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The map label for this gene is ndh [H]

Identifier: 74318238

GI number: 74318238

Start: 2298966

End: 2300279

Strand: Reverse

Name: ndh [H]

Synonym: Tbd_2220

Alternate gene names: 74318238

Gene position: 2300279-2298966 (Counterclockwise)

Preceding gene: 74318240

Following gene: 74318237

Centisome position: 79.05

GC content: 65.98

Gene sequence:

>1314_bases
GTGACAGAGAAACACGAAATCGTCATCGTCGGCGGCGGTGCGGGCGGTCTGGAACTCGCGACGCGGCTCGGCGACAAGCT
CGGAGGCAAGAAGCGCGCGAACATCACGCTGATCGACGCCTCACCCTCGCATCTGTGGAAGCCGTTGCTTTACGAAGTCG
CTGCAGGCAGCCTCGATTCCTACGCCGAGCGTCTCGAATATCTGGCGCAGGGCCACTGGCACGGCTTCACCTTCCGCCTC
GGGCGCATGGACGGCCTCGACCGCGCACGCCAGGAGGTCAGCGTCGCACCGACTTTCGACGAGGAGGGTCGCGAGATCAT
CCCGCGCCGCAGCTTCCGCTACGACACGCTGGTCATCGCGGTCGGTTCGGTCGGCAACGACTTCGGCGTCCCGGGCGTCA
AGGAGCATTGCATCATGCTCGATACGCCGGAACAGGCGCGCGAATTCCATCGCCGCCACATCAACGCCTGCCTGCGCGCC
AACACCCAGACCGAGGCCGTCGCGCCCGGACAGCTCACGGTCGGCATCGTCGGTGCCGGCGCGACCGGTGTCGAACTCGC
CGCCGAACTGCACGACACGACGCGCGAGCTTTCGTCCTACGGCATGGATCAGATCGAGCCGGACAAGAGCCTGAAGCTTC
TGATCGTGGAGGCGTCGGACCGCATCCTGCCCGGATTGCCGCCGCGCCTGTCGGCGGCCGCCGCCGAGCGCCTCGCCGAG
CTCGGCGTCGAAATGCATACCCGCGAGCGCATCGTCGAGGTGCGCGAGAACGGCATGGTCACTGCCGACGGCAAGCTCAT
CCCGGCGAGCATGATGGTGTGGTCGGCCGGCATCAAGGCGCCCGATTTCCTCAAGGACATCGACGGCCTCGAGACCAATC
GCATCAACCAGCTGGTCGTGCGACCGACGCTGCAGACGACGCGCGACGACAACATCTTCGCCTTCGGCGATTGCGCCGCG
TGCCCACTGCCCGACGGCAGCGGCTTCGTGCCACCGCGGGCGCAGGCCGCGCACCAGCAGGCATCGATGCTCGTCAAGTC
GATCTGCCGGCGCTTCCGCGGCAAATCCCTGCCTGAATACGTCTATCGCGACTACGGTTCACTGGTCGCGCTCGGACGTT
TTTCCACCGTCGGCAACCTGATGGGTGGACTCACCGGCGGCAGCATCATGATCGAGGGCGCGCTGGCCCGACTCGTGTAC
TGGTCGCTGCACAAGATGCACCAGGTCGCATTGCACGGCTGGTTCAAGACCTCGCTCACGACCTACGCGCATTTCATCAG
CACGCCGACACGGGCGCGGATCAAGCTGCACTGA

Upstream 100 bases:

>100_bases
GGATGCGAGGATTCTAAACGGCTTCCCGCCGCCGCCCGCGCCCTATAGAAGCGCCGGCTAATGTTGCGGTTATCATCGCC
GCCTATCAAAAGGGGGACAC

Downstream 100 bases:

>100_bases
TTTTTCCCGAATTGTTGCTGCATGCGATCGGGCCACCGGCACACTTCCGCTCATAGGGCGGCGTGCGCTCGCCGCTTAGC
TTCAGGTGGACAGCAATCCG

Product: NADH dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MTEKHEIVIVGGGAGGLELATRLGDKLGGKKRANITLIDASPSHLWKPLLYEVAAGSLDSYAERLEYLAQGHWHGFTFRL
GRMDGLDRARQEVSVAPTFDEEGREIIPRRSFRYDTLVIAVGSVGNDFGVPGVKEHCIMLDTPEQAREFHRRHINACLRA
NTQTEAVAPGQLTVGIVGAGATGVELAAELHDTTRELSSYGMDQIEPDKSLKLLIVEASDRILPGLPPRLSAAAAERLAE
LGVEMHTRERIVEVRENGMVTADGKLIPASMMVWSAGIKAPDFLKDIDGLETNRINQLVVRPTLQTTRDDNIFAFGDCAA
CPLPDGSGFVPPRAQAAHQQASMLVKSICRRFRGKSLPEYVYRDYGSLVALGRFSTVGNLMGGLTGGSIMIEGALARLVY
WSLHKMHQVALHGWFKTSLTTYAHFISTPTRARIKLH

Sequences:

>Translated_437_residues
MTEKHEIVIVGGGAGGLELATRLGDKLGGKKRANITLIDASPSHLWKPLLYEVAAGSLDSYAERLEYLAQGHWHGFTFRL
GRMDGLDRARQEVSVAPTFDEEGREIIPRRSFRYDTLVIAVGSVGNDFGVPGVKEHCIMLDTPEQAREFHRRHINACLRA
NTQTEAVAPGQLTVGIVGAGATGVELAAELHDTTRELSSYGMDQIEPDKSLKLLIVEASDRILPGLPPRLSAAAAERLAE
LGVEMHTRERIVEVRENGMVTADGKLIPASMMVWSAGIKAPDFLKDIDGLETNRINQLVVRPTLQTTRDDNIFAFGDCAA
CPLPDGSGFVPPRAQAAHQQASMLVKSICRRFRGKSLPEYVYRDYGSLVALGRFSTVGNLMGGLTGGSIMIEGALARLVY
WSLHKMHQVALHGWFKTSLTTYAHFISTPTRARIKLH
>Mature_436_residues
TEKHEIVIVGGGAGGLELATRLGDKLGGKKRANITLIDASPSHLWKPLLYEVAAGSLDSYAERLEYLAQGHWHGFTFRLG
RMDGLDRARQEVSVAPTFDEEGREIIPRRSFRYDTLVIAVGSVGNDFGVPGVKEHCIMLDTPEQAREFHRRHINACLRAN
TQTEAVAPGQLTVGIVGAGATGVELAAELHDTTRELSSYGMDQIEPDKSLKLLIVEASDRILPGLPPRLSAAAAERLAEL
GVEMHTRERIVEVRENGMVTADGKLIPASMMVWSAGIKAPDFLKDIDGLETNRINQLVVRPTLQTTRDDNIFAFGDCAAC
PLPDGSGFVPPRAQAAHQQASMLVKSICRRFRGKSLPEYVYRDYGSLVALGRFSTVGNLMGGLTGGSIMIEGALARLVYW
SLHKMHQVALHGWFKTSLTTYAHFISTPTRARIKLH

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=432, Percent_Identity=56.4814814814815, Blast_Score=478, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6323515, Length=453, Percent_Identity=25.3863134657837, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6320118, Length=445, Percent_Identity=25.1685393258427, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323794, Length=373, Percent_Identity=25.7372654155496, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 47829; Mature: 47697

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKHEIVIVGGGAGGLELATRLGDKLGGKKRANITLIDASPSHLWKPLLYEVAAGSLDS
CCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCHHH
YAERLEYLAQGHWHGFTFRLGRMDGLDRARQEVSVAPTFDEEGREIIPRRSFRYDTLVIA
HHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCHHCCCCCCCCEEEEEE
VGSVGNDFGVPGVKEHCIMLDTPEQAREFHRRHINACLRANTQTEAVAPGQLTVGIVGAG
ECCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEEECC
ATGVELAAELHDTTRELSSYGMDQIEPDKSLKLLIVEASDRILPGLPPRLSAAAAERLAE
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHH
LGVEMHTRERIVEVRENGMVTADGKLIPASMMVWSAGIKAPDFLKDIDGLETNRINQLVV
HCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEE
RPTLQTTRDDNIFAFGDCAACPLPDGSGFVPPRAQAAHQQASMLVKSICRRFRGKSLPEY
ECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
VYRDYGSLVALGRFSTVGNLMGGLTGGSIMIEGALARLVYWSLHKMHQVALHGWFKTSLT
HHHCCCCEEEHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TYAHFISTPTRARIKLH
HHHHHHCCCCCEEEEEC
>Mature Secondary Structure 
TEKHEIVIVGGGAGGLELATRLGDKLGGKKRANITLIDASPSHLWKPLLYEVAAGSLDS
CCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCHHH
YAERLEYLAQGHWHGFTFRLGRMDGLDRARQEVSVAPTFDEEGREIIPRRSFRYDTLVIA
HHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCHHCCCCCCCCEEEEEE
VGSVGNDFGVPGVKEHCIMLDTPEQAREFHRRHINACLRANTQTEAVAPGQLTVGIVGAG
ECCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEECCCCEEEEEEECC
ATGVELAAELHDTTRELSSYGMDQIEPDKSLKLLIVEASDRILPGLPPRLSAAAAERLAE
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHH
LGVEMHTRERIVEVRENGMVTADGKLIPASMMVWSAGIKAPDFLKDIDGLETNRINQLVV
HCCHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEEE
RPTLQTTRDDNIFAFGDCAACPLPDGSGFVPPRAQAAHQQASMLVKSICRRFRGKSLPEY
ECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
VYRDYGSLVALGRFSTVGNLMGGLTGGSIMIEGALARLVYWSLHKMHQVALHGWFKTSLT
HHHCCCCEEEHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TYAHFISTPTRARIKLH
HHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]