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The map label for this gene is lptD

Identifier: 74318355

GI number: 74318355

Start: 2410789

End: 2412975

Strand: Direct

Name: lptD

Synonym: Tbd_2337

Alternate gene names: 74318355

Gene position: 2410789-2412975 (Clockwise)

Preceding gene: 74318347

Following gene: 74318356

Centisome position: 82.85

GC content: 65.39

Gene sequence:

>2187_bases
TTGTCCGCCTTGCCCGGTTTCACGCTCGCTGCGCTGTTGCTGAACGTCTCCCTCGCGGAGGCGAACGGGCTCGTGCTGAA
GAAGGACCTCGAACTGAAGGGTTCGACCGTTGCCGGGAAGGAGGCGCCGCTCTTCCTCACCGCCGACCGGATCGACTCGA
CGGCCGTGGGCATCATCGAAGCGGCCGGCCGCGTCGAGGCACGCCAGGCCGGGCGCAACTTCTTCGCCGACTGGCTGCGC
TACGACACCCGCGAGAACAGCGTCCAGGCGCGCGGCAAGGTCCGGCTCGAACAGCCGGCCCTGCTCGTGACCGGCGACTC
GCTGGACATCGATCTCGATACCTACAGCGGACAGCTCGCCGCACCCGTCTACCGCTTCGTCGGCCAGCCGGGACGCGGCG
ACGCCGAGCGCATCGACTTCATCGACGAAAACAATTTCAGCCTGGCCGACGCGACCTATACGACCTGCTCGGTCGAGGAC
GAGGACTGGTACCTCAAGATCGCCGACCTCGACATCGACCGCGGCCGCGACGTCGGCACCGCCCACCACGCGTCGCTGCG
CTTTCTCGGCGTACCGATCCTGTATACGCCGTGGATGAGTTTTCCGCTCGGCGACGCGCGCAAGAGCGGCATCCTCGCGC
CGACGATCGGCACGACCGAACGCAGCGGCCTCGACATCGTCGTGCCGTATTACCTCAACCTCGCGCCCAACTACGACGCT
ACGCTCTACCCCCGTCTGCTGTCGAAGCGCGGCGTGCAGCTCGGCGGCGAATTTCGCTATCTGCTCGAAGACGCCCGGGG
CGTGAACCGTGTCGAATACCTCGACGACAGCGAGGCCGCGCGGACGCGCTGGAGCGTCGCGCTCAACAACAGCTATCGGC
TGAACGCGAACACCCAGGCCGGCATGCTGTTCGACCGCGTGTCCGACGACGACTATTTCCGTGACCTCTCCAACCTGATC
TCGATCACGTCGCTCAGCCACCTCAACCGCGAGGTATGGGTGACGACGCAGCATGCCCACTGGAACGCCGAGCTGCGCGC
ACAGAGCTTCCAGACCCTGCAGGACTCGACCGCGTCGACGCCGATCGCCGAGCCCTATGCGCGCCTGCCGCACGCCCGTC
TCGGTGCGGCCCAGACCTTCGGCCGATTCGAGTTCACGCTTGAAAGCGAAGCGACGCGCTTCGCCCATCCGACGAAGACC
GAGGGAACGCGCGTCCTCGCCTACCCGACGCTGCGCATGCCGCTCGTCAACGATTACGGCTTCCTCACCCCGCAGATCGG
CTGGCACAGCACCTATTACGCGCTCGACGAGAGTGCGGCCGACGACAATATCGTGCGCAACCTGCCGATCTTCAGCCTCG
ACAGCGGCGTCGTGTTCGACCGGCCGATGCGCTTTTCGGGCGTCGATTTCGAACAAACGCTCGAACCGCGCGTCTACTAC
GTCTACGCGCCCTATCGCGATCAGGACGACATTCCGATCTTCGACACCGGGCTGCTCGATTTCAGCTACGCGCAGATGTT
CACGCCGAACCAGTTCATCGGCGGCGACCGCATCAACGACGCGAACCAGCTGACCGTCGCCGTGACGAGCCGTTTCGTCG
AGGCCGAAAGCGGGCTCGAGCGCCTGCAGGTCACGCTCGGCCAGCGCTACTACTTCACGCCCCAGCGCGTCACGCTGCCC
GGCGTCGACCCCCGGAGTGACAACACGACCGACCTGCTCGCGGCCGTGAGCGGACAGATCACGCGAGACTGGCGCATCGA
CACGGCCTGGCAGTTCGACACCCAGAACGGCACGGTCATCCGCCAGAACCTCGGCGCGTCCTACCGTCCGGGCCCCGGCC
GCGCGATCAACTTCGGCTATCGCTTCATCGACCAGACCACCGAGCAGGTCGACGTGTCCGCGCAGTGGCCCCTGGGCAGG
CGCTGGTACGGCATGTTCCGCTACAACTACTCCTTCCAGGACGACAAGCTCGTCGAAGGGCTTGCCGGCCTTGAATACAA
TGGCGGCTGCTGGGCGCTGCGCACCGTATTCCAGCGCCTTGCCACGAAGGAAGACCAGTCGACCGACGCGCTGTTCTTCC
AGCTCGAGCTCAACGGCATGGGCCGCCTCGGCTCCAACCCGCTCGACGTTTTGAAACAAAGTGTTCCCGGATACAGGCCA
AGCAATGAAATTCTTCCAACGCCCTGA

Upstream 100 bases:

>100_bases
CGGTTTCCTGGCCCAGCTGACGCGCGGCCCAGGCCTCCAATGCTTGCAAACGTTCCACTGCCGGTCGGCTCCGAATAACG
AACTCCGGATTTTACATCGC

Downstream 100 bases:

>100_bases
ACGACGCCTCAAGCAGTGGGGACTGGCGCTTCTCCTCGCCGCGTCGGCGCTCCTGCCCGCACGCGCCGACGTCGTGCCGC
TCAACCACATCGTCGCGGTC

Product: organic solvent tolerance transmembrane protein

Products: NA

Alternate protein names: Organic solvent tolerance protein

Number of amino acids: Translated: 728; Mature: 727

Protein sequence:

>728_residues
MSALPGFTLAALLLNVSLAEANGLVLKKDLELKGSTVAGKEAPLFLTADRIDSTAVGIIEAAGRVEARQAGRNFFADWLR
YDTRENSVQARGKVRLEQPALLVTGDSLDIDLDTYSGQLAAPVYRFVGQPGRGDAERIDFIDENNFSLADATYTTCSVED
EDWYLKIADLDIDRGRDVGTAHHASLRFLGVPILYTPWMSFPLGDARKSGILAPTIGTTERSGLDIVVPYYLNLAPNYDA
TLYPRLLSKRGVQLGGEFRYLLEDARGVNRVEYLDDSEAARTRWSVALNNSYRLNANTQAGMLFDRVSDDDYFRDLSNLI
SITSLSHLNREVWVTTQHAHWNAELRAQSFQTLQDSTASTPIAEPYARLPHARLGAAQTFGRFEFTLESEATRFAHPTKT
EGTRVLAYPTLRMPLVNDYGFLTPQIGWHSTYYALDESAADDNIVRNLPIFSLDSGVVFDRPMRFSGVDFEQTLEPRVYY
VYAPYRDQDDIPIFDTGLLDFSYAQMFTPNQFIGGDRINDANQLTVAVTSRFVEAESGLERLQVTLGQRYYFTPQRVTLP
GVDPRSDNTTDLLAAVSGQITRDWRIDTAWQFDTQNGTVIRQNLGASYRPGPGRAINFGYRFIDQTTEQVDVSAQWPLGR
RWYGMFRYNYSFQDDKLVEGLAGLEYNGGCWALRTVFQRLATKEDQSTDALFFQLELNGMGRLGSNPLDVLKQSVPGYRP
SNEILPTP

Sequences:

>Translated_728_residues
MSALPGFTLAALLLNVSLAEANGLVLKKDLELKGSTVAGKEAPLFLTADRIDSTAVGIIEAAGRVEARQAGRNFFADWLR
YDTRENSVQARGKVRLEQPALLVTGDSLDIDLDTYSGQLAAPVYRFVGQPGRGDAERIDFIDENNFSLADATYTTCSVED
EDWYLKIADLDIDRGRDVGTAHHASLRFLGVPILYTPWMSFPLGDARKSGILAPTIGTTERSGLDIVVPYYLNLAPNYDA
TLYPRLLSKRGVQLGGEFRYLLEDARGVNRVEYLDDSEAARTRWSVALNNSYRLNANTQAGMLFDRVSDDDYFRDLSNLI
SITSLSHLNREVWVTTQHAHWNAELRAQSFQTLQDSTASTPIAEPYARLPHARLGAAQTFGRFEFTLESEATRFAHPTKT
EGTRVLAYPTLRMPLVNDYGFLTPQIGWHSTYYALDESAADDNIVRNLPIFSLDSGVVFDRPMRFSGVDFEQTLEPRVYY
VYAPYRDQDDIPIFDTGLLDFSYAQMFTPNQFIGGDRINDANQLTVAVTSRFVEAESGLERLQVTLGQRYYFTPQRVTLP
GVDPRSDNTTDLLAAVSGQITRDWRIDTAWQFDTQNGTVIRQNLGASYRPGPGRAINFGYRFIDQTTEQVDVSAQWPLGR
RWYGMFRYNYSFQDDKLVEGLAGLEYNGGCWALRTVFQRLATKEDQSTDALFFQLELNGMGRLGSNPLDVLKQSVPGYRP
SNEILPTP
>Mature_727_residues
SALPGFTLAALLLNVSLAEANGLVLKKDLELKGSTVAGKEAPLFLTADRIDSTAVGIIEAAGRVEARQAGRNFFADWLRY
DTRENSVQARGKVRLEQPALLVTGDSLDIDLDTYSGQLAAPVYRFVGQPGRGDAERIDFIDENNFSLADATYTTCSVEDE
DWYLKIADLDIDRGRDVGTAHHASLRFLGVPILYTPWMSFPLGDARKSGILAPTIGTTERSGLDIVVPYYLNLAPNYDAT
LYPRLLSKRGVQLGGEFRYLLEDARGVNRVEYLDDSEAARTRWSVALNNSYRLNANTQAGMLFDRVSDDDYFRDLSNLIS
ITSLSHLNREVWVTTQHAHWNAELRAQSFQTLQDSTASTPIAEPYARLPHARLGAAQTFGRFEFTLESEATRFAHPTKTE
GTRVLAYPTLRMPLVNDYGFLTPQIGWHSTYYALDESAADDNIVRNLPIFSLDSGVVFDRPMRFSGVDFEQTLEPRVYYV
YAPYRDQDDIPIFDTGLLDFSYAQMFTPNQFIGGDRINDANQLTVAVTSRFVEAESGLERLQVTLGQRYYFTPQRVTLPG
VDPRSDNTTDLLAAVSGQITRDWRIDTAWQFDTQNGTVIRQNLGASYRPGPGRAINFGYRFIDQTTEQVDVSAQWPLGRR
WYGMFRYNYSFQDDKLVEGLAGLEYNGGCWALRTVFQRLATKEDQSTDALFFQLELNGMGRLGSNPLDVLKQSVPGYRPS
NEILPTP

Specific function: Involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis

COG id: COG1452

COG function: function code M; Organic solvent tolerance protein OstA

Gene ontology:

Cell location: Cell outer membrane

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lptD family

Homologues:

Organism=Escherichia coli, GI1786239, Length=739, Percent_Identity=26.7929634641407, Blast_Score=271, Evalue=1e-73,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): LPTD_THIDA (Q3SGG0)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_316095.1
- STRING:   Q3SGG0
- GeneID:   3673465
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2337
- NMPDR:   fig|292415.3.peg.2410
- eggNOG:   COG1452
- HOGENOM:   HBG701380
- OMA:   TPYYWNI
- PhylomeDB:   Q3SGG0
- BioCyc:   TDEN292415:TBD_2337-MONOMER
- HAMAP:   MF_01411
- InterPro:   IPR020889
- InterPro:   IPR005653
- InterPro:   IPR007543

Pfam domain/function: PF03968 OstA; PF04453 OstA_C

EC number: NA

Molecular weight: Translated: 81658; Mature: 81527

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSALPGFTLAALLLNVSLAEANGLVLKKDLELKGSTVAGKEAPLFLTADRIDSTAVGIIE
CCCCCHHHHHHHHHHHEEECCCCEEEEECCCCCCCEECCCCCCEEEEECCCCCCHHHHHH
AAGRVEARQAGRNFFADWLRYDTRENSVQARGKVRLEQPALLVTGDSLDIDLDTYSGQLA
HCCCHHHHHHHHHHHHHHHHCCCCCCCEECCCEEEEECCEEEEECCCEEEEEECCCCCHH
APVYRFVGQPGRGDAERIDFIDENNFSLADATYTTCSVEDEDWYLKIADLDIDRGRDVGT
HHHHHHCCCCCCCCHHHEEEECCCCCEEECCEEEEEEECCCCCEEEEEEEECCCCCCCCC
AHHASLRFLGVPILYTPWMSFPLGDARKSGILAPTIGTTERSGLDIVVPYYLNLAPNYDA
CHHCEEEEECCCEEECCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEEEEEEEECCCCCC
TLYPRLLSKRGVQLGGEFRYLLEDARGVNRVEYLDDSEAARTRWSVALNNSYRLNANTQA
CHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEECCCCHHHHEEEEEEECCEEEECCCCCC
GMLFDRVSDDDYFRDLSNLISITSLSHLNREVWVTTQHAHWNAELRAQSFQTLQDSTAST
CEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCC
PIAEPYARLPHARLGAAQTFGRFEFTLESEATRFAHPTKTEGTRVLAYPTLRMPLVNDYG
CCCCHHHHCCCHHHCHHHHCCEEEEEECCCCHHCCCCCCCCCCEEEEECCEECCEECCCC
FLTPQIGWHSTYYALDESAADDNIVRNLPIFSLDSGVVFDRPMRFSGVDFEQTLEPRVYY
CCCCCCCCCCEEEEECCCCCCCCHHHCCCEEEECCCCEECCCCCCCCCCHHHCCCCEEEE
VYAPYRDQDDIPIFDTGLLDFSYAQMFTPNQFIGGDRINDANQLTVAVTSRFVEAESGLE
EECCCCCCCCCCEEECCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHH
RLQVTLGQRYYFTPQRVTLPGVDPRSDNTTDLLAAVSGQITRDWRIDTAWQFDTQNGTVI
HHHHHHCCEEEECCCEEECCCCCCCCCCHHHHHHHHCCCCEECEEECEEEEEECCCCEEE
RQNLGASYRPGPGRAINFGYRFIDQTTEQVDVSAQWPLGRRWYGMFRYNYSFQDDKLVEG
EECCCCCCCCCCCCEEECCCHHHHCCCHHEEEEECCCCCCEEEEEEEEECCCCCCHHHHH
LAGLEYNGGCWALRTVFQRLATKEDQSTDALFFQLELNGMGRLGSNPLDVLKQSVPGYRP
HHCCEECCCCHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCC
SNEILPTP
CCCCCCCC
>Mature Secondary Structure 
SALPGFTLAALLLNVSLAEANGLVLKKDLELKGSTVAGKEAPLFLTADRIDSTAVGIIE
CCCCHHHHHHHHHHHEEECCCCEEEEECCCCCCCEECCCCCCEEEEECCCCCCHHHHHH
AAGRVEARQAGRNFFADWLRYDTRENSVQARGKVRLEQPALLVTGDSLDIDLDTYSGQLA
HCCCHHHHHHHHHHHHHHHHCCCCCCCEECCCEEEEECCEEEEECCCEEEEEECCCCCHH
APVYRFVGQPGRGDAERIDFIDENNFSLADATYTTCSVEDEDWYLKIADLDIDRGRDVGT
HHHHHHCCCCCCCCHHHEEEECCCCCEEECCEEEEEEECCCCCEEEEEEEECCCCCCCCC
AHHASLRFLGVPILYTPWMSFPLGDARKSGILAPTIGTTERSGLDIVVPYYLNLAPNYDA
CHHCEEEEECCCEEECCCCCCCCCCCCCCCEEECCCCCCCCCCCEEEEEEEEEECCCCCC
TLYPRLLSKRGVQLGGEFRYLLEDARGVNRVEYLDDSEAARTRWSVALNNSYRLNANTQA
CHHHHHHHHCCCCCCCHHHHHHHHCCCCCEEEECCCCHHHHEEEEEEECCEEEECCCCCC
GMLFDRVSDDDYFRDLSNLISITSLSHLNREVWVTTQHAHWNAELRAQSFQTLQDSTAST
CEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCC
PIAEPYARLPHARLGAAQTFGRFEFTLESEATRFAHPTKTEGTRVLAYPTLRMPLVNDYG
CCCCHHHHCCCHHHCHHHHCCEEEEEECCCCHHCCCCCCCCCCEEEEECCEECCEECCCC
FLTPQIGWHSTYYALDESAADDNIVRNLPIFSLDSGVVFDRPMRFSGVDFEQTLEPRVYY
CCCCCCCCCCEEEEECCCCCCCCHHHCCCEEEECCCCEECCCCCCCCCCHHHCCCCEEEE
VYAPYRDQDDIPIFDTGLLDFSYAQMFTPNQFIGGDRINDANQLTVAVTSRFVEAESGLE
EECCCCCCCCCCEEECCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHH
RLQVTLGQRYYFTPQRVTLPGVDPRSDNTTDLLAAVSGQITRDWRIDTAWQFDTQNGTVI
HHHHHHCCEEEECCCEEECCCCCCCCCCHHHHHHHHCCCCEECEEECEEEEEECCCCEEE
RQNLGASYRPGPGRAINFGYRFIDQTTEQVDVSAQWPLGRRWYGMFRYNYSFQDDKLVEG
EECCCCCCCCCCCCEEECCCHHHHCCCHHEEEEECCCCCCEEEEEEEEECCCCCCHHHHH
LAGLEYNGGCWALRTVFQRLATKEDQSTDALFFQLELNGMGRLGSNPLDVLKQSVPGYRP
HHCCEECCCCHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHCCCCCC
SNEILPTP
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA