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The map label for this gene is hisI

Identifier: 74317725

GI number: 74317725

Start: 1796154

End: 1796555

Strand: Reverse

Name: hisI

Synonym: Tbd_1707

Alternate gene names: 74317725

Gene position: 1796555-1796154 (Counterclockwise)

Preceding gene: 74317726

Following gene: 74317724

Centisome position: 61.74

GC content: 62.69

Gene sequence:

>402_bases
GTGAGCGACTGGCTCGACGCGGTGAAATGGGACGCCCAGGGCCTCGTCCCGGCGATCGCCCAGGATGCGGCGAGCGGGGA
AATCCTCATGGTGGCGTGGATGAATCGGGAAGCGCTCGAGGAAACCGCGCGCACCGGCCGCGGCGTCTATTTTTCCCGCT
CCCGCCACAAGCTGTGGCGCAAGGGCGAGGAATCGGGTCACGTCCAGACGGTCAGCGAAATCCGTCTCGACTGCGACAAC
GACGTCATTCTGCTCAAGATCGAACAATTGGGAGGCATCGCCTGTCATACGGGACGACGCTCGTGTTTCTTCCACAAGCT
CACGACCGATGATCGGGGCCACGCGGACTGGGTGGCGACCGAGCCGGTGTTGAAGAATCCTGACGAGATCTACCGCAGAT
GA

Upstream 100 bases:

>100_bases
GGGCCGATGCCGTCCTCGCCGCGAGCATTTTTCATTTCGGCGAATACCGGGTCGACGAGGCCAAGGCCTACATGAAGCGG
CACGGAATCGAGGTGCGCCT

Downstream 100 bases:

>100_bases
GCGATATCCTCGACCGCCTGGCGGAAATCCTCGAGGCGCGCAAGCAGGCCTCGCCGGACGCTTCCTACGTCGCCCGACTC
TATGCCAAGGGCACCGACGC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 133; Mature: 132

Protein sequence:

>133_residues
MSDWLDAVKWDAQGLVPAIAQDAASGEILMVAWMNREALEETARTGRGVYFSRSRHKLWRKGEESGHVQTVSEIRLDCDN
DVILLKIEQLGGIACHTGRRSCFFHKLTTDDRGHADWVATEPVLKNPDEIYRR

Sequences:

>Translated_133_residues
MSDWLDAVKWDAQGLVPAIAQDAASGEILMVAWMNREALEETARTGRGVYFSRSRHKLWRKGEESGHVQTVSEIRLDCDN
DVILLKIEQLGGIACHTGRRSCFFHKLTTDDRGHADWVATEPVLKNPDEIYRR
>Mature_132_residues
SDWLDAVKWDAQGLVPAIAQDAASGEILMVAWMNREALEETARTGRGVYFSRSRHKLWRKGEESGHVQTVSEIRLDCDND
VILLKIEQLGGIACHTGRRSCFFHKLTTDDRGHADWVATEPVLKNPDEIYRR

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=90, Percent_Identity=47.7777777777778, Blast_Score=96, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6319819, Length=75, Percent_Identity=38.6666666666667, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_THIDA (Q3SEU9)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315465.1
- ProteinModelPortal:   Q3SEU9
- SMR:   Q3SEU9
- STRING:   Q3SEU9
- GeneID:   3671290
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1707
- NMPDR:   fig|292415.3.peg.1804
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   LWLKGES
- BioCyc:   TDEN292415:TBD_1707-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 15122; Mature: 14991

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDWLDAVKWDAQGLVPAIAQDAASGEILMVAWMNREALEETARTGRGVYFSRSRHKLWR
CCCHHHHHHCCCCCCCHHHHHCCCCCCEEEEEECCHHHHHHHHHCCCCEEEECHHHHHHH
KGEESGHVQTVSEIRLDCDNDVILLKIEQLGGIACHTGRRSCFFHKLTTDDRGHADWVAT
CCCCCCCEEEHHHEEECCCCCEEEEEECCCCCEEEECCCCCEEEEECCCCCCCCCCEEEC
EPVLKNPDEIYRR
CCCCCCHHHHHCC
>Mature Secondary Structure 
SDWLDAVKWDAQGLVPAIAQDAASGEILMVAWMNREALEETARTGRGVYFSRSRHKLWR
CCHHHHHHCCCCCCCHHHHHCCCCCCEEEEEECCHHHHHHHHHCCCCEEEECHHHHHHH
KGEESGHVQTVSEIRLDCDNDVILLKIEQLGGIACHTGRRSCFFHKLTTDDRGHADWVAT
CCCCCCCEEEHHHEEECCCCCEEEEEECCCCCEEEECCCCCEEEEECCCCCCCCCCEEEC
EPVLKNPDEIYRR
CCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA