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The map label for this gene is hisD [H]

Identifier: 75674446

GI number: 75674446

Start: 276758

End: 278092

Strand: Direct

Name: hisD [H]

Synonym: Nwi_0247

Alternate gene names: 75674446

Gene position: 276758-278092 (Clockwise)

Preceding gene: 75674445

Following gene: 75674447

Centisome position: 8.13

GC content: 68.16

Gene sequence:

>1335_bases
GTGACCCGTGATATTGTTCCACATCCGCCGGAAGCATCCCAGCCCATGCCGATCCGCATCGATAGCCGCAACGCCGATTT
CGTCCCGCGCTTCAAGGCGTTTCTTGCGACCAAGCGCGAGGTCTCGGCCGATATCGAGGCGGCCACGCGCGCTATCGTCG
ACGACGTGGCGGCGCGGGGCGATGCGGCGCTGATCGAGGCCACGTGCAAGTTCGACCGGCTGTCCGTCGACGCCGCGGGT
CTCCGCTTCACCGCAGCCGAGATCGACGCCGCCGTGGCGGCTTGCGACGCCGCGACGCTGGACGCGCTGAAGCTGGCGCG
CGACCGGATCGAGACCTTTCATCGCCGCCAGTTGCCAAAGGACGACCGTTTCATCGACGCGCTCGGCGTCGAACTCGGCT
CGCGCTGGACCGCGATCGAGGCGGTCGGACTTTACGTGCCGGGCGGCTCCGCGGCCTATCCTTCCTCGGTGCTGATGAAT
GCGGTGCCGGCTATGGTCGCCGGGGTCGCGCGCGTCGTCATGGTGGTGCCCTCGCCGGCGGGCAGGATCAATCCGCTGGT
GCTGGCGGCGGCGCGGCTCGGCGGCGTCTCCGAAATCTATCGCGTGGGCGGCGCGCAGGCGGTCGCCGCACTCGCCTACG
GCACCGCGACCATCGCGCCGGTGGCCAAGATTGTCGGACCCGGCAACGCCTATGTCGCCGCCGCCAAGCGGCAGGTGTTC
GGCAAGGTCGGCATCGACATGATCGCCGGTCCCTCGGAGGTGCTTGTCATCGCCGACCAAACCGGCAACGCCGGCTGGAT
CGCCGCCGATCTGCTCGCGCAGGCGGAGCATGACGCCAACGCGCAATCGATCCTGATCACCGACAGCGAGGCGCTCGCCG
CCGATGTCGAGCGCGCCGTGGAGACGCAACTCGCAACGTTGCCGCGGGCCGGGATCGCGCGCGCCTCCTGGAACGACTTT
GGCGCCGTCATTCTGGTGACGGATCTCGATGAAGCGGTGGTGCTGGCGGATTCGATCGCCGCGGAACATCTGGAGATCAT
GACCGCCGATCCCGAAGGCCTCGCAGCGCGGATCCGTAATGCCGGCGCGATCTTTCTCGGGCCGCATACGCCGGAAGCCA
TCGGCGATTATGTCGGCGGCTCCAATCACGTCCTGCCGACGGCACGCTCCGCGCGGTTTTCGTCGGGCCTTGGCGTGCTT
GACTTCATGAAGCGAACGTCAATCCTCAAATGCGGGCCGGACCAGTTGCGGGCGCTGGGGCCGGCGGCGATGACCCTGGG
CAAGGCCGAGGGCCTCGATGCCCATGCCCGTTCGGTCGGAGTGCGTCTCAACTAG

Upstream 100 bases:

>100_bases
GCGCCGGATCGGGGTTGGTGCGAACCAATGGCGTTTTCGAGCGAAATGATCTCGAAGGGTTGACGGCGATTTGAGGTCGC
GCCATTGAGCCGGTGTCCCT

Downstream 100 bases:

>100_bases
AGCATTTTCCGGCGAAGTGGATGACCTGTTCGCCGCAAGAAAATGCGATCAGACAACCATTTCTAGAGCATGGTCCGATT
CAACTTGATCGGATCATGCT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTRDIVPHPPEASQPMPIRIDSRNADFVPRFKAFLATKREVSADIEAATRAIVDDVAARGDAALIEATCKFDRLSVDAAG
LRFTAAEIDAAVAACDAATLDALKLARDRIETFHRRQLPKDDRFIDALGVELGSRWTAIEAVGLYVPGGSAAYPSSVLMN
AVPAMVAGVARVVMVVPSPAGRINPLVLAAARLGGVSEIYRVGGAQAVAALAYGTATIAPVAKIVGPGNAYVAAAKRQVF
GKVGIDMIAGPSEVLVIADQTGNAGWIAADLLAQAEHDANAQSILITDSEALAADVERAVETQLATLPRAGIARASWNDF
GAVILVTDLDEAVVLADSIAAEHLEIMTADPEGLAARIRNAGAIFLGPHTPEAIGDYVGGSNHVLPTARSARFSSGLGVL
DFMKRTSILKCGPDQLRALGPAAMTLGKAEGLDAHARSVGVRLN

Sequences:

>Translated_444_residues
MTRDIVPHPPEASQPMPIRIDSRNADFVPRFKAFLATKREVSADIEAATRAIVDDVAARGDAALIEATCKFDRLSVDAAG
LRFTAAEIDAAVAACDAATLDALKLARDRIETFHRRQLPKDDRFIDALGVELGSRWTAIEAVGLYVPGGSAAYPSSVLMN
AVPAMVAGVARVVMVVPSPAGRINPLVLAAARLGGVSEIYRVGGAQAVAALAYGTATIAPVAKIVGPGNAYVAAAKRQVF
GKVGIDMIAGPSEVLVIADQTGNAGWIAADLLAQAEHDANAQSILITDSEALAADVERAVETQLATLPRAGIARASWNDF
GAVILVTDLDEAVVLADSIAAEHLEIMTADPEGLAARIRNAGAIFLGPHTPEAIGDYVGGSNHVLPTARSARFSSGLGVL
DFMKRTSILKCGPDQLRALGPAAMTLGKAEGLDAHARSVGVRLN
>Mature_443_residues
TRDIVPHPPEASQPMPIRIDSRNADFVPRFKAFLATKREVSADIEAATRAIVDDVAARGDAALIEATCKFDRLSVDAAGL
RFTAAEIDAAVAACDAATLDALKLARDRIETFHRRQLPKDDRFIDALGVELGSRWTAIEAVGLYVPGGSAAYPSSVLMNA
VPAMVAGVARVVMVVPSPAGRINPLVLAAARLGGVSEIYRVGGAQAVAALAYGTATIAPVAKIVGPGNAYVAAAKRQVFG
KVGIDMIAGPSEVLVIADQTGNAGWIAADLLAQAEHDANAQSILITDSEALAADVERAVETQLATLPRAGIARASWNDFG
AVILVTDLDEAVVLADSIAAEHLEIMTADPEGLAARIRNAGAIFLGPHTPEAIGDYVGGSNHVLPTARSARFSSGLGVLD
FMKRTSILKCGPDQLRALGPAAMTLGKAEGLDAHARSVGVRLN

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=406, Percent_Identity=44.3349753694581, Blast_Score=285, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6319819, Length=414, Percent_Identity=38.1642512077295, Blast_Score=256, Evalue=6e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46153; Mature: 46022

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRDIVPHPPEASQPMPIRIDSRNADFVPRFKAFLATKREVSADIEAATRAIVDDVAARG
CCCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DAALIEATCKFDRLSVDAAGLRFTAAEIDAAVAACDAATLDALKLARDRIETFHRRQLPK
CCEEEEEECCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DDRFIDALGVELGSRWTAIEAVGLYVPGGSAAYPSSVLMNAVPAMVAGVARVVMVVPSPA
CCCHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCC
GRINPLVLAAARLGGVSEIYRVGGAQAVAALAYGTATIAPVAKIVGPGNAYVAAAKRQVF
CCCCHHHHHHHHHCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCEEHHHHHHHH
GKVGIDMIAGPSEVLVIADQTGNAGWIAADLLAQAEHDANAQSILITDSEALAADVERAV
HHCCCCEECCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHH
ETQLATLPRAGIARASWNDFGAVILVTDLDEAVVLADSIAAEHLEIMTADPEGLAARIRN
HHHHHHCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHEEEEECCCHHHHHHHCC
AGAIFLGPHTPEAIGDYVGGSNHVLPTARSARFSSGLGVLDFMKRTSILKCGPDQLRALG
CCEEEECCCCHHHHHHHCCCCCCCCCCCCCCHHCCCCCHHHHHHHHCCCCCCHHHHHHCC
PAAMTLGKAEGLDAHARSVGVRLN
HHHHHHCCCCCCCCHHHCCCCCCC
>Mature Secondary Structure 
TRDIVPHPPEASQPMPIRIDSRNADFVPRFKAFLATKREVSADIEAATRAIVDDVAARG
CCCCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DAALIEATCKFDRLSVDAAGLRFTAAEIDAAVAACDAATLDALKLARDRIETFHRRQLPK
CCEEEEEECCCCEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DDRFIDALGVELGSRWTAIEAVGLYVPGGSAAYPSSVLMNAVPAMVAGVARVVMVVPSPA
CCCHHHHHHHHHCCCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCC
GRINPLVLAAARLGGVSEIYRVGGAQAVAALAYGTATIAPVAKIVGPGNAYVAAAKRQVF
CCCCHHHHHHHHHCCHHHHHHCCCHHHHHHHHHCCHHHHHHHHHCCCCCCEEHHHHHHHH
GKVGIDMIAGPSEVLVIADQTGNAGWIAADLLAQAEHDANAQSILITDSEALAADVERAV
HHCCCCEECCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHH
ETQLATLPRAGIARASWNDFGAVILVTDLDEAVVLADSIAAEHLEIMTADPEGLAARIRN
HHHHHHCCCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHEEEEECCCHHHHHHHCC
AGAIFLGPHTPEAIGDYVGGSNHVLPTARSARFSSGLGVLDFMKRTSILKCGPDQLRALG
CCEEEECCCCHHHHHHHCCCCCCCCCCCCCCHHCCCCCHHHHHHHHCCCCCCHHHHHHCC
PAAMTLGKAEGLDAHARSVGVRLN
HHHHHHCCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA