Click here to switch to the map view.

The map label for this gene is rpfC [H]

Identifier: 74318689

GI number: 74318689

Start: 2744919

End: 2747444

Strand: Direct

Name: rpfC [H]

Synonym: Tbd_2671

Alternate gene names: 74318689

Gene position: 2744919-2747444 (Clockwise)

Preceding gene: 74318688

Following gene: 74318693

Centisome position: 94.33

GC content: 62.98

Gene sequence:

>2526_bases
ATGAAGACCGCGCTTCATCAGCTATTGCCTGCATTTCTGCGGCGTCTTCTCAAACGAATAAAAGACCGGCCGGATTCAGA
GTTCCAGCAGACGCTAATCCGCATTGTCATTGGGCTCGGGTTCCTGCTGTATTTCTCCCGGGATCTCGCGACGCTCGATG
AGTCGACCCGCGAAATAGCCCAGCTTATTAGCGCGTTTTTCACCGCAATTGCAGTGGTGATCACAGCGCTTTCATTGACC
AGCCTCAAAGTGTCTCCCCCGCGTCGGATTGTCGCGATGGCGCTGGATTACGCTACCTGTTCGTTTCTACTGACCTATAC
CGGGGAGGCGGGCAGCCCGCTGCTCGTCGTGTACCTGTGGGTAACGCTAGGCAACGGCTTCAGATATGGCGTTTTCTACC
TGTATATCGCAGCTGCCATGGCGATCACGGGCTTCCTGCTCGTGCTTACCTACTCGTCCTATTGGAACAGCCACATGTCC
ATCGGGCTGGCATTTTTGCTGTCCATGATCGCGGTTCCCCTTTATTCTGCATCGCTGCTGAAGCAGCTTCACTCCGCTGT
TGAGCGGGAACGCAAGGCCAGCCTGGCGAAATCGAGCTTCCTCGCCAATATGAGCCACGAGCTTCGGACCCCGTTGAACG
GCGTCATAGGCGTCGCCGACCTGCTTGCCGAGACGAAGCTCAACAAGGAGCAAAAGGAGTTCGCGCAGATCATCCGCACC
TCTGCCGACACCCTGCTCGAACTGATCGATAACGTGCTCGACATCTCGCGCATCGAGGCCGGTCGCATCCTCACAAGCAG
CGAGGATTTCGACCTACACCGCGTCATCAACGGCACGGTCGCGATGATGGAAACGCAGGCCAACGCCAAGGGTCTCGTGC
TCGCCGCGCACATCGCGCCGCAGACCCCGTTCCAGCTGCAAGGCGACGCGCCCCATCTGCGTCAGGTACTGATCAATCTG
ATCGGCAATGCCGTCAAATTCACCGAGCACGGACGGGTCGACGTCTACGTCCGCCCGGTCGGACAGGGCAACCCCCAACG
ATTGCGACTCGAAGTCGTCGATACCGGCATCGGCATACCGCCCGACGCCCAGATCCGCATCTTCGACAGCTTCACCCAGG
CCGACGCGTCGATCACCCGCCGCTTCGGCGGTACCGGCCTGGGTACGACGATCGCCAAGCAACTCGTCGAAGCGATGGGG
GGCGAAATCGGCCTGCACAGCCGCGAAGGCGAAGGCACGACTTTCTGGTTCGAACTGCCCTTCGCGCTGCGCAGCAGCGG
GCAACCCGCCGAAGAACGGTTCGATGCACCAATGCGCGTCGCGCTCCTCGCGAGCGGCGACCTTGCCGATCGCATGCAAG
CGGCGATCCGCGCTTGGGATGTCGAAGCAGTTACGCTCCGCAGCGCCGCGCAATTAGGCTCCCAACTGTCGGCATCTCCC
GCGAGCGAGGCATCGTTCGGGGCGATCGTCGTGGAGCGAAGCCTGCTTCCCGCGGACCCGGTCGCCTTCCTGAGCCAGTT
GCGCGAAGGCCCCGTTCGCTCGTCGCTGCCCGTGATCCTGATCGAATCAGACGCACGCATCCCACCTTCCGAGGACGCAC
TGCTGCTACGTGCAGGCTACGCCTCGGTGCTGCGATCGCCGGTCAACACAGGTCTTCTTTTCAACGCGATCCACGCCGTC
ACAAGCCGGGAACTGCCGCCCAATGTCATCTCGCTCGCCAACCGCTTCCAGGCGCAGACCGCACAGGCGACCGGACTCAA
CATCCTGGTCGCCGAAGACAATCCGGTCAATCAGCGCGTGCTGCGCGGCCTGCTCGAGCACGCGGGACACAAAACCACGC
TTGCCCACGACGGCGAAGAAGCGCTCGATCTGCTCGATTCGGATGGCGCGAGCTTCGATCTCGCGATCATCGACATGCAC
ATGCCCGAGCTGTCCGGCCCCGAGGTGGTGCAGCGCTGGCGCTTCCTGGAAAAAGGTCATCTCCCGATCATCATGCTCAC
GGCCGACGCGCGCAGCGAGGCCGAGACCGCCTGCAAGGAAGCCGGGGCTGACGCCTTTCTGACCAAGCCGGTCAACAGCC
GCGAGTTGATTGACGCGATCACACGGCTCGGGGTGCCATCGCCCTCGCCCGTCACTGCGCCGGCGGCGAAAGCTGTGCGC
ACCGGTGAACTCGACGAGACGGTGCTCGACGATCTCGCCGAGCTCGGCGGCGCCGAATTCGTGCGTGAACTCCTCGCGAG
TTTCGAGGACGACAGCGCGCGCGCCCTGCGTGACGCAGAGTTCGCGCTCGTGGCCCATGAGTACGGCCAGTGGCATCATC
ACCTGCACATGCTGAAAGGCGGCGCCAGCGACGTCGGCGCGAATCTGCTCGCCGAGCGCTGCGCCGAAGCCGAACGCGTC
AAACCTTTCGAGCTCGCCACCCCGCTCGCGCGCACCCGACTCGACGCGGTGCGGACCGCGCTCGAGGAAGCGCGAACTGC
CTTGTCGCGCTACCAGGAGCGCCGCCTACGCGCTGAGCACAGCTGA

Upstream 100 bases:

>100_bases
CGCCACTTCGACCCGGCCTGCGTGCGCGCCTTCGAGCGGCGCATCGATGCAGTCGCGGCGATCGCGCGCGAACTCAGCGA
TCCGCAGTCCTAAGCGGCCC

Downstream 100 bases:

>100_bases
ACCCGCTCCGCTCAAGCTCTCGGCTTTACCGGTCTGCCGCGCAACCAAGCGCTCCATCATGCGCAGATCTTTCGCCTCGA
GCCGCAAGGCCGCGTCAACC

Product: periplasmic sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 841; Mature: 841

Protein sequence:

>841_residues
MKTALHQLLPAFLRRLLKRIKDRPDSEFQQTLIRIVIGLGFLLYFSRDLATLDESTREIAQLISAFFTAIAVVITALSLT
SLKVSPPRRIVAMALDYATCSFLLTYTGEAGSPLLVVYLWVTLGNGFRYGVFYLYIAAAMAITGFLLVLTYSSYWNSHMS
IGLAFLLSMIAVPLYSASLLKQLHSAVERERKASLAKSSFLANMSHELRTPLNGVIGVADLLAETKLNKEQKEFAQIIRT
SADTLLELIDNVLDISRIEAGRILTSSEDFDLHRVINGTVAMMETQANAKGLVLAAHIAPQTPFQLQGDAPHLRQVLINL
IGNAVKFTEHGRVDVYVRPVGQGNPQRLRLEVVDTGIGIPPDAQIRIFDSFTQADASITRRFGGTGLGTTIAKQLVEAMG
GEIGLHSREGEGTTFWFELPFALRSSGQPAEERFDAPMRVALLASGDLADRMQAAIRAWDVEAVTLRSAAQLGSQLSASP
ASEASFGAIVVERSLLPADPVAFLSQLREGPVRSSLPVILIESDARIPPSEDALLLRAGYASVLRSPVNTGLLFNAIHAV
TSRELPPNVISLANRFQAQTAQATGLNILVAEDNPVNQRVLRGLLEHAGHKTTLAHDGEEALDLLDSDGASFDLAIIDMH
MPELSGPEVVQRWRFLEKGHLPIIMLTADARSEAETACKEAGADAFLTKPVNSRELIDAITRLGVPSPSPVTAPAAKAVR
TGELDETVLDDLAELGGAEFVRELLASFEDDSARALRDAEFALVAHEYGQWHHHLHMLKGGASDVGANLLAERCAEAERV
KPFELATPLARTRLDAVRTALEEARTALSRYQERRLRAEHS

Sequences:

>Translated_841_residues
MKTALHQLLPAFLRRLLKRIKDRPDSEFQQTLIRIVIGLGFLLYFSRDLATLDESTREIAQLISAFFTAIAVVITALSLT
SLKVSPPRRIVAMALDYATCSFLLTYTGEAGSPLLVVYLWVTLGNGFRYGVFYLYIAAAMAITGFLLVLTYSSYWNSHMS
IGLAFLLSMIAVPLYSASLLKQLHSAVERERKASLAKSSFLANMSHELRTPLNGVIGVADLLAETKLNKEQKEFAQIIRT
SADTLLELIDNVLDISRIEAGRILTSSEDFDLHRVINGTVAMMETQANAKGLVLAAHIAPQTPFQLQGDAPHLRQVLINL
IGNAVKFTEHGRVDVYVRPVGQGNPQRLRLEVVDTGIGIPPDAQIRIFDSFTQADASITRRFGGTGLGTTIAKQLVEAMG
GEIGLHSREGEGTTFWFELPFALRSSGQPAEERFDAPMRVALLASGDLADRMQAAIRAWDVEAVTLRSAAQLGSQLSASP
ASEASFGAIVVERSLLPADPVAFLSQLREGPVRSSLPVILIESDARIPPSEDALLLRAGYASVLRSPVNTGLLFNAIHAV
TSRELPPNVISLANRFQAQTAQATGLNILVAEDNPVNQRVLRGLLEHAGHKTTLAHDGEEALDLLDSDGASFDLAIIDMH
MPELSGPEVVQRWRFLEKGHLPIIMLTADARSEAETACKEAGADAFLTKPVNSRELIDAITRLGVPSPSPVTAPAAKAVR
TGELDETVLDDLAELGGAEFVRELLASFEDDSARALRDAEFALVAHEYGQWHHHLHMLKGGASDVGANLLAERCAEAERV
KPFELATPLARTRLDAVRTALEEARTALSRYQERRLRAEHS
>Mature_841_residues
MKTALHQLLPAFLRRLLKRIKDRPDSEFQQTLIRIVIGLGFLLYFSRDLATLDESTREIAQLISAFFTAIAVVITALSLT
SLKVSPPRRIVAMALDYATCSFLLTYTGEAGSPLLVVYLWVTLGNGFRYGVFYLYIAAAMAITGFLLVLTYSSYWNSHMS
IGLAFLLSMIAVPLYSASLLKQLHSAVERERKASLAKSSFLANMSHELRTPLNGVIGVADLLAETKLNKEQKEFAQIIRT
SADTLLELIDNVLDISRIEAGRILTSSEDFDLHRVINGTVAMMETQANAKGLVLAAHIAPQTPFQLQGDAPHLRQVLINL
IGNAVKFTEHGRVDVYVRPVGQGNPQRLRLEVVDTGIGIPPDAQIRIFDSFTQADASITRRFGGTGLGTTIAKQLVEAMG
GEIGLHSREGEGTTFWFELPFALRSSGQPAEERFDAPMRVALLASGDLADRMQAAIRAWDVEAVTLRSAAQLGSQLSASP
ASEASFGAIVVERSLLPADPVAFLSQLREGPVRSSLPVILIESDARIPPSEDALLLRAGYASVLRSPVNTGLLFNAIHAV
TSRELPPNVISLANRFQAQTAQATGLNILVAEDNPVNQRVLRGLLEHAGHKTTLAHDGEEALDLLDSDGASFDLAIIDMH
MPELSGPEVVQRWRFLEKGHLPIIMLTADARSEAETACKEAGADAFLTKPVNSRELIDAITRLGVPSPSPVTAPAAKAVR
TGELDETVLDDLAELGGAEFVRELLASFEDDSARALRDAEFALVAHEYGQWHHHLHMLKGGASDVGANLLAERCAEAERV
KPFELATPLARTRLDAVRTALEEARTALSRYQERRLRAEHS

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=243, Percent_Identity=44.4444444444444, Blast_Score=214, Evalue=3e-56,
Organism=Escherichia coli, GI145693157, Length=279, Percent_Identity=35.1254480286738, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI87081816, Length=251, Percent_Identity=37.4501992031873, Blast_Score=153, Evalue=4e-38,
Organism=Escherichia coli, GI48994928, Length=236, Percent_Identity=36.864406779661, Blast_Score=151, Evalue=2e-37,
Organism=Escherichia coli, GI1788713, Length=278, Percent_Identity=30.5755395683453, Blast_Score=133, Evalue=6e-32,
Organism=Escherichia coli, GI1786912, Length=250, Percent_Identity=32, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=30.9322033898305, Blast_Score=95, Evalue=2e-20,
Organism=Escherichia coli, GI1786600, Length=227, Percent_Identity=30.8370044052863, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI87082128, Length=228, Percent_Identity=30.2631578947368, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1786783, Length=254, Percent_Identity=25.5905511811024, Blast_Score=80, Evalue=6e-16,
Organism=Escherichia coli, GI1790300, Length=238, Percent_Identity=30.2521008403361, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1788549, Length=237, Percent_Identity=26.1603375527426, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1788393, Length=246, Percent_Identity=27.6422764227642, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790346, Length=253, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=252, Percent_Identity=26.984126984127, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=381, Percent_Identity=27.8215223097113, Blast_Score=117, Evalue=8e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 91633; Mature: 91633

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTALHQLLPAFLRRLLKRIKDRPDSEFQQTLIRIVIGLGFLLYFSRDLATLDESTREIA
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLISAFFTAIAVVITALSLTSLKVSPPRRIVAMALDYATCSFLLTYTGEAGSPLLVVYLW
HHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHEEECCCCCCCCEEEHHH
VTLGNGFRYGVFYLYIAAAMAITGFLLVLTYSSYWNSHMSIGLAFLLSMIAVPLYSASLL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQLHSAVERERKASLAKSSFLANMSHELRTPLNGVIGVADLLAETKLNKEQKEFAQIIRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
SADTLLELIDNVLDISRIEAGRILTSSEDFDLHRVINGTVAMMETQANAKGLVLAAHIAP
HHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHCCHHEEEEECCCCCCEEEEEECCC
QTPFQLQGDAPHLRQVLINLIGNAVKFTEHGRVDVYVRPVGQGNPQRLRLEVVDTGIGIP
CCCCEECCCCHHHHHHHHHHHCCHHEECCCCCEEEEEEECCCCCCCEEEEEEEECCCCCC
PDAQIRIFDSFTQADASITRRFGGTGLGTTIAKQLVEAMGGEIGLHSREGEGTTFWFELP
CCCCEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECC
FALRSSGQPAEERFDAPMRVALLASGDLADRMQAAIRAWDVEAVTLRSAAQLGSQLSASP
HHHCCCCCCHHHHCCCCEEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCC
ASEASFGAIVVERSLLPADPVAFLSQLREGPVRSSLPVILIESDARIPPSEDALLLRAGY
CCCCCCCHHEEECCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCEEEEHHH
ASVLRSPVNTGLLFNAIHAVTSRELPPNVISLANRFQAQTAQATGLNILVAEDNPVNQRV
HHHHHCCHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
LRGLLEHAGHKTTLAHDGEEALDLLDSDGASFDLAIIDMHMPELSGPEVVQRWRFLEKGH
HHHHHHHCCCCCEECCCCHHHHHHHCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHCCC
LPIIMLTADARSEAETACKEAGADAFLTKPVNSRELIDAITRLGVPSPSPVTAPAAKAVR
CCEEEEECCCCHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHH
TGELDETVLDDLAELGGAEFVRELLASFEDDSARALRDAEFALVAHEYGQWHHHLHMLKG
CCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GASDVGANLLAERCAEAERVKPFELATPLARTRLDAVRTALEEARTALSRYQERRLRAEH
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
S
C
>Mature Secondary Structure
MKTALHQLLPAFLRRLLKRIKDRPDSEFQQTLIRIVIGLGFLLYFSRDLATLDESTREIA
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QLISAFFTAIAVVITALSLTSLKVSPPRRIVAMALDYATCSFLLTYTGEAGSPLLVVYLW
HHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHHEEECCCCCCCCEEEHHH
VTLGNGFRYGVFYLYIAAAMAITGFLLVLTYSSYWNSHMSIGLAFLLSMIAVPLYSASLL
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KQLHSAVERERKASLAKSSFLANMSHELRTPLNGVIGVADLLAETKLNKEQKEFAQIIRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
SADTLLELIDNVLDISRIEAGRILTSSEDFDLHRVINGTVAMMETQANAKGLVLAAHIAP
HHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHCCHHEEEEECCCCCCEEEEEECCC
QTPFQLQGDAPHLRQVLINLIGNAVKFTEHGRVDVYVRPVGQGNPQRLRLEVVDTGIGIP
CCCCEECCCCHHHHHHHHHHHCCHHEECCCCCEEEEEEECCCCCCCEEEEEEEECCCCCC
PDAQIRIFDSFTQADASITRRFGGTGLGTTIAKQLVEAMGGEIGLHSREGEGTTFWFELP
CCCCEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECC
FALRSSGQPAEERFDAPMRVALLASGDLADRMQAAIRAWDVEAVTLRSAAQLGSQLSASP
HHHCCCCCCHHHHCCCCEEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCC
ASEASFGAIVVERSLLPADPVAFLSQLREGPVRSSLPVILIESDARIPPSEDALLLRAGY
CCCCCCCHHEEECCCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCEEEEHHH
ASVLRSPVNTGLLFNAIHAVTSRELPPNVISLANRFQAQTAQATGLNILVAEDNPVNQRV
HHHHHCCHHCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHH
LRGLLEHAGHKTTLAHDGEEALDLLDSDGASFDLAIIDMHMPELSGPEVVQRWRFLEKGH
HHHHHHHCCCCCEECCCCHHHHHHHCCCCCEEEEEEEEEECCCCCCHHHHHHHHHHHCCC
LPIIMLTADARSEAETACKEAGADAFLTKPVNSRELIDAITRLGVPSPSPVTAPAAKAVR
CCEEEEECCCCHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHH
TGELDETVLDDLAELGGAEFVRELLASFEDDSARALRDAEFALVAHEYGQWHHHLHMLKG
CCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GASDVGANLLAERCAEAERVKPFELATPLARTRLDAVRTALEEARTALSRYQERRLRAEH
CCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]