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The map label for this gene is trpD

Identifier: 74318241

GI number: 74318241

Start: 2302760

End: 2303791

Strand: Reverse

Name: trpD

Synonym: Tbd_2223

Alternate gene names: 74318241

Gene position: 2303791-2302760 (Counterclockwise)

Preceding gene: 74318242

Following gene: 74318240

Centisome position: 79.17

GC content: 68.51

Gene sequence:

>1032_bases
ATGATCACGCCGCAGCAGGCGCTGACCCGCCTGGTCGAACAGCGCGAAATCTTTCACGACGAGATGCTCGCGCTGATGCG
CCAGATCATGCGCGGCGAGCTCACGCCCGTGCAGATCGCCGGCGTCATCACCGGGCTCAGGGTGAAGAAGGAGACTGTCG
GCGAGATCGCGGCGGCGGCGGAGGTCATGCGCGAGTTCGCGCTCGAGGTACCGGTGCAGCAGCGCGAGCATCTCGTCGAC
ACCTGCGGCACCGGCGGCGACGCCGCGCACACCTTCAACATTTCGACGACCGCGGCCTTCGTCGCCGCAGCTGCCGGCGC
GCGGGTCGCCAAGCACGGCGGCCGCTCGGTCTCATCGACGAGCGGCAGCGCCGACGTGCTCGAGGCGCTTGGCGTCAACC
TCGCGCTCACGCCCGAGCAGGTCGCCGCGAGCATCGACGCGATCGGCATCGGCTTCATGTTCGCGCCGAACTTCCACGGC
GCGATGAGGCACGCGGCGCCGGTCCGCCGCGAACTCGGCGTGCGCACGCTTTTCAACATTCTCGGGCCGCTGACCAATCC
GGCGAACGCGCCGCATCAACTGCTCGGCGTCTTCCACGCCGACCTCGTCGGCATCCTCGTGCGCGTGCTGCAACGCCTTG
GCAGCAGCCACGTCATGGTCGTTCACGGTAGCGACGGCATGGACGAAATCACGCTCGCCGGCGATACCCTGATCGGCGAA
CTGAAGGACGGCGAGGTCAGCGAATACACGATCAACCCGCGCGAGTTCGGGCTGCAGCCCTGCGGCAGCGACGCGCTCAA
GGTGTGGGATGCGACGCAGGCCAAGGACATGTTGCTGTCGGTGCTTGACGACCTGCCGGGCCCGGCGCGCGACATCGTGC
TGTTCAACGCCGGCGCGGCGATCTACGTCGCCGACCGCGCGGCGACGCTCGGCGAGGGCATCGAGCTGGCGCGCGAGGCG
ATCCGCAGCGGCGCTGCACGCGACAAGTTGCAACAACTCGTCGCCTACTCGACGCAGGCAAAGCAGGCGTGA

Upstream 100 bases:

>100_bases
GTCACAAGACGCTTGCGGTCGAGGGCGTGCAGTTCCATCCCGAATCGATCCTGACCGAGCACGGCCACGCGATGTTGAAG
AACTTCCTGAAGGGAACGCG

Downstream 100 bases:

>100_bases
GCACGATGTCGGACATCCTCGAAAAAATCCTCGCGACCAAACGCGCCGAGGTCGCGGCCGGCCTCGCCCGGGTGCCGCTC
GCCGAAATGCGCGCGCGTGC

Product: anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MITPQQALTRLVEQREIFHDEMLALMRQIMRGELTPVQIAGVITGLRVKKETVGEIAAAAEVMREFALEVPVQQREHLVD
TCGTGGDAAHTFNISTTAAFVAAAAGARVAKHGGRSVSSTSGSADVLEALGVNLALTPEQVAASIDAIGIGFMFAPNFHG
AMRHAAPVRRELGVRTLFNILGPLTNPANAPHQLLGVFHADLVGILVRVLQRLGSSHVMVVHGSDGMDEITLAGDTLIGE
LKDGEVSEYTINPREFGLQPCGSDALKVWDATQAKDMLLSVLDDLPGPARDIVLFNAGAAIYVADRAATLGEGIELAREA
IRSGAARDKLQQLVAYSTQAKQA

Sequences:

>Translated_343_residues
MITPQQALTRLVEQREIFHDEMLALMRQIMRGELTPVQIAGVITGLRVKKETVGEIAAAAEVMREFALEVPVQQREHLVD
TCGTGGDAAHTFNISTTAAFVAAAAGARVAKHGGRSVSSTSGSADVLEALGVNLALTPEQVAASIDAIGIGFMFAPNFHG
AMRHAAPVRRELGVRTLFNILGPLTNPANAPHQLLGVFHADLVGILVRVLQRLGSSHVMVVHGSDGMDEITLAGDTLIGE
LKDGEVSEYTINPREFGLQPCGSDALKVWDATQAKDMLLSVLDDLPGPARDIVLFNAGAAIYVADRAATLGEGIELAREA
IRSGAARDKLQQLVAYSTQAKQA
>Mature_343_residues
MITPQQALTRLVEQREIFHDEMLALMRQIMRGELTPVQIAGVITGLRVKKETVGEIAAAAEVMREFALEVPVQQREHLVD
TCGTGGDAAHTFNISTTAAFVAAAAGARVAKHGGRSVSSTSGSADVLEALGVNLALTPEQVAASIDAIGIGFMFAPNFHG
AMRHAAPVRRELGVRTLFNILGPLTNPANAPHQLLGVFHADLVGILVRVLQRLGSSHVMVVHGSDGMDEITLAGDTLIGE
LKDGEVSEYTINPREFGLQPCGSDALKVWDATQAKDMLLSVLDDLPGPARDIVLFNAGAAIYVADRAATLGEGIELAREA
IRSGAARDKLQQLVAYSTQAKQA

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=334, Percent_Identity=38.622754491018, Blast_Score=209, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6320561, Length=353, Percent_Identity=28.328611898017, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPD_THIDA (Q3SGS1)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315981.1
- ProteinModelPortal:   Q3SGS1
- SMR:   Q3SGS1
- STRING:   Q3SGS1
- GeneID:   3671982
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2223
- NMPDR:   fig|292415.3.peg.2154
- eggNOG:   COG0547
- HOGENOM:   HBG559996
- OMA:   LGVYSPE
- PhylomeDB:   Q3SGS1
- ProtClustDB:   PRK00188
- BioCyc:   TDEN292415:TBD_2223-MONOMER
- HAMAP:   MF_00211
- InterPro:   IPR005940
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- TIGRFAMs:   TIGR01245

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: =2.4.2.18

Molecular weight: Translated: 36351; Mature: 36351

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITPQQALTRLVEQREIFHDEMLALMRQIMRGELTPVQIAGVITGLRVKKETVGEIAAAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EVMREFALEVPVQQREHLVDTCGTGGDAAHTFNISTTAAFVAAAAGARVAKHGGRSVSST
HHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCC
SGSADVLEALGVNLALTPEQVAASIDAIGIGFMFAPNFHGAMRHAAPVRRELGVRTLFNI
CCHHHHHHHHCCCEEECHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LGPLTNPANAPHQLLGVFHADLVGILVRVLQRLGSSHVMVVHGSDGMDEITLAGDTLIGE
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCHHEEC
LKDGEVSEYTINPREFGLQPCGSDALKVWDATQAKDMLLSVLDDLPGPARDIVLFNAGAA
CCCCCCCEEEECHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCE
IYVADRAATLGEGIELAREAIRSGAARDKLQQLVAYSTQAKQA
EEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MITPQQALTRLVEQREIFHDEMLALMRQIMRGELTPVQIAGVITGLRVKKETVGEIAAAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EVMREFALEVPVQQREHLVDTCGTGGDAAHTFNISTTAAFVAAAAGARVAKHGGRSVSST
HHHHHHHHHCCHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCC
SGSADVLEALGVNLALTPEQVAASIDAIGIGFMFAPNFHGAMRHAAPVRRELGVRTLFNI
CCHHHHHHHHCCCEEECHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
LGPLTNPANAPHQLLGVFHADLVGILVRVLQRLGSSHVMVVHGSDGMDEITLAGDTLIGE
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCHHEEC
LKDGEVSEYTINPREFGLQPCGSDALKVWDATQAKDMLLSVLDDLPGPARDIVLFNAGAA
CCCCCCCEEEECHHHHCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEECCCE
IYVADRAATLGEGIELAREAIRSGAARDKLQQLVAYSTQAKQA
EEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA