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The map label for this gene is vipB [H]

Identifier: 74318082

GI number: 74318082

Start: 2156459

End: 2157442

Strand: Direct

Name: vipB [H]

Synonym: Tbd_2064

Alternate gene names: 74318082

Gene position: 2156459-2157442 (Clockwise)

Preceding gene: 74318073

Following gene: 74318084

Centisome position: 74.11

GC content: 67.78

Gene sequence:

>984_bases
ATGCATGTCTTGATCACGGGCGGTGCCGGCTTCATTGGCTCGCATCTGGCCGAACACCATCTGGCCCTGGGCGACCAGGT
CTACGTCGTCGACAACCTGAGCACGGGATCGATGGCCAATCTGAAACCGTTCCGCACGCATCCGGCCTTCCGCTTCGCAG
ACGCGGACATCGTGCACTGGAGCGGGCTGGCCGAGGCAATCGGCTGGGCCGACCGGGTCTATCACATGGCCGCGGTCGTC
GGCGTGAAGAAGGTGCTCGACGACCCGGTCGCCGTCATGGCGACGAACATGACAGGGACCGAGCGCATCCTCGCGACGAT
GCGCGACGGCCACTGGAACCCCCAGGTCGTGATCGCCTCGTCGGCCGAGATCTACGGCTTCAACCCGGCCAAGGGCTTTT
GCGAGACCGACGACATCGTCCTGCCATCGGCCGGTCGCCTGCGCTGGAGCAGCGCGGTCGCCAAGGTCGCCGACGAATTC
CTCGCCTTCGGCCACGCCCGGCGGCACGGGCTCAGGATCGTCGTCGCGCGCCTGTTCAACACGATCGGCCCGAACCAGAC
CGGCGACCACGGCATGGTCGTGCCGACCTTCGTCAGGCAGGCGCTCCGCGGCGAGCCGCTCACGATCCACGGTGAAGGCA
ACCAGACACGCACTTTCTGCGACGTGCGCGATGTCGTCGTCGCACTCGACCGGCTCGCGGGCTGCCCCGAGGCATGGGGC
GAGGCCGTGAACGTCGGCAACGAAGACGAAATTTCGATCCGCGCGCTCGCCGAACTCGTCGTCGCGCGCGCGCAGAGCAA
GTCGCCCCTGCACTTCGTTTCCTGGCGCGACGCCTACGGCGAAGACTTCGACGAAGTCGGCCATCGGCGGCCCGTCATCA
ACAAGCTGCGCGCGTTGACGGCGTACACGCCGGCATGGTCGCTCGCCGATTCGCTCGACGACCTGATCGAGCGGGCGCGC
GGGCGGAGCCTGCGCGCGGCGTAG

Upstream 100 bases:

>100_bases
CTGTTTTCATTGGGCTCTGGTCGAGCCCCAGCGCCGCCGCCTGCGGCCGGGGGTGTTAAGCGCTCGGCGCCAGCCGGCGA
AAACTCGTTAGGTAGCGAAC

Downstream 100 bases:

>100_bases
GCAGCCTCGGCGCGCCGTCGCTGCGCACCCCGGTGGCGCGCGGCGGGTGGTGCATCCTAGATCTCGAGCTGCGCGCCGAG
CTCGACGACGCGGTTCGGCG

Product: nucleoside-diphosphate-sugar epimerase

Products: UDPgalactose

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MHVLITGGAGFIGSHLAEHHLALGDQVYVVDNLSTGSMANLKPFRTHPAFRFADADIVHWSGLAEAIGWADRVYHMAAVV
GVKKVLDDPVAVMATNMTGTERILATMRDGHWNPQVVIASSAEIYGFNPAKGFCETDDIVLPSAGRLRWSSAVAKVADEF
LAFGHARRHGLRIVVARLFNTIGPNQTGDHGMVVPTFVRQALRGEPLTIHGEGNQTRTFCDVRDVVVALDRLAGCPEAWG
EAVNVGNEDEISIRALAELVVARAQSKSPLHFVSWRDAYGEDFDEVGHRRPVINKLRALTAYTPAWSLADSLDDLIERAR
GRSLRAA

Sequences:

>Translated_327_residues
MHVLITGGAGFIGSHLAEHHLALGDQVYVVDNLSTGSMANLKPFRTHPAFRFADADIVHWSGLAEAIGWADRVYHMAAVV
GVKKVLDDPVAVMATNMTGTERILATMRDGHWNPQVVIASSAEIYGFNPAKGFCETDDIVLPSAGRLRWSSAVAKVADEF
LAFGHARRHGLRIVVARLFNTIGPNQTGDHGMVVPTFVRQALRGEPLTIHGEGNQTRTFCDVRDVVVALDRLAGCPEAWG
EAVNVGNEDEISIRALAELVVARAQSKSPLHFVSWRDAYGEDFDEVGHRRPVINKLRALTAYTPAWSLADSLDDLIERAR
GRSLRAA
>Mature_327_residues
MHVLITGGAGFIGSHLAEHHLALGDQVYVVDNLSTGSMANLKPFRTHPAFRFADADIVHWSGLAEAIGWADRVYHMAAVV
GVKKVLDDPVAVMATNMTGTERILATMRDGHWNPQVVIASSAEIYGFNPAKGFCETDDIVLPSAGRLRWSSAVAKVADEF
LAFGHARRHGLRIVVARLFNTIGPNQTGDHGMVVPTFVRQALRGEPLTIHGEGNQTRTFCDVRDVVVALDRLAGCPEAWG
EAVNVGNEDEISIRALAELVVARAQSKSPLHFVSWRDAYGEDFDEVGHRRPVINKLRALTAYTPAWSLADSLDDLIERAR
GRSLRAA

Specific function: Unknown

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=321, Percent_Identity=31.7757009345794, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI7657641, Length=284, Percent_Identity=28.169014084507, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1788589, Length=337, Percent_Identity=27.299703264095, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI48994969, Length=306, Percent_Identity=30.0653594771242, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788353, Length=290, Percent_Identity=27.9310344827586, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786974, Length=261, Percent_Identity=26.4367816091954, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17539532, Length=312, Percent_Identity=29.8076923076923, Blast_Score=130, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17568069, Length=278, Percent_Identity=25.8992805755396, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115532424, Length=274, Percent_Identity=27.3722627737226, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356223, Length=325, Percent_Identity=31.3846153846154, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 5.1.3.2

Molecular weight: Translated: 35659; Mature: 35659

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVLITGGAGFIGSHLAEHHLALGDQVYVVDNLSTGSMANLKPFRTHPAFRFADADIVHW
CEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEECCCCEEEH
SGLAEAIGWADRVYHMAAVVGVKKVLDDPVAVMATNMTGTERILATMRDGHWNPQVVIAS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEEE
SAEIYGFNPAKGFCETDDIVLPSAGRLRWSSAVAKVADEFLAFGHARRHGLRIVVARLFN
CCEEEECCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIGPNQTGDHGMVVPTFVRQALRGEPLTIHGEGNQTRTFCDVRDVVVALDRLAGCPEAWG
HCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHH
EAVNVGNEDEISIRALAELVVARAQSKSPLHFVSWRDAYGEDFDEVGHRRPVINKLRALT
HHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCCHHHHCCCCHHHHHHHHHH
AYTPAWSLADSLDDLIERARGRSLRAA
HCCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MHVLITGGAGFIGSHLAEHHLALGDQVYVVDNLSTGSMANLKPFRTHPAFRFADADIVHW
CEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEEECCCCEEEH
SGLAEAIGWADRVYHMAAVVGVKKVLDDPVAVMATNMTGTERILATMRDGHWNPQVVIAS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCEEEEEE
SAEIYGFNPAKGFCETDDIVLPSAGRLRWSSAVAKVADEFLAFGHARRHGLRIVVARLFN
CCEEEECCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIGPNQTGDHGMVVPTFVRQALRGEPLTIHGEGNQTRTFCDVRDVVVALDRLAGCPEAWG
HCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHH
EAVNVGNEDEISIRALAELVVARAQSKSPLHFVSWRDAYGEDFDEVGHRRPVINKLRALT
HHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCCHHHHCCCCHHHHHHHHHH
AYTPAWSLADSLDDLIERARGRSLRAA
HCCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-glucose

Specific reaction: UDP-glucose = UDP-galactose

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8248629; 8331073; 11677608; 12644504 [H]