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The map label for this gene is fabF [H]

Identifier: 74318771

GI number: 74318771

Start: 2832708

End: 2833928

Strand: Direct

Name: fabF [H]

Synonym: Tbd_2753

Alternate gene names: 74318771

Gene position: 2832708-2833928 (Clockwise)

Preceding gene: 74318770

Following gene: 74318772

Centisome position: 97.35

GC content: 72.73

Gene sequence:

>1221_bases
TTGCGCCCCGATCGAAGGCCGGCCGTGATTCCCCTCCATCTGTCCCACTTCACCGCGAGCAGTTGCCTCGGCGCCGGGCT
CGACCCGACGCTCGCCGCGCTGCGCGCGGGACGCAGCGGCCTGGCGCCGTGCCGCTTCGAGACCGTGCACGACCTCGATA
CGCACATCGGCGAAGTCGCCGGCGTCGACGAAACGCCGCTGCCGGCGGACTTCGCCGAGCACGACTGCCGCAACAACCGC
CTCGCCTGGCTCGGCCTGCAACAGGACGGCTTCGACGCTGCCGTGCGCGCCGCAATCGCGCGCCACGGCCGGCGCCGCGT
CGGCGTCTTCCTCGGCACGAGCACGGCCGGCATCCTGCAGACCGAGCAGGCCTACCGCCGGCGCGACGCGGCGAGCGGCG
CGCTGCCCGCGGACTTCGTCTACCGCACGACCCACAACACCTATTCGCTCGCCGGTTTCGTGCGCGCGCTCTACGGCATC
GAAGGCCCGGCCGCCGTCGCCTCGACCGCGTGCTCGTCGGGCGCCAAGGTGTTCGCGAGCGCGCAACGCATGATCGCGAC
GGGCCTCATCGACGCGGCGATCGTCGGCGGCGTCGATTCGCTCTGCCTGACGACGCTCTACGGCTTCAATTCGCTCGAGC
TGCTCTCGCCCGAGCCGTGCCGGCCCTTCGACGCCGGCCGCCGCGGCCTGTCGATCGGCGAGGCTGCTGCCTTCGCGCTG
CTGGAAGCCGTGCCGGCGAGCCTCGACGCCGACGCCGTGCTGCTGCTCGGCGCGGGCGAAAGCTCGGACGCGCATCACAT
GTCCTCGCCGCATCCCGAAGGCGCGGGGGCGCGCCAGGCGATGGCGGCCACGCTGGCGGCAGCCGGCCTTGCCCCCGACC
AGATCGACTACGTCAATCTCCACGGTACCGCAACGCCGAGCAACGACGCGGCCGAAGGCCGCGCGGTCGCTGCCTTGTTC
GGCGACCGGGTCGCCTGCAGTTCGACCAAGGGCGCGACCGGCCACACGCTCGGCGCGGCTGGCGGCCTCGAGGCCGTGAT
CGCGGCGCTCGCGCTGCAGCACGGCTTCATGCCCGGCGGCGTCAATACCCGCACGCCCGACCCCGCGATTCCGGTCCGCT
ATCTGCGCACCAACACCGACGTCGCCCCGCGCCGCGTGCTGAGCAATTCCTTCGGCTTCGGCGGCACCAATTGCAGCCTC
GTTCTGGGGCGGGCAGGCTGA

Upstream 100 bases:

>100_bases
CGGTCGAAACGGCGTCGATGAACGGCGACCTGCCCTTCGCTAACGTCATGCTGGTCGCCCGCCTGGGCGCGGCGGACGGG
CCCGCGATCTAAGTTAGAAT

Downstream 100 bases:

>100_bases
GATGGCGGCGAGACTCAGCGTCTGGATCGAGGGCGTCGGCCTGCTCGGCCCCGGATTCGAGGACTGGGCCGGCGCACTGC
CGGTTCTCGACGGGTCCTCG

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MRPDRRPAVIPLHLSHFTASSCLGAGLDPTLAALRAGRSGLAPCRFETVHDLDTHIGEVAGVDETPLPADFAEHDCRNNR
LAWLGLQQDGFDAAVRAAIARHGRRRVGVFLGTSTAGILQTEQAYRRRDAASGALPADFVYRTTHNTYSLAGFVRALYGI
EGPAAVASTACSSGAKVFASAQRMIATGLIDAAIVGGVDSLCLTTLYGFNSLELLSPEPCRPFDAGRRGLSIGEAAAFAL
LEAVPASLDADAVLLLGAGESSDAHHMSSPHPEGAGARQAMAATLAAAGLAPDQIDYVNLHGTATPSNDAAEGRAVAALF
GDRVACSSTKGATGHTLGAAGGLEAVIAALALQHGFMPGGVNTRTPDPAIPVRYLRTNTDVAPRRVLSNSFGFGGTNCSL
VLGRAG

Sequences:

>Translated_406_residues
MRPDRRPAVIPLHLSHFTASSCLGAGLDPTLAALRAGRSGLAPCRFETVHDLDTHIGEVAGVDETPLPADFAEHDCRNNR
LAWLGLQQDGFDAAVRAAIARHGRRRVGVFLGTSTAGILQTEQAYRRRDAASGALPADFVYRTTHNTYSLAGFVRALYGI
EGPAAVASTACSSGAKVFASAQRMIATGLIDAAIVGGVDSLCLTTLYGFNSLELLSPEPCRPFDAGRRGLSIGEAAAFAL
LEAVPASLDADAVLLLGAGESSDAHHMSSPHPEGAGARQAMAATLAAAGLAPDQIDYVNLHGTATPSNDAAEGRAVAALF
GDRVACSSTKGATGHTLGAAGGLEAVIAALALQHGFMPGGVNTRTPDPAIPVRYLRTNTDVAPRRVLSNSFGFGGTNCSL
VLGRAG
>Mature_406_residues
MRPDRRPAVIPLHLSHFTASSCLGAGLDPTLAALRAGRSGLAPCRFETVHDLDTHIGEVAGVDETPLPADFAEHDCRNNR
LAWLGLQQDGFDAAVRAAIARHGRRRVGVFLGTSTAGILQTEQAYRRRDAASGALPADFVYRTTHNTYSLAGFVRALYGI
EGPAAVASTACSSGAKVFASAQRMIATGLIDAAIVGGVDSLCLTTLYGFNSLELLSPEPCRPFDAGRRGLSIGEAAAFAL
LEAVPASLDADAVLLLGAGESSDAHHMSSPHPEGAGARQAMAATLAAAGLAPDQIDYVNLHGTATPSNDAAEGRAVAALF
GDRVACSSTKGATGHTLGAAGGLEAVIAALALQHGFMPGGVNTRTPDPAIPVRYLRTNTDVAPRRVLSNSFGFGGTNCSL
VLGRAG

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=269, Percent_Identity=41.2639405204461, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI223972627, Length=147, Percent_Identity=45.578231292517, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI41872631, Length=276, Percent_Identity=31.1594202898551, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1787337, Length=281, Percent_Identity=39.1459074733096, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788663, Length=398, Percent_Identity=31.4070351758794, Blast_Score=125, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI71983541, Length=298, Percent_Identity=34.2281879194631, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI71983535, Length=260, Percent_Identity=35, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI212642053, Length=366, Percent_Identity=27.8688524590164, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17550940, Length=338, Percent_Identity=27.810650887574, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=425, Percent_Identity=27.7647058823529, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24644341, Length=315, Percent_Identity=35.5555555555556, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24581345, Length=319, Percent_Identity=26.6457680250784, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221330659, Length=317, Percent_Identity=26.4984227129338, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19920632, Length=317, Percent_Identity=26.4984227129338, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 41783; Mature: 41783

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPDRRPAVIPLHLSHFTASSCLGAGLDPTLAALRAGRSGLAPCRFETVHDLDTHIGEVA
CCCCCCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHC
GVDETPLPADFAEHDCRNNRLAWLGLQQDGFDAAVRAAIARHGRRRVGVFLGTSTAGILQ
CCCCCCCCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEEECCCCHHHH
TEQAYRRRDAASGALPADFVYRTTHNTYSLAGFVRALYGIEGPAAVASTACSSGAKVFAS
HHHHHHHHHHCCCCCCHHHEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHH
AQRMIATGLIDAAIVGGVDSLCLTTLYGFNSLELLSPEPCRPFDAGRRGLSIGEAAAFAL
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCCCCCCCHHHCCCCCCHHHHHHHHH
LEAVPASLDADAVLLLGAGESSDAHHMSSPHPEGAGARQAMAATLAAAGLAPDQIDYVNL
HHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEE
HGTATPSNDAAEGRAVAALFGDRVACSSTKGATGHTLGAAGGLEAVIAALALQHGFMPGG
CCCCCCCCCCCCCCEEEEHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
VNTRTPDPAIPVRYLRTNTDVAPRRVLSNSFGFGGTNCSLVLGRAG
CCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCEEEEEECCC
>Mature Secondary Structure
MRPDRRPAVIPLHLSHFTASSCLGAGLDPTLAALRAGRSGLAPCRFETVHDLDTHIGEVA
CCCCCCCCEEEEEHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHC
GVDETPLPADFAEHDCRNNRLAWLGLQQDGFDAAVRAAIARHGRRRVGVFLGTSTAGILQ
CCCCCCCCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEEECCCCHHHH
TEQAYRRRDAASGALPADFVYRTTHNTYSLAGFVRALYGIEGPAAVASTACSSGAKVFAS
HHHHHHHHHHCCCCCCHHHEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHH
AQRMIATGLIDAAIVGGVDSLCLTTLYGFNSLELLSPEPCRPFDAGRRGLSIGEAAAFAL
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEECCCCCCCCHHHCCCCCCHHHHHHHHH
LEAVPASLDADAVLLLGAGESSDAHHMSSPHPEGAGARQAMAATLAAAGLAPDQIDYVNL
HHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEE
HGTATPSNDAAEGRAVAALFGDRVACSSTKGATGHTLGAAGGLEAVIAALALQHGFMPGG
CCCCCCCCCCCCCCEEEEHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCC
VNTRTPDPAIPVRYLRTNTDVAPRRVLSNSFGFGGTNCSLVLGRAG
CCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]