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The map label for this gene is flp [H]

Identifier: 74318611

GI number: 74318611

Start: 2668109

End: 2668873

Strand: Direct

Name: flp [H]

Synonym: Tbd_2593

Alternate gene names: 74318611

Gene position: 2668109-2668873 (Clockwise)

Preceding gene: 74318608

Following gene: 74318622

Centisome position: 91.69

GC content: 66.27

Gene sequence:

>765_bases
ATGGCGTCGCCCGCGTCCCCTCTTTCGCTCCTGCACGATGCGCCGCTCTTCGCAGGCGTCGACGCCGGCCATCTCGCCAC
GCTGGCCCAGGCTGCGCGTTCGCGGGACGCGCGGGCCGGCCAGCTGCTCTTCGCCGAAGGCGACGAGGCCCGCGCGTTCT
ACCTCGTCGCGCAAGGCGAGGTCCACCTCTACCGGTTCTCGCCGCAGGGGGAGGAAAAGGTGTTCCAGATGCTCGGGGAC
GGCGACCTGCTGGCCGAAGCCGCAATGTTTCTCAGCCCCGCGGTCTATCCGATGACGGCGCGCGCCGTACGCGACAGCAC
GCTGTTCGCCGTGCCGCGGCAGGCATTGTTGTCGTTGTGCGCGGCCTCGCCGCCCTTGATGCTGACGCTCCTGTCCGCCC
TGGCGAGACGCCTATACCAGGCGATGAACCGCATCGACCATCTCACCCTCAACAACGCCGGCCAGCGGCTCGTCGCCTAT
TTGCTTGATTTGCGGCGGCAACAGCATGGCAACTGGATCAGCATTCCGGTGAATTTCGCCGTCCTGGCGGCCCAACTCGG
CATGACGCCCGAAACTCTGTCGCGTCTACTGCAGAAATTTCGCCAGGACGGACTCCTGAGCGGCAAGGGGCGCACGCTGG
TCCTGCTCGACGCCGACATGTTGTGTGAAAAGGTGGCGCTGCCCCGACAAGCCATGCGGCCACCCTCCCACATCGGAGGC
AATCCTTCGATGACCGGGTGCTGCAATCTCGCAGGCAAGCGGTGA

Upstream 100 bases:

>100_bases
TGCCGTGCAGCATGGAAGTTCCTTGGGTGCGATTAAGAACAATTCGCATTCATGATAAGATCGCGGCCACCCAAGCCCCA
ATGACAATTGTCAATTCGCC

Downstream 100 bases:

>100_bases
AGCGTAGCGAGGGTTGGCCGCGCGCGGCTGGCACGGACGCCCATTCGCCAGCGAACACGGGATAGCGGCCAAGCATCGTC
CGTGTTCGGCGCGCCGGCCG

Product: Crp/FNR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MASPASPLSLLHDAPLFAGVDAGHLATLAQAARSRDARAGQLLFAEGDEARAFYLVAQGEVHLYRFSPQGEEKVFQMLGD
GDLLAEAAMFLSPAVYPMTARAVRDSTLFAVPRQALLSLCAASPPLMLTLLSALARRLYQAMNRIDHLTLNNAGQRLVAY
LLDLRRQQHGNWISIPVNFAVLAAQLGMTPETLSRLLQKFRQDGLLSGKGRTLVLLDADMLCEKVALPRQAMRPPSHIGG
NPSMTGCCNLAGKR

Sequences:

>Translated_254_residues
MASPASPLSLLHDAPLFAGVDAGHLATLAQAARSRDARAGQLLFAEGDEARAFYLVAQGEVHLYRFSPQGEEKVFQMLGD
GDLLAEAAMFLSPAVYPMTARAVRDSTLFAVPRQALLSLCAASPPLMLTLLSALARRLYQAMNRIDHLTLNNAGQRLVAY
LLDLRRQQHGNWISIPVNFAVLAAQLGMTPETLSRLLQKFRQDGLLSGKGRTLVLLDADMLCEKVALPRQAMRPPSHIGG
NPSMTGCCNLAGKR
>Mature_253_residues
ASPASPLSLLHDAPLFAGVDAGHLATLAQAARSRDARAGQLLFAEGDEARAFYLVAQGEVHLYRFSPQGEEKVFQMLGDG
DLLAEAAMFLSPAVYPMTARAVRDSTLFAVPRQALLSLCAASPPLMLTLLSALARRLYQAMNRIDHLTLNNAGQRLVAYL
LDLRRQQHGNWISIPVNFAVLAAQLGMTPETLSRLLQKFRQDGLLSGKGRTLVLLDADMLCEKVALPRQAMRPPSHIGGN
PSMTGCCNLAGKR

Specific function: Global Transcription Factor That Controls The Expression Of Over 100 Target Genes In Response To Anoxia. It Facilitates The Adaptation To Anaerobic Growth Conditions By Regulating The Expression Of Gene Products That Are Involved In Anaerobic Energy Metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=196, Percent_Identity=27.5510204081633, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1789756, Length=177, Percent_Identity=22.5988700564972, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 27501; Mature: 27370

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPASPLSLLHDAPLFAGVDAGHLATLAQAARSRDARAGQLLFAEGDEARAFYLVAQGE
CCCCCCHHHHHHCCCHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEEECE
VHLYRFSPQGEEKVFQMLGDGDLLAEAAMFLSPAVYPMTARAVRDSTLFAVPRQALLSLC
EEEEEECCCCHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AASPPLMLTLLSALARRLYQAMNRIDHLTLNNAGQRLVAYLLDLRRQQHGNWISIPVNFA
HCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHCCCEEEECHHHH
VLAAQLGMTPETLSRLLQKFRQDGLLSGKGRTLVLLDADMLCEKVALPRQAMRPPSHIGG
HHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHCCHHHCCCCCCCCC
NPSMTGCCNLAGKR
CCCCCHHCCCCCCC
>Mature Secondary Structure 
ASPASPLSLLHDAPLFAGVDAGHLATLAQAARSRDARAGQLLFAEGDEARAFYLVAQGE
CCCCCHHHHHHCCCHHCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCEEEEEEEECE
VHLYRFSPQGEEKVFQMLGDGDLLAEAAMFLSPAVYPMTARAVRDSTLFAVPRQALLSLC
EEEEEECCCCHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
AASPPLMLTLLSALARRLYQAMNRIDHLTLNNAGQRLVAYLLDLRRQQHGNWISIPVNFA
HCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHHCCCEEEECHHHH
VLAAQLGMTPETLSRLLQKFRQDGLLSGKGRTLVLLDADMLCEKVALPRQAMRPPSHIGG
HHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECHHHHHHHHHCCHHHCCCCCCCCC
NPSMTGCCNLAGKR
CCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2113923; 8441692 [H]