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The map label for this gene is metC [H]

Identifier: 75675722

GI number: 75675722

Start: 1670394

End: 1671590

Strand: Direct

Name: metC [H]

Synonym: Nwi_1530

Alternate gene names: 75675722

Gene position: 1670394-1671590 (Clockwise)

Preceding gene: 75675717

Following gene: 75675728

Centisome position: 49.1

GC content: 63.32

Gene sequence:

>1197_bases
ATGACCTTGTCGAAGAGCGACGGATCGACGGATTCGCTTCGGGCGGAAACCAGACTGGTCGTTTCGGGTCGAGACACCGC
GTCCCAGAAAGGGTTCGTCAATCCTCCCATCGTCCGCGGCTCGACGGTGCTCTATCCGACTGCCGGCGACCTTTACGCCC
ACCGCGGAGAATTCCAGTACGGACGGCACGGCACGCCTTCGACCCGTGCGCTGCAGGATGCGCTGATGGCGTTGGAGGGC
CCGCATTGCGCGGGCGTCGGCCTGGTTCCGTCAGGTGTCTCCGCGCTTTCCACGGCGCTGTTGTCAGTGCTGAAGGCCGG
CGATCATCTCCTCGTCTGCGATAACGTTTATCGTCCGACGCGACAGTTCTGCGATGGGTTTCTGGCGCGCTACGGAGTTG
AAACGACTTACTTCGATCCGTTGATCGGTTCGGGGATCGCCGCGCTGCTCCGTCCGGAAACCCGCGTGGTGATGGTCGAG
GCGCCAGGCTCACAGTCCCTGGAGATGCCGGATGTTCCCGCGATCGCGGCCGCCGCTCACGCGCGCGGAGCGATTGTGAT
CGACGACAATACGTGGGCGACCCCCCTCTTCCGCCGCGCGCTCGAGCAAGGCGTGGACATCAGCATCCAGGCGGCGACCA
AGTACATCGGAGGTCATTCCGACGTCATGTTCGGAACCATCGCCGCCAATGCCAGCGCCTGGCCGGCGCTCACTGAGACC
ATCAGACTACTCGGTCTATGCGTCGGTCCCGACGACGTGTTTCTGACCCTGCGAGGATTACGCACCCTTGCGGTGCGGCT
TTATCATCACCAGCAGGCCGCGATGAACATGGCGCAGTGGCTCGCGCGGCGGCCGGAGGTGACCAGAATTCTGTATCCGG
CATGGCCGGACGATCCGGGTCATGCGATCTGGAAACGGGACTTCACCGGCGCACCGGGATTGTTTAGCATCGTCCTCAAG
CCCGCGCCGCAGCAGGCCGTCAGCGCGCTGCTCGATACGCTGAAGCTGTTCGGCATGGGTTACTCGTGGGGCGGCTTTGA
GAGCCTCATCATTCCCTTCGATTGCGCATCGTATCGGACCGCGACAAAGTGGACGCCGGGCGGCCCCACGCTGCGGCTAC
AGATCGGGCTTGAGAACGTGGACGATCTCAAGGCCGATCTCGAACGGGGTTTTGCGGCCTTCAACGCCCATCAATGA

Upstream 100 bases:

>100_bases
CTTTTCTTTCCTGTTACTACCGATCCGCTTTGGAACTGACATCCGTCGAATTTCGGGACAGTGTCAGCGGCAAAATGCCT
CGTTTAGCAACGCAGAAGAT

Downstream 100 bases:

>100_bases
AGGCTCCCGCGATGAAGGCTCCCGCCTCCCGCTTTTGACGGGTTGCTTCAGCCCAACAACCAGCGCCTGACTCGCGTCGG
TCTCTCACGTCGATGATTGG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 398; Mature: 397

Protein sequence:

>398_residues
MTLSKSDGSTDSLRAETRLVVSGRDTASQKGFVNPPIVRGSTVLYPTAGDLYAHRGEFQYGRHGTPSTRALQDALMALEG
PHCAGVGLVPSGVSALSTALLSVLKAGDHLLVCDNVYRPTRQFCDGFLARYGVETTYFDPLIGSGIAALLRPETRVVMVE
APGSQSLEMPDVPAIAAAAHARGAIVIDDNTWATPLFRRALEQGVDISIQAATKYIGGHSDVMFGTIAANASAWPALTET
IRLLGLCVGPDDVFLTLRGLRTLAVRLYHHQQAAMNMAQWLARRPEVTRILYPAWPDDPGHAIWKRDFTGAPGLFSIVLK
PAPQQAVSALLDTLKLFGMGYSWGGFESLIIPFDCASYRTATKWTPGGPTLRLQIGLENVDDLKADLERGFAAFNAHQ

Sequences:

>Translated_398_residues
MTLSKSDGSTDSLRAETRLVVSGRDTASQKGFVNPPIVRGSTVLYPTAGDLYAHRGEFQYGRHGTPSTRALQDALMALEG
PHCAGVGLVPSGVSALSTALLSVLKAGDHLLVCDNVYRPTRQFCDGFLARYGVETTYFDPLIGSGIAALLRPETRVVMVE
APGSQSLEMPDVPAIAAAAHARGAIVIDDNTWATPLFRRALEQGVDISIQAATKYIGGHSDVMFGTIAANASAWPALTET
IRLLGLCVGPDDVFLTLRGLRTLAVRLYHHQQAAMNMAQWLARRPEVTRILYPAWPDDPGHAIWKRDFTGAPGLFSIVLK
PAPQQAVSALLDTLKLFGMGYSWGGFESLIIPFDCASYRTATKWTPGGPTLRLQIGLENVDDLKADLERGFAAFNAHQ
>Mature_397_residues
TLSKSDGSTDSLRAETRLVVSGRDTASQKGFVNPPIVRGSTVLYPTAGDLYAHRGEFQYGRHGTPSTRALQDALMALEGP
HCAGVGLVPSGVSALSTALLSVLKAGDHLLVCDNVYRPTRQFCDGFLARYGVETTYFDPLIGSGIAALLRPETRVVMVEA
PGSQSLEMPDVPAIAAAAHARGAIVIDDNTWATPLFRRALEQGVDISIQAATKYIGGHSDVMFGTIAANASAWPALTETI
RLLGLCVGPDDVFLTLRGLRTLAVRLYHHQQAAMNMAQWLARRPEVTRILYPAWPDDPGHAIWKRDFTGAPGLFSIVLKP
APQQAVSALLDTLKLFGMGYSWGGFESLIIPFDCASYRTATKWTPGGPTLRLQIGLENVDDLKADLERGFAAFNAHQ

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=323, Percent_Identity=35.2941176470588, Blast_Score=185, Evalue=8e-47,
Organism=Homo sapiens, GI299473759, Length=322, Percent_Identity=32.9192546583851, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI25453487, Length=322, Percent_Identity=31.3664596273292, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1789383, Length=390, Percent_Identity=44.6153846153846, Blast_Score=331, Evalue=4e-92,
Organism=Escherichia coli, GI1790375, Length=385, Percent_Identity=32.2077922077922, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71980708, Length=391, Percent_Identity=30.1790281329923, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17538055, Length=325, Percent_Identity=32.3076923076923, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17560056, Length=356, Percent_Identity=33.4269662921348, Blast_Score=169, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321170, Length=330, Percent_Identity=46.0606060606061, Blast_Score=310, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6319307, Length=358, Percent_Identity=30.7262569832402, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6321904, Length=275, Percent_Identity=29.0909090909091, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6323333, Length=396, Percent_Identity=26.010101010101, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321254, Length=404, Percent_Identity=26.2376237623762, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19922554, Length=367, Percent_Identity=34.3324250681199, Blast_Score=196, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42886; Mature: 42755

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSKSDGSTDSLRAETRLVVSGRDTASQKGFVNPPIVRGSTVLYPTAGDLYAHRGEFQY
CCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCHHHCCCCCCC
GRHGTPSTRALQDALMALEGPHCAGVGLVPSGVSALSTALLSVLKAGDHLLVCDNVYRPT
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHH
RQFCDGFLARYGVETTYFDPLIGSGIAALLRPETRVVMVEAPGSQSLEMPDVPAIAAAAH
HHHHHHHHHHHCCCHHCCCHHHHCCHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHH
ARGAIVIDDNTWATPLFRRALEQGVDISIQAATKYIGGHSDVMFGTIAANASAWPALTET
CCCEEEECCCCCCCHHHHHHHHCCCCEEEEEHHHHCCCCCCEEEEEEECCCCCCHHHHHH
IRLLGLCVGPDDVFLTLRGLRTLAVRLYHHQQAAMNMAQWLARRPEVTRILYPAWPDDPG
HHHHEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
HAIWKRDFTGAPGLFSIVLKPAPQQAVSALLDTLKLFGMGYSWGGFESLIIPFDCASYRT
CCEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCC
ATKWTPGGPTLRLQIGLENVDDLKADLERGFAAFNAHQ
CCEECCCCCEEEEEECCCCHHHHHHHHHHCHHHCCCCC
>Mature Secondary Structure 
TLSKSDGSTDSLRAETRLVVSGRDTASQKGFVNPPIVRGSTVLYPTAGDLYAHRGEFQY
CCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCHHHCCCCCCC
GRHGTPSTRALQDALMALEGPHCAGVGLVPSGVSALSTALLSVLKAGDHLLVCDNVYRPT
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCHHH
RQFCDGFLARYGVETTYFDPLIGSGIAALLRPETRVVMVEAPGSQSLEMPDVPAIAAAAH
HHHHHHHHHHHCCCHHCCCHHHHCCHHHHCCCCEEEEEEECCCCCCCCCCCCCHHHHHHH
ARGAIVIDDNTWATPLFRRALEQGVDISIQAATKYIGGHSDVMFGTIAANASAWPALTET
CCCEEEECCCCCCCHHHHHHHHCCCCEEEEEHHHHCCCCCCEEEEEEECCCCCCHHHHHH
IRLLGLCVGPDDVFLTLRGLRTLAVRLYHHQQAAMNMAQWLARRPEVTRILYPAWPDDPG
HHHHEEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
HAIWKRDFTGAPGLFSIVLKPAPQQAVSALLDTLKLFGMGYSWGGFESLIIPFDCASYRT
CCEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCC
ATKWTPGGPTLRLQIGLENVDDLKADLERGFAAFNAHQ
CCEECCCCCEEEEEECCCCHHHHHHHHHHCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]