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The map label for this gene is ppiD [H]

Identifier: 74317691

GI number: 74317691

Start: 1758762

End: 1760705

Strand: Reverse

Name: ppiD [H]

Synonym: Tbd_1673

Alternate gene names: 74317691

Gene position: 1760705-1758762 (Counterclockwise)

Preceding gene: 74317692

Following gene: 74317689

Centisome position: 60.51

GC content: 65.48

Gene sequence:

>1944_bases
GTGCGCGAGAATTCGCCTGACCCAATTTCCGGAGTAGAAACAGTGCTGGAAGCAATCCGCAAGCATGCAAAGGGCTGGCT
GGCCAAAGTCATTCTCGGCCTGATCGCCGTGACGTTCGCCCTCTTCGGCATCGACTCCTACATGTCCGGGGATCGCAGCG
GCGGGGTGGTGGCCGAAGTCGGCAAGGTGGGGATCACGCGCGAAGAATTGACGCGCGAAATCCAGGCGCAGAGCGATCGC
CTGCGCGAGTCGCTCGGGCCCGCATTCGACCCCTCGATGACCGAAACCGCCGCGTTTCGCAAACAGGTGCTGGATAGCCT
GATCGAGCGCAAGGCCTTGCTGCTCGAAGCCGAGAAGCTCAAATTCCTCGCGCCGGATTCCTACGTCGCCGCCGCGATCG
GGCAGATTCCCGCGTTTCAACAGGACGGCAAGTTCTCGCCGCAGCGTTATGAAGCGATCCTCCGGCAGAACGGACGTACC
CCGGCGTCCTTCGAGAACGAACTGCGCCAGGCGTTCATGCTGGAGGGCGTGACGAGCCCGGTGACGCTCGCCGCCTTCAA
CGCGACTACCACGCTCGAGCAGGTCGCGCGGCTGGTCGCGCAGCAGCGCGAAATCTCCTGGGTCGATCTGCCGGTCGCCA
GCGTCGCCGACGAGGTCAAGGTGACCCCGGCGGACGTCGAACGCCATTACGCCGCCAACAAACCGGCCTTTACCGAACCC
GAACAGATTCGCGCCGAGTATGTCGTTCTCGATGCGGCTGCACTCGTCGCCGGCATCAGCGTCAGCGAACAGGCCGTCCG
CGACTACTATGCGGCGAATGCAGCGCAGTTCGGTCAGCCCGAACAGCGCAGCGCGAGTCACATCCTGATCGCGGCCGACA
AGGACAGCGACGCGGCCACTCGTGCCAAGGCCAAGGCGAAGGCGACCGCGCTGATGGAGACTCTGCGCAAGCAACCCGAG
CGTTTCGGCGAATTGGCGCGCAGCACCTCGCAGGATCCGGGGTCGGCGGAGCAGGACGGGAGCCTCGGCAGCTTCGGTCG
TGGCATGATGGTCAAGCCCTTCGAGGACGCCGTCTTCGCGATGAAGCCGAAGGAAATCCGCGGCCCCGTCGAGAGCGATT
TCGGCTATCACATCATCCGCCTGGACAGCATCGAGCCGGGCAAGGCGGCGCCGCTCGCCGAAGTCCGCGCCGCGATCGTC
GACGAGTTGCGCAAGCAGCAGGCGCAGAAGACCTTCGCCGACCTTGCCGACAACTTCAGCAATCTCGTCTATGAAAATGC
CGAGTCGCTGCAGCCCGCCGCGGCGGCTGCCAAACTCACGGTCCAACAAAGCGGCTGGATGAACGCGAAGGCAGCACCGC
CGCCCTTCGACAATCCGGCGCTCTCGGCCGCACTCTTCAGCCCCGAGTCGATCAAGTCCAGGCAGAACACCGAGGCGATC
GAGATCAAGCCGGGCACGCTCGTCGCCGCCCGTGTCGTCGAGCACCGCGCCGCCCGGCTGCGGCCGCTGTCGGAAGTGTC
GGCCGAGATCGAGCGGACGATGCGCGCGGAACAGACCGCGCAGCTGCTTGCGAAAAAGGCCGAGGCGACGATCAAGTCCC
TGCAGGACGGCAAGGAGTCGGGTCTCGACTGGACAGCGTTTCAGGTCGTCGGTCGCCAGCCCGGCGCGTCCCTCGACGCG
GCGGGTGTCAAGGCCGTGTTCCGCGCGAATGCTGAGAAAACGCCGGCGTATACCGGGTTTGCGCGACCCGACGGGTCGTA
TCGCATCGTGCGCGTGACGCGCGTGGTCGAGCCTGCGTCGCTCGATCCCATGCTCATGGAGTCGATCGGGTCGGGCGTCA
TGCAGGCGCAGCAGCGCGCCGACATGAAAGCCCTGATCGCGCTGGTGACCGCCGGCCACAAGGTCAAGATCCAGCCGAAC
GCGATCGAGGGCCGGGAAGACTAA

Upstream 100 bases:

>100_bases
AGTCCCGTCCACTCCGCCAACACCAAAAAGGCGAACGCGAGTTCGCCTTTTTTCATTTCGGCGTGTTTTCGTCCGGGGAG
GGCGAGACGCCGGGTGCAAA

Downstream 100 bases:

>100_bases
AAAAAACGCGCCTTCGGGCGCGTTTTTTTGGGGCTTTAGCGGCTCACGATTCGGCGCCCGCCGTCGAATTGAATCCGGCA
TCGACGTAGGTGATTTCCCC

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 647; Mature: 647

Protein sequence:

>647_residues
MRENSPDPISGVETVLEAIRKHAKGWLAKVILGLIAVTFALFGIDSYMSGDRSGGVVAEVGKVGITREELTREIQAQSDR
LRESLGPAFDPSMTETAAFRKQVLDSLIERKALLLEAEKLKFLAPDSYVAAAIGQIPAFQQDGKFSPQRYEAILRQNGRT
PASFENELRQAFMLEGVTSPVTLAAFNATTTLEQVARLVAQQREISWVDLPVASVADEVKVTPADVERHYAANKPAFTEP
EQIRAEYVVLDAAALVAGISVSEQAVRDYYAANAAQFGQPEQRSASHILIAADKDSDAATRAKAKAKATALMETLRKQPE
RFGELARSTSQDPGSAEQDGSLGSFGRGMMVKPFEDAVFAMKPKEIRGPVESDFGYHIIRLDSIEPGKAAPLAEVRAAIV
DELRKQQAQKTFADLADNFSNLVYENAESLQPAAAAAKLTVQQSGWMNAKAAPPPFDNPALSAALFSPESIKSRQNTEAI
EIKPGTLVAARVVEHRAARLRPLSEVSAEIERTMRAEQTAQLLAKKAEATIKSLQDGKESGLDWTAFQVVGRQPGASLDA
AGVKAVFRANAEKTPAYTGFARPDGSYRIVRVTRVVEPASLDPMLMESIGSGVMQAQQRADMKALIALVTAGHKVKIQPN
AIEGRED

Sequences:

>Translated_647_residues
MRENSPDPISGVETVLEAIRKHAKGWLAKVILGLIAVTFALFGIDSYMSGDRSGGVVAEVGKVGITREELTREIQAQSDR
LRESLGPAFDPSMTETAAFRKQVLDSLIERKALLLEAEKLKFLAPDSYVAAAIGQIPAFQQDGKFSPQRYEAILRQNGRT
PASFENELRQAFMLEGVTSPVTLAAFNATTTLEQVARLVAQQREISWVDLPVASVADEVKVTPADVERHYAANKPAFTEP
EQIRAEYVVLDAAALVAGISVSEQAVRDYYAANAAQFGQPEQRSASHILIAADKDSDAATRAKAKAKATALMETLRKQPE
RFGELARSTSQDPGSAEQDGSLGSFGRGMMVKPFEDAVFAMKPKEIRGPVESDFGYHIIRLDSIEPGKAAPLAEVRAAIV
DELRKQQAQKTFADLADNFSNLVYENAESLQPAAAAAKLTVQQSGWMNAKAAPPPFDNPALSAALFSPESIKSRQNTEAI
EIKPGTLVAARVVEHRAARLRPLSEVSAEIERTMRAEQTAQLLAKKAEATIKSLQDGKESGLDWTAFQVVGRQPGASLDA
AGVKAVFRANAEKTPAYTGFARPDGSYRIVRVTRVVEPASLDPMLMESIGSGVMQAQQRADMKALIALVTAGHKVKIQPN
AIEGRED
>Mature_647_residues
MRENSPDPISGVETVLEAIRKHAKGWLAKVILGLIAVTFALFGIDSYMSGDRSGGVVAEVGKVGITREELTREIQAQSDR
LRESLGPAFDPSMTETAAFRKQVLDSLIERKALLLEAEKLKFLAPDSYVAAAIGQIPAFQQDGKFSPQRYEAILRQNGRT
PASFENELRQAFMLEGVTSPVTLAAFNATTTLEQVARLVAQQREISWVDLPVASVADEVKVTPADVERHYAANKPAFTEP
EQIRAEYVVLDAAALVAGISVSEQAVRDYYAANAAQFGQPEQRSASHILIAADKDSDAATRAKAKAKATALMETLRKQPE
RFGELARSTSQDPGSAEQDGSLGSFGRGMMVKPFEDAVFAMKPKEIRGPVESDFGYHIIRLDSIEPGKAAPLAEVRAAIV
DELRKQQAQKTFADLADNFSNLVYENAESLQPAAAAAKLTVQQSGWMNAKAAPPPFDNPALSAALFSPESIKSRQNTEAI
EIKPGTLVAARVVEHRAARLRPLSEVSAEIERTMRAEQTAQLLAKKAEATIKSLQDGKESGLDWTAFQVVGRQPGASLDA
AGVKAVFRANAEKTPAYTGFARPDGSYRIVRVTRVVEPASLDPMLMESIGSGVMQAQQRADMKALIALVTAGHKVKIQPN
AIEGRED

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=534, Percent_Identity=28.4644194756554, Blast_Score=198, Evalue=9e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 69979; Mature: 69979

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRENSPDPISGVETVLEAIRKHAKGWLAKVILGLIAVTFALFGIDSYMSGDRSGGVVAEV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
GKVGITREELTREIQAQSDRLRESLGPAFDPSMTETAAFRKQVLDSLIERKALLLEAEKL
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFLAPDSYVAAAIGQIPAFQQDGKFSPQRYEAILRQNGRTPASFENELRQAFMLEGVTSP
HEECCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
VTLAAFNATTTLEQVARLVAQQREISWVDLPVASVADEVKVTPADVERHYAANKPAFTEP
EEEEEECHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHCCCCHHHHHHHHCCCCCCCCCH
EQIRAEYVVLDAAALVAGISVSEQAVRDYYAANAAQFGQPEQRSASHILIAADKDSDAAT
HHHHHHHHEEHHHHHHHCCCHHHHHHHHHHHHCHHHCCCCCCCCCCEEEEEECCCCCHHH
RAKAKAKATALMETLRKQPERFGELARSTSQDPGSAEQDGSLGSFGRGMMVKPFEDAVFA
HHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHE
MKPKEIRGPVESDFGYHIIRLDSIEPGKAAPLAEVRAAIVDELRKQQAQKTFADLADNFS
ECCHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLVYENAESLQPAAAAAKLTVQQSGWMNAKAAPPPFDNPALSAALFSPESIKSRQNTEAI
HHHHHCHHHCCHHHHHHHEEEECCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHCCCCCEE
EIKPGTLVAARVVEHRAARLRPLSEVSAEIERTMRAEQTAQLLAKKAEATIKSLQDGKES
EECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHC
GLDWTAFQVVGRQPGASLDAAGVKAVFRANAEKTPAYTGFARPDGSYRIVRVTRVVEPAS
CCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCC
LDPMLMESIGSGVMQAQQRADMKALIALVTAGHKVKIQPNAIEGRED
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MRENSPDPISGVETVLEAIRKHAKGWLAKVILGLIAVTFALFGIDSYMSGDRSGGVVAEV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
GKVGITREELTREIQAQSDRLRESLGPAFDPSMTETAAFRKQVLDSLIERKALLLEAEKL
HHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFLAPDSYVAAAIGQIPAFQQDGKFSPQRYEAILRQNGRTPASFENELRQAFMLEGVTSP
HEECCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
VTLAAFNATTTLEQVARLVAQQREISWVDLPVASVADEVKVTPADVERHYAANKPAFTEP
EEEEEECHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHCCCCHHHHHHHHCCCCCCCCCH
EQIRAEYVVLDAAALVAGISVSEQAVRDYYAANAAQFGQPEQRSASHILIAADKDSDAAT
HHHHHHHHEEHHHHHHHCCCHHHHHHHHHHHHCHHHCCCCCCCCCCEEEEEECCCCCHHH
RAKAKAKATALMETLRKQPERFGELARSTSQDPGSAEQDGSLGSFGRGMMVKPFEDAVFA
HHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHE
MKPKEIRGPVESDFGYHIIRLDSIEPGKAAPLAEVRAAIVDELRKQQAQKTFADLADNFS
ECCHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLVYENAESLQPAAAAAKLTVQQSGWMNAKAAPPPFDNPALSAALFSPESIKSRQNTEAI
HHHHHCHHHCCHHHHHHHEEEECCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHCCCCCEE
EIKPGTLVAARVVEHRAARLRPLSEVSAEIERTMRAEQTAQLLAKKAEATIKSLQDGKES
EECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHC
GLDWTAFQVVGRQPGASLDAAGVKAVFRANAEKTPAYTGFARPDGSYRIVRVTRVVEPAS
CCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCC
LDPMLMESIGSGVMQAQQRADMKALIALVTAGHKVKIQPNAIEGRED
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]