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The map label for this gene is irlR [H]

Identifier: 74317767

GI number: 74317767

Start: 1840147

End: 1840875

Strand: Direct

Name: irlR [H]

Synonym: Tbd_1749

Alternate gene names: 74317767

Gene position: 1840147-1840875 (Clockwise)

Preceding gene: 74317760

Following gene: 74317768

Centisome position: 63.24

GC content: 64.47

Gene sequence:

>729_bases
GTGGCAGGATGCGGGCTCTTCCCAGGGTTTTACGTCATGAAAATTCTGATCGTCGAAGACGAGCCCAAAACGGGCGCTTA
CCTCAGGCAAGGGCTCACCGAAGCCGGCTTCGTCACCGATCTCGCCCGCGACGGGTGGGACGGACTGGAACTCGCCAAGT
CCGGGCATTACGACCTCATGATTCTCGACGTCATGTTGCCCGGTCTCGACGGCTGGCAGGTGCTCGAAGGCGTGCGCCGC
GCTGGCATCGGTACGCCGGTGCTGTTCCTGACCGCGCGCGATCGCGTCGAAGACCGGGTCAAGGGGCTGGAACTCGGCGC
CGACGACTATCTCGTGAAGCCCTTCGCCTTTGCCGAACTGCTCGCCCGCGTCCACAGCCTGATGCGCCGCGGGCAGGCCG
CCCTCGAGTCGGCCGTGCTCAAGGCGGCGGACCTCGAACTCGATCTGCTGCGCCGCCGCGCGACCCGCGCGGGCCGCCGG
ATCGATCTCACGGCCAAGGAATTCGCCCTGCTCGAACTGTTTCTTCGCCGTAAAGGCGAAGTGTTGCCGCGTAGCCTGAT
CGCATCCCAGGTGTGGGACATGAATTTCGACTCGGACACCAATGTCATCGACGTCGCGGTGCGGCGGCTGCGCGTCAAGA
TCGACGAAGGCTTCGACGCCAAACTCATCCACACCGTGCGCGGCATGGGTTACGTGCTGGAGACGAGCGCGGAAAGCGCA
GCTTCATGA

Upstream 100 bases:

>100_bases
GACGACACGTTTTGGTGACGGCATCTTGGCGCGCTGCGCCCAACAGCAATCTGACGCGAGGGTTACAAATCTGTAATGGG
TGCCGGCGCGGCGAGGCGCT

Downstream 100 bases:

>100_bases
GACCGCTGTCGCTGACCGCCCGGATCAGCGCGCTTTTCGCCGTGGCGGCGACCGTGGTCCTGCTCGTCACCGCGTATTTC
CTGACCCAGGCGGTGGAGGC

Product: two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MAGCGLFPGFYVMKILIVEDEPKTGAYLRQGLTEAGFVTDLARDGWDGLELAKSGHYDLMILDVMLPGLDGWQVLEGVRR
AGIGTPVLFLTARDRVEDRVKGLELGADDYLVKPFAFAELLARVHSLMRRGQAALESAVLKAADLELDLLRRRATRAGRR
IDLTAKEFALLELFLRRKGEVLPRSLIASQVWDMNFDSDTNVIDVAVRRLRVKIDEGFDAKLIHTVRGMGYVLETSAESA
AS

Sequences:

>Translated_242_residues
MAGCGLFPGFYVMKILIVEDEPKTGAYLRQGLTEAGFVTDLARDGWDGLELAKSGHYDLMILDVMLPGLDGWQVLEGVRR
AGIGTPVLFLTARDRVEDRVKGLELGADDYLVKPFAFAELLARVHSLMRRGQAALESAVLKAADLELDLLRRRATRAGRR
IDLTAKEFALLELFLRRKGEVLPRSLIASQVWDMNFDSDTNVIDVAVRRLRVKIDEGFDAKLIHTVRGMGYVLETSAESA
AS
>Mature_241_residues
AGCGLFPGFYVMKILIVEDEPKTGAYLRQGLTEAGFVTDLARDGWDGLELAKSGHYDLMILDVMLPGLDGWQVLEGVRRA
GIGTPVLFLTARDRVEDRVKGLELGADDYLVKPFAFAELLARVHSLMRRGQAALESAVLKAADLELDLLRRRATRAGRRI
DLTAKEFALLELFLRRKGEVLPRSLIASQVWDMNFDSDTNVIDVAVRRLRVKIDEGFDAKLIHTVRGMGYVLETSAESAA
S

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=66.6666666666667, Blast_Score=298, Evalue=2e-82,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=53.8812785388128, Blast_Score=237, Evalue=6e-64,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=44.8430493273543, Blast_Score=163, Evalue=9e-42,
Organism=Escherichia coli, GI1790552, Length=231, Percent_Identity=38.0952380952381, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=35.2678571428571, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=34.2342342342342, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=36.0869565217391, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=34.3612334801762, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=35.2941176470588, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=32.8947368421053, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=34.0807174887892, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=35.3448275862069, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=29.646017699115, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=28.0851063829787, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=36.697247706422, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=42.5742574257426, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=34.3137254901961, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790437, Length=122, Percent_Identity=33.6065573770492, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788713, Length=118, Percent_Identity=33.0508474576271, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=32.2314049586777, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26835; Mature: 26704

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGCGLFPGFYVMKILIVEDEPKTGAYLRQGLTEAGFVTDLARDGWDGLELAKSGHYDLM
CCCCCCCHHHHHHEEEEECCCCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHCCCCCCEE
ILDVMLPGLDGWQVLEGVRRAGIGTPVLFLTARDRVEDRVKGLELGADDYLVKPFAFAEL
EEEHHCCCCCHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCCCCEECHHHHHHH
LARVHSLMRRGQAALESAVLKAADLELDLLRRRATRAGRRIDLTAKEFALLELFLRRKGE
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHCCC
VLPRSLIASQVWDMNFDSDTNVIDVAVRRLRVKIDEGFDAKLIHTVRGMGYVLETSAESA
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEECCCHHC
AS
CC
>Mature Secondary Structure 
AGCGLFPGFYVMKILIVEDEPKTGAYLRQGLTEAGFVTDLARDGWDGLELAKSGHYDLM
CCCCCCHHHHHHEEEEECCCCCCHHHHHHCCCHHHHHHHHHHCCCCHHHHHCCCCCCEE
ILDVMLPGLDGWQVLEGVRRAGIGTPVLFLTARDRVEDRVKGLELGADDYLVKPFAFAEL
EEEHHCCCCCHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHHCCCCCCEECHHHHHHH
LARVHSLMRRGQAALESAVLKAADLELDLLRRRATRAGRRIDLTAKEFALLELFLRRKGE
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHCCC
VLPRSLIASQVWDMNFDSDTNVIDVAVRRLRVKIDEGFDAKLIHTVRGMGYVLETSAESA
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEECCCHHC
AS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]