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The map label for this gene is argD [H]

Identifier: 74317869

GI number: 74317869

Start: 1945217

End: 1946401

Strand: Reverse

Name: argD [H]

Synonym: Tbd_1851

Alternate gene names: 74317869

Gene position: 1946401-1945217 (Counterclockwise)

Preceding gene: 74317870

Following gene: 74317868

Centisome position: 66.89

GC content: 67.59

Gene sequence:

>1185_bases
ATGACAACAACACACTTGATGAACACCTACGCGCGCCAGCCGGTGGCCTTCGTTCGCGGTGAGGGTGCCTACCTGTGGGA
CGAGGCCGGCAAGCGCTACCTCGATGCGGTCGCCGGCGTCGCGGTCAACGCGCTCGGACACGCCCATCCGAGACTGGTCA
AGGCGATCGCCGAACAGGCCGCGACGCTCATCCATTCGTCCAACCTGTATCGCGTGCTGCGTCAGGAGGAGTTGGCGGAC
AAGCTCTGTGCGCTGTCGGGCATGGACCGCGCCTTTTTCTGCAATTCGGGTTGCGAGGCCAACGAAGCGGCGATCAAGCT
TGCGCGTCTTTATGGCCACGGCAAGGGGATCGAGCTGCCGACGATCATCGTCGTCGAAAAGGCCTTCCACGGCCGCACCA
TGGCGACGCTGACCGCAACCGGCAGCCGCAAGATCCAGGCGGGTTTCGAGCCCCTGCTGTCGGGCTTCGCGCGCGTGCCT
TTCAACGACATCGAAGCGATCCGCCATGTCGCCGAGCACAACAAGAGCGTGGTCGCGGTGTTGATCGAAACCGTGCAGGG
CGAGGGCGGCATCAATATCCTGCCGGCCGAGTACCTCGCGGAATTGCGGACGCTGTGCGACGCACAGGGCTGGCTGCTGA
TGCTCGACGAAGTGCAGACCGGAATCGGCCGCACGGGCACCTGGTTCGGTTTCCAGCACGCCGGCGTCGTACCCGACGTG
ATCGCGCTGGCCAAGGGGCTCGGCGGCGGCGTTCCGATTGGGGCCTGTCTCGCGCGCGGCGCCGCGGCCGAGGTCTTCAC
GCCGGGAACGCACGGCTCGACCTTCGGCGGCAATCCGCTCGCCTGCGCCGCCGCGCTCGCGACGCTTGAGACGATCGAGG
CGGAGCATCTGCTCGACAACGCGCGGTTGCGCGGCGACGCGATCCGGGCCGGATTGCGCGGCGCACTGGACGGCGTGCAC
GGGGTGCTCGACATCCGAGGCGAGGGCCTCATGATCGGGATCGAGCTCGACCGGCCCTGCGCCGAACTCGTCGGCGTCGC
GCGCGACGCCGGCGTGCTGATCAACGTGACCGCCGACTCGGTGATCCGTCTGGTGCCGCCGCTGATCTACGGCGCGGACG
AAGTCGACCTGCTCGTCGCCACCGTCGCCGACGTGGTCCGGAACTATCTGCAGCAGGCGGCCTGA

Upstream 100 bases:

>100_bases
CGCTGCATGACAAGCACGGCGGCTTCGGCCGCCGTTTTCTATTTTGCTGTTATCACGCCCATACAGCAGCAATTGACGGG
ACAGCCCGGGTGAGACTGCC

Downstream 100 bases:

>100_bases
TGCTGAAGCACTTTCTCCAGTTCAGGGACCTCTCGCGCGACGAACATCTCTATCTGTTCGAACGTGCGCGCGTGATCAAG
TCGCGCTTCAAGCGCTACGA

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTTTHLMNTYARQPVAFVRGEGAYLWDEAGKRYLDAVAGVAVNALGHAHPRLVKAIAEQAATLIHSSNLYRVLRQEELAD
KLCALSGMDRAFFCNSGCEANEAAIKLARLYGHGKGIELPTIIVVEKAFHGRTMATLTATGSRKIQAGFEPLLSGFARVP
FNDIEAIRHVAEHNKSVVAVLIETVQGEGGINILPAEYLAELRTLCDAQGWLLMLDEVQTGIGRTGTWFGFQHAGVVPDV
IALAKGLGGGVPIGACLARGAAAEVFTPGTHGSTFGGNPLACAAALATLETIEAEHLLDNARLRGDAIRAGLRGALDGVH
GVLDIRGEGLMIGIELDRPCAELVGVARDAGVLINVTADSVIRLVPPLIYGADEVDLLVATVADVVRNYLQQAA

Sequences:

>Translated_394_residues
MTTTHLMNTYARQPVAFVRGEGAYLWDEAGKRYLDAVAGVAVNALGHAHPRLVKAIAEQAATLIHSSNLYRVLRQEELAD
KLCALSGMDRAFFCNSGCEANEAAIKLARLYGHGKGIELPTIIVVEKAFHGRTMATLTATGSRKIQAGFEPLLSGFARVP
FNDIEAIRHVAEHNKSVVAVLIETVQGEGGINILPAEYLAELRTLCDAQGWLLMLDEVQTGIGRTGTWFGFQHAGVVPDV
IALAKGLGGGVPIGACLARGAAAEVFTPGTHGSTFGGNPLACAAALATLETIEAEHLLDNARLRGDAIRAGLRGALDGVH
GVLDIRGEGLMIGIELDRPCAELVGVARDAGVLINVTADSVIRLVPPLIYGADEVDLLVATVADVVRNYLQQAA
>Mature_393_residues
TTTHLMNTYARQPVAFVRGEGAYLWDEAGKRYLDAVAGVAVNALGHAHPRLVKAIAEQAATLIHSSNLYRVLRQEELADK
LCALSGMDRAFFCNSGCEANEAAIKLARLYGHGKGIELPTIIVVEKAFHGRTMATLTATGSRKIQAGFEPLLSGFARVPF
NDIEAIRHVAEHNKSVVAVLIETVQGEGGINILPAEYLAELRTLCDAQGWLLMLDEVQTGIGRTGTWFGFQHAGVVPDVI
ALAKGLGGGVPIGACLARGAAAEVFTPGTHGSTFGGNPLACAAALATLETIEAEHLLDNARLRGDAIRAGLRGALDGVHG
VLDIRGEGLMIGIELDRPCAELVGVARDAGVLINVTADSVIRLVPPLIYGADEVDLLVATVADVVRNYLQQAA

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=376, Percent_Identity=35.1063829787234, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI284507298, Length=289, Percent_Identity=36.6782006920415, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI13994255, Length=442, Percent_Identity=30.0904977375566, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI37574042, Length=428, Percent_Identity=29.9065420560748, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI24119277, Length=419, Percent_Identity=29.3556085918854, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI226442705, Length=428, Percent_Identity=29.2056074766355, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI226442709, Length=393, Percent_Identity=29.2620865139949, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI188536080, Length=432, Percent_Identity=25.462962962963, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI38679950, Length=432, Percent_Identity=25.462962962963, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI38679946, Length=432, Percent_Identity=25.462962962963, Blast_Score=112, Evalue=8e-25,
Organism=Escherichia coli, GI1788044, Length=376, Percent_Identity=42.0212765957447, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1789759, Length=380, Percent_Identity=41.0526315789474, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI145693181, Length=373, Percent_Identity=39.9463806970509, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1789016, Length=389, Percent_Identity=33.1619537275064, Blast_Score=188, Evalue=7e-49,
Organism=Escherichia coli, GI1787560, Length=339, Percent_Identity=35.9882005899705, Blast_Score=183, Evalue=1e-47,
Organism=Escherichia coli, GI1786991, Length=399, Percent_Identity=30.3258145363409, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1786349, Length=295, Percent_Identity=33.2203389830508, Blast_Score=120, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25144271, Length=394, Percent_Identity=34.5177664974619, Blast_Score=237, Evalue=8e-63,
Organism=Caenorhabditis elegans, GI32564660, Length=434, Percent_Identity=30.6451612903226, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71992977, Length=415, Percent_Identity=29.3975903614458, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25144274, Length=277, Percent_Identity=33.5740072202166, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71981843, Length=164, Percent_Identity=35.3658536585366, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17541228, Length=435, Percent_Identity=25.0574712643678, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71992985, Length=123, Percent_Identity=37.3983739837398, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324432, Length=376, Percent_Identity=35.3723404255319, Blast_Score=230, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6323470, Length=402, Percent_Identity=34.8258706467662, Blast_Score=226, Evalue=7e-60,
Organism=Saccharomyces cerevisiae, GI6321456, Length=434, Percent_Identity=24.1935483870968, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324386, Length=318, Percent_Identity=24.5283018867925, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21357415, Length=386, Percent_Identity=32.9015544041451, Blast_Score=217, Evalue=9e-57,
Organism=Drosophila melanogaster, GI161085790, Length=437, Percent_Identity=29.2906178489703, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28574759, Length=410, Percent_Identity=30.4878048780488, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21356575, Length=411, Percent_Identity=29.683698296837, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI281366494, Length=432, Percent_Identity=24.7685185185185, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24667139, Length=432, Percent_Identity=24.7685185185185, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24667143, Length=432, Percent_Identity=24.7685185185185, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 41590; Mature: 41459

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTHLMNTYARQPVAFVRGEGAYLWDEAGKRYLDAVAGVAVNALGHAHPRLVKAIAEQA
CCCHHHHHHHHHCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ATLIHSSNLYRVLRQEELADKLCALSGMDRAFFCNSGCEANEAAIKLARLYGHGKGIELP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCC
TIIVVEKAFHGRTMATLTATGSRKIQAGFEPLLSGFARVPFNDIEAIRHVAEHNKSVVAV
EEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEH
LIETVQGEGGINILPAEYLAELRTLCDAQGWLLMLDEVQTGIGRTGTWFGFQHAGVVPDV
HHHHHCCCCCCEEECHHHHHHHHHHHCCCCCEEEHHHHHHCCCCCCCCCCCCCCCCHHHH
IALAKGLGGGVPIGACLARGAAAEVFTPGTHGSTFGGNPLACAAALATLETIEAEHLLDN
HHHHHCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ARLRGDAIRAGLRGALDGVHGVLDIRGEGLMIGIELDRPCAELVGVARDAGVLINVTADS
HHHHHHHHHHHHHHHHHHHCEEEEECCCEEEEEEECCCCHHHHHHHHCCCCEEEEECHHH
VIRLVPPLIYGADEVDLLVATVADVVRNYLQQAA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTTHLMNTYARQPVAFVRGEGAYLWDEAGKRYLDAVAGVAVNALGHAHPRLVKAIAEQA
CCHHHHHHHHHCCEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
ATLIHSSNLYRVLRQEELADKLCALSGMDRAFFCNSGCEANEAAIKLARLYGHGKGIELP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCC
TIIVVEKAFHGRTMATLTATGSRKIQAGFEPLLSGFARVPFNDIEAIRHVAEHNKSVVAV
EEEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEH
LIETVQGEGGINILPAEYLAELRTLCDAQGWLLMLDEVQTGIGRTGTWFGFQHAGVVPDV
HHHHHCCCCCCEEECHHHHHHHHHHHCCCCCEEEHHHHHHCCCCCCCCCCCCCCCCHHHH
IALAKGLGGGVPIGACLARGAAAEVFTPGTHGSTFGGNPLACAAALATLETIEAEHLLDN
HHHHHCCCCCCCHHHHHHCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ARLRGDAIRAGLRGALDGVHGVLDIRGEGLMIGIELDRPCAELVGVARDAGVLINVTADS
HHHHHHHHHHHHHHHHHHHCEEEEECCCEEEEEEECCCCHHHHHHHHCCCCEEEEECHHH
VIRLVPPLIYGADEVDLLVATVADVVRNYLQQAA
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]