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The map label for this gene is hbdA [H]

Identifier: 75674951

GI number: 75674951

Start: 840321

End: 841202

Strand: Direct

Name: hbdA [H]

Synonym: Nwi_0755

Alternate gene names: 75674951

Gene position: 840321-841202 (Clockwise)

Preceding gene: 75674950

Following gene: 75674954

Centisome position: 24.7

GC content: 60.09

Gene sequence:

>882_bases
ATGGCGGCAATGATCAGAAAAGTCGGCGTGATCGGCTCGGGCCAGATGGGCAACGGCATTGCGCATGTGACCGCCCTCGC
AGGGTTCGACGTCGTGCTGAACGATGTTTCCGCCGATCAGCTCAATGCGGCGATAGCGACGATCAACGCAAACCTGTCCC
GCCAGGTCGCGAAGAAGATCATTACCGACGGTGATCGCGAAAAGGCGCTTACGCGGATTTCGCAAACCGAAACTCTCGAC
GGGTTGGCGGATTGCGATCTCGTGATCGAAACCGCCGTCGAGAAAGAGGACGTGAAGCGCAAGATTTTTCATGATCTGTG
CGCCGTGCTCAAGCCCGAGGCCATCGTCGCGTCCAACACGTCATCGATCTCGATCACGCGGCTGGCCGCCTCGACCGATC
GGCCGGAAAAGTTCATCGGCATTCATTTCATGAATCCGGTGCCGCTGATGGAGTTGGTCGAACTCATCCGGGGCATCGCG
ACCGGCGATGCGACCTTCGATGCGGCCAAGGAATTCGTCGCCAAGCTCGGCAAGCAGATCGCCGTCTCCGAGGACTTTCC
TGCCTTCATCGTCAACCGCATTCTGTTGCCGATGATCAACGAGGCCATCTACACGCTGTACGAAGGCGTGGGGAACGTCG
AGGCGATCGATGCCGCCATGCGGCTCGGTGCGCATCACCCGATGGGGCCGCTTGAACTCGCCGATTTCATCGGGCTCGAC
ACCTGTCTGTCGATCATGCAGGTGCTGCATGAGGGGCTTGCGGACTCCAAATACCGGCCTTGTCCGCTGCTGGTAAAATA
CGTCGAGGCCGGCTGGCTCGGACGCAAGAGCCAGCGCGGCTTCTACGACTACCGCGGCGAAAAGCCGGTTCCGACGCGCT
GA

Upstream 100 bases:

>100_bases
ATCCGGAGGAGTGCTGTCGGCGCAACGGACTCCCGCCGGTGGTTGTGCAAGAATGGAGTGCGCCGCGGTCTGCGCGGCTC
GGGACCGGTGAGATGACGAG

Downstream 100 bases:

>100_bases
ACGCCAGAGAGCATCTCGCTTCTGATTGAATCAGGAGTGGAGCTCTCTGGATTATTGTTGGTCGGGGGTTGGTTTCGCGC
GAATCGGTATGCGCCTCGCC

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MAAMIRKVGVIGSGQMGNGIAHVTALAGFDVVLNDVSADQLNAAIATINANLSRQVAKKIITDGDREKALTRISQTETLD
GLADCDLVIETAVEKEDVKRKIFHDLCAVLKPEAIVASNTSSISITRLAASTDRPEKFIGIHFMNPVPLMELVELIRGIA
TGDATFDAAKEFVAKLGKQIAVSEDFPAFIVNRILLPMINEAIYTLYEGVGNVEAIDAAMRLGAHHPMGPLELADFIGLD
TCLSIMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKSQRGFYDYRGEKPVPTR

Sequences:

>Translated_293_residues
MAAMIRKVGVIGSGQMGNGIAHVTALAGFDVVLNDVSADQLNAAIATINANLSRQVAKKIITDGDREKALTRISQTETLD
GLADCDLVIETAVEKEDVKRKIFHDLCAVLKPEAIVASNTSSISITRLAASTDRPEKFIGIHFMNPVPLMELVELIRGIA
TGDATFDAAKEFVAKLGKQIAVSEDFPAFIVNRILLPMINEAIYTLYEGVGNVEAIDAAMRLGAHHPMGPLELADFIGLD
TCLSIMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKSQRGFYDYRGEKPVPTR
>Mature_292_residues
AAMIRKVGVIGSGQMGNGIAHVTALAGFDVVLNDVSADQLNAAIATINANLSRQVAKKIITDGDREKALTRISQTETLDG
LADCDLVIETAVEKEDVKRKIFHDLCAVLKPEAIVASNTSSISITRLAASTDRPEKFIGIHFMNPVPLMELVELIRGIAT
GDATFDAAKEFVAKLGKQIAVSEDFPAFIVNRILLPMINEAIYTLYEGVGNVEAIDAAMRLGAHHPMGPLELADFIGLDT
CLSIMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKSQRGFYDYRGEKPVPTR

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=290, Percent_Identity=42.0689655172414, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI296179427, Length=308, Percent_Identity=40.5844155844156, Blast_Score=194, Evalue=6e-50,
Organism=Homo sapiens, GI20127408, Length=282, Percent_Identity=32.6241134751773, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI261878539, Length=299, Percent_Identity=31.438127090301, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI68989263, Length=299, Percent_Identity=31.438127090301, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI115430219, Length=236, Percent_Identity=27.5423728813559, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1787661, Length=285, Percent_Identity=41.4035087719298, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1788682, Length=270, Percent_Identity=37.037037037037, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1790281, Length=267, Percent_Identity=31.0861423220974, Blast_Score=130, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17549919, Length=288, Percent_Identity=40.2777777777778, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17553560, Length=287, Percent_Identity=40.418118466899, Blast_Score=208, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=37.1527777777778, Blast_Score=181, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI25144276, Length=291, Percent_Identity=33.3333333333333, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17508951, Length=291, Percent_Identity=33.3333333333333, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17508953, Length=291, Percent_Identity=33.3333333333333, Blast_Score=149, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17558304, Length=291, Percent_Identity=32.9896907216495, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71985923, Length=284, Percent_Identity=30.6338028169014, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71985930, Length=283, Percent_Identity=27.208480565371, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI115533614, Length=200, Percent_Identity=25.5, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI193203623, Length=200, Percent_Identity=25.5, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI19921000, Length=286, Percent_Identity=33.9160839160839, Blast_Score=151, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24583077, Length=286, Percent_Identity=33.9160839160839, Blast_Score=151, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24583079, Length=286, Percent_Identity=33.9160839160839, Blast_Score=151, Evalue=4e-37,
Organism=Drosophila melanogaster, GI45549573, Length=247, Percent_Identity=27.9352226720648, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI20129993, Length=237, Percent_Identity=24.0506329113924, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31777; Mature: 31646

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAMIRKVGVIGSGQMGNGIAHVTALAGFDVVLNDVSADQLNAAIATINANLSRQVAKKI
CCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHH
ITDGDREKALTRISQTETLDGLADCDLVIETAVEKEDVKRKIFHDLCAVLKPEAIVASNT
HCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
SSISITRLAASTDRPEKFIGIHFMNPVPLMELVELIRGIATGDATFDAAKEFVAKLGKQI
CCEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHE
AVSEDFPAFIVNRILLPMINEAIYTLYEGVGNVEAIDAAMRLGAHHPMGPLELADFIGLD
ECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TCLSIMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKSQRGFYDYRGEKPVPTR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AAMIRKVGVIGSGQMGNGIAHVTALAGFDVVLNDVSADQLNAAIATINANLSRQVAKKI
CHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHH
ITDGDREKALTRISQTETLDGLADCDLVIETAVEKEDVKRKIFHDLCAVLKPEAIVASNT
HCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
SSISITRLAASTDRPEKFIGIHFMNPVPLMELVELIRGIATGDATFDAAKEFVAKLGKQI
CCEEEEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHE
AVSEDFPAFIVNRILLPMINEAIYTLYEGVGNVEAIDAAMRLGAHHPMGPLELADFIGLD
ECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHH
TCLSIMQVLHEGLADSKYRPCPLLVKYVEAGWLGRKSQRGFYDYRGEKPVPTR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]