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The map label for this gene is fbp

Identifier: 75907901

GI number: 75907901

Start: 2107031

End: 2108080

Strand: Direct

Name: fbp

Synonym: Ava_1680

Alternate gene names: 75907901

Gene position: 2107031-2108080 (Clockwise)

Preceding gene: 75907900

Following gene: 75907902

Centisome position: 33.1

GC content: 45.05

Gene sequence:

>1050_bases
ATGGCTAAAGCCTCAGAATCCTTGGATTTGTCTGTCAACGAGTCTACAGACAAAGCTCTAGACCGCGACTGTACAACCTT
ATCCCGTCACGTCCTCCAACAACTCCAAAGTTTTTCCGCAGATGCACAAGATTTAAGTGCGCTGATGAACCGGATTGCTT
TAGCTGGTAAATTAGTTGCCCGTCGCCTTAGCCGCGCTGGTTTAATGGAAGGGGTTCTCGGATTTACTGGGGAGGTGAAC
GTACAAGGGGAATCCGTCAAAAAGATGGATGTCTATGCCAATGACGTGTTTATCTCCGTTTTTAAGCAAAGCGGCTTAGT
TTGTCGTCTTGCATCTGAGGAAATGGATGAACCATACTACATTCCCGAAAATTGCCCCGTAGGTCGTTATACCTTACTGT
ACGACCCCATAGATGGTTCCTCAAACACAGATACCAATCTCAGTTTGGGTTCCATTTTCTCCATCCGTCAACAGGAAGGT
GATGATAGTGATGGTCAGGCTAAAGACCTCCTCACCAATGGACGCAAGCAAATTGCGGCGGGTTACATTTTATATGGGCC
TAGCACGATGCTAGTTTATACAATGGGTAAGGGAGTTCACTCATTTACCCTTGACCCCAGTTTAGGAGAATTCATCCTCA
GTGAAGAAAATATCCGCATTCCCGACCACGGCGCAGTTTACAGCGTGAATGAAGGTAACTTCTGGCAATGGGAAGAATCA
ATGCGGGAATATATCCGCTATGTTCACCGTACAGAAGGCTACACTGCTCGTTATAGTGGTGCGATGGTGAGTGATATCCA
TAGAATCTTGGTACAAGGTGGTGTGTTTCTCTACCCAGGGACAGTTCAAAACCCTGAAGGTAAATTACGGTTGTTGTATG
AATCTGCTCCCCTAGCCTTTTTAATTCAACAAGCTGGTGGTCGGGCAACTACGGGATTAGTAGATATCTTAGATGTTGTA
CCGAAAAAACTACATCAACGTACACCTCTGATTATTGGCAGTAAAGAAGACGTAGCCAAGGTTGAATCATTTATTCAGAA
TGGTCATTAA

Upstream 100 bases:

>100_bases
CATCTAGGTTATCAAATTACCTTTCTAAGATAGAAGCAGCAACTATGTGTTGCCGCGCAAACTTGATCCAACTAACAGCA
GTCACAAGAAAGTACATAAC

Downstream 100 bases:

>100_bases
GAGCCAGGGAGTAGGGAGCAGAGGAATAAATTTTTACTCATAACTCAGCACTCAGCACTTTCTCAGCTAAATGTGAGAGA
TTATCTCAGCTGGCCGATGT

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MAKASESLDLSVNESTDKALDRDCTTLSRHVLQQLQSFSADAQDLSALMNRIALAGKLVARRLSRAGLMEGVLGFTGEVN
VQGESVKKMDVYANDVFISVFKQSGLVCRLASEEMDEPYYIPENCPVGRYTLLYDPIDGSSNTDTNLSLGSIFSIRQQEG
DDSDGQAKDLLTNGRKQIAAGYILYGPSTMLVYTMGKGVHSFTLDPSLGEFILSEENIRIPDHGAVYSVNEGNFWQWEES
MREYIRYVHRTEGYTARYSGAMVSDIHRILVQGGVFLYPGTVQNPEGKLRLLYESAPLAFLIQQAGGRATTGLVDILDVV
PKKLHQRTPLIIGSKEDVAKVESFIQNGH

Sequences:

>Translated_349_residues
MAKASESLDLSVNESTDKALDRDCTTLSRHVLQQLQSFSADAQDLSALMNRIALAGKLVARRLSRAGLMEGVLGFTGEVN
VQGESVKKMDVYANDVFISVFKQSGLVCRLASEEMDEPYYIPENCPVGRYTLLYDPIDGSSNTDTNLSLGSIFSIRQQEG
DDSDGQAKDLLTNGRKQIAAGYILYGPSTMLVYTMGKGVHSFTLDPSLGEFILSEENIRIPDHGAVYSVNEGNFWQWEES
MREYIRYVHRTEGYTARYSGAMVSDIHRILVQGGVFLYPGTVQNPEGKLRLLYESAPLAFLIQQAGGRATTGLVDILDVV
PKKLHQRTPLIIGSKEDVAKVESFIQNGH
>Mature_348_residues
AKASESLDLSVNESTDKALDRDCTTLSRHVLQQLQSFSADAQDLSALMNRIALAGKLVARRLSRAGLMEGVLGFTGEVNV
QGESVKKMDVYANDVFISVFKQSGLVCRLASEEMDEPYYIPENCPVGRYTLLYDPIDGSSNTDTNLSLGSIFSIRQQEGD
DSDGQAKDLLTNGRKQIAAGYILYGPSTMLVYTMGKGVHSFTLDPSLGEFILSEENIRIPDHGAVYSVNEGNFWQWEESM
REYIRYVHRTEGYTARYSGAMVSDIHRILVQGGVFLYPGTVQNPEGKLRLLYESAPLAFLIQQAGGRATTGLVDILDVVP
KKLHQRTPLIIGSKEDVAKVESFIQNGH

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family

Homologues:

Organism=Homo sapiens, GI189083692, Length=323, Percent_Identity=42.7244582043344, Blast_Score=255, Evalue=4e-68,
Organism=Homo sapiens, GI16579888, Length=323, Percent_Identity=42.7244582043344, Blast_Score=255, Evalue=4e-68,
Organism=Homo sapiens, GI22907028, Length=339, Percent_Identity=41.5929203539823, Blast_Score=255, Evalue=4e-68,
Organism=Escherichia coli, GI1790679, Length=327, Percent_Identity=44.6483180428135, Blast_Score=296, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17508131, Length=337, Percent_Identity=44.5103857566766, Blast_Score=291, Evalue=5e-79,
Organism=Saccharomyces cerevisiae, GI6323409, Length=330, Percent_Identity=40.6060606060606, Blast_Score=259, Evalue=7e-70,
Organism=Drosophila melanogaster, GI45550998, Length=331, Percent_Identity=44.1087613293051, Blast_Score=289, Evalue=2e-78,
Organism=Drosophila melanogaster, GI19921562, Length=331, Percent_Identity=44.1087613293051, Blast_Score=288, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): F16PA_ANAVT (Q3MCI4)

Other databases:

- EMBL:   CP000117
- RefSeq:   YP_322197.1
- HSSP:   P0A993
- ProteinModelPortal:   Q3MCI4
- SMR:   Q3MCI4
- STRING:   Q3MCI4
- GeneID:   3682236
- GenomeReviews:   CP000117_GR
- KEGG:   ava:Ava_1680
- NMPDR:   fig|240292.3.peg.2760
- eggNOG:   COG0158
- HOGENOM:   HBG731261
- OMA:   YSINEGS
- PhylomeDB:   Q3MCI4
- ProtClustDB:   PRK09293
- BioCyc:   AVAR240292:AVA_1680-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01855
- InterPro:   IPR000146
- InterPro:   IPR020548
- PANTHER:   PTHR11556
- PRINTS:   PR00115

Pfam domain/function: PF00316 FBPase

EC number: =3.1.3.11

Molecular weight: Translated: 38518; Mature: 38387

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00124 FBPASE

Important sites: BINDING 230-230 BINDING 258-258 BINDING 288-288

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKASESLDLSVNESTDKALDRDCTTLSRHVLQQLQSFSADAQDLSALMNRIALAGKLVA
CCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RRLSRAGLMEGVLGFTGEVNVQGESVKKMDVYANDVFISVFKQSGLVCRLASEEMDEPYY
HHHHHHHHHHHHHCCCCEEEECCCCEEEEEHHHHHHHHEEHHHCCCEEEECCCCCCCCEE
IPENCPVGRYTLLYDPIDGSSNTDTNLSLGSIFSIRQQEGDDSDGQAKDLLTNGRKQIAA
CCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHC
GYILYGPSTMLVYTMGKGVHSFTLDPSLGEFILSEENIRIPDHGAVYSVNEGNFWQWEES
CEEEECCCEEEEEEECCCCEEEEECCCHHHHHCCCCCEECCCCCCEEEECCCCCCHHHHH
MREYIRYVHRTEGYTARYSGAMVSDIHRILVQGGVFLYPGTVQNPEGKLRLLYESAPLAF
HHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCHHH
LIQQAGGRATTGLVDILDVVPKKLHQRTPLIIGSKEDVAKVESFIQNGH
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKASESLDLSVNESTDKALDRDCTTLSRHVLQQLQSFSADAQDLSALMNRIALAGKLVA
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RRLSRAGLMEGVLGFTGEVNVQGESVKKMDVYANDVFISVFKQSGLVCRLASEEMDEPYY
HHHHHHHHHHHHHCCCCEEEECCCCEEEEEHHHHHHHHEEHHHCCCEEEECCCCCCCCEE
IPENCPVGRYTLLYDPIDGSSNTDTNLSLGSIFSIRQQEGDDSDGQAKDLLTNGRKQIAA
CCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHC
GYILYGPSTMLVYTMGKGVHSFTLDPSLGEFILSEENIRIPDHGAVYSVNEGNFWQWEES
CEEEECCCEEEEEEECCCCEEEEECCCHHHHHCCCCCEECCCCCCEEEECCCCCCHHHHH
MREYIRYVHRTEGYTARYSGAMVSDIHRILVQGGVFLYPGTVQNPEGKLRLLYESAPLAF
HHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCHHH
LIQQAGGRATTGLVDILDVVPKKLHQRTPLIIGSKEDVAKVESFIQNGH
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA