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The map label for this gene is cusS [H]

Identifier: 74317768

GI number: 74317768

Start: 1840872

End: 1842263

Strand: Direct

Name: cusS [H]

Synonym: Tbd_1750

Alternate gene names: 74317768

Gene position: 1840872-1842263 (Clockwise)

Preceding gene: 74317767

Following gene: 74317771

Centisome position: 63.26

GC content: 68.32

Gene sequence:

>1392_bases
ATGAGACCGCTGTCGCTGACCGCCCGGATCAGCGCGCTTTTCGCCGTGGCGGCGACCGTGGTCCTGCTCGTCACCGCGTA
TTTCCTGACCCAGGCGGTGGAGGCCCATTTCAAGGCCGGAGACCGCCACGAACTCGACGGCAAGCTCGAACTCGTCCGCA
GCCTGTTCGCGCGCGCCGACACGCCGGAGAAACTGGCCGCGCTGCCGCACCGGCTCGACGATGCCCTGATCGGTCACCAC
GGACTCGCCGTGGCCGTGACCGACGCGGCAGGCGAACGCTGGTTCACGACCTCGGGTGCGACGTTCCCCGACACGCTGCT
GCGCGACTGCCAGGCCCGGCCGGCCGCCTGCACCTCGGGAAGCCTGCGCGAGTGGGAACACGCCGGAAGACCTTACCGCG
GCACGGCGGTCGCGATGCGGATGCCGCAGGGTGGGACGTACACCGTGGCCATCGCGCTCGACATCGCCCACCACGCCGAG
TTCATGACCAAGGCGCGCTCGGTGCTCGGCGTGGCCATCGTGTTGGCGGCCCTCGCGACGGCCGGGCTGGGATGGGTCGT
CACCCGCTGGGGGCTTTTTCCCTTGCGCCGCGTAACGGCGACGGTGGCCGGCATGTCGGCCAAGCATCTGGCGGACCGCC
TACCGACCGCGGGGCTGCCGGCCGAACTGCAGCCGCTCGCCTCCGCCTTCAACGCAATGCTCGCGCGCCTGGACGATTCG
TTCCGGCGGCTGTCCGCGTTCTCCTCCGACATCGCGCACGAGCTGCGCACGCCGATTTCCAACCTCATGACCCAGACCCA
GGTCGCGCTCTCCAATGCCCGCGGCAACGAGGAATATAAGGAAATCCTGTACTCGAATCTGGAGGAGTACGAGCGCATGG
CGCAGATGGTCGGCGACATGCTCTATCTCGCGCAGGCCGACCACGGCCTGCTCAAGCCGGGCCTCGGCGTGGTCGACCTC
GCGAGTGAGACCCGCGATCTGTTCGACTATTTCGAAGCGTGGGCGGAAGAGCGTGGCGTGTCGCTGGCGCAGGCCGGCGC
AGCTTCGGTGCCCGGTGACCGCCTGATGCTGCGGCGCGCACTCAGCAACCTGCTTGCGAACGCGATCCGTCATACACCAG
CCGGTGAGGCCGTGACGGTGTCGTTGGCGATGCACGGCGGACAGGCGGAAATATTCGTCGACAACCCCGGCATGCCGATT
CCGGCGCAACACCTTCCCCATCTCTTCGACCGCTTCTACCGCGTCGACCCGGCGCGCCAGCGCAGCGGCGACGGAGCGGG
ACTTGGCCTTGCCATCGTGAAATCGATCGTCGAAGCGCACGGCGGCTCGATTGGCGTCACCTCAACCGCGCAGAGGACGC
GCTTCCGTCTCGTCCTACCGGCGGAGGGGTGA

Upstream 100 bases:

>100_bases
GGCTGCGCGTCAAGATCGACGAAGGCTTCGACGCCAAACTCATCCACACCGTGCGCGGCATGGGTTACGTGCTGGAGACG
AGCGCGGAAAGCGCAGCTTC

Downstream 100 bases:

>100_bases
GGAAAACGCTGCGGCACCTCGCTCCGCACAAGGCTCGGGCCGGCCGACAGAATGCTTAGGTATGTGTTGCCGCTATCCGC
GGCGGACTATTCCCACTCGA

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MRPLSLTARISALFAVAATVVLLVTAYFLTQAVEAHFKAGDRHELDGKLELVRSLFARADTPEKLAALPHRLDDALIGHH
GLAVAVTDAAGERWFTTSGATFPDTLLRDCQARPAACTSGSLREWEHAGRPYRGTAVAMRMPQGGTYTVAIALDIAHHAE
FMTKARSVLGVAIVLAALATAGLGWVVTRWGLFPLRRVTATVAGMSAKHLADRLPTAGLPAELQPLASAFNAMLARLDDS
FRRLSAFSSDIAHELRTPISNLMTQTQVALSNARGNEEYKEILYSNLEEYERMAQMVGDMLYLAQADHGLLKPGLGVVDL
ASETRDLFDYFEAWAEERGVSLAQAGAASVPGDRLMLRRALSNLLANAIRHTPAGEAVTVSLAMHGGQAEIFVDNPGMPI
PAQHLPHLFDRFYRVDPARQRSGDGAGLGLAIVKSIVEAHGGSIGVTSTAQRTRFRLVLPAEG

Sequences:

>Translated_463_residues
MRPLSLTARISALFAVAATVVLLVTAYFLTQAVEAHFKAGDRHELDGKLELVRSLFARADTPEKLAALPHRLDDALIGHH
GLAVAVTDAAGERWFTTSGATFPDTLLRDCQARPAACTSGSLREWEHAGRPYRGTAVAMRMPQGGTYTVAIALDIAHHAE
FMTKARSVLGVAIVLAALATAGLGWVVTRWGLFPLRRVTATVAGMSAKHLADRLPTAGLPAELQPLASAFNAMLARLDDS
FRRLSAFSSDIAHELRTPISNLMTQTQVALSNARGNEEYKEILYSNLEEYERMAQMVGDMLYLAQADHGLLKPGLGVVDL
ASETRDLFDYFEAWAEERGVSLAQAGAASVPGDRLMLRRALSNLLANAIRHTPAGEAVTVSLAMHGGQAEIFVDNPGMPI
PAQHLPHLFDRFYRVDPARQRSGDGAGLGLAIVKSIVEAHGGSIGVTSTAQRTRFRLVLPAEG
>Mature_463_residues
MRPLSLTARISALFAVAATVVLLVTAYFLTQAVEAHFKAGDRHELDGKLELVRSLFARADTPEKLAALPHRLDDALIGHH
GLAVAVTDAAGERWFTTSGATFPDTLLRDCQARPAACTSGSLREWEHAGRPYRGTAVAMRMPQGGTYTVAIALDIAHHAE
FMTKARSVLGVAIVLAALATAGLGWVVTRWGLFPLRRVTATVAGMSAKHLADRLPTAGLPAELQPLASAFNAMLARLDDS
FRRLSAFSSDIAHELRTPISNLMTQTQVALSNARGNEEYKEILYSNLEEYERMAQMVGDMLYLAQADHGLLKPGLGVVDL
ASETRDLFDYFEAWAEERGVSLAQAGAASVPGDRLMLRRALSNLLANAIRHTPAGEAVTVSLAMHGGQAEIFVDNPGMPI
PAQHLPHLFDRFYRVDPARQRSGDGAGLGLAIVKSIVEAHGGSIGVTSTAQRTRFRLVLPAEG

Specific function: Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates CusR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=478, Percent_Identity=38.9121338912134, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1788279, Length=318, Percent_Identity=33.6477987421384, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1786600, Length=216, Percent_Identity=31.9444444444444, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788393, Length=258, Percent_Identity=31.3953488372093, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=30.4347826086957, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1787894, Length=298, Percent_Identity=28.8590604026846, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789403, Length=248, Percent_Identity=31.8548387096774, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790551, Length=259, Percent_Identity=27.7992277992278, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=26.6375545851528, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=26.9230769230769, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI145693157, Length=113, Percent_Identity=35.3982300884956, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI48994928, Length=218, Percent_Identity=26.605504587156, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI87081816, Length=249, Percent_Identity=28.5140562248996, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790861, Length=285, Percent_Identity=24.5614035087719, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789808, Length=226, Percent_Identity=28.7610619469027, Blast_Score=63, Evalue=5e-11,
Organism=Escherichia coli, GI87082128, Length=287, Percent_Identity=23.6933797909408, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49824; Mature: 49824

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPLSLTARISALFAVAATVVLLVTAYFLTQAVEAHFKAGDRHELDGKLELVRSLFARAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
TPEKLAALPHRLDDALIGHHGLAVAVTDAAGERWFTTSGATFPDTLLRDCQARPAACTSG
CHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEECCCCCCHHHHHHHCCCCCCCCCCC
SLREWEHAGRPYRGTAVAMRMPQGGTYTVAIALDIAHHAEFMTKARSVLGVAIVLAALAT
CHHHHHHCCCCCCCCEEEEECCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
AGLGWVVTRWGLFPLRRVTATVAGMSAKHLADRLPTAGLPAELQPLASAFNAMLARLDDS
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
FRRLSAFSSDIAHELRTPISNLMTQTQVALSNARGNEEYKEILYSNLEEYERMAQMVGDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LYLAQADHGLLKPGLGVVDLASETRDLFDYFEAWAEERGVSLAQAGAASVPGDRLMLRRA
HHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHH
LSNLLANAIRHTPAGEAVTVSLAMHGGQAEIFVDNPGMPIPAQHLPHLFDRFYRVDPARQ
HHHHHHHHHHCCCCCCEEEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHH
RSGDGAGLGLAIVKSIVEAHGGSIGVTSTAQRTRFRLVLPAEG
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure
MRPLSLTARISALFAVAATVVLLVTAYFLTQAVEAHFKAGDRHELDGKLELVRSLFARAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCC
TPEKLAALPHRLDDALIGHHGLAVAVTDAAGERWFTTSGATFPDTLLRDCQARPAACTSG
CHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEECCCCCCHHHHHHHCCCCCCCCCCC
SLREWEHAGRPYRGTAVAMRMPQGGTYTVAIALDIAHHAEFMTKARSVLGVAIVLAALAT
CHHHHHHCCCCCCCCEEEEECCCCCCEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
AGLGWVVTRWGLFPLRRVTATVAGMSAKHLADRLPTAGLPAELQPLASAFNAMLARLDDS
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
FRRLSAFSSDIAHELRTPISNLMTQTQVALSNARGNEEYKEILYSNLEEYERMAQMVGDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LYLAQADHGLLKPGLGVVDLASETRDLFDYFEAWAEERGVSLAQAGAASVPGDRLMLRRA
HHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHHHH
LSNLLANAIRHTPAGEAVTVSLAMHGGQAEIFVDNPGMPIPAQHLPHLFDRFYRVDPARQ
HHHHHHHHHHCCCCCCEEEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHH
RSGDGAGLGLAIVKSIVEAHGGSIGVTSTAQRTRFRLVLPAEG
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]