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The map label for this gene is pqqL [C]

Identifier: 75674429

GI number: 75674429

Start: 261266

End: 262555

Strand: Direct

Name: pqqL [C]

Synonym: Nwi_0230

Alternate gene names: 75674429

Gene position: 261266-262555 (Clockwise)

Preceding gene: 75674428

Following gene: 75674430

Centisome position: 7.68

GC content: 63.41

Gene sequence:

>1290_bases
ATGAGTGTCAATGTCACGAAGCTGTCGTCCGGCCTCACCGTCGTGACTGATGACATGCCACATCTGGAAACCGCCGCGCT
CGGTGTCTGGACCGGAGTCGGCGGCCGTGACGAGAAGCCGGACGAGCACGGCATCTCTCACCTTCTCGAACATATGGCGT
TCAAGGGCACCACCACGCGTTCGTCGCGGGCGATCGCCGAGGAGATCGAGGCCGTCGGCGGCGATCTCAACGCCGCTACC
GGGGTCGAGACGACGGCTTATTACGCGCGGGTGATGAAGGCCGACGTTCCGCTCGCGCTCGATGTGTTGAGCGACATCCT
GTCCAACCCGATCTTCGACGCAAAGGAGCTCGAATGCGAGAAGGGTGTCATCGAGCAGGAAATCGGTGCGGCGCAGGACA
CCCCTGACGACGTCGTTTTCGAGCAACTCAACGAACTCTGTTATCCCGACCAGCCCATCGGCCGTTCGCTGCTCGGAACG
CCCGAGACGCTGGAGCGATTCAACAGCGATATGCTGCATGGTTACCTCAAGACGCATTATCGCGGGCCGGACATGGTGGT
GGCGGCGGCGGGTGCGATCGAGCATGGGATGGTTGTTGCCGAAGTCGAGCGCCGCTTTGCCGGTTTCGACGCCGCGCCGC
CTCCGCAGCCGGCGGCGGCGACATTCGGCCACGGCGGCTCCAGGGTAGTGCATCGCGATTTGGAACAGGCGCATCTGACG
TTGGCGCTGGAAGGGGTGCCGCAGACCGACGGCTCGCTGTTTTCCCTCCAGGTGTTCACCAGCGTTCTTGGGGGCGGCAT
GTCCTCGCGACTGTTTCAGGAAGTTCGTGAGAAGCGCGGTCTGTGCTACTCGATCTATACTTTCCATGCACCCTATGCCG
ACACCGGCCTGTTTGGGCTCTACACCGGCACCGATCCGAGCGACGCGCCTGAAATGATGGAAGTCATCGTCGACGTTATC
AGCGAAGCCGTGGAAACGCTGACGGAAGCTGAGATCGCGCGCGCGAAGGCGCAGATGAAAGCTGGCCTGTTGATGGCGCT
GGAGAGTTGCAGCGCCCGCGCCGAACAATTGGCCCGGCATATGCTCGTTTATGGACGGCCCCAGAGCGTCGGGGAATTGA
CCGCCAGGATCGACGCCGTCAGCGTCGAATCAACGCGTGATGCGGCGCGCGGCCTCCTGGCCCGCAGCCGTCCCGCTGTC
GTCGCGCTCGGCAGCGGAAGGGGGCTGGACAGCGCAGTCGCTTTCGCGGAAGGATTGGCGCAGTCGAAGGCCCGGATCCT
GCTCCACTAG

Upstream 100 bases:

>100_bases
TGACCCGGCCCGAGCGGATCACGATCGTGAACAACGATCAGGCAGAAATCGAACGGTTCGTGCTGTCCGTCAGCCGCGCC
GCCAATCACGGAGTTACCGG

Downstream 100 bases:

>100_bases
AGCTTTTTCCGGCGAAGCGGATATCGGTTCGCCGAAGGAAATGCGACGAGACATTCACTTCCTGAGCATGATCCGATTCA
ACGTGGTCAGATTAAAATCT

Product: peptidase M16

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MSVNVTKLSSGLTVVTDDMPHLETAALGVWTGVGGRDEKPDEHGISHLLEHMAFKGTTTRSSRAIAEEIEAVGGDLNAAT
GVETTAYYARVMKADVPLALDVLSDILSNPIFDAKELECEKGVIEQEIGAAQDTPDDVVFEQLNELCYPDQPIGRSLLGT
PETLERFNSDMLHGYLKTHYRGPDMVVAAAGAIEHGMVVAEVERRFAGFDAAPPPQPAAATFGHGGSRVVHRDLEQAHLT
LALEGVPQTDGSLFSLQVFTSVLGGGMSSRLFQEVREKRGLCYSIYTFHAPYADTGLFGLYTGTDPSDAPEMMEVIVDVI
SEAVETLTEAEIARAKAQMKAGLLMALESCSARAEQLARHMLVYGRPQSVGELTARIDAVSVESTRDAARGLLARSRPAV
VALGSGRGLDSAVAFAEGLAQSKARILLH

Sequences:

>Translated_429_residues
MSVNVTKLSSGLTVVTDDMPHLETAALGVWTGVGGRDEKPDEHGISHLLEHMAFKGTTTRSSRAIAEEIEAVGGDLNAAT
GVETTAYYARVMKADVPLALDVLSDILSNPIFDAKELECEKGVIEQEIGAAQDTPDDVVFEQLNELCYPDQPIGRSLLGT
PETLERFNSDMLHGYLKTHYRGPDMVVAAAGAIEHGMVVAEVERRFAGFDAAPPPQPAAATFGHGGSRVVHRDLEQAHLT
LALEGVPQTDGSLFSLQVFTSVLGGGMSSRLFQEVREKRGLCYSIYTFHAPYADTGLFGLYTGTDPSDAPEMMEVIVDVI
SEAVETLTEAEIARAKAQMKAGLLMALESCSARAEQLARHMLVYGRPQSVGELTARIDAVSVESTRDAARGLLARSRPAV
VALGSGRGLDSAVAFAEGLAQSKARILLH
>Mature_428_residues
SVNVTKLSSGLTVVTDDMPHLETAALGVWTGVGGRDEKPDEHGISHLLEHMAFKGTTTRSSRAIAEEIEAVGGDLNAATG
VETTAYYARVMKADVPLALDVLSDILSNPIFDAKELECEKGVIEQEIGAAQDTPDDVVFEQLNELCYPDQPIGRSLLGTP
ETLERFNSDMLHGYLKTHYRGPDMVVAAAGAIEHGMVVAEVERRFAGFDAAPPPQPAAATFGHGGSRVVHRDLEQAHLTL
ALEGVPQTDGSLFSLQVFTSVLGGGMSSRLFQEVREKRGLCYSIYTFHAPYADTGLFGLYTGTDPSDAPEMMEVIVDVIS
EAVETLTEAEIARAKAQMKAGLLMALESCSARAEQLARHMLVYGRPQSVGELTARIDAVSVESTRDAARGLLARSRPAVV
ALGSGRGLDSAVAFAEGLAQSKARILLH

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI94538354, Length=412, Percent_Identity=35.1941747572816, Blast_Score=241, Evalue=9e-64,
Organism=Homo sapiens, GI46593007, Length=418, Percent_Identity=32.0574162679426, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI24308013, Length=453, Percent_Identity=25.60706401766, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI50592988, Length=398, Percent_Identity=24.1206030150754, Blast_Score=105, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71999683, Length=413, Percent_Identity=30.5084745762712, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17553678, Length=421, Percent_Identity=28.978622327791, Blast_Score=167, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI17510601, Length=465, Percent_Identity=23.6559139784946, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17569737, Length=396, Percent_Identity=22.7272727272727, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323192, Length=435, Percent_Identity=31.4942528735632, Blast_Score=233, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6321813, Length=434, Percent_Identity=27.8801843317972, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319426, Length=429, Percent_Identity=26.1072261072261, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21357875, Length=412, Percent_Identity=33.252427184466, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24646943, Length=412, Percent_Identity=33.252427184466, Blast_Score=236, Evalue=3e-62,
Organism=Drosophila melanogaster, GI19921772, Length=440, Percent_Identity=25.4545454545455, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24665395, Length=412, Percent_Identity=23.5436893203883, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 45848; Mature: 45717

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVNVTKLSSGLTVVTDDMPHLETAALGVWTGVGGRDEKPDEHGISHLLEHMAFKGTTTR
CCCCCEECCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
SSRAIAEEIEAVGGDLNAATGVETTAYYARVMKADVPLALDVLSDILSNPIFDAKELECE
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHH
KGVIEQEIGAAQDTPDDVVFEQLNELCYPDQPIGRSLLGTPETLERFNSDMLHGYLKTHY
HCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHC
RGPDMVVAAAGAIEHGMVVAEVERRFAGFDAAPPPQPAAATFGHGGSRVVHRDLEQAHLT
CCCCEEEEECCHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEE
LALEGVPQTDGSLFSLQVFTSVLGGGMSSRLFQEVREKRGLCYSIYTFHAPYADTGLFGL
EEEECCCCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEE
YTGTDPSDAPEMMEVIVDVISEAVETLTEAEIARAKAQMKAGLLMALESCSARAEQLARH
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLVYGRPQSVGELTARIDAVSVESTRDAARGLLARSRPAVVALGSGRGLDSAVAFAEGLA
HHHCCCCCHHHHHHHHHHHEECHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHH
QSKARILLH
HCCHHEECC
>Mature Secondary Structure 
SVNVTKLSSGLTVVTDDMPHLETAALGVWTGVGGRDEKPDEHGISHLLEHMAFKGTTTR
CCCCEECCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
SSRAIAEEIEAVGGDLNAATGVETTAYYARVMKADVPLALDVLSDILSNPIFDAKELECE
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHH
KGVIEQEIGAAQDTPDDVVFEQLNELCYPDQPIGRSLLGTPETLERFNSDMLHGYLKTHY
HCHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHC
RGPDMVVAAAGAIEHGMVVAEVERRFAGFDAAPPPQPAAATFGHGGSRVVHRDLEQAHLT
CCCCEEEEECCHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEE
LALEGVPQTDGSLFSLQVFTSVLGGGMSSRLFQEVREKRGLCYSIYTFHAPYADTGLFGL
EEEECCCCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEE
YTGTDPSDAPEMMEVIVDVISEAVETLTEAEIARAKAQMKAGLLMALESCSARAEQLARH
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLVYGRPQSVGELTARIDAVSVESTRDAARGLLARSRPAVVALGSGRGLDSAVAFAEGLA
HHHCCCCCHHHHHHHHHHHEECHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHH
QSKARILLH
HCCHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA