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The map label for this gene is nrdR

Identifier: 74318184

GI number: 74318184

Start: 2251542

End: 2252018

Strand: Direct

Name: nrdR

Synonym: Tbd_2166

Alternate gene names: 74318184

Gene position: 2251542-2252018 (Clockwise)

Preceding gene: 74318183

Following gene: 74318185

Centisome position: 77.38

GC content: 66.25

Gene sequence:

>477_bases
ATGAAATGTCCCTTCTGCGGCTCCCTCGACACCCAGGTCATCGACTCGCGCGCGAACGAGGCCGGCGACGCGATTCGCCG
GCGCCGGCGCTGCGCCGCCTGCGACAAGCGCTTCACGACCTGGGAGACCGCCGAATTGCGGCCGCCGCAGATCGTCAAGA
CCAACGGCACACGCGAGGATTTTTCCGAAACCAAGCTGCGTGAGGGCTTTCGCCGCGCGCTGCACAAGCGTCCCGTTTCG
ACCGAACTCGTCGATGCGGCCGTCGACCGCATCCGCCAGCGCCTCCTAACGCTCGGCGAGCGCGAGGTGCCGGCGCGCGA
GGTCGGCGAGCTCGTGATGACCGAGTTGAAGAAGCTCGACAAGATCGCCTACATCCGCTTCGCGTCGGTCTACAAAAGCT
TCAAGGACCCTGACGATTTCCGCGACGTGCTCGAGGACCTCGCGCAGGGACCGCAAGCCGGCGACGATCCCGCCTAG

Upstream 100 bases:

>100_bases
CGGGGATCAGGGAATGTTGCTTCGCGTTTCCTTGAATATGAACGCGGCCATGCCGCGCAAAACCCTCTGACCCCTGACCC
CTGGATCCCGACCCCTAACC

Downstream 100 bases:

>100_bases
GCTGCCGGAGCGCGGCCTTGACGTCCCGCTGACGCCGCCTTGACGCGCGCGCGACAGGACTTCGCGCATGCTGTTTCTTA
CCCTCACATGGAGAAAACGC

Product: transcriptional regulator NrdR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 158; Mature: 158

Protein sequence:

>158_residues
MKCPFCGSLDTQVIDSRANEAGDAIRRRRRCAACDKRFTTWETAELRPPQIVKTNGTREDFSETKLREGFRRALHKRPVS
TELVDAAVDRIRQRLLTLGEREVPAREVGELVMTELKKLDKIAYIRFASVYKSFKDPDDFRDVLEDLAQGPQAGDDPA

Sequences:

>Translated_158_residues
MKCPFCGSLDTQVIDSRANEAGDAIRRRRRCAACDKRFTTWETAELRPPQIVKTNGTREDFSETKLREGFRRALHKRPVS
TELVDAAVDRIRQRLLTLGEREVPAREVGELVMTELKKLDKIAYIRFASVYKSFKDPDDFRDVLEDLAQGPQAGDDPA
>Mature_158_residues
MKCPFCGSLDTQVIDSRANEAGDAIRRRRRCAACDKRFTTWETAELRPPQIVKTNGTREDFSETKLREGFRRALHKRPVS
TELVDAAVDRIRQRLLTLGEREVPAREVGELVMTELKKLDKIAYIRFASVYKSFKDPDDFRDVLEDLAQGPQAGDDPA

Specific function: Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes

COG id: COG1327

COG function: function code K; Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain

Homologues:

Organism=Escherichia coli, GI1786615, Length=140, Percent_Identity=57.1428571428571, Blast_Score=172, Evalue=8e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NRDR_THIDA (Q3SGX4)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315924.1
- STRING:   Q3SGX4
- GeneID:   3671947
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_2166
- NMPDR:   fig|292415.3.peg.1701
- eggNOG:   COG1327
- HOGENOM:   HBG351755
- OMA:   FASVYRD
- PhylomeDB:   Q3SGX4
- ProtClustDB:   PRK00464
- BioCyc:   TDEN292415:TBD_2166-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00440
- InterPro:   IPR005144
- InterPro:   IPR003796
- TIGRFAMs:   TIGR00244

Pfam domain/function: PF03477 ATP-cone

EC number: NA

Molecular weight: Translated: 18027; Mature: 18027

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS51161 ATP_CONE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKCPFCGSLDTQVIDSRANEAGDAIRRRRRCAACDKRFTTWETAELRPPQIVKTNGTRED
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHH
FSETKLREGFRRALHKRPVSTELVDAAVDRIRQRLLTLGEREVPAREVGELVMTELKKLD
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
KIAYIRFASVYKSFKDPDDFRDVLEDLAQGPQAGDDPA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKCPFCGSLDTQVIDSRANEAGDAIRRRRRCAACDKRFTTWETAELRPPQIVKTNGTRED
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCCCHHH
FSETKLREGFRRALHKRPVSTELVDAAVDRIRQRLLTLGEREVPAREVGELVMTELKKLD
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
KIAYIRFASVYKSFKDPDDFRDVLEDLAQGPQAGDDPA
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA