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The map label for this gene is cyp18 [H]

Identifier: 74317922

GI number: 74317922

Start: 2000887

End: 2001378

Strand: Direct

Name: cyp18 [H]

Synonym: Tbd_1904

Alternate gene names: 74317922

Gene position: 2000887-2001378 (Clockwise)

Preceding gene: 74317921

Following gene: 74317923

Centisome position: 68.76

GC content: 60.98

Gene sequence:

>492_bases
ATGGTCAAGCTGCATACGAATCACGGCACCATCACACTCGAACTCGACGCCGAGAAGGCTCCCAAGACCGTCGAGAATTT
TCTCCAGTACGTCCGTGACGGCTTCTTCGACGGCACGATCTTCCACCGTGTGATCGACGGATTCATGATCCAGGGCGGCG
GCTTCGAGCCGGGCCTCGCGCAGAAACCGACGCGCGACGCGATCGAGAACGAAGCCTCCAACGGCCTCAAGAACGACGCC
TATACCGTCGCGATGGCGCGCACGCCGAACCCCAATTCGGCCACCGCGCAGTTCTTCATCAACGTCGCCAACAACAGCTT
CCTGAACTTCACTTCGCCGACCCCGCAGGGCTACGGCTATGCCGTCTTCGGCAAGGTCGTCGAGGGGACCGACGTCGTCG
ACAAGATCAAGAAGGTCAAGACCGGAAGCCGCGGCGGCCACCAGGACGTGCCGCTGGAAGACGTCGTCATCACGAAGGCC
GAAATCATCTGA

Upstream 100 bases:

>100_bases
GAAACAGGCGGCGTCGCGTGGCGGCGCCTGGGGACTGCCCGATGACCAACACCCGTGCGGACATCAGGCGAATTCATCAA
GAACCGGGGGAAGGACATCC

Downstream 100 bases:

>100_bases
TTTCGGCCGTGGGCGCAAAACCGGGTGCGGGCCGGGCCTTCTTCGTCGCCGACCTCCATCTGACCGACGACCGCCCGCGC
GCGACCGAGCGTTTCTTCCG

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MVKLHTNHGTITLELDAEKAPKTVENFLQYVRDGFFDGTIFHRVIDGFMIQGGGFEPGLAQKPTRDAIENEASNGLKNDA
YTVAMARTPNPNSATAQFFINVANNSFLNFTSPTPQGYGYAVFGKVVEGTDVVDKIKKVKTGSRGGHQDVPLEDVVITKA
EII

Sequences:

>Translated_163_residues
MVKLHTNHGTITLELDAEKAPKTVENFLQYVRDGFFDGTIFHRVIDGFMIQGGGFEPGLAQKPTRDAIENEASNGLKNDA
YTVAMARTPNPNSATAQFFINVANNSFLNFTSPTPQGYGYAVFGKVVEGTDVVDKIKKVKTGSRGGHQDVPLEDVVITKA
EII
>Mature_163_residues
MVKLHTNHGTITLELDAEKAPKTVENFLQYVRDGFFDGTIFHRVIDGFMIQGGGFEPGLAQKPTRDAIENEASNGLKNDA
YTVAMARTPNPNSATAQFFINVANNSFLNFTSPTPQGYGYAVFGKVVEGTDVVDKIKKVKTGSRGGHQDVPLEDVVITKA
EII

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=163, Percent_Identity=37.4233128834356, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI19557636, Length=161, Percent_Identity=33.5403726708075, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI24308049, Length=160, Percent_Identity=37.5, Blast_Score=83, Evalue=9e-17,
Organism=Homo sapiens, GI22547215, Length=162, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI22547212, Length=162, Percent_Identity=32.7160493827161, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI7657473, Length=162, Percent_Identity=32.7160493827161, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI310110104, Length=143, Percent_Identity=35.6643356643357, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI10863927, Length=143, Percent_Identity=34.965034965035, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI310129267, Length=143, Percent_Identity=34.2657342657343, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI310120620, Length=143, Percent_Identity=34.2657342657343, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI4758950, Length=154, Percent_Identity=34.4155844155844, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=62.962962962963, Blast_Score=214, Evalue=2e-57,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=54.320987654321, Blast_Score=169, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17532641, Length=168, Percent_Identity=34.5238095238095, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71980590, Length=147, Percent_Identity=33.3333333333333, Blast_Score=83, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71980594, Length=147, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17506311, Length=158, Percent_Identity=35.4430379746835, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17539496, Length=162, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17552780, Length=158, Percent_Identity=35.4430379746835, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320510, Length=160, Percent_Identity=35, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19922912, Length=160, Percent_Identity=36.875, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17986117, Length=166, Percent_Identity=31.9277108433735, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19922376, Length=168, Percent_Identity=27.3809523809524, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24652460, Length=143, Percent_Identity=31.4685314685315, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45549139, Length=143, Percent_Identity=35.6643356643357, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17748; Mature: 17748

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKLHTNHGTITLELDAEKAPKTVENFLQYVRDGFFDGTIFHRVIDGFMIQGGGFEPGLA
CEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCEEEECCCCCCCCC
QKPTRDAIENEASNGLKNDAYTVAMARTPNPNSATAQFFINVANNSFLNFTSPTPQGYGY
CCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCEEEEEEEECCCCEEEECCCCCCCCCE
AVFGKVVEGTDVVDKIKKVKTGSRGGHQDVPLEDVVITKAEII
EEECEECCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MVKLHTNHGTITLELDAEKAPKTVENFLQYVRDGFFDGTIFHRVIDGFMIQGGGFEPGLA
CEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCEEEECCCCCCCCC
QKPTRDAIENEASNGLKNDAYTVAMARTPNPNSATAQFFINVANNSFLNFTSPTPQGYGY
CCCCHHHHHHHHCCCCCCCEEEEEEEECCCCCCCEEEEEEEECCCCEEEECCCCCCCCCE
AVFGKVVEGTDVVDKIKKVKTGSRGGHQDVPLEDVVITKAEII
EEECEECCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]