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The map label for this gene is mutA [H]

Identifier: 75676421

GI number: 75676421

Start: 2430469

End: 2432388

Strand: Direct

Name: mutA [H]

Synonym: Nwi_2236

Alternate gene names: 75676421

Gene position: 2430469-2432388 (Clockwise)

Preceding gene: 75676420

Following gene: 75676422

Centisome position: 71.44

GC content: 66.93

Gene sequence:

>1920_bases
ATGCCCGCTGCTCCCCATGAACCCATCGATCCGCCGTTGGCAGCCGATTTCGCACCGGCGCTCGCGGCCGACTGGCGCAA
GCTGGTCGATGGCGTGCTGAAGGGCGCGCCCTTCGAGAGGCTGGTGGGAAAGACCTATGACGGTCTCCGGATCGAACCGA
TCTACACGCGCGCGGAAGGTGCCCCCCCGATCGCCGGCCGCGCCGCGGCCACGCCATGGCGGATCATGCAGCGGATCGAT
CATCCCGAGCCCGCGCAGGCCAACGCGCAGGCGCTGCACGACCTCGATAACGGCGCCGGCGGCCTGACCCTGGTGTTCGC
GGGGGCCAACGGCGCGCGCGGTTTCGGGCTGCCGCCGACCGCCAAGGCTGTCGCCAGAGTGCTGGACGGCGTCTTTCTCG
ATGCAGGCATCACCATCGAGTTGCACATCGCCCCGCAATCGCTCGGGGTCGCTTTCCAGATCGCAGACCACATCAGGACA
AAAGGAATAGACCCGGCCGCCTGCGATATCCATTTCGGTCTCGATCCGCTCGGTGCCTGCGCGACATCCGGATCCAGCAC
CAACGAATGGGCTGAGATCGTTGCGGCCGCGACGGAGACCGCGAAGACGCTCGCCGCCCGAGGCTTCAAGGGGCCGTTCC
TTGTCGCCGACGGCCGCGTGATCCACGACGCCGGCGGATCGGAGGCTCAGGAACTCGCCTTCGTCCTTGCGTCGGCGGTC
ACATATCTCCGCGCGCTCGAAAGCGCCGGCGTCGTTCTCGATGACGCGCGCGGCATGATCCACGCGCGGCTCAGCACTGA
TGCCGACCAGTTCCTGACGCTGGCCAAATTCCGCGCTCTGCGGCTGTTGTGGGCACGGGTCGAGCAGGCCTGCGGCCTCG
CGCCGAGGCCATTGCTGATTGCCGCCGAGACCTCGTGGCGGATGCTGACCCGGCGCGATCCCTACATGAATATGCTGCGC
GCCACCGTCGCGGCATTCTCGGCGGGCCTCGGCGGCGCTGACAGCGTCTGCGTGCTTCCGCATACGCAGGCATTGGGCCT
GCCGGACGGCTTCGCGCGACGCATGGCGCGAAACACGCAGCTCATCCTGCTGGAGGAAGCCAACCTCGCCAAAGTCGCGG
ATCCGGCGGCAGGCTCTGGTGGCATCGAGACCTTGACGCGCGAGCTTTGTCAAAAGAGCTGGGCGCTGTTTCAGGATACC
GAGAGAGCGGGTGGAGCGTTCGCCGCGCTCGAACAGAACCTGATCCAGCGCGGCGTCGCCGCGACGCGCGACGCGCGCCA
GACCAGTGTCGCCAAACGGCGCGACGTGCTCACCGGCATCAGCGAATTTCCCGACCTGCACGAAACGCCGATCGACGTGC
TCGATGTGGAGCCTGTCACGCTCGCGCCCTCCGGCGAGGCAAAAATCAGCTTCGAGGCGCTGACGCCGATACGGCTGGCC
GCCCCCTTCGAACAACTGCGCGATCATTCCGACGATTGGCTCAAGGCCACCGGCGCGCGGCCGAAGATCCTGCTCGCCAC
TCTCGGCGTCCCTGCCGGCTTCGCCGCGCGCGCGGCCTTTGCCAGAAGTTTTTTCGAGGCCGGCGGCATCGAGGCCGTCG
ATCCGCCCTCCCCCCGCTCGCGGCAGGGAGATGTCGAAGGCGCCGCTCGGCGAGAAGATGAAAACGCGCTCGCCGAAGCC
TTCAAGGCATCCGGCGCTCGAATGGTCTGCCTTTGCTCCTCGGATGAGGTCTATGCCGAACAGGCGGTGCTTGCAGCGCG
GGCCTTTCATGCCGCCGGTGCAGGCCATATCTATCTGGCGGGACGACCGAATGAACTGGAACCTGTGTTGCGCCAGGCAG
GCGTGCGCGATTTCATCTTCGCGGGGAACGATGCGTTGGCGGTGCTGAACGAGGTCTGGCAGCGACTGGAGCAACCATGA

Upstream 100 bases:

>100_bases
GCCTCCCCGACCTTCCCTGATCGCGCGCAAACGACCGTTTGGCTTGTCCGCCGCTGCGTGGCATTTTGAGAATCCGGATT
CTGCCGGACACGAGCGAACA

Downstream 100 bases:

>100_bases
CAGAGCAGATGAGCCCGTCGCTGACCGGCGGATGCCAATGCGGCGCCATTCGTTTCGCGCTGACGGCCCCGCCGGTGCGC
ATCAGCATCTGCCACTGCCG

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM-beta [H]

Number of amino acids: Translated: 639; Mature: 638

Protein sequence:

>639_residues
MPAAPHEPIDPPLAADFAPALAADWRKLVDGVLKGAPFERLVGKTYDGLRIEPIYTRAEGAPPIAGRAAATPWRIMQRID
HPEPAQANAQALHDLDNGAGGLTLVFAGANGARGFGLPPTAKAVARVLDGVFLDAGITIELHIAPQSLGVAFQIADHIRT
KGIDPAACDIHFGLDPLGACATSGSSTNEWAEIVAAATETAKTLAARGFKGPFLVADGRVIHDAGGSEAQELAFVLASAV
TYLRALESAGVVLDDARGMIHARLSTDADQFLTLAKFRALRLLWARVEQACGLAPRPLLIAAETSWRMLTRRDPYMNMLR
ATVAAFSAGLGGADSVCVLPHTQALGLPDGFARRMARNTQLILLEEANLAKVADPAAGSGGIETLTRELCQKSWALFQDT
ERAGGAFAALEQNLIQRGVAATRDARQTSVAKRRDVLTGISEFPDLHETPIDVLDVEPVTLAPSGEAKISFEALTPIRLA
APFEQLRDHSDDWLKATGARPKILLATLGVPAGFAARAAFARSFFEAGGIEAVDPPSPRSRQGDVEGAARREDENALAEA
FKASGARMVCLCSSDEVYAEQAVLAARAFHAAGAGHIYLAGRPNELEPVLRQAGVRDFIFAGNDALAVLNEVWQRLEQP

Sequences:

>Translated_639_residues
MPAAPHEPIDPPLAADFAPALAADWRKLVDGVLKGAPFERLVGKTYDGLRIEPIYTRAEGAPPIAGRAAATPWRIMQRID
HPEPAQANAQALHDLDNGAGGLTLVFAGANGARGFGLPPTAKAVARVLDGVFLDAGITIELHIAPQSLGVAFQIADHIRT
KGIDPAACDIHFGLDPLGACATSGSSTNEWAEIVAAATETAKTLAARGFKGPFLVADGRVIHDAGGSEAQELAFVLASAV
TYLRALESAGVVLDDARGMIHARLSTDADQFLTLAKFRALRLLWARVEQACGLAPRPLLIAAETSWRMLTRRDPYMNMLR
ATVAAFSAGLGGADSVCVLPHTQALGLPDGFARRMARNTQLILLEEANLAKVADPAAGSGGIETLTRELCQKSWALFQDT
ERAGGAFAALEQNLIQRGVAATRDARQTSVAKRRDVLTGISEFPDLHETPIDVLDVEPVTLAPSGEAKISFEALTPIRLA
APFEQLRDHSDDWLKATGARPKILLATLGVPAGFAARAAFARSFFEAGGIEAVDPPSPRSRQGDVEGAARREDENALAEA
FKASGARMVCLCSSDEVYAEQAVLAARAFHAAGAGHIYLAGRPNELEPVLRQAGVRDFIFAGNDALAVLNEVWQRLEQP
>Mature_638_residues
PAAPHEPIDPPLAADFAPALAADWRKLVDGVLKGAPFERLVGKTYDGLRIEPIYTRAEGAPPIAGRAAATPWRIMQRIDH
PEPAQANAQALHDLDNGAGGLTLVFAGANGARGFGLPPTAKAVARVLDGVFLDAGITIELHIAPQSLGVAFQIADHIRTK
GIDPAACDIHFGLDPLGACATSGSSTNEWAEIVAAATETAKTLAARGFKGPFLVADGRVIHDAGGSEAQELAFVLASAVT
YLRALESAGVVLDDARGMIHARLSTDADQFLTLAKFRALRLLWARVEQACGLAPRPLLIAAETSWRMLTRRDPYMNMLRA
TVAAFSAGLGGADSVCVLPHTQALGLPDGFARRMARNTQLILLEEANLAKVADPAAGSGGIETLTRELCQKSWALFQDTE
RAGGAFAALEQNLIQRGVAATRDARQTSVAKRRDVLTGISEFPDLHETPIDVLDVEPVTLAPSGEAKISFEALTPIRLAA
PFEQLRDHSDDWLKATGARPKILLATLGVPAGFAARAAFARSFFEAGGIEAVDPPSPRSRQGDVEGAARREDENALAEAF
KASGARMVCLCSSDEVYAEQAVLAARAFHAAGAGHIYLAGRPNELEPVLRQAGVRDFIFAGNDALAVLNEVWQRLEQP

Specific function: Catalyzes the isomerization of succinyl-CoA to methylmalonyl-CoA during synthesis of propionate from tricarboxylic acid-cycle intermediates. This conversion most likely represents an important source of building blocks for polyketide antibiotic biosynthes

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methylmalonyl-CoA mutase family [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=478, Percent_Identity=26.1506276150628, Blast_Score=119, Evalue=1e-26,
Organism=Escherichia coli, GI1789284, Length=485, Percent_Identity=27.8350515463918, Blast_Score=158, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI25144500, Length=257, Percent_Identity=28.7937743190661, Blast_Score=128, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR004608 [H]

Pfam domain/function: PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 67731; Mature: 67599

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAAPHEPIDPPLAADFAPALAADWRKLVDGVLKGAPFERLVGKTYDGLRIEPIYTRAEG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEEEEECCCC
APPIAGRAAATPWRIMQRIDHPEPAQANAQALHDLDNGAGGLTLVFAGANGARGFGLPPT
CCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHH
AKAVARVLDGVFLDAGITIELHIAPQSLGVAFQIADHIRTKGIDPAACDIHFGLDPLGAC
HHHHHHHHCCCEECCCCEEEEEECCHHHCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHH
ATSGSSTNEWAEIVAAATETAKTLAARGFKGPFLVADGRVIHDAGGSEAQELAFVLASAV
HCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCHHHHHHHHHHHHH
TYLRALESAGVVLDDARGMIHARLSTDADQFLTLAKFRALRLLWARVEQACGLAPRPLLI
HHHHHHHHCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
AAETSWRMLTRRDPYMNMLRATVAAFSAGLGGADSVCVLPHTQALGLPDGFARRMARNTQ
EECCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHCCCE
LILLEEANLAKVADPAAGSGGIETLTRELCQKSWALFQDTERAGGAFAALEQNLIQRGVA
EEEEECCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ATRDARQTSVAKRRDVLTGISEFPDLHETPIDVLDVEPVTLAPSGEAKISFEALTPIRLA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCEEECCCCCCEEEEEECCCCHHH
APFEQLRDHSDDWLKATGARPKILLATLGVPAGFAARAAFARSFFEAGGIEAVDPPSPRS
CCHHHHHCCCCCHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
RQGDVEGAARREDENALAEAFKASGARMVCLCSSDEVYAEQAVLAARAFHAAGAGHIYLA
CCCCCCCHHHCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEC
GRPNELEPVLRQAGVRDFIFAGNDALAVLNEVWQRLEQP
CCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PAAPHEPIDPPLAADFAPALAADWRKLVDGVLKGAPFERLVGKTYDGLRIEPIYTRAEG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEEEEEEEECCCC
APPIAGRAAATPWRIMQRIDHPEPAQANAQALHDLDNGAGGLTLVFAGANGARGFGLPPT
CCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCHH
AKAVARVLDGVFLDAGITIELHIAPQSLGVAFQIADHIRTKGIDPAACDIHFGLDPLGAC
HHHHHHHHCCCEECCCCEEEEEECCHHHCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHH
ATSGSSTNEWAEIVAAATETAKTLAARGFKGPFLVADGRVIHDAGGSEAQELAFVLASAV
HCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCEEEECCCCCHHHHHHHHHHHHH
TYLRALESAGVVLDDARGMIHARLSTDADQFLTLAKFRALRLLWARVEQACGLAPRPLLI
HHHHHHHHCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
AAETSWRMLTRRDPYMNMLRATVAAFSAGLGGADSVCVLPHTQALGLPDGFARRMARNTQ
EECCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHCCCE
LILLEEANLAKVADPAAGSGGIETLTRELCQKSWALFQDTERAGGAFAALEQNLIQRGVA
EEEEECCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ATRDARQTSVAKRRDVLTGISEFPDLHETPIDVLDVEPVTLAPSGEAKISFEALTPIRLA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCEEECCCCCCEEEEEECCCCHHH
APFEQLRDHSDDWLKATGARPKILLATLGVPAGFAARAAFARSFFEAGGIEAVDPPSPRS
CCHHHHHCCCCCHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
RQGDVEGAARREDENALAEAFKASGARMVCLCSSDEVYAEQAVLAARAFHAAGAGHIYLA
CCCCCCCHHHCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEC
GRPNELEPVLRQAGVRDFIFAGNDALAVLNEVWQRLEQP
CCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8099072 [H]