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The map label for this gene is mltA [H]

Identifier: 74318250

GI number: 74318250

Start: 2311277

End: 2312479

Strand: Direct

Name: mltA [H]

Synonym: Tbd_2232

Alternate gene names: 74318250

Gene position: 2311277-2312479 (Clockwise)

Preceding gene: 74318249

Following gene: 74318253

Centisome position: 79.43

GC content: 69.58

Gene sequence:

>1203_bases
GTGACGCCACTACGCGCAAGTCCGTGGCTGGTCGCGCTGCTGCTTTCGGCGTGCGCGGTCCGTCCTCCCGCGCCCGAGGT
CCCGCCGCCCGCGCAAGCACCGCAACCCGTCCCGCCGGTGGCCGCGCCCCTGCTGCCAACGCTCGTTCCGGCCGACTGGT
CGGCGGTCACTTCCTGGCAGAGCGACAGCGCCGAAGAAGCCTGGGGCGCGTTCCTGCAAAGCTGCAGCGCGCTCGGCAAG
CGTCCGGCGTGGCAGGCGGTCTGCGCCGACGCCGCGGCCATGCCCACGCCCGACGCGGCCGCTGCCCGCGCCTTTTTCGA
GCAGCGCTTCCAGCCCCACGAAGCGCGCCAGGAGGACGGCAGCGCCGAAGGGCTCGTAACCGGCTACTACGAACCGCTGC
TCAAGGGCGACCGCGTGCGCACCCAACGCGCGCGCTACCCGCTCTACGCCGCGCCCGACGATCTCGTCGCGGTCGAACTG
GCGAGCGTCTACCCCGAGTTGAAGAACCTGCGGCTGCGCGGACGTCTGGTCGGGAAAAAGGTCGTGCCCTACCCGTCGCG
TGGCGAGATCACCACGGGCGGCGACAACGGGGGCTTCCGCGGCAGGCCGATCGCCTGGGCCGAAGACCCGGTCGACCTGT
TCTTTCTGCAGATCCAGGGGTCAGGCCGCATCGAATTGCCCGACGGTTCGCACTTGCGCGTCGGCTATGCGGACCAGAAC
GGCCACCCCTACCGCTCGATCGGCAAGCTCCTGGTCGAACGCGGCGAACTCAAGCTCGAAGAGGCTTCGATGCAGGGAAT
CAAGAACTGGGGCGCGAAAAATCCCGAGAAGCTGCCCGAACTTCTCGCCAGCAATCCGAGCTACGTCTTCTTCCGCGAGT
TGCCGAACGGCACTGAGGGGCCCCTCGGCGCGCTCGGTGTGCCGCTCACGGGCGGGCGCTCCATCGCGGTCGACCCGCGC
TTCATTCCACTCGGCGCGCCGGTCTTTCTCGCGACGACCGAGCCGAACTCGAGCGTTCCGCTAAACCGGCTGGTCATGGC
ACAGGACACGGGCGGTGCGATTCGCGGCGGCGTGCGCGCGGATTTCTTCTGGGGGTTCGGCACGGCGGCCGGGGAACAAG
CGGGCCGCATGAAGCAGCGCGGCCGGATGTGGGTATTGCTGCCGCGTACGGCAATCGAGACCGCAGCCGAGCTGCGGCGC
TAA

Upstream 100 bases:

>100_bases
CTTCCAGCACCAGCCAGCCCAAGCCCTGGCTCTCCATGAGTCGTCCTCCTCGCTTGCTATACTCGGCGCTCGTTTTTCCT
GCCGTGAACGATATTCACCC

Downstream 100 bases:

>100_bases
CCGGCTCGGAACGACAACGCCGGCCGGATCGCGCGACTGCGCGGACTCAGTGCAGCAAGTCCGCCAGCTCGTCGGCGTGG
TCCTCCTCCATCGCGAGGAT

Product: membrane-bound lytic murein transglycosylase A

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MTPLRASPWLVALLLSACAVRPPAPEVPPPAQAPQPVPPVAAPLLPTLVPADWSAVTSWQSDSAEEAWGAFLQSCSALGK
RPAWQAVCADAAAMPTPDAAAARAFFEQRFQPHEARQEDGSAEGLVTGYYEPLLKGDRVRTQRARYPLYAAPDDLVAVEL
ASVYPELKNLRLRGRLVGKKVVPYPSRGEITTGGDNGGFRGRPIAWAEDPVDLFFLQIQGSGRIELPDGSHLRVGYADQN
GHPYRSIGKLLVERGELKLEEASMQGIKNWGAKNPEKLPELLASNPSYVFFRELPNGTEGPLGALGVPLTGGRSIAVDPR
FIPLGAPVFLATTEPNSSVPLNRLVMAQDTGGAIRGGVRADFFWGFGTAAGEQAGRMKQRGRMWVLLPRTAIETAAELRR

Sequences:

>Translated_400_residues
MTPLRASPWLVALLLSACAVRPPAPEVPPPAQAPQPVPPVAAPLLPTLVPADWSAVTSWQSDSAEEAWGAFLQSCSALGK
RPAWQAVCADAAAMPTPDAAAARAFFEQRFQPHEARQEDGSAEGLVTGYYEPLLKGDRVRTQRARYPLYAAPDDLVAVEL
ASVYPELKNLRLRGRLVGKKVVPYPSRGEITTGGDNGGFRGRPIAWAEDPVDLFFLQIQGSGRIELPDGSHLRVGYADQN
GHPYRSIGKLLVERGELKLEEASMQGIKNWGAKNPEKLPELLASNPSYVFFRELPNGTEGPLGALGVPLTGGRSIAVDPR
FIPLGAPVFLATTEPNSSVPLNRLVMAQDTGGAIRGGVRADFFWGFGTAAGEQAGRMKQRGRMWVLLPRTAIETAAELRR
>Mature_399_residues
TPLRASPWLVALLLSACAVRPPAPEVPPPAQAPQPVPPVAAPLLPTLVPADWSAVTSWQSDSAEEAWGAFLQSCSALGKR
PAWQAVCADAAAMPTPDAAAARAFFEQRFQPHEARQEDGSAEGLVTGYYEPLLKGDRVRTQRARYPLYAAPDDLVAVELA
SVYPELKNLRLRGRLVGKKVVPYPSRGEITTGGDNGGFRGRPIAWAEDPVDLFFLQIQGSGRIELPDGSHLRVGYADQNG
HPYRSIGKLLVERGELKLEEASMQGIKNWGAKNPEKLPELLASNPSYVFFRELPNGTEGPLGALGVPLTGGRSIAVDPRF
IPLGAPVFLATTEPNSSVPLNRLVMAQDTGGAIRGGVRADFFWGFGTAAGEQAGRMKQRGRMWVLLPRTAIETAAELRR

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=267, Percent_Identity=37.8277153558052, Blast_Score=147, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 43109; Mature: 42977

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLRASPWLVALLLSACAVRPPAPEVPPPAQAPQPVPPVAAPLLPTLVPADWSAVTSWQ
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHCCC
SDSAEEAWGAFLQSCSALGKRPAWQAVCADAAAMPTPDAAAARAFFEQRFQPHEARQEDG
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHCCC
SAEGLVTGYYEPLLKGDRVRTQRARYPLYAAPDDLVAVELASVYPELKNLRLRGRLVGKK
CCCCEEEHHHHHHHCCCCHHHHHHCCCCEECCCHHHHHHHHHHHHHHHCCEEEEEEECCE
VVPYPSRGEITTGGDNGGFRGRPIAWAEDPVDLFFLQIQGSGRIELPDGSHLRVGYADQN
ECCCCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEECCCCCEEEEEEECCC
GHPYRSIGKLLVERGELKLEEASMQGIKNWGAKNPEKLPELLASNPSYVFFRELPNGTEG
CCCHHHHHHHHHHHCCCEEHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCC
PLGALGVPLTGGRSIAVDPRFIPLGAPVFLATTEPNSSVPLNRLVMAQDTGGAIRGGVRA
CCCCCCCCCCCCCEEEECCEEEECCCCEEEEECCCCCCCCCEEEEEEECCCCCEECCCEE
DFFWGFGTAAGEQAGRMKQRGRMWVLLPRTAIETAAELRR
EEEECCCCCCHHHHHHHHHCCCEEEEECHHHHHHHHHHCC
>Mature Secondary Structure 
TPLRASPWLVALLLSACAVRPPAPEVPPPAQAPQPVPPVAAPLLPTLVPADWSAVTSWQ
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHCCC
SDSAEEAWGAFLQSCSALGKRPAWQAVCADAAAMPTPDAAAARAFFEQRFQPHEARQEDG
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHCCC
SAEGLVTGYYEPLLKGDRVRTQRARYPLYAAPDDLVAVELASVYPELKNLRLRGRLVGKK
CCCCEEEHHHHHHHCCCCHHHHHHCCCCEECCCHHHHHHHHHHHHHHHCCEEEEEEECCE
VVPYPSRGEITTGGDNGGFRGRPIAWAEDPVDLFFLQIQGSGRIELPDGSHLRVGYADQN
ECCCCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEECCCCCEEEEEEECCC
GHPYRSIGKLLVERGELKLEEASMQGIKNWGAKNPEKLPELLASNPSYVFFRELPNGTEG
CCCHHHHHHHHHHHCCCEEHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEECCCCCCC
PLGALGVPLTGGRSIAVDPRFIPLGAPVFLATTEPNSSVPLNRLVMAQDTGGAIRGGVRA
CCCCCCCCCCCCCEEEECCEEEECCCCEEEEECCCCCCCCCEEEEEEECCCCCEECCCEE
DFFWGFGTAAGEQAGRMKQRGRMWVLLPRTAIETAAELRR
EEEECCCCCCHHHHHHHHHCCCEEEEECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]