Click here to switch to the map view.

The map label for this gene is yfhK [H]

Identifier: 74318787

GI number: 74318787

Start: 2851281

End: 2852735

Strand: Direct

Name: yfhK [H]

Synonym: Tbd_2769

Alternate gene names: 74318787

Gene position: 2851281-2852735 (Clockwise)

Preceding gene: 74318786

Following gene: 74318788

Centisome position: 97.99

GC content: 69.28

Gene sequence:

>1455_bases
ATGTCCGCGCCTTCAGCCCGCATGCTTTCCGGTCCCTATTACCCGCGCTCGTTCACGATCCTCGTGATCGCCGCCATGGG
CGTGCTCATCGTGCCGCTCGCGAGCGGGCTCATCAACGCAGTGCACGTGCTGCAGGGCGTGCTCGACACCCAGCGGCAGT
TCACGCGCGACAGCCTCGCGGTCACGCGCGACGTGCGCCAGGTCGTCGACTCGGTCAGCCAGCTGCAGCGCGCGGCCGGG
CAGTACCACCTGCTCCAGGACAAGGAGTTCGGTCCGGCGCTGCACGCGCGCTTCGACGCGCTGCAGAAGCAGCTCGCCGA
ACTCGAGCCGCGCCTGAGCGACCCGCTCGCGCGCAGCACGCTGGCGACGCTGCGCACGCGCAGCCTCGCGCTCTACCGCA
CGCTGCAGCCCGGCCGCTTTCTCGACAGCGAGCGTTTCCACGCGCTCGACCCGGCCTTCGACGATCTGCACGTCGGCGCC
GAAAACCTGCTGCACGAGGCCGACACCGCGGTCGAGGGAGAACTGCAAGTACTCGAGGCAACCGTGCAAGCGACGCAACA
ACGCCTGATTGCGCTCGGGCTCGCGCTGATCCCGCTGACGCTGCTCCTCGCGGCCGTGTTTTCCTGGCTCATCAACCGCC
CGATCAAGCAGCTCAAGGCCTCGATCCAGCAGCTCGGACAGGCCGATCTCGGCCCGCTGCCCGCGATCAGCGGGCCGCAG
GACATCGTCGAACTCGGGCGCGAGATGGACTGGCTGCGCCAGCGCCTGCAGGCGCTCGAGGAACAGAAACTGCAGTTCCT
GCGCCAGGTCTCGCACGAACTCAAGACCCCGCTGGCCTCGCTGCGCGAAGGCGTCGCCCTGCTCGGCGACGAACTCGCCG
GCAGCCTCAATCCGCGTCAGCGCGCGATCGTGACGATCATGGATACCGGCAGCCGCGACCTGCAGCAGCGCATCGAGGAT
CTGCTCCGCTACGGCAACCTCCAGGATGCGCGCCCGCCCGCGGTGCCGGTGGCGCTAGCCGAGGCGCTCGCGAGCGTGCT
CGAACGCCAGCGCCTCGCGCTCGAGGCGCGCCGCATCGTGGTCGAGACCGAATTCGCGGCGCCCGCCGTGCTCGCCGATC
GCGCACTGCTCGAAACCGTGCTCGACAACCTGCTCTCGAATGCGGTCAAATTCAGCCCGGACGAGGGACGCATCCTGGTC
AGGAGCGAAGTCGCCGACGACGCCGTCGTGCTCTGGTTCTGCGACCAGGGCGAAGGCATCCCCGAAGCCTTGCGCGCCCG
CGTCTTCGAGCCCTTCTTCCAGGGTCCGCGCCAGCCCGCGAGCACGGTCAAGGGCAGCGGGCTCGGCCTGTCGATCGTGC
GCGAATCGGTGCTCGCCGCCGGCGGCGCGATCGGCATCGTCGACGCACCGCCCTGGTCCACCTGTTTCCGTCTAAGCCTG
CCGCTCCCACCATGA

Upstream 100 bases:

>100_bases
GAAGGCCGCGAGGCCGCCAAGGGTATCCTCGCCTACCTCGAGATCTAGCATCGCCCGCGCGCCGGCGGCTGCCGGCGCGC
GAACCGGGTATGCTGCGACA

Downstream 100 bases:

>100_bases
AGCTGAAATTCCTCTCCATCGCCATGCTCTCGCTGCTGCTCGCGGCCTGCGCCGCGACCCGTCCGCCCGAACGTGCGCCC
GCACGGGACTGTCCGCCGGC

Product: signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSAPSARMLSGPYYPRSFTILVIAAMGVLIVPLASGLINAVHVLQGVLDTQRQFTRDSLAVTRDVRQVVDSVSQLQRAAG
QYHLLQDKEFGPALHARFDALQKQLAELEPRLSDPLARSTLATLRTRSLALYRTLQPGRFLDSERFHALDPAFDDLHVGA
ENLLHEADTAVEGELQVLEATVQATQQRLIALGLALIPLTLLLAAVFSWLINRPIKQLKASIQQLGQADLGPLPAISGPQ
DIVELGREMDWLRQRLQALEEQKLQFLRQVSHELKTPLASLREGVALLGDELAGSLNPRQRAIVTIMDTGSRDLQQRIED
LLRYGNLQDARPPAVPVALAEALASVLERQRLALEARRIVVETEFAAPAVLADRALLETVLDNLLSNAVKFSPDEGRILV
RSEVADDAVVLWFCDQGEGIPEALRARVFEPFFQGPRQPASTVKGSGLGLSIVRESVLAAGGAIGIVDAPPWSTCFRLSL
PLPP

Sequences:

>Translated_484_residues
MSAPSARMLSGPYYPRSFTILVIAAMGVLIVPLASGLINAVHVLQGVLDTQRQFTRDSLAVTRDVRQVVDSVSQLQRAAG
QYHLLQDKEFGPALHARFDALQKQLAELEPRLSDPLARSTLATLRTRSLALYRTLQPGRFLDSERFHALDPAFDDLHVGA
ENLLHEADTAVEGELQVLEATVQATQQRLIALGLALIPLTLLLAAVFSWLINRPIKQLKASIQQLGQADLGPLPAISGPQ
DIVELGREMDWLRQRLQALEEQKLQFLRQVSHELKTPLASLREGVALLGDELAGSLNPRQRAIVTIMDTGSRDLQQRIED
LLRYGNLQDARPPAVPVALAEALASVLERQRLALEARRIVVETEFAAPAVLADRALLETVLDNLLSNAVKFSPDEGRILV
RSEVADDAVVLWFCDQGEGIPEALRARVFEPFFQGPRQPASTVKGSGLGLSIVRESVLAAGGAIGIVDAPPWSTCFRLSL
PLPP
>Mature_483_residues
SAPSARMLSGPYYPRSFTILVIAAMGVLIVPLASGLINAVHVLQGVLDTQRQFTRDSLAVTRDVRQVVDSVSQLQRAAGQ
YHLLQDKEFGPALHARFDALQKQLAELEPRLSDPLARSTLATLRTRSLALYRTLQPGRFLDSERFHALDPAFDDLHVGAE
NLLHEADTAVEGELQVLEATVQATQQRLIALGLALIPLTLLLAAVFSWLINRPIKQLKASIQQLGQADLGPLPAISGPQD
IVELGREMDWLRQRLQALEEQKLQFLRQVSHELKTPLASLREGVALLGDELAGSLNPRQRAIVTIMDTGSRDLQQRIEDL
LRYGNLQDARPPAVPVALAEALASVLERQRLALEARRIVVETEFAAPAVLADRALLETVLDNLLSNAVKFSPDEGRILVR
SEVADDAVVLWFCDQGEGIPEALRARVFEPFFQGPRQPASTVKGSGLGLSIVRESVLAAGGAIGIVDAPPWSTCFRLSLP
LPP

Specific function: Probable member of a two-component regulatory system yfhA/yfhK. May activate yfhA by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082128, Length=476, Percent_Identity=32.7731092436975, Blast_Score=215, Evalue=5e-57,
Organism=Escherichia coli, GI1790861, Length=395, Percent_Identity=26.5822784810127, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI87081816, Length=455, Percent_Identity=27.4725274725275, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1787894, Length=313, Percent_Identity=30.3514376996805, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI145693157, Length=246, Percent_Identity=28.4552845528455, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=26.6903914590747, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790346, Length=274, Percent_Identity=25.9124087591241, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1789149, Length=251, Percent_Identity=26.2948207171315, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786912, Length=237, Percent_Identity=28.6919831223629, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=224, Percent_Identity=27.2321428571429, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790551, Length=267, Percent_Identity=27.3408239700375, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786783, Length=277, Percent_Identity=25.6317689530686, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786600, Length=235, Percent_Identity=26.3829787234043, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1786837, Length=268, Percent_Identity=26.4925373134328, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52916; Mature: 52785

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN ; PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPSARMLSGPYYPRSFTILVIAAMGVLIVPLASGLINAVHVLQGVLDTQRQFTRDSLA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTRDVRQVVDSVSQLQRAAGQYHLLQDKEFGPALHARFDALQKQLAELEPRLSDPLARST
HHHHHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHCCHHHHHH
LATLRTRSLALYRTLQPGRFLDSERFHALDPAFDDLHVGAENLLHEADTAVEGELQVLEA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
TVQATQQRLIALGLALIPLTLLLAAVFSWLINRPIKQLKASIQQLGQADLGPLPAISGPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
DIVELGREMDWLRQRLQALEEQKLQFLRQVSHELKTPLASLREGVALLGDELAGSLNPRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCC
RAIVTIMDTGSRDLQQRIEDLLRYGNLQDARPPAVPVALAEALASVLERQRLALEARRIV
CEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VETEFAAPAVLADRALLETVLDNLLSNAVKFSPDEGRILVRSEVADDAVVLWFCDQGEGI
EEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEECCCCCC
PEALRARVFEPFFQGPRQPASTVKGSGLGLSIVRESVLAAGGAIGIVDAPPWSTCFRLSL
HHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEC
PLPP
CCCC
>Mature Secondary Structure 
SAPSARMLSGPYYPRSFTILVIAAMGVLIVPLASGLINAVHVLQGVLDTQRQFTRDSLA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTRDVRQVVDSVSQLQRAAGQYHLLQDKEFGPALHARFDALQKQLAELEPRLSDPLARST
HHHHHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHCCHHHHHH
LATLRTRSLALYRTLQPGRFLDSERFHALDPAFDDLHVGAENLLHEADTAVEGELQVLEA
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
TVQATQQRLIALGLALIPLTLLLAAVFSWLINRPIKQLKASIQQLGQADLGPLPAISGPQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
DIVELGREMDWLRQRLQALEEQKLQFLRQVSHELKTPLASLREGVALLGDELAGSLNPRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCCC
RAIVTIMDTGSRDLQQRIEDLLRYGNLQDARPPAVPVALAEALASVLERQRLALEARRIV
CEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VETEFAAPAVLADRALLETVLDNLLSNAVKFSPDEGRILVRSEVADDAVVLWFCDQGEGI
EEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEECCCCCC
PEALRARVFEPFFQGPRQPASTVKGSGLGLSIVRESVLAAGGAIGIVDAPPWSTCFRLSL
HHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCEEEEEC
PLPP
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]