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The map label for this gene is etfA [H]

Identifier: 75674950

GI number: 75674950

Start: 839271

End: 840215

Strand: Direct

Name: etfA [H]

Synonym: Nwi_0754

Alternate gene names: 75674950

Gene position: 839271-840215 (Clockwise)

Preceding gene: 75674949

Following gene: 75674951

Centisome position: 24.67

GC content: 64.76

Gene sequence:

>945_bases
ATGACCACACTGCTGATCGCCGAACACGACAACGCTTCTCTTAAGGATGTGACGGGCAAGGCGCTGACCGCCGCCATTCA
ACTCGGCTCGCCGGTCGAGGTCCTTGTCGCGGGCGAGAATGCCAGGGGCGCTGCCGAGAGCGCGGCGAAACTGCAAGGCG
TCGCCAAAGTGCTGCTCGCGGATGACCCGGCCTATGCCCACGACCTCGCCGAGCCGCTCGCCGCGCTGATCCGCTCGCTG
GCGTCGGGTTACGATGCGTTGGTCGCGCCGGCGACCTCCCGTTTCAAGAATGTGATGCCGCGCGTCGCGGCGCTGCTCGA
CGTGATGCAGATCTCGGAAATCATCAAGGTGGTCGCGGCCGATACCTTTGAACGGCCGATCTACGCGGGCAATGCGATCC
AGACGGTCAGGTCCAGGGACGCCAGACGGGTCATCACGGTGCGCACCTCGACCTTTGCCGCGGCCGGGGAGGGCGGCAAC
GCTCCGGTGGAGACTATCGCCGCAACGGCCGATCCAGGATTGTCGAGTTTCGTCGGCGAGCGGGTCGCCAGGAACAACCG
CCCGGAACTGGCTTCAGCGAGGATCATCGTCTCCGGAGGCCGCGGTATGCGAAGCAGCGCGAACTTCACCAAGTACATCG
AGCCGCTGGCGGACAAGCTCGGCGCCGGCGTCGGTGCGTCGCGCGCCGCGGTGGATGCGGGTTTCGCGCCGAATGACTGG
CAGGTCGGGCAGACGGGCAAGGTGGTGGCGCCGGATCTCTACATCGCTGTCGGCATTTCCGGCGCGATCCAGCATCTCGC
CGGAATGAAGGATTCCAAGGTGATCGTGGCGATCAACAAGGACGCTGATGCGCCTATTTTCCAGGTCGCGGATTACGGCC
TGGTGGCGGACCTGTATCAGGCGGTTCCTGAACTCACGGAAGAACTTGGAAAGCTGGACCGCTGA

Upstream 100 bases:

>100_bases
TCCTCAAAACCACCGAACCTCCGGGCCGCAAGGCGGGCGTCAAGGTCAAGGATGTCGCCGAATTGGTGTCCAGGCTCAGG
AACGAGGCCGGGGTAATCTG

Downstream 100 bases:

>100_bases
CGATGATCCGGAGGAGTGCTGTCGGCGCAACGGACTCCCGCCGGTGGTTGTGCAAGAATGGAGTGCGCCGCGGTCTGCGC
GGCTCGGGACCGGTGAGATG

Product: electron transfer flavoprotein alpha and beta-subunits

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MTTLLIAEHDNASLKDVTGKALTAAIQLGSPVEVLVAGENARGAAESAAKLQGVAKVLLADDPAYAHDLAEPLAALIRSL
ASGYDALVAPATSRFKNVMPRVAALLDVMQISEIIKVVAADTFERPIYAGNAIQTVRSRDARRVITVRTSTFAAAGEGGN
APVETIAATADPGLSSFVGERVARNNRPELASARIIVSGGRGMRSSANFTKYIEPLADKLGAGVGASRAAVDAGFAPNDW
QVGQTGKVVAPDLYIAVGISGAIQHLAGMKDSKVIVAINKDADAPIFQVADYGLVADLYQAVPELTEELGKLDR

Sequences:

>Translated_314_residues
MTTLLIAEHDNASLKDVTGKALTAAIQLGSPVEVLVAGENARGAAESAAKLQGVAKVLLADDPAYAHDLAEPLAALIRSL
ASGYDALVAPATSRFKNVMPRVAALLDVMQISEIIKVVAADTFERPIYAGNAIQTVRSRDARRVITVRTSTFAAAGEGGN
APVETIAATADPGLSSFVGERVARNNRPELASARIIVSGGRGMRSSANFTKYIEPLADKLGAGVGASRAAVDAGFAPNDW
QVGQTGKVVAPDLYIAVGISGAIQHLAGMKDSKVIVAINKDADAPIFQVADYGLVADLYQAVPELTEELGKLDR
>Mature_313_residues
TTLLIAEHDNASLKDVTGKALTAAIQLGSPVEVLVAGENARGAAESAAKLQGVAKVLLADDPAYAHDLAEPLAALIRSLA
SGYDALVAPATSRFKNVMPRVAALLDVMQISEIIKVVAADTFERPIYAGNAIQTVRSRDARRVITVRTSTFAAAGEGGNA
PVETIAATADPGLSSFVGERVARNNRPELASARIIVSGGRGMRSSANFTKYIEPLADKLGAGVGASRAAVDAGFAPNDWQ
VGQTGKVVAPDLYIAVGISGAIQHLAGMKDSKVIVAINKDADAPIFQVADYGLVADLYQAVPELTEELGKLDR

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=313, Percent_Identity=53.9936102236422, Blast_Score=312, Evalue=2e-85,
Organism=Homo sapiens, GI189181759, Length=277, Percent_Identity=54.5126353790614, Blast_Score=282, Evalue=3e-76,
Organism=Escherichia coli, GI1787990, Length=251, Percent_Identity=32.2709163346614, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1786226, Length=251, Percent_Identity=34.2629482071713, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI87082157, Length=217, Percent_Identity=30.8755760368664, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17506929, Length=314, Percent_Identity=56.0509554140127, Blast_Score=321, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6325261, Length=293, Percent_Identity=45.3924914675768, Blast_Score=250, Evalue=2e-67,
Organism=Drosophila melanogaster, GI17136898, Length=312, Percent_Identity=57.0512820512821, Blast_Score=322, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24652801, Length=312, Percent_Identity=57.0512820512821, Blast_Score=322, Evalue=2e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 32612; Mature: 32481

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLLIAEHDNASLKDVTGKALTAAIQLGSPVEVLVAGENARGAAESAAKLQGVAKVLLA
CCEEEEEECCCCCHHHHCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHC
DDPAYAHDLAEPLAALIRSLASGYDALVAPATSRFKNVMPRVAALLDVMQISEIIKVVAA
CCCHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTFERPIYAGNAIQTVRSRDARRVITVRTSTFAAAGEGGNAPVETIAATADPGLSSFVGE
HHHCCCCCCCHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCHHHHEECCCCCHHHHHHH
RVARNNRPELASARIIVSGGRGMRSSANFTKYIEPLADKLGAGVGASRAAVDAGFAPNDW
HHHCCCCCCHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCC
QVGQTGKVVAPDLYIAVGISGAIQHLAGMKDSKVIVAINKDADAPIFQVADYGLVADLYQ
CCCCCCCEECCCEEEEECHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
AVPELTEELGKLDR
HHHHHHHHHHCCCC
>Mature Secondary Structure 
TTLLIAEHDNASLKDVTGKALTAAIQLGSPVEVLVAGENARGAAESAAKLQGVAKVLLA
CEEEEEECCCCCHHHHCHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHC
DDPAYAHDLAEPLAALIRSLASGYDALVAPATSRFKNVMPRVAALLDVMQISEIIKVVAA
CCCHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTFERPIYAGNAIQTVRSRDARRVITVRTSTFAAAGEGGNAPVETIAATADPGLSSFVGE
HHHCCCCCCCHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCHHHHEECCCCCHHHHHHH
RVARNNRPELASARIIVSGGRGMRSSANFTKYIEPLADKLGAGVGASRAAVDAGFAPNDW
HHHCCCCCCHHHEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCC
QVGQTGKVVAPDLYIAVGISGAIQHLAGMKDSKVIVAINKDADAPIFQVADYGLVADLYQ
CCCCCCCEECCCEEEEECHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
AVPELTEELGKLDR
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8599534; 12597275 [H]