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The map label for this gene is degS [H]

Identifier: 74318253

GI number: 74318253

Start: 2313456

End: 2314829

Strand: Direct

Name: degS [H]

Synonym: Tbd_2235

Alternate gene names: 74318253

Gene position: 2313456-2314829 (Clockwise)

Preceding gene: 74318250

Following gene: 74318258

Centisome position: 79.51

GC content: 64.41

Gene sequence:

>1374_bases
ATGCCCAACGCCTCCGCCCGCCCCCCTATTCACGCGCTGCCGCGGCCATCCGAGGATTTGCGCGTCAGCACGCATTTGTA
TCTTGCAGCCGGCATGGCGCTGCTGATCGGCATGCTCGTCGCGAGCTACATGCAGGCCTCGGCGGGCCTCACCGCGCTCA
AGCAATTCGGCGTCGCCAACCAACGCGCCGACCATCTCGACCGCCTGAGCCAGCTCCTGCTCCATGCGCAGTCGGCGACG
CGCGGCTACGCGCTGACCGGCAGTCAGTCGCAGCTCGATTCCTATCGCGCGACCGTGCCCCTGATCCAGGACATCCTGCG
CGTGATCGAGCGCGACCACGTCACGGAATCGCGCTCCGACACCGCCCGCCTGGTACAGCTCGCGCACGGCGTCGCCGCGC
GCCAGGAAATCACGACGCGCCACCTCGAAAGCGGCCTTCCGGCGAAGAAAACTTGGTTCGAGGAAGGCACGCTGGCGATG
GACGCCTACCTCCAGCAACACAACAAGATCAAAGTCGATCTGCTCACCGACAACCTGCAGAACGTCCGCCAGTCGGTCAG
CGGCTTCGAGATGGCGCGCGTGAGCACGGTCCTGCTCGCGATTGCCTCCTTGCTGCTGCTGTTGCTGACGATCTCGCAGC
AGCAGAAGAAGCAGGAGCTGCAAGCCAGGATTCGTCACCTGCTCGAAGCGGAAAACGAACGGCTCGATCACGAGGTCCAG
CTGCGCACGGCCGAATTGACGAATCTTGCGACCTACCTCACGGACGTGCGCGAGAGCGAGAAACTGCATCTCGCGCGCGA
ACTGCACGACGAACTCGGCGCCCTGCTCACCGCGGCCAAGCTCGACGCGGACTGGATCGAGCGCAAGCTGCCGCCGGAAA
TGCGCGCCCTCGTCGAGCAGCGGCTCACGCGTCTGCGCCAAAGCCTGGTCGGGGGGATCACGCTCAAGCGACGGATCACG
AACAACCTGCGTCCTGCGCTGCTCTATGACCTCGGGCTGATCGAGGCCCTCAAGTCGCTGGTCGCCGAGTTCCGCGAGGA
CGGCGAGGCGGATATCACCGCGGAACTTCCGGAAGACTGCCCCGAACTCTCCGAAGAGGTGTCATTGAGCCTTTTTCGCA
TCGTCCAGGAAGCGCTCACCAATGTGCGCAAATACGCCCAGGCGAAGCACGTACATATCGCACTACGGACGAAGAGCGAC
GCGGTCGAGTTGTCGATCACGGACGACGGCGTCGGCTTCGACCCGCATTCGCCGAAAGTCGCGCGCCACGGTCTCGCGGG
AATCAAGCATCGGGTGTTCGACCACGGCGGCCAACTCGATATTCGTACGGCGCCGGGAAAAGGCGTGGCGATCAGCGTGA
TGCTGCCGCTCTGA

Upstream 100 bases:

>100_bases
TCCTAAGCGCCGGCCCGGGCGCCATCTGTCAGTGCGCGCGGATTGACCTGTCGGAAGATTCCTGCAATAACAAACGACCA
TTCGCGTTACGCTATCGATC

Downstream 100 bases:

>100_bases
GTCAGTGCGCGGACTTGTCGTGCGCGGCGGCCGCGACGTAATCCAGGAGCTGGTTGATGTGCAGGGACTTGTCGAAGAAG
GCATCCATGCCGAAGCGCTC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MPNASARPPIHALPRPSEDLRVSTHLYLAAGMALLIGMLVASYMQASAGLTALKQFGVANQRADHLDRLSQLLLHAQSAT
RGYALTGSQSQLDSYRATVPLIQDILRVIERDHVTESRSDTARLVQLAHGVAARQEITTRHLESGLPAKKTWFEEGTLAM
DAYLQQHNKIKVDLLTDNLQNVRQSVSGFEMARVSTVLLAIASLLLLLLTISQQQKKQELQARIRHLLEAENERLDHEVQ
LRTAELTNLATYLTDVRESEKLHLARELHDELGALLTAAKLDADWIERKLPPEMRALVEQRLTRLRQSLVGGITLKRRIT
NNLRPALLYDLGLIEALKSLVAEFREDGEADITAELPEDCPELSEEVSLSLFRIVQEALTNVRKYAQAKHVHIALRTKSD
AVELSITDDGVGFDPHSPKVARHGLAGIKHRVFDHGGQLDIRTAPGKGVAISVMLPL

Sequences:

>Translated_457_residues
MPNASARPPIHALPRPSEDLRVSTHLYLAAGMALLIGMLVASYMQASAGLTALKQFGVANQRADHLDRLSQLLLHAQSAT
RGYALTGSQSQLDSYRATVPLIQDILRVIERDHVTESRSDTARLVQLAHGVAARQEITTRHLESGLPAKKTWFEEGTLAM
DAYLQQHNKIKVDLLTDNLQNVRQSVSGFEMARVSTVLLAIASLLLLLLTISQQQKKQELQARIRHLLEAENERLDHEVQ
LRTAELTNLATYLTDVRESEKLHLARELHDELGALLTAAKLDADWIERKLPPEMRALVEQRLTRLRQSLVGGITLKRRIT
NNLRPALLYDLGLIEALKSLVAEFREDGEADITAELPEDCPELSEEVSLSLFRIVQEALTNVRKYAQAKHVHIALRTKSD
AVELSITDDGVGFDPHSPKVARHGLAGIKHRVFDHGGQLDIRTAPGKGVAISVMLPL
>Mature_456_residues
PNASARPPIHALPRPSEDLRVSTHLYLAAGMALLIGMLVASYMQASAGLTALKQFGVANQRADHLDRLSQLLLHAQSATR
GYALTGSQSQLDSYRATVPLIQDILRVIERDHVTESRSDTARLVQLAHGVAARQEITTRHLESGLPAKKTWFEEGTLAMD
AYLQQHNKIKVDLLTDNLQNVRQSVSGFEMARVSTVLLAIASLLLLLLTISQQQKKQELQARIRHLLEAENERLDHEVQL
RTAELTNLATYLTDVRESEKLHLARELHDELGALLTAAKLDADWIERKLPPEMRALVEQRLTRLRQSLVGGITLKRRITN
NLRPALLYDLGLIEALKSLVAEFREDGEADITAELPEDCPELSEEVSLSLFRIVQEALTNVRKYAQAKHVHIALRTKSDA
VELSITDDGVGFDPHSPKVARHGLAGIKHRVFDHGGQLDIRTAPGKGVAISVMLPL

Specific function: Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=220, Percent_Identity=34.0909090909091, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50745; Mature: 50614

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNASARPPIHALPRPSEDLRVSTHLYLAAGMALLIGMLVASYMQASAGLTALKQFGVAN
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QRADHLDRLSQLLLHAQSATRGYALTGSQSQLDSYRATVPLIQDILRVIERDHVTESRSD
CHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
TARLVQLAHGVAARQEITTRHLESGLPAKKTWFEEGTLAMDAYLQQHNKIKVDLLTDNLQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHCCCEEEEEEHHHHH
NVRQSVSGFEMARVSTVLLAIASLLLLLLTISQQQKKQELQARIRHLLEAENERLDHEVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LRTAELTNLATYLTDVRESEKLHLARELHDELGALLTAAKLDADWIERKLPPEMRALVEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHH
RLTRLRQSLVGGITLKRRITNNLRPALLYDLGLIEALKSLVAEFREDGEADITAELPEDC
HHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHH
PELSEEVSLSLFRIVQEALTNVRKYAQAKHVHIALRTKSDAVELSITDDGVGFDPHSPKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCEEEEEEECCCCCCCCCCCHH
ARHGLAGIKHRVFDHGGQLDIRTAPGKGVAISVMLPL
HHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEECC
>Mature Secondary Structure 
PNASARPPIHALPRPSEDLRVSTHLYLAAGMALLIGMLVASYMQASAGLTALKQFGVAN
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QRADHLDRLSQLLLHAQSATRGYALTGSQSQLDSYRATVPLIQDILRVIERDHVTESRSD
CHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
TARLVQLAHGVAARQEITTRHLESGLPAKKTWFEEGTLAMDAYLQQHNKIKVDLLTDNLQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHCCCEEEEEEHHHHH
NVRQSVSGFEMARVSTVLLAIASLLLLLLTISQQQKKQELQARIRHLLEAENERLDHEVQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LRTAELTNLATYLTDVRESEKLHLARELHDELGALLTAAKLDADWIERKLPPEMRALVEQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHH
RLTRLRQSLVGGITLKRRITNNLRPALLYDLGLIEALKSLVAEFREDGEADITAELPEDC
HHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHH
PELSEEVSLSLFRIVQEALTNVRKYAQAKHVHIALRTKSDAVELSITDDGVGFDPHSPKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCEEEEEEECCCCCCCCCCCHH
ARHGLAGIKHRVFDHGGQLDIRTAPGKGVAISVMLPL
HHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]