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The map label for this gene is aroE

Identifier: 74318522

GI number: 74318522

Start: 2576774

End: 2577571

Strand: Direct

Name: aroE

Synonym: Tbd_2504

Alternate gene names: 74318522

Gene position: 2576774-2577571 (Clockwise)

Preceding gene: 74318517

Following gene: 74318523

Centisome position: 88.55

GC content: 70.93

Gene sequence:

>798_bases
ATGACCGACCGCTACGCCGTATTCGGGCACCCGATCGCCCACTCCAAGTCGCCTCAGATCCACGCCGCGTTCGCCCGCCA
GACCGGGCAGGACATGTGCTACGAGGCGATCCTCGCGCCGCTCGAGGGTTTCACCGAAAGCATTGCGCGGTTCGCCGCCC
AAGGCGGACGCGGTGCCAATGTCACGGTCCCGTTCAAGGAGGAGGCCTTCCGTCTCGCCGATCGCCTGACGCCGCGCGCC
GAGCGCGCCGGCGCCGTCAACACGCTCATGTTCGACGCCGACGGCATACTCGGCGACAACACCGACGGCACAGGGCTCGT
CGCCGACCTGACGGGTAATCTCAAGCGCCCCCTCGCCACGAGGCGAATCCTGCTCGTCGGCGCCGGCGGGGCCGCGCGCG
GCGTGATCGCGCCGTTGCTCGAGCAGGCGCCCGCCGAGCTCGTGATCGCCAACCGTACGGTCAGCCGCGCGGAGCAACTT
GCCGAACTGTTCGACGGCCGGCTTCGGGCCTGTGGCTTCGACGCGCTCGACACGCCGTTCGACGTCGTCATCAACGCCAC
CGCAGCGAGCCTCGCCGGCGAGCTGCCGCCCCTGCCCCCGCAGGTCTTCGGCACCGGCGCGCTCGCCTACGACATGATGT
ACGGCCGCGACACGCCCTTTCTCGCGTTTGCCAGAGCGCACGGCGCGGACACCGCCGACGGCCTCGGCATGCTCGTCGAA
CAGGCGGCGGAAGCCTTCCACCTCTGGCGCGGCGTGCGCCCTGACACGGCACCGGTCATCGCCGCCCTGCGCGCGTGA

Upstream 100 bases:

>100_bases
ACGTCCGTGCCCCGTCTTGGTGCACACCTTTTTCGAGCCTTATGGCCGTATACGAGACGACAACGCGAATAGGCCCCGGG
AACGCTAGAATACGCCCGCC

Downstream 100 bases:

>100_bases
TGCGCACGCTATGGCGCTGGCTCGGCAAGGGCGTCGCGGCAGCCGTCGCGCTGGTGCTGCTCTACCAGCTCTGGATCTTT
GCGCACGTGTTGTGGTGGAT

Product: shikimate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MTDRYAVFGHPIAHSKSPQIHAAFARQTGQDMCYEAILAPLEGFTESIARFAAQGGRGANVTVPFKEEAFRLADRLTPRA
ERAGAVNTLMFDADGILGDNTDGTGLVADLTGNLKRPLATRRILLVGAGGAARGVIAPLLEQAPAELVIANRTVSRAEQL
AELFDGRLRACGFDALDTPFDVVINATAASLAGELPPLPPQVFGTGALAYDMMYGRDTPFLAFARAHGADTADGLGMLVE
QAAEAFHLWRGVRPDTAPVIAALRA

Sequences:

>Translated_265_residues
MTDRYAVFGHPIAHSKSPQIHAAFARQTGQDMCYEAILAPLEGFTESIARFAAQGGRGANVTVPFKEEAFRLADRLTPRA
ERAGAVNTLMFDADGILGDNTDGTGLVADLTGNLKRPLATRRILLVGAGGAARGVIAPLLEQAPAELVIANRTVSRAEQL
AELFDGRLRACGFDALDTPFDVVINATAASLAGELPPLPPQVFGTGALAYDMMYGRDTPFLAFARAHGADTADGLGMLVE
QAAEAFHLWRGVRPDTAPVIAALRA
>Mature_264_residues
TDRYAVFGHPIAHSKSPQIHAAFARQTGQDMCYEAILAPLEGFTESIARFAAQGGRGANVTVPFKEEAFRLADRLTPRAE
RAGAVNTLMFDADGILGDNTDGTGLVADLTGNLKRPLATRRILLVGAGGAARGVIAPLLEQAPAELVIANRTVSRAEQLA
ELFDGRLRACGFDALDTPFDVVINATAASLAGELPPLPPQVFGTGALAYDMMYGRDTPFLAFARAHGADTADGLGMLVEQ
AAEAFHLWRGVRPDTAPVIAALRA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1789675, Length=269, Percent_Identity=53.5315985130111, Blast_Score=250, Evalue=8e-68,
Organism=Escherichia coli, GI1787983, Length=277, Percent_Identity=28.8808664259928, Blast_Score=87, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320332, Length=180, Percent_Identity=30.5555555555556, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_THIDA (Q3SFZ9)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_316262.1
- ProteinModelPortal:   Q3SFZ9
- SMR:   Q3SFZ9
- STRING:   Q3SFZ9
- GeneID:   3671823
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2504
- NMPDR:   fig|292415.3.peg.2577
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   FAAQTGI
- PhylomeDB:   Q3SFZ9
- BioCyc:   TDEN292415:TBD_2504-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 27996; Mature: 27865

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: ACT_SITE 66-66

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRYAVFGHPIAHSKSPQIHAAFARQTGQDMCYEAILAPLEGFTESIARFAAQGGRGAN
CCCCEEEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
VTVPFKEEAFRLADRLTPRAERAGAVNTLMFDADGILGDNTDGTGLVADLTGNLKRPLAT
EEECCHHHHHHHHHHCCCHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHH
RRILLVGAGGAARGVIAPLLEQAPAELVIANRTVSRAEQLAELFDGRLRACGFDALDTPF
CEEEEEECCCCHHHHHHHHHHHCCHHEEEECCHHHHHHHHHHHHCCHHHHCCCCCCCCCH
DVVINATAASLAGELPPLPPQVFGTGALAYDMMYGRDTPFLAFARAHGADTADGLGMLVE
HHEEECHHHHHCCCCCCCCHHHHCCCHHHHHHHHCCCCCCEEEEHHCCCCCHHHHHHHHH
QAAEAFHLWRGVRPDTAPVIAALRA
HHHHHHHHHCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
TDRYAVFGHPIAHSKSPQIHAAFARQTGQDMCYEAILAPLEGFTESIARFAAQGGRGAN
CCCEEEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
VTVPFKEEAFRLADRLTPRAERAGAVNTLMFDADGILGDNTDGTGLVADLTGNLKRPLAT
EEECCHHHHHHHHHHCCCHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCHHH
RRILLVGAGGAARGVIAPLLEQAPAELVIANRTVSRAEQLAELFDGRLRACGFDALDTPF
CEEEEEECCCCHHHHHHHHHHHCCHHEEEECCHHHHHHHHHHHHCCHHHHCCCCCCCCCH
DVVINATAASLAGELPPLPPQVFGTGALAYDMMYGRDTPFLAFARAHGADTADGLGMLVE
HHEEECHHHHHCCCCCCCCHHHHCCCHHHHHHHHCCCCCCEEEEHHCCCCCHHHHHHHHH
QAAEAFHLWRGVRPDTAPVIAALRA
HHHHHHHHHCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA