Click here to switch to the map view.

The map label for this gene is trpC

Identifier: 74318240

GI number: 74318240

Start: 2301966

End: 2302754

Strand: Reverse

Name: trpC

Synonym: Tbd_2222

Alternate gene names: 74318240

Gene position: 2302754-2301966 (Counterclockwise)

Preceding gene: 74318241

Following gene: 74318238

Centisome position: 79.14

GC content: 67.68

Gene sequence:

>789_bases
ATGTCGGACATCCTCGAAAAAATCCTCGCGACCAAACGCGCCGAGGTCGCGGCCGGCCTCGCCCGGGTGCCGCTCGCCGA
AATGCGCGCGCGTGCCGAGGCGGCCGCGCCGGCACGCGATTTCGTCGGCGCGCTGCGGGCAAAGCGCGATGCCGGCCGGC
CGGCCGTGATCGCAGAGATCAAGAAGGCAAGTCCGTCCAAGGGCGTGATCCGGGCCGACTTCCGGCCCGCGGAAATCGCC
GCCAGTTATGAAAAGGGCGGCGCGGCATGTCTGTCCATACTGACCGACGCGGAATATTTCCAGGGCAGCGCGGACTACCT
CAAGGCCGCACGCGCGGCCTGTACGCTTCCGGTCCTGCGCAAGGATTTCATGATCGACGCCTACCAGGTCTACGAGGCGC
GCGCGATGGGCGCCGACTGCATCCTGCTGATCGTCGCCGCGCTCGAGTTGCCGGCGATGCAGGCGCTCGAAGCGCTGGCG
AATGAATTGGGGATGGCGGTTCTCGTGGAGTCGCACGACGCCGCCGAACTCGACGCCGCGCTGACGCTGCGCACGCCGCT
GCAGGGCATCAACAACCGCAACCTGCGCACCTTCGAGGTCAGCCTCGATACCACGCTTTCGCTGCTGCCGAAGATAGGCC
CCGAGCGCATCGTCGTCACCGAGTCCGGCATCCTCGCGCCGGCCGACGTGGATACGATGCGCAGCCGCGGCGTCAATACC
TTTCTGGTCGGCGAGGCCTTCATGCGTGCGGCCGACCCGGGCGCCGAGCTTGCCAGGCTGTTTGCCTGA

Upstream 100 bases:

>100_bases
GCATCGAGCTGGCGCGCGAGGCGATCCGCAGCGGCGCTGCACGCGACAAGTTGCAACAACTCGTCGCCTACTCGACGCAG
GCAAAGCAGGCGTGAGCACG

Downstream 100 bases:

>100_bases
CGCGTCTCCGGGGCGACGTCAAAAACGACTTCACGAGAGAGGGGCTTCCGGCGACTCCTCGGGAAGGCTCGGCGTTCAGC
GCTTGCCGCCGAAAAGACTC

Product: indole-3-glycerol phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MSDILEKILATKRAEVAAGLARVPLAEMRARAEAAAPARDFVGALRAKRDAGRPAVIAEIKKASPSKGVIRADFRPAEIA
ASYEKGGAACLSILTDAEYFQGSADYLKAARAACTLPVLRKDFMIDAYQVYEARAMGADCILLIVAALELPAMQALEALA
NELGMAVLVESHDAAELDAALTLRTPLQGINNRNLRTFEVSLDTTLSLLPKIGPERIVVTESGILAPADVDTMRSRGVNT
FLVGEAFMRAADPGAELARLFA

Sequences:

>Translated_262_residues
MSDILEKILATKRAEVAAGLARVPLAEMRARAEAAAPARDFVGALRAKRDAGRPAVIAEIKKASPSKGVIRADFRPAEIA
ASYEKGGAACLSILTDAEYFQGSADYLKAARAACTLPVLRKDFMIDAYQVYEARAMGADCILLIVAALELPAMQALEALA
NELGMAVLVESHDAAELDAALTLRTPLQGINNRNLRTFEVSLDTTLSLLPKIGPERIVVTESGILAPADVDTMRSRGVNT
FLVGEAFMRAADPGAELARLFA
>Mature_261_residues
SDILEKILATKRAEVAAGLARVPLAEMRARAEAAAPARDFVGALRAKRDAGRPAVIAEIKKASPSKGVIRADFRPAEIAA
SYEKGGAACLSILTDAEYFQGSADYLKAARAACTLPVLRKDFMIDAYQVYEARAMGADCILLIVAALELPAMQALEALAN
ELGMAVLVESHDAAELDAALTLRTPLQGINNRNLRTFEVSLDTTLSLLPKIGPERIVVTESGILAPADVDTMRSRGVNTF
LVGEAFMRAADPGAELARLFA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=261, Percent_Identity=41.7624521072797, Blast_Score=168, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322638, Length=264, Percent_Identity=35.2272727272727, Blast_Score=148, Evalue=7e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_THIDA (Q3SGS2)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315980.1
- HSSP:   Q56319
- ProteinModelPortal:   Q3SGS2
- SMR:   Q3SGS2
- STRING:   Q3SGS2
- GeneID:   3671981
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2222
- NMPDR:   fig|292415.3.peg.2153
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- PhylomeDB:   Q3SGS2
- BioCyc:   TDEN292415:TBD_2222-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 27869; Mature: 27737

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILEKILATKRAEVAAGLARVPLAEMRARAEAAAPARDFVGALRAKRDAGRPAVIAEI
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHH
KKASPSKGVIRADFRPAEIAASYEKGGAACLSILTDAEYFQGSADYLKAARAACTLPVLR
HHCCCCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KDFMIDAYQVYEARAMGADCILLIVAALELPAMQALEALANELGMAVLVESHDAAELDAA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHCCEEEEEECCCCHHHHHH
LTLRTPLQGINNRNLRTFEVSLDTTLSLLPKIGPERIVVTESGILAPADVDTMRSRGVNT
EEECCHHCCCCCCCEEEEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHCCCCE
FLVGEAFMRAADPGAELARLFA
EEHHHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure 
SDILEKILATKRAEVAAGLARVPLAEMRARAEAAAPARDFVGALRAKRDAGRPAVIAEI
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHH
KKASPSKGVIRADFRPAEIAASYEKGGAACLSILTDAEYFQGSADYLKAARAACTLPVLR
HHCCCCCCEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
KDFMIDAYQVYEARAMGADCILLIVAALELPAMQALEALANELGMAVLVESHDAAELDAA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHCCEEEEEECCCCHHHHHH
LTLRTPLQGINNRNLRTFEVSLDTTLSLLPKIGPERIVVTESGILAPADVDTMRSRGVNT
EEECCHHCCCCCCCEEEEEEEHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHCCCCE
FLVGEAFMRAADPGAELARLFA
EEHHHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA