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The map label for this gene is hisB [H]

Identifier: 161567475

GI number: 161567475

Start: 4098424

End: 4099053

Strand: Direct

Name: hisB [H]

Synonym: Ava_3285

Alternate gene names: 161567475

Gene position: 4098424-4099053 (Clockwise)

Preceding gene: 75909491

Following gene: 75909493

Centisome position: 64.38

GC content: 44.44

Gene sequence:

>630_bases
ATGCAAATCAGCGATTATCCCCAACTTAACTTATCCTCAGTCCCTCGGATTGCTTCAGTACATCGCATAACTGGGGAAAC
GAATGTGCAGGTTACTGTCAATTTGGATGGTACGGGAATTTGTACAGCAGCTACTGGCATTCCCTTTTTAGATCATATGT
TGCATCAGATTTCCTCCCACGGCTTGATTGATTTGGATGTCCAAGCCAAAGGAGATTGGGAAATTGATGACCACCACACA
AATGAAGATGTGGGTATTACTTTAGGTCAAGCTTTGGCTAAGGCATTAGGCGATAGAAAAGGTATAGTCCGCTTTGGTAA
TTTCCTCGCACCTTTAGACGAAGCTTTAGTACAGGTAGCACTAGATTTTTCTGGTCGTCCTCACCTCAGCTACGGCTTAC
AAATTCCTACCGAACGTGTGGGAACTTATGACACCCAATTAGTTAGAGAATTTTTTGTGGCATTAGTCAACCATAGCCAA
ATGACTCTGCACATTCGCCAATTAGATGGCATTAATTCCCATCACATTATTGAGGCGACCTTCAAAGCCTTTGCCAGAGC
AGCCAGAATGGCTATAGAAGCCGATCCTCGCCGCGCTGGGACGATTCCTAGTTCTAAGGGGGTTTTGTAA

Upstream 100 bases:

>100_bases
GAGGAACAAACAAGGTGGAAAAAGAATGATTTTTTCACCACTTTTTCCTTATATGCCCAGTCCCCAATCCCCGATCCCCA
ATCCCCAATCCCTAGTCCCT

Downstream 100 bases:

>100_bases
GAAGTAGGGGGCAGGGGAAGCAGGGGGGCAGGGGGCAAGGGGGAGAAATCCCCAGTCACCAGTCACCAATCCCCAATCCG
CAATGCCCAGTCCCCAAAAT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MQISDYPQLNLSSVPRIASVHRITGETNVQVTVNLDGTGICTAATGIPFLDHMLHQISSHGLIDLDVQAKGDWEIDDHHT
NEDVGITLGQALAKALGDRKGIVRFGNFLAPLDEALVQVALDFSGRPHLSYGLQIPTERVGTYDTQLVREFFVALVNHSQ
MTLHIRQLDGINSHHIIEATFKAFARAARMAIEADPRRAGTIPSSKGVL

Sequences:

>Translated_209_residues
MQISDYPQLNLSSVPRIASVHRITGETNVQVTVNLDGTGICTAATGIPFLDHMLHQISSHGLIDLDVQAKGDWEIDDHHT
NEDVGITLGQALAKALGDRKGIVRFGNFLAPLDEALVQVALDFSGRPHLSYGLQIPTERVGTYDTQLVREFFVALVNHSQ
MTLHIRQLDGINSHHIIEATFKAFARAARMAIEADPRRAGTIPSSKGVL
>Mature_209_residues
MQISDYPQLNLSSVPRIASVHRITGETNVQVTVNLDGTGICTAATGIPFLDHMLHQISSHGLIDLDVQAKGDWEIDDHHT
NEDVGITLGQALAKALGDRKGIVRFGNFLAPLDEALVQVALDFSGRPHLSYGLQIPTERVGTYDTQLVREFFVALVNHSQ
MTLHIRQLDGINSHHIIEATFKAFARAARMAIEADPRRAGTIPSSKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=207, Percent_Identity=46.3768115942029, Blast_Score=177, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6324776, Length=216, Percent_Identity=39.3518518518519, Blast_Score=150, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 22835; Mature: 22835

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQISDYPQLNLSSVPRIASVHRITGETNVQVTVNLDGTGICTAATGIPFLDHMLHQISSH
CCCCCCCCCCCCCCCCHHHHHEECCCCCEEEEEEECCCEEEEHHCCCHHHHHHHHHHHCC
GLIDLDVQAKGDWEIDDHHTNEDVGITLGQALAKALGDRKGIVRFGNFLAPLDEALVQVA
CEEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LDFSGRPHLSYGLQIPTERVGTYDTQLVREFFVALVNHSQMTLHIRQLDGINSHHIIEAT
HCCCCCCCEEECCCCCHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHH
FKAFARAARMAIEADPRRAGTIPSSKGVL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQISDYPQLNLSSVPRIASVHRITGETNVQVTVNLDGTGICTAATGIPFLDHMLHQISSH
CCCCCCCCCCCCCCCCHHHHHEECCCCCEEEEEEECCCEEEEHHCCCHHHHHHHHHHHCC
GLIDLDVQAKGDWEIDDHHTNEDVGITLGQALAKALGDRKGIVRFGNFLAPLDEALVQVA
CEEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LDFSGRPHLSYGLQIPTERVGTYDTQLVREFFVALVNHSQMTLHIRQLDGINSHHIIEAT
HCCCCCCCEEECCCCCHHHCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHH
FKAFARAARMAIEADPRRAGTIPSSKGVL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8391534; 11759840 [H]