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The map label for this gene is surA

Identifier: 74318356

GI number: 74318356

Start: 2412953

End: 2414263

Strand: Direct

Name: surA

Synonym: Tbd_2338

Alternate gene names: 74318356

Gene position: 2412953-2414263 (Clockwise)

Preceding gene: 74318355

Following gene: 74318357

Centisome position: 82.92

GC content: 67.35

Gene sequence:

>1311_bases
ATGAAATTCTTCCAACGCCCTGAACGACGCCTCAAGCAGTGGGGACTGGCGCTTCTCCTCGCCGCGTCGGCGCTCCTGCC
CGCACGCGCCGACGTCGTGCCGCTCAACCACATCGTCGCGGTCGTCAACGACGAAGTCATCACCCGCCAGGAACTCGCCA
AGCGCTACGACGAGGTCGTGCGCAACCTGTCGCGGCAGAACACGCCGCTGCCGCCGCGCAACGTGCTTGAAAAGCAGTTG
CTCGAACGCATGGTCACCGAACTTGCCCTGCAGCAGCATGCCCGCAACACGGGGGTGCGCGCCGACCCGACGCTGGTCGA
GCGCGCGCTGCAGCGCATCGCGGCGCAGAACAAGCTTGACATGGCGGGCCTGCAGGCGGCCCTCGAGAAAGAGGGCCAGA
CGCTCGACGGCATGCGCAATACGATCCGCAACGAGCTCCTCATCGCGCGCGCGCGCGAGCGCGACGTCGACAACCGCATC
TCGGTCAGCGACGCCGAAATCGACGGCTATCTGCAGACGCAGGCGCAGCAGGGTGCGGAAACCGAATACAACTTCTCGCA
CATCCTCGTCAGCGTTCCCGAGAACGCGTCGCCCGAGCAGATCAGGGAGCGCCGCGCCCGCGCCGAGGACATACTGGCCC
AGCTCGCGGCGGGCGCCGATTTCGCGCAGTTGTCGGCGAGCCATTCCGACGCGCCCGACGCGCTGAAGGGCGGCAATTTC
GGCTGGCGCGCGAGCGGCAAGCTGCCGGCGCTGTTCGTCGAGGCGCTGAAGCCGATGCAGCCCGGGGAGATCAGCCCCCT
GCTGCGCAGCGGCAACGGTTTCCACATCCTCAAGCTCGTCGACAAGCGCGGTCTGGACGCCACGCTCAGCGTCACCCAGA
CGCATGCGCGGCACATCCTGATCAAGACGAACGAAATCACCTCCGAAGCCGACGCGCGCAACCGCCTGCTGCAGCTGAAG
GAGCGCATCGACAACGGCGTCAAGTTCGACGAGCTCGCGCGTCTGCACTCCGAGGACGCGAGCGCGTCGAAAGGCGGCGA
CCTCGGCTGGATCAACCCGGGCGACACGGTCCCCGACTTCGAGAAGGCGATGAACGCGCTGCAGCCCGGCGAGGTCAGTG
CGCCGGTCCAGTCGCCCTTCGGCTGGCACCTGATCCAGGTCCTCGAACGCCGTGACCAGGACGTGACGCAGGAGCGCCAG
AAGCTGATGGCGCGCCAGGCGATCCGCGAGCGCAAGGCCGAAGAGGCCTTCCAGGACTGGGTCCGGCAGATACGCGACGC
CGCCTACGTCGAACTGCGCCCGATCGATTGA

Upstream 100 bases:

>100_bases
GACGCGCTGTTCTTCCAGCTCGAGCTCAACGGCATGGGCCGCCTCGGCTCCAACCCGCTCGACGTTTTGAAACAAAGTGT
TCCCGGATACAGGCCAAGCA

Downstream 100 bases:

>100_bases
CGCCCGCTACGGCCGTGCGCGCACCGTGAACCCGCCCGTTGTCGCGCTGACCGCCGGCGAGCCGGCAGGCGTCGGCCCCG
ACCTCTGCATCGCCCTCTCG

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase surA; PPIase surA; Rotamase surA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MKFFQRPERRLKQWGLALLLAASALLPARADVVPLNHIVAVVNDEVITRQELAKRYDEVVRNLSRQNTPLPPRNVLEKQL
LERMVTELALQQHARNTGVRADPTLVERALQRIAAQNKLDMAGLQAALEKEGQTLDGMRNTIRNELLIARARERDVDNRI
SVSDAEIDGYLQTQAQQGAETEYNFSHILVSVPENASPEQIRERRARAEDILAQLAAGADFAQLSASHSDAPDALKGGNF
GWRASGKLPALFVEALKPMQPGEISPLLRSGNGFHILKLVDKRGLDATLSVTQTHARHILIKTNEITSEADARNRLLQLK
ERIDNGVKFDELARLHSEDASASKGGDLGWINPGDTVPDFEKAMNALQPGEVSAPVQSPFGWHLIQVLERRDQDVTQERQ
KLMARQAIRERKAEEAFQDWVRQIRDAAYVELRPID

Sequences:

>Translated_436_residues
MKFFQRPERRLKQWGLALLLAASALLPARADVVPLNHIVAVVNDEVITRQELAKRYDEVVRNLSRQNTPLPPRNVLEKQL
LERMVTELALQQHARNTGVRADPTLVERALQRIAAQNKLDMAGLQAALEKEGQTLDGMRNTIRNELLIARARERDVDNRI
SVSDAEIDGYLQTQAQQGAETEYNFSHILVSVPENASPEQIRERRARAEDILAQLAAGADFAQLSASHSDAPDALKGGNF
GWRASGKLPALFVEALKPMQPGEISPLLRSGNGFHILKLVDKRGLDATLSVTQTHARHILIKTNEITSEADARNRLLQLK
ERIDNGVKFDELARLHSEDASASKGGDLGWINPGDTVPDFEKAMNALQPGEVSAPVQSPFGWHLIQVLERRDQDVTQERQ
KLMARQAIRERKAEEAFQDWVRQIRDAAYVELRPID
>Mature_436_residues
MKFFQRPERRLKQWGLALLLAASALLPARADVVPLNHIVAVVNDEVITRQELAKRYDEVVRNLSRQNTPLPPRNVLEKQL
LERMVTELALQQHARNTGVRADPTLVERALQRIAAQNKLDMAGLQAALEKEGQTLDGMRNTIRNELLIARARERDVDNRI
SVSDAEIDGYLQTQAQQGAETEYNFSHILVSVPENASPEQIRERRARAEDILAQLAAGADFAQLSASHSDAPDALKGGNF
GWRASGKLPALFVEALKPMQPGEISPLLRSGNGFHILKLVDKRGLDATLSVTQTHARHILIKTNEITSEADARNRLLQLK
ERIDNGVKFDELARLHSEDASASKGGDLGWINPGDTVPDFEKAMNALQPGEVSAPVQSPFGWHLIQVLERRDQDVTQERQ
KLMARQAIRERKAEEAFQDWVRQIRDAAYVELRPID

Specific function: Chaperone involved in the correct folding and assembly of outer membrane proteins. It recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Periplasm. Note=Is capable of associating with the outer membrane (By similarity)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PpiC domains

Homologues:

Organism=Escherichia coli, GI1786238, Length=366, Percent_Identity=37.7049180327869, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI1790211, Length=95, Percent_Identity=37.8947368421053, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): SURA_THIDA (Q3SGF9)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_316096.1
- HSSP:   P24327
- ProteinModelPortal:   Q3SGF9
- SMR:   Q3SGF9
- STRING:   Q3SGF9
- GeneID:   3673466
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2338
- NMPDR:   fig|292415.3.peg.2411
- eggNOG:   COG0760
- HOGENOM:   HBG391483
- OMA:   RHILIKT
- PhylomeDB:   Q3SGF9
- BioCyc:   TDEN292415:TBD_2338-MONOMER
- HAMAP:   MF_01183
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR023034
- InterPro:   IPR015391
- InterPro:   IPR008880

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N; SSF109998 Trigger_fac_C_bac

EC number: =5.2.1.8

Molecular weight: Translated: 48843; Mature: 48843

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS01096 PPIC_PPIASE_1; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFFQRPERRLKQWGLALLLAASALLPARADVVPLNHIVAVVNDEVITRQELAKRYDEVV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
RNLSRQNTPLPPRNVLEKQLLERMVTELALQQHARNTGVRADPTLVERALQRIAAQNKLD
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHH
MAGLQAALEKEGQTLDGMRNTIRNELLIARARERDVDNRISVSDAEIDGYLQTQAQQGAE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCC
TEYNFSHILVSVPENASPEQIRERRARAEDILAQLAAGADFAQLSASHSDAPDALKGGNF
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHCCCCC
GWRASGKLPALFVEALKPMQPGEISPLLRSGNGFHILKLVDKRGLDATLSVTQTHARHIL
CCCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCCEEEEEEHHHCCCCCCHHHHHHHHCEEE
IKTNEITSEADARNRLLQLKERIDNGVKFDELARLHSEDASASKGGDLGWINPGDTVPDF
EECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
EKAMNALQPGEVSAPVQSPFGWHLIQVLERRDQDVTQERQKLMARQAIRERKAEEAFQDW
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRQIRDAAYVELRPID
HHHHHHCCEEEEEECC
>Mature Secondary Structure
MKFFQRPERRLKQWGLALLLAASALLPARADVVPLNHIVAVVNDEVITRQELAKRYDEVV
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHH
RNLSRQNTPLPPRNVLEKQLLERMVTELALQQHARNTGVRADPTLVERALQRIAAQNKLD
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHH
MAGLQAALEKEGQTLDGMRNTIRNELLIARARERDVDNRISVSDAEIDGYLQTQAQQGAE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCC
TEYNFSHILVSVPENASPEQIRERRARAEDILAQLAAGADFAQLSASHSDAPDALKGGNF
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHCCCCC
GWRASGKLPALFVEALKPMQPGEISPLLRSGNGFHILKLVDKRGLDATLSVTQTHARHIL
CCCCCCCCHHHHHHHHCCCCCCCCCHHHHCCCCEEEEEEHHHCCCCCCHHHHHHHHCEEE
IKTNEITSEADARNRLLQLKERIDNGVKFDELARLHSEDASASKGGDLGWINPGDTVPDF
EECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
EKAMNALQPGEVSAPVQSPFGWHLIQVLERRDQDVTQERQKLMARQAIRERKAEEAFQDW
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRQIRDAAYVELRPID
HHHHHHCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA