Mature Secondary Structure
MLDIKQIRENPQLIQERLNSRSGTYDIQPILQLDKQQRELEATRSQIQARSNEIGKIVGQ
CCCHHHHHCCHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KIKSGINPQDPEIQALRDEGNSIKAQLSELEPREKELKAEIEQLILALPNLPSDSTPIGK
HHHCCCCCCCCCHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
SEEENVEVRRWGDEYLPQNPNIIPHWEIGEKLGILNFERAVKVAQSRFVNLIGAGAALER
CCCCCCHHEECCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
ALINFMLKTQTVAGYVEVSPPLLVNTDSLTGTGQLPKFAEESFKCADDELWLIPTAEVPV
HHHHHHHHHHHHEEEEEECCCEEEECCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCC
TNLYRGEILAAENLPIYHCAYTPCFRREAGSYGRDMRGLIRLHQFNKVELVKVVHPSTSF
CCCCCCCEEEECCCCEEEECCCCHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCH
DELEKLVGNAEAILQALKLPYRVINLCTGDLGFGATKTYDLEVWLPSSGKYREISSCSNC
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHH
FDFQARRADIRFKEAGKKGTQFVHTLNGSGLAVGRTMAAILENYQQPDGTILIPEVLQVY
HHHHHHHHCCCHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
LGREVL
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA