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The map label for this gene is pgm [H]

Identifier: 74318156

GI number: 74318156

Start: 2223562

End: 2224935

Strand: Direct

Name: pgm [H]

Synonym: Tbd_2138

Alternate gene names: 74318156

Gene position: 2223562-2224935 (Clockwise)

Preceding gene: 74318155

Following gene: 74318157

Centisome position: 76.42

GC content: 64.85

Gene sequence:

>1374_bases
GTGGAATACCCCAAGGAAATCTTCAAGGCCTACGACATTCGCGGCATCGTCGGCAAGACCTTCACGCCTGAAATCGTCGA
GGCCATCGGTCATGCCATCGGCTCGGAAGCCGCCGCCCGCGGCCAGAAGGAAATCTGCATCGGCCGCGACGGCCGTCTCT
CGGGGCCCGATCTCGCCGCTGCGCTGGCGCGCGGCATCCGCAAGGCCGGCATCGGCGTGGTCGACCTCGGCATGGTCGCG
ACGCCGATGACTTACTTCGCCGCCTACCAGCTCGGCACGAACAGCGCAGTAATGGTCACCGGCAGCCATAATCCGCCCGA
CTACAACGGCCTGAAAATGGTGCTCGGCGGCGAGACGCTCTCCGGCGCCACGATCCAGGCGCTGCGCCAGCGCCTCGTCG
ACGGCAATCTTGCCCACGGCGAAGGCGGCTACCGCGAGCATGACATCGCGGGCGAGTATCTCGCGCGCATCGTCTCCGAC
GTCAAGCTCGCGCGTCCGATGAAGATCATCGTCGACTGCGGCAACGGCGTGCCCGGCGCGTTCGTGCCCAAGCTCTACCG
CGACATGGGATGCGAGGTCGAGGAACTCTTCTGCGAGGTCGACGGCAACTTCCCCAATCACCACCCCGACCCTTCTCAGC
CGAAAAACCTGCAGGACCTGATTTCTGCACTGAAGACGAGCGACGCCGAGATCGGCCTCGCCTTCGACGGCGACGGCGAC
CGCCTTGGCGTCGTCACCAAGGACGGCAGCATCATCTTCCCCGACCGCCAGCTGATGCTGTTCGCCGACGACGTGCTGAG
CCGCAATCCAGGCGCCGAAATCATTTTCGACGTGAAATCGACGCGCAAGCTGTTCGACTGGATCCGCGCGCGCGGCGGCA
AACCCACGCTGTGGAAAACCGGCCACAGCTTCATCAAGGCCAAGATGAAGGAGACCGGCGCGCTGCTCGCCGGCGAAATG
TCGGGCCACGTGTTCTTCAAGGAACGCTGGTTCGGCTTCGACGACGGCCTCTATGCCGGGGCACGCCTGCTCGAATACCT
GTCGAAGCAGGCCGACATCAACGCCACGCTGCACGGCCTGCCCGACACCGTGAACACGCCCGAACTCAACATCAAGATGG
CCGAGGGCGAGCACTACGCGCTGATGGAGCGGCTGCAGAAAACCGCGAAATTCCCCGACGCGCAGGAAGTCATCACGCTC
GACGGCCTGCGCGTCGAATACGCCGACGGCTTCGGCCTCGCCCGCCCGTCCAACACCACGCCGGTCGTCGTGCTGCGCTT
CGAAGCCGACAATACCCAGGCACTCGAGCGCATACAGGCCGACTTCCGGCGCGTCATCCACGAGGCCGCACCGTCGCTCA
GCCTTCCGTTTTGA

Upstream 100 bases:

>100_bases
CCCTTCCCAGGCCGGCTCGGCTGGCTCACGCGTCGCCTGATGCGGCACTTCGAAGCAGGGCGCGGTTAGAATCGATCCCT
CTGAGATCAAGGAGCGCGCT

Downstream 100 bases:

>100_bases
GCGCGAACGACAGGCCGCGCAGCCTCCACGTCATCGGCGGCAAGCGGCTCGGCGGCGCCGAGCGCTTTTTCGTCCGCCTG
GTGAACGCGCTGGCGCGACG

Product: phosphomannomutase

Products: NA

Alternate protein names: PGM; Glucose phosphomutase [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MEYPKEIFKAYDIRGIVGKTFTPEIVEAIGHAIGSEAAARGQKEICIGRDGRLSGPDLAAALARGIRKAGIGVVDLGMVA
TPMTYFAAYQLGTNSAVMVTGSHNPPDYNGLKMVLGGETLSGATIQALRQRLVDGNLAHGEGGYREHDIAGEYLARIVSD
VKLARPMKIIVDCGNGVPGAFVPKLYRDMGCEVEELFCEVDGNFPNHHPDPSQPKNLQDLISALKTSDAEIGLAFDGDGD
RLGVVTKDGSIIFPDRQLMLFADDVLSRNPGAEIIFDVKSTRKLFDWIRARGGKPTLWKTGHSFIKAKMKETGALLAGEM
SGHVFFKERWFGFDDGLYAGARLLEYLSKQADINATLHGLPDTVNTPELNIKMAEGEHYALMERLQKTAKFPDAQEVITL
DGLRVEYADGFGLARPSNTTPVVVLRFEADNTQALERIQADFRRVIHEAAPSLSLPF

Sequences:

>Translated_457_residues
MEYPKEIFKAYDIRGIVGKTFTPEIVEAIGHAIGSEAAARGQKEICIGRDGRLSGPDLAAALARGIRKAGIGVVDLGMVA
TPMTYFAAYQLGTNSAVMVTGSHNPPDYNGLKMVLGGETLSGATIQALRQRLVDGNLAHGEGGYREHDIAGEYLARIVSD
VKLARPMKIIVDCGNGVPGAFVPKLYRDMGCEVEELFCEVDGNFPNHHPDPSQPKNLQDLISALKTSDAEIGLAFDGDGD
RLGVVTKDGSIIFPDRQLMLFADDVLSRNPGAEIIFDVKSTRKLFDWIRARGGKPTLWKTGHSFIKAKMKETGALLAGEM
SGHVFFKERWFGFDDGLYAGARLLEYLSKQADINATLHGLPDTVNTPELNIKMAEGEHYALMERLQKTAKFPDAQEVITL
DGLRVEYADGFGLARPSNTTPVVVLRFEADNTQALERIQADFRRVIHEAAPSLSLPF
>Mature_457_residues
MEYPKEIFKAYDIRGIVGKTFTPEIVEAIGHAIGSEAAARGQKEICIGRDGRLSGPDLAAALARGIRKAGIGVVDLGMVA
TPMTYFAAYQLGTNSAVMVTGSHNPPDYNGLKMVLGGETLSGATIQALRQRLVDGNLAHGEGGYREHDIAGEYLARIVSD
VKLARPMKIIVDCGNGVPGAFVPKLYRDMGCEVEELFCEVDGNFPNHHPDPSQPKNLQDLISALKTSDAEIGLAFDGDGD
RLGVVTKDGSIIFPDRQLMLFADDVLSRNPGAEIIFDVKSTRKLFDWIRARGGKPTLWKTGHSFIKAKMKETGALLAGEM
SGHVFFKERWFGFDDGLYAGARLLEYLSKQADINATLHGLPDTVNTPELNIKMAEGEHYALMERLQKTAKFPDAQEVITL
DGLRVEYADGFGLARPSNTTPVVVLRFEADNTQALERIQADFRRVIHEAAPSLSLPF

Specific function: This enzyme participates in both the breakdown and synthesis of glucose [H]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=441, Percent_Identity=34.2403628117914, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1789566, Length=371, Percent_Identity=29.9191374663073, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 49820; Mature: 49820

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEYPKEIFKAYDIRGIVGKTFTPEIVEAIGHAIGSEAAARGQKEICIGRDGRLSGPDLAA
CCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCEEECCCCCCCCHHHHH
ALARGIRKAGIGVVDLGMVATPMTYFAAYQLGTNSAVMVTGSHNPPDYNGLKMVLGGETL
HHHHHHHHHCCCEEEHHHHHHHHHHHHHHEECCCCEEEEECCCCCCCCCCEEEEECCCCC
SGATIQALRQRLVDGNLAHGEGGYREHDIAGEYLARIVSDVKLARPMKIIVDCGNGVPGA
CCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCH
FVPKLYRDMGCEVEELFCEVDGNFPNHHPDPSQPKNLQDLISALKTSDAEIGLAFDGDGD
HHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCC
RLGVVTKDGSIIFPDRQLMLFADDVLSRNPGAEIIFDVKSTRKLFDWIRARGGKPTLWKT
EEEEEECCCCEECCCCEEEEEEHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCCCCEECC
GHSFIKAKMKETGALLAGEMSGHVFFKERWFGFDDGLYAGARLLEYLSKQADINATLHGL
CHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEECCC
PDTVNTPELNIKMAEGEHYALMERLQKTAKFPDAQEVITLDGLRVEYADGFGLARPSNTT
CCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHEEEECCEEEEECCCCCCCCCCCCC
PVVVLRFEADNTQALERIQADFRRVIHEAAPSLSLPF
CEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MEYPKEIFKAYDIRGIVGKTFTPEIVEAIGHAIGSEAAARGQKEICIGRDGRLSGPDLAA
CCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCHHHHCCCCCEEECCCCCCCCHHHHH
ALARGIRKAGIGVVDLGMVATPMTYFAAYQLGTNSAVMVTGSHNPPDYNGLKMVLGGETL
HHHHHHHHHCCCEEEHHHHHHHHHHHHHHEECCCCEEEEECCCCCCCCCCEEEEECCCCC
SGATIQALRQRLVDGNLAHGEGGYREHDIAGEYLARIVSDVKLARPMKIIVDCGNGVPGA
CCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCH
FVPKLYRDMGCEVEELFCEVDGNFPNHHPDPSQPKNLQDLISALKTSDAEIGLAFDGDGD
HHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCC
RLGVVTKDGSIIFPDRQLMLFADDVLSRNPGAEIIFDVKSTRKLFDWIRARGGKPTLWKT
EEEEEECCCCEECCCCEEEEEEHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCCCCEECC
GHSFIKAKMKETGALLAGEMSGHVFFKERWFGFDDGLYAGARLLEYLSKQADINATLHGL
CHHHHHHHHHHHCCEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEECCC
PDTVNTPELNIKMAEGEHYALMERLQKTAKFPDAQEVITLDGLRVEYADGFGLARPSNTT
CCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCHHHEEEECCEEEEECCCCCCCCCCCCC
PVVVLRFEADNTQALERIQADFRRVIHEAAPSLSLPF
CEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8157643; 8188595 [H]