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The map label for this gene is ribB [H]

Identifier: 74318208

GI number: 74318208

Start: 2272077

End: 2273162

Strand: Direct

Name: ribB [H]

Synonym: Tbd_2190

Alternate gene names: 74318208

Gene position: 2272077-2273162 (Clockwise)

Preceding gene: 74318207

Following gene: 74318209

Centisome position: 78.08

GC content: 67.59

Gene sequence:

>1086_bases
ATGAGCCTCGCCTCCACCCTCGAAATCATCGAAGAACTGAAGGCCGGCCGCATGGTCGTGCTCGTCGACGAGGAGGACAG
GGAAAACGAGGGCGACCTCGTGATGGCCGCCGAGCATGTCACGCCCGACGCGATCAACTTCATGGCCAAATACGGCCGCG
GCCTCATCTGCCTCACGCTGACCGACGCGCGCTGCCGCCAGCTCGGCCTGAAGCAGATGGTCTCCGACAACCAGACGCCG
CACGGCACCGCGTTCACGATCTCGATCGAAGCGGCCGAGGGGGTGACCACGGGCATCTCGGCGGCCGACCGCGCGGTCAC
GATCCGCGCCGCGGTCACGAAGGACGCGAAGCCCTCCGACATCATCCAGCCCGGCCACATCTTCCCGCTGCGCGCCCAGC
CCGGCGGCGTGCTCGTGCGCGCCGGCCACACCGAGGCCGGCTGCGACCTCGCCGGGCTCGCGGGCCTCGAGCCGGCGTCG
GTCATCTGCGAAATCCTCAAGGACGACGGCAGCATGGCGCGCCTGCCCGACCTCGTTCCGTTCGCGCAGGAACACGGCCT
CAAGATCGGCGCGATCGCCGACCTGATCCATTACCGCAACCAGACCGAGAGCCTCGTCGAGCGCGCGGCCGACCGCCTGA
TCCAGACGATCTACGGCGCCTTCCGCCTGATCGCGTATCGCGACAAGTGCGCCAAGGAAACGCACATCGCGCTGGTCAAG
GGCGAGATCCACGCCGACCGCGAAACCCTCGTGCGCGTGCACGAGCCCTTGAGCGTGATGGATTTTCTCGACGTGACGGG
CGGTGGCCATTCGTGGCCGATCATGGGCGCGATGGAGCGCATCGCCGAGTCGCAGAGCGGCGTGCTGGTCTTGCTGCACC
GTCCCGAAACCGCCGACGCGCTGCTCGGCCGCATCAATCCCGCGCCCGCCGCGAGCCACAAATACGACCTGCGCGACTAC
GGCATCGGCGCACAGATCCTGCGCGACCTCGGCGTCGGCAAGATGAAGCTGCTCGCCAGCCCGCGCAAGATGCCGGCGAT
GGACGGCTTCGGCCTGGAAGTCACCGGCTATTCTGAAAAAGCATAA

Upstream 100 bases:

>100_bases
AGCATTTGCGCCCGGGCAGCCGCGTCAACCTCGAAGTCGACATGATCGCGCGCTACGTCGAGCGCATGACGCAATTCACC
CATCCTACGGACAAAGACTG

Downstream 100 bases:

>100_bases
TCAACGAAGGCACGACCATGGGAACCAGCAGCGACATTTTTGAGCTCGACCCGATCTACCAGGGCAAGGGGCTCAGGATC
GGCATCGTCATGAGCCGCTT

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MSLASTLEIIEELKAGRMVVLVDEEDRENEGDLVMAAEHVTPDAINFMAKYGRGLICLTLTDARCRQLGLKQMVSDNQTP
HGTAFTISIEAAEGVTTGISAADRAVTIRAAVTKDAKPSDIIQPGHIFPLRAQPGGVLVRAGHTEAGCDLAGLAGLEPAS
VICEILKDDGSMARLPDLVPFAQEHGLKIGAIADLIHYRNQTESLVERAADRLIQTIYGAFRLIAYRDKCAKETHIALVK
GEIHADRETLVRVHEPLSVMDFLDVTGGGHSWPIMGAMERIAESQSGVLVLLHRPETADALLGRINPAPAASHKYDLRDY
GIGAQILRDLGVGKMKLLASPRKMPAMDGFGLEVTGYSEKA

Sequences:

>Translated_361_residues
MSLASTLEIIEELKAGRMVVLVDEEDRENEGDLVMAAEHVTPDAINFMAKYGRGLICLTLTDARCRQLGLKQMVSDNQTP
HGTAFTISIEAAEGVTTGISAADRAVTIRAAVTKDAKPSDIIQPGHIFPLRAQPGGVLVRAGHTEAGCDLAGLAGLEPAS
VICEILKDDGSMARLPDLVPFAQEHGLKIGAIADLIHYRNQTESLVERAADRLIQTIYGAFRLIAYRDKCAKETHIALVK
GEIHADRETLVRVHEPLSVMDFLDVTGGGHSWPIMGAMERIAESQSGVLVLLHRPETADALLGRINPAPAASHKYDLRDY
GIGAQILRDLGVGKMKLLASPRKMPAMDGFGLEVTGYSEKA
>Mature_360_residues
SLASTLEIIEELKAGRMVVLVDEEDRENEGDLVMAAEHVTPDAINFMAKYGRGLICLTLTDARCRQLGLKQMVSDNQTPH
GTAFTISIEAAEGVTTGISAADRAVTIRAAVTKDAKPSDIIQPGHIFPLRAQPGGVLVRAGHTEAGCDLAGLAGLEPASV
ICEILKDDGSMARLPDLVPFAQEHGLKIGAIADLIHYRNQTESLVERAADRLIQTIYGAFRLIAYRDKCAKETHIALVKG
EIHADRETLVRVHEPLSVMDFLDVTGGGHSWPIMGAMERIAESQSGVLVLLHRPETADALLGRINPAPAASHKYDLRDYG
IGAQILRDLGVGKMKLLASPRKMPAMDGFGLEVTGYSEKA

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=206, Percent_Identity=50.4854368932039, Blast_Score=220, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6320695, Length=199, Percent_Identity=42.713567839196, Blast_Score=169, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 38870; Mature: 38739

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLASTLEIIEELKAGRMVVLVDEEDRENEGDLVMAAEHVTPDAINFMAKYGRGLICLTL
CCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEE
TDARCRQLGLKQMVSDNQTPHGTAFTISIEAAEGVTTGISAADRAVTIRAAVTKDAKPSD
CHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCC
IIQPGHIFPLRAQPGGVLVRAGHTEAGCDLAGLAGLEPASVICEILKDDGSMARLPDLVP
CCCCCCEEEEECCCCCEEEECCCCCCCCCHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
FAQEHGLKIGAIADLIHYRNQTESLVERAADRLIQTIYGAFRLIAYRDKCAKETHIALVK
HHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
GEIHADRETLVRVHEPLSVMDFLDVTGGGHSWPIMGAMERIAESQSGVLVLLHRPETADA
CCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHH
LLGRINPAPAASHKYDLRDYGIGAQILRDLGVGKMKLLASPRKMPAMDGFGLEVTGYSEK
HHHCCCCCCCCCCCCCHHHCCCHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEECCCCC
A
C
>Mature Secondary Structure 
SLASTLEIIEELKAGRMVVLVDEEDRENEGDLVMAAEHVTPDAINFMAKYGRGLICLTL
CHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEE
TDARCRQLGLKQMVSDNQTPHGTAFTISIEAAEGVTTGISAADRAVTIRAAVTKDAKPSD
CHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEEEEECCCCCCCC
IIQPGHIFPLRAQPGGVLVRAGHTEAGCDLAGLAGLEPASVICEILKDDGSMARLPDLVP
CCCCCCEEEEECCCCCEEEECCCCCCCCCHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
FAQEHGLKIGAIADLIHYRNQTESLVERAADRLIQTIYGAFRLIAYRDKCAKETHIALVK
HHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
GEIHADRETLVRVHEPLSVMDFLDVTGGGHSWPIMGAMERIAESQSGVLVLLHRPETADA
CCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHH
LLGRINPAPAASHKYDLRDYGIGAQILRDLGVGKMKLLASPRKMPAMDGFGLEVTGYSEK
HHHCCCCCCCCCCCCCHHHCCCHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEECCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]