Click here to switch to the map view.

The map label for this gene is hisB

Identifier: 74317729

GI number: 74317729

Start: 1798848

End: 1799435

Strand: Reverse

Name: hisB

Synonym: Tbd_1711

Alternate gene names: 74317729

Gene position: 1799435-1798848 (Counterclockwise)

Preceding gene: 74317730

Following gene: 74317728

Centisome position: 61.84

GC content: 64.46

Gene sequence:

>588_bases
ATGCGCACCGCCCAAGTCAGCCGCAATACCCTCGAAACCGAGATTACGGTCAGCCTCAATCTCGACGGCTCGGGCACGTC
CAGGCTGGCGACCGGTGTGCCGTTCCTCGATCACATGCTCGACCAGATCGCGCGCCACGGTCTGATCGATCTCGACATCG
CGGCCAAGGGCGACCTGCACATCGACGCTCACCACACCGTCGAAGACACCGGCATCACGCTCGGGCAGGCGTTCGCCAAG
GCCTTGGCCGACAAGAAGGGCATTCGCCGCTACGGCCACGCCTACGTGCCGCTCGATGAGGCCTTGTCGCGGGTCGTGAT
CGATCTGTCGGGGCGTCCGGGACTCGAATACCACGTCGACTACACGCGTGCGCGCATCGGCGATTTCGACGTCGACCTGT
TTCTCGAATTTTTCCGCGGCTTCGTCAACCATGCGGGCGTCACGCTGCACATCGACAACCTGCGCGGCATCAATGCGCAC
CACCAGGCCGAAACGATCTTCAAGGCCTTCGGCCGCGCGCTGCGCATGGCGGTCGAGACCGACGCGCGGCTGGGCGACGT
GACCCCTTCGACCAAAGGTGCGCTGTGA

Upstream 100 bases:

>100_bases
CCGACGCACAATGCGATGCGCTCGTAGACGCCTTGAAAGCCCTGTGCTGAAAACGACAGCGGCCTGCTAAAATCCTTTTT
ACCGTCCGAAAAACGTCGCC

Downstream 100 bases:

>100_bases
CGATGGTCCGCTTCGCCTGCTGTGTTCAAGCGCGACCTTCCTCAGCGGGAGCCGGAGCGTGAGCGTCGATATCGCCGTCG
TCGACTACGGCATGGGCAAC

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MRTAQVSRNTLETEITVSLNLDGSGTSRLATGVPFLDHMLDQIARHGLIDLDIAAKGDLHIDAHHTVEDTGITLGQAFAK
ALADKKGIRRYGHAYVPLDEALSRVVIDLSGRPGLEYHVDYTRARIGDFDVDLFLEFFRGFVNHAGVTLHIDNLRGINAH
HQAETIFKAFGRALRMAVETDARLGDVTPSTKGAL

Sequences:

>Translated_195_residues
MRTAQVSRNTLETEITVSLNLDGSGTSRLATGVPFLDHMLDQIARHGLIDLDIAAKGDLHIDAHHTVEDTGITLGQAFAK
ALADKKGIRRYGHAYVPLDEALSRVVIDLSGRPGLEYHVDYTRARIGDFDVDLFLEFFRGFVNHAGVTLHIDNLRGINAH
HQAETIFKAFGRALRMAVETDARLGDVTPSTKGAL
>Mature_195_residues
MRTAQVSRNTLETEITVSLNLDGSGTSRLATGVPFLDHMLDQIARHGLIDLDIAAKGDLHIDAHHTVEDTGITLGQAFAK
ALADKKGIRRYGHAYVPLDEALSRVVIDLSGRPGLEYHVDYTRARIGDFDVDLFLEFFRGFVNHAGVTLHIDNLRGINAH
HQAETIFKAFGRALRMAVETDARLGDVTPSTKGAL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=194, Percent_Identity=51.5463917525773, Blast_Score=196, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=39.9082568807339, Blast_Score=156, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_THIDA (Q3SEU5)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315469.1
- HSSP:   P34047
- ProteinModelPortal:   Q3SEU5
- SMR:   Q3SEU5
- STRING:   Q3SEU5
- GeneID:   3671294
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1711
- NMPDR:   fig|292415.3.peg.1808
- eggNOG:   COG0131
- HOGENOM:   HBG289010
- OMA:   TLHVETL
- PhylomeDB:   Q3SEU5
- ProtClustDB:   PRK00951
- BioCyc:   TDEN292415:TBD_1711-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 21367; Mature: 21367

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTAQVSRNTLETEITVSLNLDGSGTSRLATGVPFLDHMLDQIARHGLIDLDIAAKGDLH
CCCCCCCCCCEEEEEEEEEEECCCCCCHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCEE
IDAHHTVEDTGITLGQAFAKALADKKGIRRYGHAYVPLDEALSRVVIDLSGRPGLEYHVD
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCCCEEEEC
YTRARIGDFDVDLFLEFFRGFVNHAGVTLHIDNLRGINAHHQAETIFKAFGRALRMAVET
HHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHC
DARLGDVTPSTKGAL
CCCCCCCCCCCCCCC
>Mature Secondary Structure
MRTAQVSRNTLETEITVSLNLDGSGTSRLATGVPFLDHMLDQIARHGLIDLDIAAKGDLH
CCCCCCCCCCEEEEEEEEEEECCCCCCHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCEE
IDAHHTVEDTGITLGQAFAKALADKKGIRRYGHAYVPLDEALSRVVIDLSGRPGLEYHVD
ECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHEEECCCCCCCEEEEC
YTRARIGDFDVDLFLEFFRGFVNHAGVTLHIDNLRGINAHHQAETIFKAFGRALRMAVET
HHHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHC
DARLGDVTPSTKGAL
CCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA