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The map label for this gene is grxD [H]

Identifier: 74318517

GI number: 74318517

Start: 2571495

End: 2571815

Strand: Direct

Name: grxD [H]

Synonym: Tbd_2499

Alternate gene names: 74318517

Gene position: 2571495-2571815 (Clockwise)

Preceding gene: 74318516

Following gene: 74318522

Centisome position: 88.37

GC content: 59.19

Gene sequence:

>321_bases
ATGACCCCCCTCGATCGCATCCGCGAGCAAGTCACCAACAACGCCATCGTTCTGTACATGAAAGGCACGCCGCAGTTTCC
GCAGTGCGGTTTCTCGTCGCGCGCGGCGCAGGTGCTGCAGGCCTGCGGCGTCAAGGATTTCCTGGCCGTCAATGTGCTGG
CCGACCCTGAAATCTTCGAGAACCTGAAGTACTACGCGAACTGGCCGACCTTCCCCCAGCTCTACGTCAAGGGCGAACTG
ATCGGCGGGTCCGACATCATGATCGAGATGTACCAGAAGGGCGAAATCCAGAAACTGCTCGAAGAAGCGCAAACCGCCTG
A

Upstream 100 bases:

>100_bases
CTTCGTCAGTCCCACTCGCCGCACGCCGAAGACCGCTTGACGGCGATGGCCGCGTGCGTATAATTCCCGAGTATTCCACT
CAGGTATTCAGGAGCGCTTC

Downstream 100 bases:

>100_bases
CCCGCGCGACGCCGACTTGAAACGCCGACCCTAGGTCGGCGTTTTTCATGCCCTCACCCCGGCTGCTCCGGGCTCGGCTC
GTCGCCCCCCGCGCCGTCGA

Product: glutaredoxin-like protein

Products: NA

Alternate protein names: Grx4; Monothiol glutaredoxin [H]

Number of amino acids: Translated: 106; Mature: 105

Protein sequence:

>106_residues
MTPLDRIREQVTNNAIVLYMKGTPQFPQCGFSSRAAQVLQACGVKDFLAVNVLADPEIFENLKYYANWPTFPQLYVKGEL
IGGSDIMIEMYQKGEIQKLLEEAQTA

Sequences:

>Translated_106_residues
MTPLDRIREQVTNNAIVLYMKGTPQFPQCGFSSRAAQVLQACGVKDFLAVNVLADPEIFENLKYYANWPTFPQLYVKGEL
IGGSDIMIEMYQKGEIQKLLEEAQTA
>Mature_105_residues
TPLDRIREQVTNNAIVLYMKGTPQFPQCGFSSRAAQVLQACGVKDFLAVNVLADPEIFENLKYYANWPTFPQLYVKGELI
GGSDIMIEMYQKGEIQKLLEEAQTA

Specific function: Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters [H]

COG id: COG0278

COG function: function code O; Glutaredoxin-related protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI42516576, Length=86, Percent_Identity=48.8372093023256, Blast_Score=108, Evalue=9e-25,
Organism=Homo sapiens, GI95113651, Length=96, Percent_Identity=41.6666666666667, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787943, Length=101, Percent_Identity=55.4455445544555, Blast_Score=127, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17556042, Length=97, Percent_Identity=48.4536082474227, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71988153, Length=85, Percent_Identity=40, Blast_Score=81, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71988159, Length=95, Percent_Identity=37.8947368421053, Blast_Score=78, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6325198, Length=100, Percent_Identity=49, Blast_Score=102, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6320303, Length=84, Percent_Identity=41.6666666666667, Blast_Score=76, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321022, Length=84, Percent_Identity=39.2857142857143, Blast_Score=74, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24642023, Length=93, Percent_Identity=39.7849462365591, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19921242, Length=97, Percent_Identity=35.0515463917526, Blast_Score=79, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002109
- InterPro:   IPR014434
- InterPro:   IPR004480
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 11948; Mature: 11817

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLDRIREQVTNNAIVLYMKGTPQFPQCGFSSRAAQVLQACGVKDFLAVNVLADPEIFE
CCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHEEEECCCHHHHH
NLKYYANWPTFPQLYVKGELIGGSDIMIEMYQKGEIQKLLEEAQTA
CCHHHCCCCCCCEEEEEEEEECCCCEEEEECCCCHHHHHHHHHCCC
>Mature Secondary Structure 
TPLDRIREQVTNNAIVLYMKGTPQFPQCGFSSRAAQVLQACGVKDFLAVNVLADPEIFE
CHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCHHHEEEECCCHHHHH
NLKYYANWPTFPQLYVKGELIGGSDIMIEMYQKGEIQKLLEEAQTA
CCHHHCCCCCCCEEEEEEEEECCCCEEEEECCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]