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The map label for this gene is argF [H]

Identifier: 74317868

GI number: 74317868

Start: 1944300

End: 1945217

Strand: Reverse

Name: argF [H]

Synonym: Tbd_1850

Alternate gene names: 74317868

Gene position: 1945217-1944300 (Counterclockwise)

Preceding gene: 74317869

Following gene: 161899032

Centisome position: 66.85

GC content: 62.09

Gene sequence:

>918_bases
ATGCTGAAGCACTTTCTCCAGTTCAGGGACCTCTCGCGCGACGAACATCTCTATCTGTTCGAACGTGCGCGCGTGATCAA
GTCGCGCTTCAAGCGCTACGAACCCTACCATCCGCTCGCTGACCGCACGCTCGCGATGATCTTCGAGAAGAGCTCGACGC
GGACGCGTCTGAGCTTCGAAGCCGGCATGCACCAACTTGGCGGTTCGGCAATCTATCTCAACACCCGCGACACCCAGCTC
GGCCGGGGCGAGCCGGTCGAGGACGCGGGCGAAGTCATTTCGCGCATGGTCGACATCGTGATGATCCGCACCTTCGAACA
GGAGATCATCGAGCGGTTTGCCTCCCATTCGCGCGTGCCCGTCATCAACGGCCTGACCAACGAATATCACCCATGCCAGG
TGCTCGCGGACATCTTCACGTTCATCGAACACCGCGGGCCGATCCACGGCAAGACGGTCGCCTGGATCGGCGACTCGAAC
AACATGTGCAACACCTGGCTGCAGGCCGCAGAGCTGCTCGACTTCAACGTCCACGTCTCGACCCCGCCCGGCTACGAGGT
CGAGCCCGAACGCGCGGGCCTGTATGGCACCGACCACTTCGAAAGCTTCGTCGACCCGATGGACGCCTGCCGCGGCGCCG
ATCTTGTGACCACCGACGTGTGGACGAGCATGGGCTGGGAAGCGGAAAACGACGCACGCATGAAGGCCTTCGCCGACTGG
CAGGTCGACGCCGAGATGATGGCGGTGGCGAAGCCTGAAGCGGTTTTCATGCACTGCCTGCCGGCGCATCGCGGCGAGGA
AGTGACCGCCGAAGTCATCGACGGGCGGCAGTCCGTGGTCTGGGACGAGGCGGAAAACCGGCTGCACGTGCAAAAAGCCT
TGATGGAATATCTTCTCCTCGGAAAACTGGAAACCTGA

Upstream 100 bases:

>100_bases
TCCGTCTGGTGCCGCCGCTGATCTACGGCGCGGACGAAGTCGACCTGCTCGTCGCCACCGTCGCCGACGTGGTCCGGAAC
TATCTGCAGCAGGCGGCCTG

Downstream 100 bases:

>100_bases
CATGAACATCGCCTACTTCAAGGACATGGATTCGCTGTACGTCGAAATCAGCCCCGAGAACCCCGCCCGCGCCTGGGAGG
CCCACGAGGGCATCGTGCTG

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MLKHFLQFRDLSRDEHLYLFERARVIKSRFKRYEPYHPLADRTLAMIFEKSSTRTRLSFEAGMHQLGGSAIYLNTRDTQL
GRGEPVEDAGEVISRMVDIVMIRTFEQEIIERFASHSRVPVINGLTNEYHPCQVLADIFTFIEHRGPIHGKTVAWIGDSN
NMCNTWLQAAELLDFNVHVSTPPGYEVEPERAGLYGTDHFESFVDPMDACRGADLVTTDVWTSMGWEAENDARMKAFADW
QVDAEMMAVAKPEAVFMHCLPAHRGEEVTAEVIDGRQSVVWDEAENRLHVQKALMEYLLLGKLET

Sequences:

>Translated_305_residues
MLKHFLQFRDLSRDEHLYLFERARVIKSRFKRYEPYHPLADRTLAMIFEKSSTRTRLSFEAGMHQLGGSAIYLNTRDTQL
GRGEPVEDAGEVISRMVDIVMIRTFEQEIIERFASHSRVPVINGLTNEYHPCQVLADIFTFIEHRGPIHGKTVAWIGDSN
NMCNTWLQAAELLDFNVHVSTPPGYEVEPERAGLYGTDHFESFVDPMDACRGADLVTTDVWTSMGWEAENDARMKAFADW
QVDAEMMAVAKPEAVFMHCLPAHRGEEVTAEVIDGRQSVVWDEAENRLHVQKALMEYLLLGKLET
>Mature_305_residues
MLKHFLQFRDLSRDEHLYLFERARVIKSRFKRYEPYHPLADRTLAMIFEKSSTRTRLSFEAGMHQLGGSAIYLNTRDTQL
GRGEPVEDAGEVISRMVDIVMIRTFEQEIIERFASHSRVPVINGLTNEYHPCQVLADIFTFIEHRGPIHGKTVAWIGDSN
NMCNTWLQAAELLDFNVHVSTPPGYEVEPERAGLYGTDHFESFVDPMDACRGADLVTTDVWTSMGWEAENDARMKAFADW
QVDAEMMAVAKPEAVFMHCLPAHRGEEVTAEVIDGRQSVVWDEAENRLHVQKALMEYLLLGKLET

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=304, Percent_Identity=37.171052631579, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI18105007, Length=309, Percent_Identity=26.537216828479, Blast_Score=107, Evalue=9e-24,
Organism=Escherichia coli, GI1790703, Length=325, Percent_Identity=36.9230769230769, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI1786469, Length=326, Percent_Identity=36.8098159509202, Blast_Score=188, Evalue=4e-49,
Organism=Escherichia coli, GI2367364, Length=161, Percent_Identity=37.2670807453416, Blast_Score=88, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI193204318, Length=326, Percent_Identity=26.6871165644172, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322373, Length=322, Percent_Identity=35.4037267080745, Blast_Score=200, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6322331, Length=306, Percent_Identity=27.1241830065359, Blast_Score=98, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24642586, Length=321, Percent_Identity=28.3489096573209, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 34922; Mature: 34922

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKHFLQFRDLSRDEHLYLFERARVIKSRFKRYEPYHPLADRTLAMIFEKSSTRTRLSFE
CHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEHH
AGMHQLGGSAIYLNTRDTQLGRGEPVEDAGEVISRMVDIVMIRTFEQEIIERFASHSRVP
HHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VINGLTNEYHPCQVLADIFTFIEHRGPIHGKTVAWIGDSNNMCNTWLQAAELLDFNVHVS
EECCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEC
TPPGYEVEPERAGLYGTDHFESFVDPMDACRGADLVTTDVWTSMGWEAENDARMKAFADW
CCCCCCCCCCCCCCCCCHHHHHHHCHHHHHCCCCEEEHHHHHHCCCCCCCCCHHHEEECC
QVDAEMMAVAKPEAVFMHCLPAHRGEEVTAEVIDGRQSVVWDEAENRLHVQKALMEYLLL
CCCHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHH
GKLET
HCCCC
>Mature Secondary Structure
MLKHFLQFRDLSRDEHLYLFERARVIKSRFKRYEPYHPLADRTLAMIFEKSSTRTRLSFE
CHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEHH
AGMHQLGGSAIYLNTRDTQLGRGEPVEDAGEVISRMVDIVMIRTFEQEIIERFASHSRVP
HHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VINGLTNEYHPCQVLADIFTFIEHRGPIHGKTVAWIGDSNNMCNTWLQAAELLDFNVHVS
EECCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEC
TPPGYEVEPERAGLYGTDHFESFVDPMDACRGADLVTTDVWTSMGWEAENDARMKAFADW
CCCCCCCCCCCCCCCCCHHHHHHHCHHHHHCCCCEEEHHHHHHCCCCCCCCCHHHEEECC
QVDAEMMAVAKPEAVFMHCLPAHRGEEVTAEVIDGRQSVVWDEAENRLHVQKALMEYLLL
CCCHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHH
GKLET
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA