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The map label for this gene is pdxA [H]

Identifier: 75675873

GI number: 75675873

Start: 1834071

End: 1835078

Strand: Direct

Name: pdxA [H]

Synonym: Nwi_1681

Alternate gene names: 75675873

Gene position: 1834071-1835078 (Clockwise)

Preceding gene: 75675872

Following gene: 75675874

Centisome position: 53.91

GC content: 64.29

Gene sequence:

>1008_bases
TTGGTAAAGCCAATAGCACTGACACTGGGTGAGCCGGCCGGCATCGGACCGGACATCGCGATCGCGGCCTGGCTGCGCCG
CGAGAGCGATTCCGTTCCGCCCTTCTACCTTCTTGGCGATCGCGCCTTCATCGCGGCACGGGCAAAGCTGCTCGGACATG
AAATTCCTCTGGTGGATGTCGGCCAGGGAGACGTGTCCAGGATATTTTCTGAAGCGCTTCCGATTGCCGCCACGGGCCAT
ACGGCAACCGCGCAGCCCGGCGATCCCGACGACAACAGCGCCCCCGCGGCGATCGGATCAATCCGTCAGGCGGTCAGCGA
CGTTGTGGCGGGCCACGCGGGAGCGGTGGTCACCAATCCGATCGCCAAGAGCGTGCTCTACCGGGCGGGATTCGCCCATC
CCGGTCACACCGAATTTCTCGCAGAACTGGCGGCGGCGAACGCCAATCCTCCCCAACCGGTGATGCTGCTGTGGTCGTCA
GATCTCGCGGTGGTGCCGGTCACCATCCACCTGCCGTTGCGCGATGCGATCTCAATTCTGTCGAGCCGCATGATCGTGGA
CACCGTCCGCATTGTCGTGGCGGACTTGCGCGCTCGGTTTGGGATTCGCAATCCCCGCATCGCGGTATCCGGATTGAATC
CCCATGCGGGAGAAGACGGCTCGCTTGGAACCGAGGATCAGACGATCGTGGCCCCCGCCATCGCAACCCTGCGCGCTGAG
GCGATCGACGTCAAAGGTCCGCTTCCGGCCGACACCATGTTCCATGAGGCCGCGCGCCGGACCTACGACTGCGCGATCTG
CATGTATCACGATCAGGCGCTGATTCCGGTCAAGACACTGGCGTTCGATCGGGCGGTCAATGTCACGCTGGGACTGCCGT
TCATCCGTACATCGCCTGATCATGGCACCGCGTTCGACATAGCCGGCACGGGGCGCGCCAGTCCATCGAGTCTGATCGCC
GCGCTGCGGCTCGCCGCGCGGATGGCAGGTCCGACGCCTTCGTCATGA

Upstream 100 bases:

>100_bases
ACGGCGTGCAAATGACGTTCTCGCGTCCCGCAGAAGTCTAAGGCGGCGGATGTCTTGAACGGCGGCACTGTCCGATCAAA
AGCCGCGCCGGAGTCACCGC

Downstream 100 bases:

>100_bases
GCATGATCGATGACCTTCCGCCGCTGCGCGACGTCATCAAGCGTCACGCTTTGTCGGCGCGAAAATCGTTGGGACAGAAT
TTTCTGCTCGATCTGAATCT

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase 2 [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MVKPIALTLGEPAGIGPDIAIAAWLRRESDSVPPFYLLGDRAFIAARAKLLGHEIPLVDVGQGDVSRIFSEALPIAATGH
TATAQPGDPDDNSAPAAIGSIRQAVSDVVAGHAGAVVTNPIAKSVLYRAGFAHPGHTEFLAELAAANANPPQPVMLLWSS
DLAVVPVTIHLPLRDAISILSSRMIVDTVRIVVADLRARFGIRNPRIAVSGLNPHAGEDGSLGTEDQTIVAPAIATLRAE
AIDVKGPLPADTMFHEAARRTYDCAICMYHDQALIPVKTLAFDRAVNVTLGLPFIRTSPDHGTAFDIAGTGRASPSSLIA
ALRLAARMAGPTPSS

Sequences:

>Translated_335_residues
MVKPIALTLGEPAGIGPDIAIAAWLRRESDSVPPFYLLGDRAFIAARAKLLGHEIPLVDVGQGDVSRIFSEALPIAATGH
TATAQPGDPDDNSAPAAIGSIRQAVSDVVAGHAGAVVTNPIAKSVLYRAGFAHPGHTEFLAELAAANANPPQPVMLLWSS
DLAVVPVTIHLPLRDAISILSSRMIVDTVRIVVADLRARFGIRNPRIAVSGLNPHAGEDGSLGTEDQTIVAPAIATLRAE
AIDVKGPLPADTMFHEAARRTYDCAICMYHDQALIPVKTLAFDRAVNVTLGLPFIRTSPDHGTAFDIAGTGRASPSSLIA
ALRLAARMAGPTPSS
>Mature_335_residues
MVKPIALTLGEPAGIGPDIAIAAWLRRESDSVPPFYLLGDRAFIAARAKLLGHEIPLVDVGQGDVSRIFSEALPIAATGH
TATAQPGDPDDNSAPAAIGSIRQAVSDVVAGHAGAVVTNPIAKSVLYRAGFAHPGHTEFLAELAAANANPPQPVMLLWSS
DLAVVPVTIHLPLRDAISILSSRMIVDTVRIVVADLRARFGIRNPRIAVSGLNPHAGEDGSLGTEDQTIVAPAIATLRAE
AIDVKGPLPADTMFHEAARRTYDCAICMYHDQALIPVKTLAFDRAVNVTLGLPFIRTSPDHGTAFDIAGTGRASPSSLIA
ALRLAARMAGPTPSS

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=340, Percent_Identity=37.9411764705882, Blast_Score=205, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 34967; Mature: 34967

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKPIALTLGEPAGIGPDIAIAAWLRRESDSVPPFYLLGDRAFIAARAKLLGHEIPLVDV
CCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCCCEEEC
GQGDVSRIFSEALPIAATGHTATAQPGDPDDNSAPAAIGSIRQAVSDVVAGHAGAVVTNP
CCCHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECH
IAKSVLYRAGFAHPGHTEFLAELAAANANPPQPVMLLWSSDLAVVPVTIHLPLRDAISIL
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEEEECHHHHHHHH
SSRMIVDTVRIVVADLRARFGIRNPRIAVSGLNPHAGEDGSLGTEDQTIVAPAIATLRAE
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHH
AIDVKGPLPADTMFHEAARRTYDCAICMYHDQALIPVKTLAFDRAVNVTLGLPFIRTSPD
EEECCCCCCHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHCCEEEEEECCCEEEECCC
HGTAFDIAGTGRASPSSLIAALRLAARMAGPTPSS
CCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVKPIALTLGEPAGIGPDIAIAAWLRRESDSVPPFYLLGDRAFIAARAKLLGHEIPLVDV
CCCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCCCEEEC
GQGDVSRIFSEALPIAATGHTATAQPGDPDDNSAPAAIGSIRQAVSDVVAGHAGAVVTNP
CCCHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEECH
IAKSVLYRAGFAHPGHTEFLAELAAANANPPQPVMLLWSSDLAVVPVTIHLPLRDAISIL
HHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEEEEECHHHHHHHH
SSRMIVDTVRIVVADLRARFGIRNPRIAVSGLNPHAGEDGSLGTEDQTIVAPAIATLRAE
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHH
AIDVKGPLPADTMFHEAARRTYDCAICMYHDQALIPVKTLAFDRAVNVTLGLPFIRTSPD
EEECCCCCCHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHCCEEEEEECCCEEEECCC
HGTAFDIAGTGRASPSSLIAALRLAARMAGPTPSS
CCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]