Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 75676031

GI number: 75676031

Start: 2014016

End: 2015230

Strand: Direct

Name: moeA [H]

Synonym: Nwi_1840

Alternate gene names: 75676031

Gene position: 2014016-2015230 (Clockwise)

Preceding gene: 75676030

Following gene: 75676032

Centisome position: 59.2

GC content: 68.07

Gene sequence:

>1215_bases
ATGGCCCTGATGGCGGTCGCCGATGCCCTTGCGGCTGTTCTTGACGGAGTCGAACCACTCCCGGAGGAAACAGCGGCTCT
CGAAGCGGCGCATCGCCGGGTGCTGGCGCGCGATCTGCCCTCGCGCCGGACCCAGCCACCGGTCGCAATGTCGGCGATGG
ACGGCTATGCCGTGCGCGCCGCGGACATCGCGACAATTCCCTCACGTCTTCGCGTGATCGGCGAAAGCGCCGCGGGTCGG
CCGCTCGATCGCGCGCTGCGTGCGGGCGAGGCCTTGCGGATCTTTACCGGAGGGGTGGTGCCGGACGGCGCCGACACCGT
CGTCATTCAGGAAGACACGGACCGCGACGGCGACCACGTCATCGTCAAGGAGGCCACGGCTTCCGGCAAGAACATCCGTC
CCGCAGGGGTGGATTTTCGCGAAGGCGACGTCCTCATCCGAGCGCGCACGCGCCTCACCGACCGCCATCTCTCGCTTGCC
GCCGGCATGAACTATCCGGACCTGCCGGTGCACCGCCGTCCCACCATCGCCATGCTCGCCACCGGCGACGAACTGGTCTT
GCCGGGCGCGACGCCCGGTCCCGGCCAGATCATCTTGTCCAACGGATACGCGCTTCGCGCCCTCGCCCGAGGTGAAGGCG
CCGAGGCGATCGACCTCGGCCTGGCCGCCGACACCATGGACGCCACGACGGCCGCCATCCGCCGCGCCCGCGACAGCGGC
GCCGATATCCTCGTCACCACCGGCGGCGCATCGGTCGGCGACCATGATTTCATCAAGCGCGCGCTTGAGGCGGAAGGCGT
GGAGATGACGTTCTGGCGAATCGCGATGCGGCCCGGCAAGCCGATGATGTATGGCCGGCTCGGCGCGATGCGGGTGATCG
GCCTCCCCGGCAATCCCGTCTCGGCCTACATCTGCGCGTTCCTGTTCATGGTGCCGCTGATCCGCGCGCTATCGGGACGT
GTAGACGTGCACCACCGTGTTGAACCGGCGCTGCTCGGAGGCGATGTCGCCGCCAATCAGGCCAGGCAGGATTATCTGCG
CGCGCGACTCACGTACTCAACGGACGGCCTGCCGATCGCAACGCCGGTTACGCATCAGGACAGTTCGCTGATGGGAAATC
TTGCCGCGGCGGATGCACTCGTGGTCCGCGCGCCATTCGCGCCGGCCGCCAGCAAAGGCGCGCCCTGTACCGTCATCAAG
CTCTCCCTGTCATAA

Upstream 100 bases:

>100_bases
GATTGAATCAGAAGCGAAGTTCCAGATTATTGTTTTGGCGCGTTTTCTTCACGCGAACCGGTTTCCACTTCGCTCGAAAA
CGCTATAGGAGAATATGGTC

Downstream 100 bases:

>100_bases
AGTCTCGCGTTGTTGACCTTAAATTAAGGGTTGCGGAACACATATCGAACATATAGTGTATGTTCATGATTTGTTTCGAG
TTCTCGTGCCGCGGAGTTGG

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MALMAVADALAAVLDGVEPLPEETAALEAAHRRVLARDLPSRRTQPPVAMSAMDGYAVRAADIATIPSRLRVIGESAAGR
PLDRALRAGEALRIFTGGVVPDGADTVVIQEDTDRDGDHVIVKEATASGKNIRPAGVDFREGDVLIRARTRLTDRHLSLA
AGMNYPDLPVHRRPTIAMLATGDELVLPGATPGPGQIILSNGYALRALARGEGAEAIDLGLAADTMDATTAAIRRARDSG
ADILVTTGGASVGDHDFIKRALEAEGVEMTFWRIAMRPGKPMMYGRLGAMRVIGLPGNPVSAYICAFLFMVPLIRALSGR
VDVHHRVEPALLGGDVAANQARQDYLRARLTYSTDGLPIATPVTHQDSSLMGNLAAADALVVRAPFAPAASKGAPCTVIK
LSLS

Sequences:

>Translated_404_residues
MALMAVADALAAVLDGVEPLPEETAALEAAHRRVLARDLPSRRTQPPVAMSAMDGYAVRAADIATIPSRLRVIGESAAGR
PLDRALRAGEALRIFTGGVVPDGADTVVIQEDTDRDGDHVIVKEATASGKNIRPAGVDFREGDVLIRARTRLTDRHLSLA
AGMNYPDLPVHRRPTIAMLATGDELVLPGATPGPGQIILSNGYALRALARGEGAEAIDLGLAADTMDATTAAIRRARDSG
ADILVTTGGASVGDHDFIKRALEAEGVEMTFWRIAMRPGKPMMYGRLGAMRVIGLPGNPVSAYICAFLFMVPLIRALSGR
VDVHHRVEPALLGGDVAANQARQDYLRARLTYSTDGLPIATPVTHQDSSLMGNLAAADALVVRAPFAPAASKGAPCTVIK
LSLS
>Mature_403_residues
ALMAVADALAAVLDGVEPLPEETAALEAAHRRVLARDLPSRRTQPPVAMSAMDGYAVRAADIATIPSRLRVIGESAAGRP
LDRALRAGEALRIFTGGVVPDGADTVVIQEDTDRDGDHVIVKEATASGKNIRPAGVDFREGDVLIRARTRLTDRHLSLAA
GMNYPDLPVHRRPTIAMLATGDELVLPGATPGPGQIILSNGYALRALARGEGAEAIDLGLAADTMDATTAAIRRARDSGA
DILVTTGGASVGDHDFIKRALEAEGVEMTFWRIAMRPGKPMMYGRLGAMRVIGLPGNPVSAYICAFLFMVPLIRALSGRV
DVHHRVEPALLGGDVAANQARQDYLRARLTYSTDGLPIATPVTHQDSSLMGNLAAADALVVRAPFAPAASKGAPCTVIKL
SLS

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=397, Percent_Identity=32.9974811083123, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI10880983, Length=397, Percent_Identity=32.9974811083123, Blast_Score=179, Evalue=3e-45,
Organism=Escherichia coli, GI1787049, Length=385, Percent_Identity=38.4415584415584, Blast_Score=223, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI25147659, Length=366, Percent_Identity=33.6065573770492, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17562606, Length=341, Percent_Identity=28.1524926686217, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI17136978, Length=391, Percent_Identity=28.6445012787724, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24638841, Length=391, Percent_Identity=28.6445012787724, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42486; Mature: 42355

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALMAVADALAAVLDGVEPLPEETAALEAAHRRVLARDLPSRRTQPPVAMSAMDGYAVRA
CHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEE
ADIATIPSRLRVIGESAAGRPLDRALRAGEALRIFTGGVVPDGADTVVIQEDTDRDGDHV
HHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCCCCCEE
IVKEATASGKNIRPAGVDFREGDVLIRARTRLTDRHLSLAAGMNYPDLPVHRRPTIAMLA
EEEECCCCCCCCCCCCCCCCCCCEEEEEECHHCHHHHHHCCCCCCCCCCCCCCCCEEEEE
TGDELVLPGATPGPGQIILSNGYALRALARGEGAEAIDLGLAADTMDATTAAIRRARDSG
CCCEEEECCCCCCCCEEEEECCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHCCC
ADILVTTGGASVGDHDFIKRALEAEGVEMTFWRIAMRPGKPMMYGRLGAMRVIGLPGNPV
CEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCEEEECCCCEEEEECCCCHH
SAYICAFLFMVPLIRALSGRVDVHHRVEPALLGGDVAANQARQDYLRARLTYSTDGLPIA
HHHHHHHHHHHHHHHHHCCCCCEEECCCCEEECCCHHHHHHHHHHHHEEEEECCCCCEEE
TPVTHQDSSLMGNLAAADALVVRAPFAPAASKGAPCTVIKLSLS
CCCCCCCHHHHHHHHHHCEEEEECCCCCCCCCCCCEEEEEEEEC
>Mature Secondary Structure 
ALMAVADALAAVLDGVEPLPEETAALEAAHRRVLARDLPSRRTQPPVAMSAMDGYAVRA
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCEEEE
ADIATIPSRLRVIGESAAGRPLDRALRAGEALRIFTGGVVPDGADTVVIQEDTDRDGDHV
HHHHHHHHHHHHHCCCCCCCCHHHHHHCCCEEEEEECCCCCCCCCEEEEECCCCCCCCEE
IVKEATASGKNIRPAGVDFREGDVLIRARTRLTDRHLSLAAGMNYPDLPVHRRPTIAMLA
EEEECCCCCCCCCCCCCCCCCCCEEEEEECHHCHHHHHHCCCCCCCCCCCCCCCCEEEEE
TGDELVLPGATPGPGQIILSNGYALRALARGEGAEAIDLGLAADTMDATTAAIRRARDSG
CCCEEEECCCCCCCCEEEEECCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHCCC
ADILVTTGGASVGDHDFIKRALEAEGVEMTFWRIAMRPGKPMMYGRLGAMRVIGLPGNPV
CEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEEEEECCCCCEEEECCCCEEEEECCCCHH
SAYICAFLFMVPLIRALSGRVDVHHRVEPALLGGDVAANQARQDYLRARLTYSTDGLPIA
HHHHHHHHHHHHHHHHHCCCCCEEECCCCEEECCCHHHHHHHHHHHHEEEEECCCCCEEE
TPVTHQDSSLMGNLAAADALVVRAPFAPAASKGAPCTVIKLSLS
CCCCCCCHHHHHHHHHHCEEEEECCCCCCCCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]