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The map label for this gene is zwf [H]

Identifier: 75907903

GI number: 75907903

Start: 2109575

End: 2111104

Strand: Direct

Name: zwf [H]

Synonym: Ava_1682

Alternate gene names: 75907903

Gene position: 2109575-2111104 (Clockwise)

Preceding gene: 75907902

Following gene: 75907904

Centisome position: 33.14

GC content: 47.84

Gene sequence:

>1530_bases
ATGGTTAGTCTCCTGGAAAATCCCTTGCGCGTTGGTCTGCAACAACAAGGGATGCCCGAACCCCAAATTATAGTCATCTT
TGGCGCTTCTGGTGATCTTACCTGGCGCAAACTCGTCCCCGCACTTTACAAATTGCGCCGGGAACGACGCATTCCCCCAG
AAACTACCATTGTTGGTGTAGCCCGTCGGGAATGGAGCCACGAATACTTCCGCGAACAAATGCAAAAAGGCATGGAAGAG
GCTCATAGCAGTGTCGAACTTGGAGAACTATGGCAAGATTTCTCTCAAGGTCTGTTCTACTGCCCTGGAGATATAGATAA
CCCGGAAAGTTATCAAAAACTCAAGAATTTGTTAAGCGAATTAGACGAGAAACGAGGTACACGGGGAAACCGGATGTTTT
ACCTCTCCGTCGCCCCTAACTTCTTCCCTGAAGCCATCAGGCAACTAGGGGGAGCAGGAATGCTAGACGACCCCTACAAA
CATCGTCTAGTAATTGAAAAACCCTTTGGTCGAGATTTGGCATCAGCCCAAAGCCTCAATGCAGTTGTGCAGAAGTATTG
CAAAGAAAACCAAGTCTACCGCATTGACCACTACTTGGGTAAAGAAACAGTTCAAAACTTGTTGGTATTCCGCTTCGCCA
ATGCCATTTTTGAACCCTTGTGGAATCGTCACTTTGTTGACCACGTACAAATTACCGTCGCAGAAACCGTAGGCGTGGAA
GACCGAGCTGGTTATTACGAAAAAGCCGGTGCACTGCGGGATATGTTGCAGAACCACTTGATGCAGCTTTATTGCCTCAC
AGCAATGGAAGCACCAAACTCAATGGATGCCGATAGTATCCGTACAGAAAAAGTCAAAGTGTTACAAGCTACCCGTCTAG
CTGATGTACACAACCTGTCACGTTCAGCTATACGTGGACAATACAGCGCTGGCTGGATGAAAGGTCAACAAGTTCCTGGG
TATCGGACAGAACCAGGAGTTGATCCCAATTCCTCCACACCTACTTATGTAGGTATGAAGTTTTTAGTTGACAACTGGCG
TTGGCAAGGTGTTCCTTTTTACCTGCGTACTGGCAAACGGATGCCGAAAAAAGTCAGTGAGATTTCTATCCACTTCCGCG
ATGTACCTTCTCGGATGTTCCAATCAGCCGCGCAACAAAGAAACGCGAACATTTTAGCCATGCGGATTCAGCCAAACGAA
GGTATTTCCTTGCGTTTTGATGTGAAAATGCCAGGAGCAGAATTCCGCACCCGTTCCGTAGATATGGATTTCAGCTATGG
TTCCTTTGGGATTGAAGCTACTTCTGACGCTTACGATCGCCTATTCTTAGATTGTATGATGGGCGACCAAACATTATTCA
CCAGAGCCGACGAAGTAGAAGCAGCTTGGCAAGTAGTCACCCCCGCCCTTTCTGTTTGGGACTTACCCACAGACCCAGCC
ACCATTCCCCAGTACGAAGCCGGAACCTGGGAACCAGCAGAAGCAGAATTTCTGATTAACCAAGATGGTCGTCGCTGGCG
CAGACTTTAA

Upstream 100 bases:

>100_bases
GCAGGGGAGAAAACATTTACCTGATCCCAATCCCCAATCCCCAGTACCCAGTCCCCAGTACCCCACGTCCCAAACCTCCA
TCTAAAATCCCAAAACTGTT

Downstream 100 bases:

>100_bases
TTAGTCATTAGGCATTAGTCATTTGTCATTTGTCCTTGGTCATTAGTCATTAGTCATTAGATTAAGAACAGATGATTACT
TGACAACTGACAACTGACAA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MVSLLENPLRVGLQQQGMPEPQIIVIFGASGDLTWRKLVPALYKLRRERRIPPETTIVGVARREWSHEYFREQMQKGMEE
AHSSVELGELWQDFSQGLFYCPGDIDNPESYQKLKNLLSELDEKRGTRGNRMFYLSVAPNFFPEAIRQLGGAGMLDDPYK
HRLVIEKPFGRDLASAQSLNAVVQKYCKENQVYRIDHYLGKETVQNLLVFRFANAIFEPLWNRHFVDHVQITVAETVGVE
DRAGYYEKAGALRDMLQNHLMQLYCLTAMEAPNSMDADSIRTEKVKVLQATRLADVHNLSRSAIRGQYSAGWMKGQQVPG
YRTEPGVDPNSSTPTYVGMKFLVDNWRWQGVPFYLRTGKRMPKKVSEISIHFRDVPSRMFQSAAQQRNANILAMRIQPNE
GISLRFDVKMPGAEFRTRSVDMDFSYGSFGIEATSDAYDRLFLDCMMGDQTLFTRADEVEAAWQVVTPALSVWDLPTDPA
TIPQYEAGTWEPAEAEFLINQDGRRWRRL

Sequences:

>Translated_509_residues
MVSLLENPLRVGLQQQGMPEPQIIVIFGASGDLTWRKLVPALYKLRRERRIPPETTIVGVARREWSHEYFREQMQKGMEE
AHSSVELGELWQDFSQGLFYCPGDIDNPESYQKLKNLLSELDEKRGTRGNRMFYLSVAPNFFPEAIRQLGGAGMLDDPYK
HRLVIEKPFGRDLASAQSLNAVVQKYCKENQVYRIDHYLGKETVQNLLVFRFANAIFEPLWNRHFVDHVQITVAETVGVE
DRAGYYEKAGALRDMLQNHLMQLYCLTAMEAPNSMDADSIRTEKVKVLQATRLADVHNLSRSAIRGQYSAGWMKGQQVPG
YRTEPGVDPNSSTPTYVGMKFLVDNWRWQGVPFYLRTGKRMPKKVSEISIHFRDVPSRMFQSAAQQRNANILAMRIQPNE
GISLRFDVKMPGAEFRTRSVDMDFSYGSFGIEATSDAYDRLFLDCMMGDQTLFTRADEVEAAWQVVTPALSVWDLPTDPA
TIPQYEAGTWEPAEAEFLINQDGRRWRRL
>Mature_509_residues
MVSLLENPLRVGLQQQGMPEPQIIVIFGASGDLTWRKLVPALYKLRRERRIPPETTIVGVARREWSHEYFREQMQKGMEE
AHSSVELGELWQDFSQGLFYCPGDIDNPESYQKLKNLLSELDEKRGTRGNRMFYLSVAPNFFPEAIRQLGGAGMLDDPYK
HRLVIEKPFGRDLASAQSLNAVVQKYCKENQVYRIDHYLGKETVQNLLVFRFANAIFEPLWNRHFVDHVQITVAETVGVE
DRAGYYEKAGALRDMLQNHLMQLYCLTAMEAPNSMDADSIRTEKVKVLQATRLADVHNLSRSAIRGQYSAGWMKGQQVPG
YRTEPGVDPNSSTPTYVGMKFLVDNWRWQGVPFYLRTGKRMPKKVSEISIHFRDVPSRMFQSAAQQRNANILAMRIQPNE
GISLRFDVKMPGAEFRTRSVDMDFSYGSFGIEATSDAYDRLFLDCMMGDQTLFTRADEVEAAWQVVTPALSVWDLPTDPA
TIPQYEAGTWEPAEAEFLINQDGRRWRRL

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=492, Percent_Identity=37.6016260162602, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI108773793, Length=492, Percent_Identity=37.6016260162602, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI52145310, Length=490, Percent_Identity=29.7959183673469, Blast_Score=166, Evalue=4e-41,
Organism=Escherichia coli, GI1788158, Length=486, Percent_Identity=42.798353909465, Blast_Score=406, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17538218, Length=487, Percent_Identity=37.3716632443532, Blast_Score=333, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6324088, Length=464, Percent_Identity=35.5603448275862, Blast_Score=289, Evalue=6e-79,
Organism=Drosophila melanogaster, GI24643350, Length=481, Percent_Identity=36.3825363825364, Blast_Score=295, Evalue=6e-80,
Organism=Drosophila melanogaster, GI24643352, Length=481, Percent_Identity=36.3825363825364, Blast_Score=294, Evalue=8e-80,
Organism=Drosophila melanogaster, GI221513548, Length=476, Percent_Identity=29.2016806722689, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 58375; Mature: 58375

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSLLENPLRVGLQQQGMPEPQIIVIFGASGDLTWRKLVPALYKLRRERRIPPETTIVGV
CCCHHCCHHHHCHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEH
ARREWSHEYFREQMQKGMEEAHSSVELGELWQDFSQGLFYCPGDIDNPESYQKLKNLLSE
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHH
LDEKRGTRGNRMFYLSVAPNFFPEAIRQLGGAGMLDDPYKHRLVIEKPFGRDLASAQSLN
HHHHHCCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHHH
AVVQKYCKENQVYRIDHYLGKETVQNLLVFRFANAIFEPLWNRHFVDHVQITVAETVGVE
HHHHHHHCCCCEEEHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEEHHCCCC
DRAGYYEKAGALRDMLQNHLMQLYCLTAMEAPNSMDADSIRTEKVKVLQATRLADVHNLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RSAIRGQYSAGWMKGQQVPGYRTEPGVDPNSSTPTYVGMKFLVDNWRWQGVPFYLRTGKR
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEECCCCC
MPKKVSEISIHFRDVPSRMFQSAAQQRNANILAMRIQPNEGISLRFDVKMPGAEFRTRSV
CHHHHHHHEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCCEEEEE
DMDFSYGSFGIEATSDAYDRLFLDCMMGDQTLFTRADEVEAAWQVVTPALSVWDLPTDPA
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCC
TIPQYEAGTWEPAEAEFLINQDGRRWRRL
CCCCCCCCCCCCCCCEEEECCCCHHHHCC
>Mature Secondary Structure
MVSLLENPLRVGLQQQGMPEPQIIVIFGASGDLTWRKLVPALYKLRRERRIPPETTIVGV
CCCHHCCHHHHCHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEH
ARREWSHEYFREQMQKGMEEAHSSVELGELWQDFSQGLFYCPGDIDNPESYQKLKNLLSE
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHH
LDEKRGTRGNRMFYLSVAPNFFPEAIRQLGGAGMLDDPYKHRLVIEKPFGRDLASAQSLN
HHHHHCCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCHHHHHHHH
AVVQKYCKENQVYRIDHYLGKETVQNLLVFRFANAIFEPLWNRHFVDHVQITVAETVGVE
HHHHHHHCCCCEEEHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEEHHCCCC
DRAGYYEKAGALRDMLQNHLMQLYCLTAMEAPNSMDADSIRTEKVKVLQATRLADVHNLS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
RSAIRGQYSAGWMKGQQVPGYRTEPGVDPNSSTPTYVGMKFLVDNWRWQGVPFYLRTGKR
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCEEECCCCC
MPKKVSEISIHFRDVPSRMFQSAAQQRNANILAMRIQPNEGISLRFDVKMPGAEFRTRSV
CHHHHHHHEEEHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEECCCCCCEEEEE
DMDFSYGSFGIEATSDAYDRLFLDCMMGDQTLFTRADEVEAAWQVVTPALSVWDLPTDPA
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCC
TIPQYEAGTWEPAEAEFLINQDGRRWRRL
CCCCCCCCCCCCCCCEEEECCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7870816 [H]