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The map label for this gene is rppH

Identifier: 75674649

GI number: 75674649

Start: 508093

End: 508605

Strand: Direct

Name: rppH

Synonym: Nwi_0451

Alternate gene names: 75674649

Gene position: 508093-508605 (Clockwise)

Preceding gene: 75674648

Following gene: 75674659

Centisome position: 14.93

GC content: 61.6

Gene sequence:

>513_bases
ATGACACGTTACGACGATCTACCCTATCGCACTTGCGTCGGCATGATGCTGATCAACGAGCGGGGGCTGGTTTTCGTCGG
TCGCCGCGCGGGCGTTGAGCAGGTCGATGACAGCTACGTCTGGCAGATGCCGCAAGGCGGCGTCGATCCCGGCGAGGATA
CGTGGCTCGCAGCGAAACGCGAACTCTATGAGGAGACCAGCGTTCGTTCGATCGAGAAGCTTGCCGAAATCCCGGATTGG
CTGACCTACGATATTCCGCGTGTCGTGGCCGGCCGGGCGTGGAAGGGCCGTTACCGCGGTCAGCGCCAGAAGTGGTATGC
GGTGCGCTTCATCGGCGAGGACAACGAGATCAACATCGCGAACCCCGGCGACGGTCACAAGCCGGAATTTACGGCATGGC
GCTGGGAGCCGATGCAGAATCTGACCGGGTTGATCATCCCGTTCAAGCGTCCGGTCTATGAGCGCGTGGTCAAGGAGTTC
GCGAGCCTCGCGGGCGCTCAAGCCGGAACATAA

Upstream 100 bases:

>100_bases
TCACACCGACCGGTATCCAATTCGCTTGAAAACGCTATAAGATCAGCATTCGTATCCGTCCCGTTCTCAGAGCGGTGGAG
GCGCACGGGGCATTGATGGA

Downstream 100 bases:

>100_bases
CCCCAGATTCGTTAGAGATTTTTCGCTCTGATAATCGGAAGCGGAACTCTCAGATCTTGATTTGACGTGTTTTCTTCAAC
TGCGAACCATTTCGCTTGAA

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 170; Mature: 169

Protein sequence:

>170_residues
MTRYDDLPYRTCVGMMLINERGLVFVGRRAGVEQVDDSYVWQMPQGGVDPGEDTWLAAKRELYEETSVRSIEKLAEIPDW
LTYDIPRVVAGRAWKGRYRGQRQKWYAVRFIGEDNEINIANPGDGHKPEFTAWRWEPMQNLTGLIIPFKRPVYERVVKEF
ASLAGAQAGT

Sequences:

>Translated_170_residues
MTRYDDLPYRTCVGMMLINERGLVFVGRRAGVEQVDDSYVWQMPQGGVDPGEDTWLAAKRELYEETSVRSIEKLAEIPDW
LTYDIPRVVAGRAWKGRYRGQRQKWYAVRFIGEDNEINIANPGDGHKPEFTAWRWEPMQNLTGLIIPFKRPVYERVVKEF
ASLAGAQAGT
>Mature_169_residues
TRYDDLPYRTCVGMMLINERGLVFVGRRAGVEQVDDSYVWQMPQGGVDPGEDTWLAAKRELYEETSVRSIEKLAEIPDWL
TYDIPRVVAGRAWKGRYRGQRQKWYAVRFIGEDNEINIANPGDGHKPEFTAWRWEPMQNLTGLIIPFKRPVYERVVKEFA
SLAGAQAGT

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=162, Percent_Identity=38.2716049382716, Blast_Score=105, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_NITWN (Q3SVH3)

Other databases:

- EMBL:   CP000115
- RefSeq:   YP_317070.1
- ProteinModelPortal:   Q3SVH3
- SMR:   Q3SVH3
- STRING:   Q3SVH3
- GeneID:   3676626
- GenomeReviews:   CP000115_GR
- KEGG:   nwi:Nwi_0451
- NMPDR:   fig|323098.3.peg.143
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   AGRAWKG
- PhylomeDB:   Q3SVH3
- ProtClustDB:   PRK00714
- BioCyc:   NWIN323098:NWI_0451-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 19584; Mature: 19453

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRYDDLPYRTCVGMMLINERGLVFVGRRAGVEQVDDSYVWQMPQGGVDPGEDTWLAAKR
CCCCCCCCHHHHHHHHEECCCCEEEEECCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHH
ELYEETSVRSIEKLAEIPDWLTYDIPRVVAGRAWKGRYRGQRQKWYAVRFIGEDNEINIA
HHHHHHHHHHHHHHHHCCCHHHHCCHHHHHCCCCCCCCCCCCCEEEEEEEECCCCEEEEC
NPGDGHKPEFTAWRWEPMQNLTGLIIPFKRPVYERVVKEFASLAGAQAGT
CCCCCCCCCCCEEECCHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TRYDDLPYRTCVGMMLINERGLVFVGRRAGVEQVDDSYVWQMPQGGVDPGEDTWLAAKR
CCCCCCCHHHHHHHHEECCCCEEEEECCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHH
ELYEETSVRSIEKLAEIPDWLTYDIPRVVAGRAWKGRYRGQRQKWYAVRFIGEDNEINIA
HHHHHHHHHHHHHHHHCCCHHHHCCHHHHHCCCCCCCCCCCCCEEEEEEEECCCCEEEEC
NPGDGHKPEFTAWRWEPMQNLTGLIIPFKRPVYERVVKEFASLAGAQAGT
CCCCCCCCCCCEEECCHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA