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The map label for this gene is hisE

Identifier: 74317724

GI number: 74317724

Start: 1795831

End: 1796157

Strand: Reverse

Name: hisE

Synonym: Tbd_1706

Alternate gene names: 74317724

Gene position: 1796157-1795831 (Counterclockwise)

Preceding gene: 74317725

Following gene: 74317723

Centisome position: 61.73

GC content: 63.0

Gene sequence:

>327_bases
ATGAGCGATATCCTCGACCGCCTGGCGGAAATCCTCGAGGCGCGCAAGCAGGCCTCGCCGGACGCTTCCTACGTCGCCCG
ACTCTATGCCAAGGGCACCGACGCGATCCTCAAGAAGATCGGCGAGGAGGCAACCGAAACCGTGATGGCCGCGAAGGACG
ACCAGGCGGAAAAGATCATCTACGAGGTCGCGGATTTGTGGTTCCATACGCTCGTACTGCTCGCGCACAAGGGCCTCAAG
CCGGCGGACGTGCTCGAGGAACTGGCGCGCCGCGAGGGGCTTTCGGGGCTGACGGAAAAAGCGAACCGGCAAGGTGGATC
GACATGA

Upstream 100 bases:

>100_bases
GCTCGTGTTTCTTCCACAAGCTCACGACCGATGATCGGGGCCACGCGGACTGGGTGGCGACCGAGCCGGTGTTGAAGAAT
CCTGACGAGATCTACCGCAG

Downstream 100 bases:

>100_bases
GTGACTGCATCTTCTGCAAGATCGTCCGAGGCGAACTGCCCGCCAGCAAGGTCTATGAAGACGAGGAATTACTCGCCTTC
CACGACATCCATCCGTTTGC

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSDILDRLAEILEARKQASPDASYVARLYAKGTDAILKKIGEEATETVMAAKDDQAEKIIYEVADLWFHTLVLLAHKGLK
PADVLEELARREGLSGLTEKANRQGGST

Sequences:

>Translated_108_residues
MSDILDRLAEILEARKQASPDASYVARLYAKGTDAILKKIGEEATETVMAAKDDQAEKIIYEVADLWFHTLVLLAHKGLK
PADVLEELARREGLSGLTEKANRQGGST
>Mature_107_residues
SDILDRLAEILEARKQASPDASYVARLYAKGTDAILKKIGEEATETVMAAKDDQAEKIIYEVADLWFHTLVLLAHKGLKP
ADVLEELARREGLSGLTEKANRQGGST

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=88, Percent_Identity=43.1818181818182, Blast_Score=72, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_THIDA (Q3SI69)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315464.1
- ProteinModelPortal:   Q3SI69
- SMR:   Q3SI69
- STRING:   Q3SI69
- GeneID:   3671289
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1706
- NMPDR:   fig|292415.3.peg.1803
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- BioCyc:   TDEN292415:TBD_1706-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11840; Mature: 11708

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILDRLAEILEARKQASPDASYVARLYAKGTDAILKKIGEEATETVMAAKDDQAEKII
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
YEVADLWFHTLVLLAHKGLKPADVLEELARREGLSGLTEKANRQGGST
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCC
>Mature Secondary Structure 
SDILDRLAEILEARKQASPDASYVARLYAKGTDAILKKIGEEATETVMAAKDDQAEKII
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
YEVADLWFHTLVLLAHKGLKPADVLEELARREGLSGLTEKANRQGGST
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA