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The map label for this gene is lon [H]

Identifier: 74317693

GI number: 74317693

Start: 1761469

End: 1763886

Strand: Reverse

Name: lon [H]

Synonym: Tbd_1675

Alternate gene names: 74317693

Gene position: 1763886-1761469 (Counterclockwise)

Preceding gene: 74317694

Following gene: 74317692

Centisome position: 60.62

GC content: 62.41

Gene sequence:

>2418_bases
ATGATGAGCGACAACGTATCCACGGAAGAGATCGATCTGCCACTGTTGCCGCTTAGGGACGTGGTGGTGTTCCCGCATAT
GGTCATCCCCTTGTTCGTGGGGCGGCCGAAGTCGATCAAGGCGCTGGAAACCTCGATGGAATCCGGCAAGAGCATCCTCC
TCGTCGCGCAAAAAACGGCAGCGCAGGACGACCCGACCCCCGACGACCTCTACGACACCGGCAGCGTCGCCACCGTGCTG
CAGATGCTGAAACTGCCCGACGGTACCGTGAAGGTGCTGGTCGAAGGCAATCAGCGCGCGCGCGTGCTCAACGTCGCGGA
TACGGGCACGCATCTGAGCGCGCGCGCGCGCATCCTGCCCGCGGAAGGCGAGGAGTTGGTCGAAGTCGAGGCGATGCGTC
GCGCGCTCCTCACCCAGTTCGATCAGTACGTCAAACTGAACAAGAAGATCCCGCCGGAAATCCTGACCTCGCTTTCGGGG
ATCGACGAGGGCGGGCGCCTGGCCGACACCATCGTCGCGCACCTGCCGCTCAAGCTCGAGCAGAAGCAGGAAGTGCTCGA
GATGATCGGCGTCAACAAGCGGCTCGAGCATCTGCTCGGCCTGCTCGAGGGCGAGCTCGACATTCTCCAGGTCGAAAAGC
GGATCCGTGGCCGCGTCAAGCGGCAGATGGAGAAGAGCCAGCGCGAGTACTACCTGAACGAGCAGGTCAAGGCGATTCAG
AAAGAGCTCGGCGACATCGAGGAAGGCGCTGAGCTGGAAGAGCTCGACAAGCGAATCCGGCAGGCGAGCATGTCCAAGGA
AGCCGAGGCCAAGGCGCTCGGCGAACTGAAGAAGCTGCGTATGATGTCGCCGATGTCGGCGGAGGCGACTGTGATCCGCA
GCTACATCGAAGCCATGGTCGGGCTGCCGTGGAAAAAGAAAACCAAGATCAGCAAGGACCTGGCGAAGGCCGAGAAAGTG
CTCGATCAGGATCACTACGGTCTCGACAAGGTCAAGGAACGCATCCTCGAATATCTCGCCGTGCAGCAGCGCGTCGACAA
GGTCAAGGCGCCGATCCTGTGTCTGGTCGGGCCGCCCGGTGTCGGCAAGACCTCGCTCGGGCAGTCGATCGCGCGGGCGA
CCAACCGTAAGTTCGTGCGCATGGCGCTCGGCGGCGTACGTGATGAATCCGAGATCCGCGGCCACCGCCGCACCTACATC
GGATCGATGCCCGGCAAGATCCTGCAGAGCCTGACCAAGGTCGGCGTGAAGAACCCGCTATTCCTGCTCGACGAGGTCGA
CAAGATGGGACAGGACTTCCGCGGAGACCCGTCGTCGGCCCTGCTTGAGGTGCTCGATCCGGAGCAGAACCACACCTTCC
AGGATCACTACGTCGAGGTCGAATACGACCTGTCGGACGTGATGTTCGTCGCGACCGCGAACTCGCTCAATCTGCCCGCG
CCGCTGCTCGATCGGATGGAAGTGATCCGCCTTTCGGGTTACACCGAAGACGAGAAGATCAATATCGCCGAGCGTTACCT
GGTGCCCAAGCAACTCAAGGTCAACGGCATCAAGGACGGCGAGCTTTCGATCGCCGAGTCGGCCATTCGTGACATCGTCC
GTTACTACACGCGGGAAGCCGGCGTGCGCAGCCTCGAGCGCGAAATATCCAAGGTCTGCCGCAAGGCGGTCAAGGCGCTT
CTGCTCAAGCGGCAAAGCACGAAAATCGCCGTCACCTCGCGCAACCTGGAGAAGTATCTCGGTGTCCGTCGCTTCAGCTT
CGGGGTCGCGGAGAAGAACAACCAGGTTGGACAGGTCACGGGCCTTGCCTGGACCGAGGTCGGCGGCGAACTGCTGACGA
TCGAAGCCGTGGCCCTGCCCGGGCGCGGCAAGATGACGACCACCGGCAAGCTCGGCGAAGTCATGCAGGAGTCGATCCAG
GCTGCGCTCTCGGTCGTGCGGTCGCGCTCGCGCAAGTTGGGAATCCAGGAGGATTTCTATCAGAAGCGCGATATCCACAT
CCACCTGCCGGAAGGCGCGACGCCGAAAGACGGCCCCTCGGCCGGCATTGCAATCTGTACGTCGATGGTCTCGATCCTCA
CCGGAATCCCGGTGCGCGCCGATGTCGCGATGACCGGCGAGATCACGCTACGGGGCGAGGTGCTGCCGATCGGCGGGCTG
AAGGAGAAGCTGCTCGCCGCGCATCGTGGCGGCATCAAGACGGTGTTGATCCCGCAGGAGAACGTCAAGGACCTCACCGA
CATTCCCGACAACATCAAGAACAAGCTCGACATCCATCCCGTCAAGTGGATCGATCAGGTGCTCGAACTCGCGCTCGAAC
ATGTGCCCGAGCCGCTGAGCGAGGAATCGGAGTCGGAAACCCCCGCGATCGCGGTTTCCGAGGAGGGCGGCACGGCCGCA
AGGGCGCTGAAACACTAG

Upstream 100 bases:

>100_bases
GGAACCAGTCGGCCATCTTGAATTCCAAACTATGCCCCCCAACTGGGACAAGCGTGGTTGACATGCCGCGCGTCCTTTCC
CCAACCCTTGCCAGGAAATC

Downstream 100 bases:

>100_bases
GTTTCCCGCGACACATCGCCACGAATCCCGCGCCAGTCGCGGGATTTTTCATTGAGGTCCCCGGAAAACCGCTTGACACA
AGGTTTTTCACGTTGCTATA

Product: Lon-A peptidase

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 805; Mature: 805

Protein sequence:

>805_residues
MMSDNVSTEEIDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETSMESGKSILLVAQKTAAQDDPTPDDLYDTGSVATVL
QMLKLPDGTVKVLVEGNQRARVLNVADTGTHLSARARILPAEGEELVEVEAMRRALLTQFDQYVKLNKKIPPEILTSLSG
IDEGGRLADTIVAHLPLKLEQKQEVLEMIGVNKRLEHLLGLLEGELDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGDIEEGAELEELDKRIRQASMSKEAEAKALGELKKLRMMSPMSAEATVIRSYIEAMVGLPWKKKTKISKDLAKAEKV
LDQDHYGLDKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDESEIRGHRRTYI
GSMPGKILQSLTKVGVKNPLFLLDEVDKMGQDFRGDPSSALLEVLDPEQNHTFQDHYVEVEYDLSDVMFVATANSLNLPA
PLLDRMEVIRLSGYTEDEKINIAERYLVPKQLKVNGIKDGELSIAESAIRDIVRYYTREAGVRSLEREISKVCRKAVKAL
LLKRQSTKIAVTSRNLEKYLGVRRFSFGVAEKNNQVGQVTGLAWTEVGGELLTIEAVALPGRGKMTTTGKLGEVMQESIQ
AALSVVRSRSRKLGIQEDFYQKRDIHIHLPEGATPKDGPSAGIAICTSMVSILTGIPVRADVAMTGEITLRGEVLPIGGL
KEKLLAAHRGGIKTVLIPQENVKDLTDIPDNIKNKLDIHPVKWIDQVLELALEHVPEPLSEESESETPAIAVSEEGGTAA
RALKH

Sequences:

>Translated_805_residues
MMSDNVSTEEIDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETSMESGKSILLVAQKTAAQDDPTPDDLYDTGSVATVL
QMLKLPDGTVKVLVEGNQRARVLNVADTGTHLSARARILPAEGEELVEVEAMRRALLTQFDQYVKLNKKIPPEILTSLSG
IDEGGRLADTIVAHLPLKLEQKQEVLEMIGVNKRLEHLLGLLEGELDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGDIEEGAELEELDKRIRQASMSKEAEAKALGELKKLRMMSPMSAEATVIRSYIEAMVGLPWKKKTKISKDLAKAEKV
LDQDHYGLDKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDESEIRGHRRTYI
GSMPGKILQSLTKVGVKNPLFLLDEVDKMGQDFRGDPSSALLEVLDPEQNHTFQDHYVEVEYDLSDVMFVATANSLNLPA
PLLDRMEVIRLSGYTEDEKINIAERYLVPKQLKVNGIKDGELSIAESAIRDIVRYYTREAGVRSLEREISKVCRKAVKAL
LLKRQSTKIAVTSRNLEKYLGVRRFSFGVAEKNNQVGQVTGLAWTEVGGELLTIEAVALPGRGKMTTTGKLGEVMQESIQ
AALSVVRSRSRKLGIQEDFYQKRDIHIHLPEGATPKDGPSAGIAICTSMVSILTGIPVRADVAMTGEITLRGEVLPIGGL
KEKLLAAHRGGIKTVLIPQENVKDLTDIPDNIKNKLDIHPVKWIDQVLELALEHVPEPLSEESESETPAIAVSEEGGTAA
RALKH
>Mature_805_residues
MMSDNVSTEEIDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETSMESGKSILLVAQKTAAQDDPTPDDLYDTGSVATVL
QMLKLPDGTVKVLVEGNQRARVLNVADTGTHLSARARILPAEGEELVEVEAMRRALLTQFDQYVKLNKKIPPEILTSLSG
IDEGGRLADTIVAHLPLKLEQKQEVLEMIGVNKRLEHLLGLLEGELDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGDIEEGAELEELDKRIRQASMSKEAEAKALGELKKLRMMSPMSAEATVIRSYIEAMVGLPWKKKTKISKDLAKAEKV
LDQDHYGLDKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDESEIRGHRRTYI
GSMPGKILQSLTKVGVKNPLFLLDEVDKMGQDFRGDPSSALLEVLDPEQNHTFQDHYVEVEYDLSDVMFVATANSLNLPA
PLLDRMEVIRLSGYTEDEKINIAERYLVPKQLKVNGIKDGELSIAESAIRDIVRYYTREAGVRSLEREISKVCRKAVKAL
LLKRQSTKIAVTSRNLEKYLGVRRFSFGVAEKNNQVGQVTGLAWTEVGGELLTIEAVALPGRGKMTTTGKLGEVMQESIQ
AALSVVRSRSRKLGIQEDFYQKRDIHIHLPEGATPKDGPSAGIAICTSMVSILTGIPVRADVAMTGEITLRGEVLPIGGL
KEKLLAAHRGGIKTVLIPQENVKDLTDIPDNIKNKLDIHPVKWIDQVLELALEHVPEPLSEESESETPAIAVSEEGGTAA
RALKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=832, Percent_Identity=38.7019230769231, Blast_Score=526, Evalue=1e-149,
Organism=Homo sapiens, GI21396489, Length=827, Percent_Identity=35.7920193470375, Blast_Score=501, Evalue=1e-141,
Organism=Escherichia coli, GI1786643, Length=770, Percent_Identity=69.4805194805195, Blast_Score=1102, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=680, Percent_Identity=40.1470588235294, Blast_Score=485, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17556486, Length=630, Percent_Identity=37.6190476190476, Blast_Score=432, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6319449, Length=717, Percent_Identity=38.3542538354254, Blast_Score=498, Evalue=1e-141,
Organism=Drosophila melanogaster, GI221513036, Length=626, Percent_Identity=43.7699680511182, Blast_Score=500, Evalue=1e-141,
Organism=Drosophila melanogaster, GI24666867, Length=626, Percent_Identity=43.6102236421725, Blast_Score=500, Evalue=1e-141,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89142; Mature: 89142

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSDNVSTEEIDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETSMESGKSILLVAQKTA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEEHHC
AQDDPTPDDLYDTGSVATVLQMLKLPDGTVKVLVEGNQRARVLNVADTGTHLSARARILP
CCCCCCCCHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCCCCCEEEEC
AEGEELVEVEAMRRALLTQFDQYVKLNKKIPPEILTSLSGIDEGGRLADTIVAHLPLKLE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCHH
QKQEVLEMIGVNKRLEHLLGLLEGELDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
HHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELGDIEEGAELEELDKRIRQASMSKEAEAKALGELKKLRMMSPMSAEATVIRSYIEAMV
HHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GLPWKKKTKISKDLAKAEKVLDQDHYGLDKVKERILEYLAVQQRVDKVKAPILCLVGPPG
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
VGKTSLGQSIARATNRKFVRMALGGVRDESEIRGHRRTYIGSMPGKILQSLTKVGVKNPL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCCH
FLLDEVDKMGQDFRGDPSSALLEVLDPEQNHTFQDHYVEVEYDLSDVMFVATANSLNLPA
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCH
PLLDRMEVIRLSGYTEDEKINIAERYLVPKQLKVNGIKDGELSIAESAIRDIVRYYTREA
HHHHHHHHHHHCCCCCCCCCCHHHHHCCCCHHEECCCCCCCHHHHHHHHHHHHHHHHHHH
GVRSLEREISKVCRKAVKALLLKRQSTKIAVTSRNLEKYLGVRRFSFGVAEKNNQVGQVT
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCHHHHHCCCCCCCCCCEEEE
GLAWTEVGGELLTIEAVALPGRGKMTTTGKLGEVMQESIQAALSVVRSRSRKLGIQEDFY
CEEHHHCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
QKRDIHIHLPEGATPKDGPSAGIAICTSMVSILTGIPVRADVAMTGEITLRGEVLPIGGL
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCCH
KEKLLAAHRGGIKTVLIPQENVKDLTDIPDNIKNKLDIHPVKWIDQVLELALEHVPEPLS
HHHHHHHHCCCCEEEEECCCCCHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
EESESETPAIAVSEEGGTAARALKH
CCCCCCCCEEEEECCCCHHHHHHCC
>Mature Secondary Structure
MMSDNVSTEEIDLPLLPLRDVVVFPHMVIPLFVGRPKSIKALETSMESGKSILLVAQKTA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEEHHC
AQDDPTPDDLYDTGSVATVLQMLKLPDGTVKVLVEGNQRARVLNVADTGTHLSARARILP
CCCCCCCCHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCCCCCEEEEC
AEGEELVEVEAMRRALLTQFDQYVKLNKKIPPEILTSLSGIDEGGRLADTIVAHLPLKLE
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCHH
QKQEVLEMIGVNKRLEHLLGLLEGELDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
HHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KELGDIEEGAELEELDKRIRQASMSKEAEAKALGELKKLRMMSPMSAEATVIRSYIEAMV
HHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GLPWKKKTKISKDLAKAEKVLDQDHYGLDKVKERILEYLAVQQRVDKVKAPILCLVGPPG
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
VGKTSLGQSIARATNRKFVRMALGGVRDESEIRGHRRTYIGSMPGKILQSLTKVGVKNPL
CCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHCCCCHHHHHHHHHHHCCCCCH
FLLDEVDKMGQDFRGDPSSALLEVLDPEQNHTFQDHYVEVEYDLSDVMFVATANSLNLPA
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCCH
PLLDRMEVIRLSGYTEDEKINIAERYLVPKQLKVNGIKDGELSIAESAIRDIVRYYTREA
HHHHHHHHHHHCCCCCCCCCCHHHHHCCCCHHEECCCCCCCHHHHHHHHHHHHHHHHHHH
GVRSLEREISKVCRKAVKALLLKRQSTKIAVTSRNLEKYLGVRRFSFGVAEKNNQVGQVT
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCHHHHHCCCCCCCCCCEEEE
GLAWTEVGGELLTIEAVALPGRGKMTTTGKLGEVMQESIQAALSVVRSRSRKLGIQEDFY
CEEHHHCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
QKRDIHIHLPEGATPKDGPSAGIAICTSMVSILTGIPVRADVAMTGEITLRGEVLPIGGL
CCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCCH
KEKLLAAHRGGIKTVLIPQENVKDLTDIPDNIKNKLDIHPVKWIDQVLELALEHVPEPLS
HHHHHHHHCCCCEEEEECCCCCHHHHCCCHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCC
EESESETPAIAVSEEGGTAARALKH
CCCCCCCCEEEEECCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]