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The map label for this gene is prlC [H]

Identifier: 74318451

GI number: 74318451

Start: 2502986

End: 2505091

Strand: Direct

Name: prlC [H]

Synonym: Tbd_2433

Alternate gene names: 74318451

Gene position: 2502986-2505091 (Clockwise)

Preceding gene: 74318445

Following gene: 74318452

Centisome position: 86.02

GC content: 66.05

Gene sequence:

>2106_bases
ATGGTCGTCGCCATGAATACCCCCAAGGGCTCCAACCCCCTGCTCGACTTCTCCGGCCTGCCCCGCTTCGCCGAGTTCAA
GCCCGAATACGTCACCCCGGCGGTCGACGCGTTGCTGGCGGAGTGCCGCGCCGCGGTCGCCCGCGCCGAGGCCGCCGACA
CGCCGGCCGAATGGGACGCCTTCGTCGCCCCGCTCGAGGATGCGAACGAGAAGCTCGGCCGCGCCTGGGGCCAGGCTTCC
CACCTGCACTCGGTCATGGATTCGCCCGAGTTGCGCGAGGTCTACAACGCCAATCTGCCGAAGATCACGGTCTATTACGC
CGAACTCGGGCAGAACGAGGCCTTGTACGCCAAATACAAGGCCCTCGCCGCGAGTCCCGCGTTTGCCGCGCTGTCGCCCG
CCCGCAGGAAAGTCGTCGACAACGAGTTGCGTGGCTTCCGTCTCGGCGGCGCCGAGCTGCCGGCCGACAAGAAGGCGCGC
TTCATGCAGGTGCAGGAGGAACTCGCGCAGTTGTCCACCAAGTTCGAGGAAAACCTGCTCGACGCGACCAACGACTACGC
GCTCATCATCGACGAGAAGGGCGAGCTCGCCGGCATTCCCGACGACGTGCTGGAAGCCGCGCGCGCCGCGGCCGAGGCCG
CCGGCACCACCGGCTGGAAGTTCACGCTGCACATGCCGTCCTACCTGCCGGTGATGCAGTACGCCGACAGCCGCGAACTT
CGGCAGATCCTTTACCGCGCCTACGTCACCCGTGCCTCCGAGTTCGGCAAGCCCGAGCTCGACAACACGCCGCTGATCGC
GCGCATCCTCAAGCTGCGCCGAGAGTCCGCCGAGTTGCTGGGTTTCAAGAGCTACGCCGAGGAGTCGCTCGAAGCCAAGA
TGGCCGAATCGCCGCGCGAGGTGCTGGATTTTCTCGACGAGCTCGCCGCGCGTGCCCGCCCCTACGCGGAGAAAGACTAC
ACCGAACTCAAGACCTTCGCCCGCGACGAACTGGGCCTGGACGAGGTCGAAGCCTGGGACACGACCTACGTCTCGGAAAA
ACTGAGCGTCGCGCGCTACAGCTTCTCGGACCACGAAGTGAAGCAGTATTTCCCCGAGCCGCGCGTGCTCGCAGGCCTGT
TCCGACTGATCGAAACGCTGTACGGCCTGCACATCCGCGAGGACAACGCGCCGGTGTGGCACCCCGACGTGAAGTTCTAC
ACGCTTTACGACCGCGCCGGCCAGCGCATCGGCCAGTTCTACCTCGACCTCTACGCGCGCGCCTCGAAGCGCGGCGGCGC
CTGGATGGACGACGTCATCACCCGCCGTCGCCTGCCTTCACTCGATGGGCGGGCAGAGGGCATGCAGACGCCGGTGGCCT
ACCTGAACTGCAATTTTTCTGCGCCGGTGGGCGACACCCCCGACGGGGGCAAGAAACCCGCGCTGTTCACCCACGACGAG
GTCATCACGCTGTTCCACGAGATGGGCCACGGCCTGCACCATCTGCTGACCCAGATCGAGGAGCTGGGCGTCTCCGGAAT
CAACGGCGTCGAATGGGACGCGGTCGAACTGCCGAGCCAGTTCATGGAAAACTTCTGCTGGGAATGGGACGTGCTCAAGC
ACATGACCGCCCACGTCGATACCGGCGAGCCGCTGCCGCGCGTGCTGTTCGACAAGATGCTCGCGGCGAAGAACTTCCAG
GCCGGCCTGCAGACGCTGCGCCAGATCGAGTTCGCGAGCTTCGACATGCATCTGCACGACGATTTCGACCCGAACGGCGT
ACGCACCGCGCAGGATCTGATCGACGACATCCGCAAGAAGGTCGCGGTCATCATCCCGCCCGCGTACAACCGCTTCCCCA
ACAACTTCTCGCACATCTTCGCCGGCGGCTACGCGGCCGGCTACTACAGCTACAAGTGGGCCGAAGTCCTGTCGGCCGAC
GCCTATGCGCTGTTCGAGGACGAGGCCGAGGGCTACGGCGGCGTGCTGAATCCCGAGGTCGGCCACCGGTTCTGGAGCGA
GATCCTGGCGCAGGGCGGCGCGCGCCCGGCGCTCGAGTCGTTCAAGGCCTTCCGAGGCCGCGAGCCGACGATCGACGCAC
TGCTGCGGCACAACGGCATGGCGTGA

Upstream 100 bases:

>100_bases
CGCCGTGATGCGGCGCGAGCGCGGAATCGTAAACCTTGTCGGTCATGGGGTTGAAAACGGGGAAGACAGCCGAAATTATA
ATTCCCCTAACTCCCCACTA

Downstream 100 bases:

>100_bases
GCCGTCGTCGACGTCCCGGGTCGGGCACCGCGCGCCGGCCCCCGTAGATTCATCGTACTCAGGCCCTGAAATGCCTTGCG
GGTAAAGCCGCAGCCGCCGG

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 701; Mature: 701

Protein sequence:

>701_residues
MVVAMNTPKGSNPLLDFSGLPRFAEFKPEYVTPAVDALLAECRAAVARAEAADTPAEWDAFVAPLEDANEKLGRAWGQAS
HLHSVMDSPELREVYNANLPKITVYYAELGQNEALYAKYKALAASPAFAALSPARRKVVDNELRGFRLGGAELPADKKAR
FMQVQEELAQLSTKFEENLLDATNDYALIIDEKGELAGIPDDVLEAARAAAEAAGTTGWKFTLHMPSYLPVMQYADSREL
RQILYRAYVTRASEFGKPELDNTPLIARILKLRRESAELLGFKSYAEESLEAKMAESPREVLDFLDELAARARPYAEKDY
TELKTFARDELGLDEVEAWDTTYVSEKLSVARYSFSDHEVKQYFPEPRVLAGLFRLIETLYGLHIREDNAPVWHPDVKFY
TLYDRAGQRIGQFYLDLYARASKRGGAWMDDVITRRRLPSLDGRAEGMQTPVAYLNCNFSAPVGDTPDGGKKPALFTHDE
VITLFHEMGHGLHHLLTQIEELGVSGINGVEWDAVELPSQFMENFCWEWDVLKHMTAHVDTGEPLPRVLFDKMLAAKNFQ
AGLQTLRQIEFASFDMHLHDDFDPNGVRTAQDLIDDIRKKVAVIIPPAYNRFPNNFSHIFAGGYAAGYYSYKWAEVLSAD
AYALFEDEAEGYGGVLNPEVGHRFWSEILAQGGARPALESFKAFRGREPTIDALLRHNGMA

Sequences:

>Translated_701_residues
MVVAMNTPKGSNPLLDFSGLPRFAEFKPEYVTPAVDALLAECRAAVARAEAADTPAEWDAFVAPLEDANEKLGRAWGQAS
HLHSVMDSPELREVYNANLPKITVYYAELGQNEALYAKYKALAASPAFAALSPARRKVVDNELRGFRLGGAELPADKKAR
FMQVQEELAQLSTKFEENLLDATNDYALIIDEKGELAGIPDDVLEAARAAAEAAGTTGWKFTLHMPSYLPVMQYADSREL
RQILYRAYVTRASEFGKPELDNTPLIARILKLRRESAELLGFKSYAEESLEAKMAESPREVLDFLDELAARARPYAEKDY
TELKTFARDELGLDEVEAWDTTYVSEKLSVARYSFSDHEVKQYFPEPRVLAGLFRLIETLYGLHIREDNAPVWHPDVKFY
TLYDRAGQRIGQFYLDLYARASKRGGAWMDDVITRRRLPSLDGRAEGMQTPVAYLNCNFSAPVGDTPDGGKKPALFTHDE
VITLFHEMGHGLHHLLTQIEELGVSGINGVEWDAVELPSQFMENFCWEWDVLKHMTAHVDTGEPLPRVLFDKMLAAKNFQ
AGLQTLRQIEFASFDMHLHDDFDPNGVRTAQDLIDDIRKKVAVIIPPAYNRFPNNFSHIFAGGYAAGYYSYKWAEVLSAD
AYALFEDEAEGYGGVLNPEVGHRFWSEILAQGGARPALESFKAFRGREPTIDALLRHNGMA
>Mature_701_residues
MVVAMNTPKGSNPLLDFSGLPRFAEFKPEYVTPAVDALLAECRAAVARAEAADTPAEWDAFVAPLEDANEKLGRAWGQAS
HLHSVMDSPELREVYNANLPKITVYYAELGQNEALYAKYKALAASPAFAALSPARRKVVDNELRGFRLGGAELPADKKAR
FMQVQEELAQLSTKFEENLLDATNDYALIIDEKGELAGIPDDVLEAARAAAEAAGTTGWKFTLHMPSYLPVMQYADSREL
RQILYRAYVTRASEFGKPELDNTPLIARILKLRRESAELLGFKSYAEESLEAKMAESPREVLDFLDELAARARPYAEKDY
TELKTFARDELGLDEVEAWDTTYVSEKLSVARYSFSDHEVKQYFPEPRVLAGLFRLIETLYGLHIREDNAPVWHPDVKFY
TLYDRAGQRIGQFYLDLYARASKRGGAWMDDVITRRRLPSLDGRAEGMQTPVAYLNCNFSAPVGDTPDGGKKPALFTHDE
VITLFHEMGHGLHHLLTQIEELGVSGINGVEWDAVELPSQFMENFCWEWDVLKHMTAHVDTGEPLPRVLFDKMLAAKNFQ
AGLQTLRQIEFASFDMHLHDDFDPNGVRTAQDLIDDIRKKVAVIIPPAYNRFPNNFSHIFAGGYAAGYYSYKWAEVLSAD
AYALFEDEAEGYGGVLNPEVGHRFWSEILAQGGARPALESFKAFRGREPTIDALLRHNGMA

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=625, Percent_Identity=32.16, Blast_Score=286, Evalue=4e-77,
Organism=Homo sapiens, GI14149738, Length=625, Percent_Identity=30.72, Blast_Score=265, Evalue=2e-70,
Organism=Homo sapiens, GI156105687, Length=711, Percent_Identity=22.6441631504923, Blast_Score=139, Evalue=1e-32,
Organism=Escherichia coli, GI1789913, Length=694, Percent_Identity=49.8559077809798, Blast_Score=673, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=704, Percent_Identity=29.1193181818182, Blast_Score=243, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71999758, Length=701, Percent_Identity=23.6804564907275, Blast_Score=133, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI32565901, Length=705, Percent_Identity=21.8439716312057, Blast_Score=90, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6319793, Length=702, Percent_Identity=27.4928774928775, Blast_Score=261, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6322715, Length=443, Percent_Identity=28.4424379232506, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI21356111, Length=708, Percent_Identity=28.2485875706215, Blast_Score=255, Evalue=7e-68,
Organism=Drosophila melanogaster, GI20129717, Length=555, Percent_Identity=25.045045045045, Blast_Score=155, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 78632; Mature: 78632

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVAMNTPKGSNPLLDFSGLPRFAEFKPEYVTPAVDALLAECRAAVARAEAADTPAEWDA
CEEEECCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHH
FVAPLEDANEKLGRAWGQASHLHSVMDSPELREVYNANLPKITVYYAELGQNEALYAKYK
HHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHH
ALAASPAFAALSPARRKVVDNELRGFRLGGAELPADKKARFMQVQEELAQLSTKFEENLL
HHHCCCHHHHHCHHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DATNDYALIIDEKGELAGIPDDVLEAARAAAEAAGTTGWKFTLHMPSYLPVMQYADSREL
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCHHHH
RQILYRAYVTRASEFGKPELDNTPLIARILKLRRESAELLGFKSYAEESLEAKMAESPRE
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VLDFLDELAARARPYAEKDYTELKTFARDELGLDEVEAWDTTYVSEKLSVARYSFSDHEV
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHH
KQYFPEPRVLAGLFRLIETLYGLHIREDNAPVWHPDVKFYTLYDRAGQRIGQFYLDLYAR
HHHCCCHHHHHHHHHHHHHHHCCEEECCCCCEECCCCEEEEHHHHHHHHHHHHHHHHHHH
ASKRGGAWMDDVITRRRLPSLDGRAEGMQTPVAYLNCNFSAPVGDTPDGGKKPALFTHDE
HHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEECHHH
VITLFHEMGHGLHHLLTQIEELGVSGINGVEWDAVELPSQFMENFCWEWDVLKHMTAHVD
HHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCC
TGEPLPRVLFDKMLAAKNFQAGLQTLRQIEFASFDMHLHDDFDPNGVRTAQDLIDDIRKK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHC
VAVIIPPAYNRFPNNFSHIFAGGYAAGYYSYKWAEVLSADAYALFEDEAEGYGGVLNPEV
EEEEECCCHHCCCCCHHHHHCCCHHHCCCHHHHHHHHCCCHHEEECCCCCCCCCCCCCHH
GHRFWSEILAQGGARPALESFKAFRGREPTIDALLRHNGMA
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MVVAMNTPKGSNPLLDFSGLPRFAEFKPEYVTPAVDALLAECRAAVARAEAADTPAEWDA
CEEEECCCCCCCCCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHH
FVAPLEDANEKLGRAWGQASHLHSVMDSPELREVYNANLPKITVYYAELGQNEALYAKYK
HHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHH
ALAASPAFAALSPARRKVVDNELRGFRLGGAELPADKKARFMQVQEELAQLSTKFEENLL
HHHCCCHHHHHCHHHHHHHHHHHCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DATNDYALIIDEKGELAGIPDDVLEAARAAAEAAGTTGWKFTLHMPSYLPVMQYADSREL
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCHHHH
RQILYRAYVTRASEFGKPELDNTPLIARILKLRRESAELLGFKSYAEESLEAKMAESPRE
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
VLDFLDELAARARPYAEKDYTELKTFARDELGLDEVEAWDTTYVSEKLSVARYSFSDHEV
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCHHHH
KQYFPEPRVLAGLFRLIETLYGLHIREDNAPVWHPDVKFYTLYDRAGQRIGQFYLDLYAR
HHHCCCHHHHHHHHHHHHHHHCCEEECCCCCEECCCCEEEEHHHHHHHHHHHHHHHHHHH
ASKRGGAWMDDVITRRRLPSLDGRAEGMQTPVAYLNCNFSAPVGDTPDGGKKPALFTHDE
HHCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEECHHH
VITLFHEMGHGLHHLLTQIEELGVSGINGVEWDAVELPSQFMENFCWEWDVLKHMTAHVD
HHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCC
TGEPLPRVLFDKMLAAKNFQAGLQTLRQIEFASFDMHLHDDFDPNGVRTAQDLIDDIRKK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHHHHC
VAVIIPPAYNRFPNNFSHIFAGGYAAGYYSYKWAEVLSADAYALFEDEAEGYGGVLNPEV
EEEEECCCHHCCCCCHHHHHCCCHHHCCCHHHHHHHHCCCHHEEECCCCCCCCCCCCCHH
GHRFWSEILAQGGARPALESFKAFRGREPTIDALLRHNGMA
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]