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The map label for this gene is lldD [H]

Identifier: 75674899

GI number: 75674899

Start: 784074

End: 785183

Strand: Direct

Name: lldD [H]

Synonym: Nwi_0702

Alternate gene names: 75674899

Gene position: 784074-785183 (Clockwise)

Preceding gene: 75674898

Following gene: 75674900

Centisome position: 23.05

GC content: 67.66

Gene sequence:

>1110_bases
ATGACCACGCCGCTTGCCAAGCTCACGCAGATTCCGCCGACGGTCGCGGCGGTTGCCGACTACGAGGTGCTGGCGCGTGA
GCGTGTGTCGCCTGGAGCCTGGGCCTATCTCGACGGCGGCGCGGCGGACGAGGTGACCGCGCGGGAAAATCGCGCGGCGT
TCGCTCGTCTGCACTTGCGCACACGGGTTTTGCGCGATCTCTCCAGCGGAAACACGGCTTGCGAGTTGTTTGGCACGCGG
CTGCGTGCGCCGATCCTGCTCGCACCTGTCGCCTACCAGAAGCTCGCATATCCGGATGGCGAACTCGCCACCGTGCTCGG
CGCTTCGGCGATGCGGATGGCGATGGTGGTCAGCACGCAGGCGAGCGTCGCTCTGGAGGAGATCGCGCGGGAAGCGCAGA
CGCCGCTGTGGTTTCAACTCTACATCCAGCACGACCGCGACTTCACGCTTCGTCTCGTGCGCCGCGCGGAATCCGCCGGC
ATTCGCGCGCTGGTGGTGAGCGTCGATGCGCCGATCAGCGGCCTGCGTAACCGCGAGCAGCGCATGGGCTTCGCTTTTCC
GGGCGGCATCGAGCCGGTCAATCTGCGCGGCCTGACGCCCTCGCCGCGAGCCGCCGGCGAGACGCTGTTCGATAGTCCGC
TGATAACCAGGGCCGCGACCTGGCGCGACATCGAGAATCTGCGCGAAGCGACCAAGCTACCGCTGGTGCTCAAGGGCATC
ATGACGGCGGAGGACGCCGAGCAGGCTCTTGCGGCCGGCGTCGATGGTCTCATCGTCTCCAACCACGGAGGGCGGGTGCT
TGATGGTCAACCCGCGACCATCGAGGTGCTTCCGGAGATCGCGGCCGCCGTATCCGGCCGCGTACCGATCCTGCTCGACG
GCGGGATCCGGCGCGGCGGCGATGTCTTCAAGGCGCTGGCGCTCGGCGCCAGTGCGGTGCTGGTCGGCCGTGCCTTCGTT
CATGGGTTGGCCGCGGCGGGCGCGGTAGGCGTTGCCCATGTGCTGCGCATCCTGCATGCCGAGTTGGAAGCGACCATGGT
GCTCACCGGCTGCCGGGATATCCGTGCGATTTCTCCGGCGTCAATCCGGCAAGCAGGACTGCGTACGTAG

Upstream 100 bases:

>100_bases
GCTTCCGGTCAAATCAGAAGCGGGCTCTATGATTTTGATTTGACGCGCTTTCTTCACGCAAACCGGTATCCACTTCGTTC
GAAAACGCTATAACACCACG

Downstream 100 bases:

>100_bases
TGGGTTGGTTCAAAAGTTCGCTTTCATTTTCAGCGCGTCCTCCGAACGAACGTCTCACACCCGATGGATCATCTGGATAA
TCGCTCAGTTCCGATCGCTA

Product: FMN-dependent alpha-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MTTPLAKLTQIPPTVAAVADYEVLARERVSPGAWAYLDGGAADEVTARENRAAFARLHLRTRVLRDLSSGNTACELFGTR
LRAPILLAPVAYQKLAYPDGELATVLGASAMRMAMVVSTQASVALEEIAREAQTPLWFQLYIQHDRDFTLRLVRRAESAG
IRALVVSVDAPISGLRNREQRMGFAFPGGIEPVNLRGLTPSPRAAGETLFDSPLITRAATWRDIENLREATKLPLVLKGI
MTAEDAEQALAAGVDGLIVSNHGGRVLDGQPATIEVLPEIAAAVSGRVPILLDGGIRRGGDVFKALALGASAVLVGRAFV
HGLAAAGAVGVAHVLRILHAELEATMVLTGCRDIRAISPASIRQAGLRT

Sequences:

>Translated_369_residues
MTTPLAKLTQIPPTVAAVADYEVLARERVSPGAWAYLDGGAADEVTARENRAAFARLHLRTRVLRDLSSGNTACELFGTR
LRAPILLAPVAYQKLAYPDGELATVLGASAMRMAMVVSTQASVALEEIAREAQTPLWFQLYIQHDRDFTLRLVRRAESAG
IRALVVSVDAPISGLRNREQRMGFAFPGGIEPVNLRGLTPSPRAAGETLFDSPLITRAATWRDIENLREATKLPLVLKGI
MTAEDAEQALAAGVDGLIVSNHGGRVLDGQPATIEVLPEIAAAVSGRVPILLDGGIRRGGDVFKALALGASAVLVGRAFV
HGLAAAGAVGVAHVLRILHAELEATMVLTGCRDIRAISPASIRQAGLRT
>Mature_368_residues
TTPLAKLTQIPPTVAAVADYEVLARERVSPGAWAYLDGGAADEVTARENRAAFARLHLRTRVLRDLSSGNTACELFGTRL
RAPILLAPVAYQKLAYPDGELATVLGASAMRMAMVVSTQASVALEEIAREAQTPLWFQLYIQHDRDFTLRLVRRAESAGI
RALVVSVDAPISGLRNREQRMGFAFPGGIEPVNLRGLTPSPRAAGETLFDSPLITRAATWRDIENLREATKLPLVLKGIM
TAEDAEQALAAGVDGLIVSNHGGRVLDGQPATIEVLPEIAAAVSGRVPILLDGGIRRGGDVFKALALGASAVLVGRAFVH
GLAAAGAVGVAHVLRILHAELEATMVLTGCRDIRAISPASIRQAGLRT

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain [H]

Homologues:

Organism=Homo sapiens, GI11068137, Length=363, Percent_Identity=41.0468319559229, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI54234014, Length=346, Percent_Identity=40.1734104046243, Blast_Score=263, Evalue=1e-70,
Organism=Homo sapiens, GI7705393, Length=346, Percent_Identity=40.1734104046243, Blast_Score=263, Evalue=1e-70,
Organism=Escherichia coli, GI1790033, Length=380, Percent_Identity=35.5263157894737, Blast_Score=223, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI193208036, Length=356, Percent_Identity=39.3258426966292, Blast_Score=257, Evalue=8e-69,
Organism=Caenorhabditis elegans, GI32566217, Length=273, Percent_Identity=36.996336996337, Blast_Score=180, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6323587, Length=366, Percent_Identity=35.792349726776, Blast_Score=228, Evalue=1e-60,
Organism=Drosophila melanogaster, GI281363140, Length=355, Percent_Identity=42.2535211267606, Blast_Score=254, Evalue=9e-68,
Organism=Drosophila melanogaster, GI78707190, Length=355, Percent_Identity=42.2535211267606, Blast_Score=254, Evalue=9e-68,
Organism=Drosophila melanogaster, GI78707188, Length=355, Percent_Identity=42.2535211267606, Blast_Score=254, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920 [H]

Pfam domain/function: PF01070 FMN_dh [H]

EC number: =1.1.2.3 [H]

Molecular weight: Translated: 39160; Mature: 39029

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPLAKLTQIPPTVAAVADYEVLARERVSPGAWAYLDGGAADEVTARENRAAFARLHLR
CCCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
TRVLRDLSSGNTACELFGTRLRAPILLAPVAYQKLAYPDGELATVLGASAMRMAMVVSTQ
HHHHHHHCCCCCCHHHHHHHHCCCEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ASVALEEIAREAQTPLWFQLYIQHDRDFTLRLVRRAESAGIRALVVSVDAPISGLRNREQ
HHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHH
RMGFAFPGGIEPVNLRGLTPSPRAAGETLFDSPLITRAATWRDIENLREATKLPLVLKGI
HCCCCCCCCCCCEEEECCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
MTAEDAEQALAAGVDGLIVSNHGGRVLDGQPATIEVLPEIAAAVSGRVPILLDGGIRRGG
HHHHHHHHHHHCCCCEEEEECCCCEEECCCCCEEHHHHHHHHHHCCCCCEEECCCCCCCH
DVFKALALGASAVLVGRAFVHGLAAAGAVGVAHVLRILHAELEATMVLTGCRDIRAISPA
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHCCCCCH
SIRQAGLRT
HHHHCCCCC
>Mature Secondary Structure 
TTPLAKLTQIPPTVAAVADYEVLARERVSPGAWAYLDGGAADEVTARENRAAFARLHLR
CCCHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
TRVLRDLSSGNTACELFGTRLRAPILLAPVAYQKLAYPDGELATVLGASAMRMAMVVSTQ
HHHHHHHCCCCCCHHHHHHHHCCCEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
ASVALEEIAREAQTPLWFQLYIQHDRDFTLRLVRRAESAGIRALVVSVDAPISGLRNREQ
HHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHCCCEEEEEEEECCCHHHHHHHHH
RMGFAFPGGIEPVNLRGLTPSPRAAGETLFDSPLITRAATWRDIENLREATKLPLVLKGI
HCCCCCCCCCCCEEEECCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
MTAEDAEQALAAGVDGLIVSNHGGRVLDGQPATIEVLPEIAAAVSGRVPILLDGGIRRGG
HHHHHHHHHHHCCCCEEEEECCCCEEECCCCCEEHHHHHHHHHHCCCCCEEECCCCCCCH
DVFKALALGASAVLVGRAFVHGLAAAGAVGVAHVLRILHAELEATMVLTGCRDIRAISPA
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHCCCCCH
SIRQAGLRT
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA