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The map label for this gene is nhaR [H]

Identifier: 74318622

GI number: 74318622

Start: 2679919

End: 2680824

Strand: Direct

Name: nhaR [H]

Synonym: Tbd_2604

Alternate gene names: 74318622

Gene position: 2679919-2680824 (Clockwise)

Preceding gene: 74318611

Following gene: 74318625

Centisome position: 92.1

GC content: 69.87

Gene sequence:

>906_bases
ATGCTCAACTACAAGCATCTCCATTACTTCAGGACCGTGGCCAAGGCCGGGGCGATCAACCGCGCGGCCGAAAAGCTGCA
CCTGACGCCGCAGACGCTGTCCGGCCAGCTCAGCGCCTTCGAGCAACGCCTCGGCGTCGCGCTGTTCCGCCGCAGCGGGC
GGCGACTCGAGTTGACCGACGCGGGCCACACTGCCCTGACCTACGCCGACGAGATCTTCCAGGTCGGCGCCGAACTCGAA
GATGCCCTGCAGAACCGCGCGGCGGCGCCGGTGCGCCCCTTCCGTGTCGGAATCGCCGACGTCGTCCCGAAAGCGATCGC
CTATCAACTGCTCGCGCCCGCGCTGACGCTCGCCGAGCCGGTACGCCTCGTATGCAAGGAGGACCGGCTCGAGGCGCTCG
CCGCGGCGCTGTCGATCCACCGCCTCGACATGGTGCTCGCGGACCGCCCGCTGCCGTCGACGATGGACGTCAAGGGCTAC
AGCCACCCGCTCGGCGAGTGCGGCATCGCGTTTCTCGCCGCCCCCGCGGTCGCCGCAAGCGCGGGCAGCGACTTCCCCGC
CAACCTGCACGGCGCACCGCTTCTCGTCCCGGGCGAAGACAGCGCCTTGCACGGGCCCTTGCTGCGCTGGCTCGAACGGC
GCGGCCTGCAACCCGTCGTTGTCGGCGAGTTCGACGACAGCGCCCTCATGAGCGCATTCGGTCAGGCCGGCGCCGGCGTG
TTCCCGGTGCCGCTCAGCACCGCCGGGGAGGTGATGCGCCAGTACGCCGTGGTCGACCTGGGGCGGACGCTGGAGATTCG
CGAGCGCTTCTTCGCGATTTCGGTCGAGCGCCGACTGAGCCACCCGGCCGTCGTCGCCGTCAGCGAAGCGGCACACCAGC
GCTTTCAGCATGCCAACGACGATTAG

Upstream 100 bases:

>100_bases
CATCTCCGCTTGCGTGACAGGATATAGAGGGCGACGACACAATAAAATTCGATTTTTATACGCTTATTATTCGGTTGTCT
CGAACTGAAAAAGCCAACCC

Downstream 100 bases:

>100_bases
GACGGCGCCGCCAGTGCGCCGAGCTCGGCCGGCGTGACGATCGCGAACCACGGCGCGCAGCCCCGCCGTAGCCGCAGCAC
GGCGCGGTCCTTGCTGACGA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Na(+)/H(+) antiporter regulatory protein [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MLNYKHLHYFRTVAKAGAINRAAEKLHLTPQTLSGQLSAFEQRLGVALFRRSGRRLELTDAGHTALTYADEIFQVGAELE
DALQNRAAAPVRPFRVGIADVVPKAIAYQLLAPALTLAEPVRLVCKEDRLEALAAALSIHRLDMVLADRPLPSTMDVKGY
SHPLGECGIAFLAAPAVAASAGSDFPANLHGAPLLVPGEDSALHGPLLRWLERRGLQPVVVGEFDDSALMSAFGQAGAGV
FPVPLSTAGEVMRQYAVVDLGRTLEIRERFFAISVERRLSHPAVVAVSEAAHQRFQHANDD

Sequences:

>Translated_301_residues
MLNYKHLHYFRTVAKAGAINRAAEKLHLTPQTLSGQLSAFEQRLGVALFRRSGRRLELTDAGHTALTYADEIFQVGAELE
DALQNRAAAPVRPFRVGIADVVPKAIAYQLLAPALTLAEPVRLVCKEDRLEALAAALSIHRLDMVLADRPLPSTMDVKGY
SHPLGECGIAFLAAPAVAASAGSDFPANLHGAPLLVPGEDSALHGPLLRWLERRGLQPVVVGEFDDSALMSAFGQAGAGV
FPVPLSTAGEVMRQYAVVDLGRTLEIRERFFAISVERRLSHPAVVAVSEAAHQRFQHANDD
>Mature_301_residues
MLNYKHLHYFRTVAKAGAINRAAEKLHLTPQTLSGQLSAFEQRLGVALFRRSGRRLELTDAGHTALTYADEIFQVGAELE
DALQNRAAAPVRPFRVGIADVVPKAIAYQLLAPALTLAEPVRLVCKEDRLEALAAALSIHRLDMVLADRPLPSTMDVKGY
SHPLGECGIAFLAAPAVAASAGSDFPANLHGAPLLVPGEDSALHGPLLRWLERRGLQPVVVGEFDDSALMSAFGQAGAGV
FPVPLSTAGEVMRQYAVVDLGRTLEIRERFFAISVERRLSHPAVVAVSEAAHQRFQHANDD

Specific function: Plays a role in the positive regulation of nhaA [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786202, Length=291, Percent_Identity=38.4879725085911, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI157672245, Length=220, Percent_Identity=27.7272727272727, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32488; Mature: 32488

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNYKHLHYFRTVAKAGAINRAAEKLHLTPQTLSGQLSAFEQRLGVALFRRSGRRLELTD
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
AGHTALTYADEIFQVGAELEDALQNRAAAPVRPFRVGIADVVPKAIAYQLLAPALTLAEP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRLVCKEDRLEALAAALSIHRLDMVLADRPLPSTMDVKGYSHPLGECGIAFLAAPAVAAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
AGSDFPANLHGAPLLVPGEDSALHGPLLRWLERRGLQPVVVGEFDDSALMSAFGQAGAGV
CCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCC
FPVPLSTAGEVMRQYAVVDLGRTLEIRERFFAISVERRLSHPAVVAVSEAAHQRFQHAND
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCC
D
C
>Mature Secondary Structure
MLNYKHLHYFRTVAKAGAINRAAEKLHLTPQTLSGQLSAFEQRLGVALFRRSGRRLELTD
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
AGHTALTYADEIFQVGAELEDALQNRAAAPVRPFRVGIADVVPKAIAYQLLAPALTLAEP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRLVCKEDRLEALAAALSIHRLDMVLADRPLPSTMDVKGYSHPLGECGIAFLAAPAVAAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
AGSDFPANLHGAPLLVPGEDSALHGPLLRWLERRGLQPVVVGEFDDSALMSAFGQAGAGV
CCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCC
FPVPLSTAGEVMRQYAVVDLGRTLEIRERFFAISVERRLSHPAVVAVSEAAHQRFQHAND
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2429258; 1630901; 9278503; 3413113; 1316901; 8168494 [H]