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The map label for this gene is appC [H]

Identifier: 74317687

GI number: 74317687

Start: 1753335

End: 1754741

Strand: Reverse

Name: appC [H]

Synonym: Tbd_1669

Alternate gene names: 74317687

Gene position: 1754741-1753335 (Counterclockwise)

Preceding gene: 74317688

Following gene: 74317686

Centisome position: 60.3

GC content: 67.95

Gene sequence:

>1407_bases
ATGACGATCCAGCCGGTGATCCTGTGGACCGACGCGCTGGTCTTCCTGTTGGTCGCCGCCTTGCTGGGGCTGGCGTGGTT
CATCCGGCGCCGACCGCATCTGCGCGCGCCCTGGCGGGCGGTCGGCGAGCGTCCGATGGCGGTCGGTGCGGCGCTGGTGC
TGGCGGTGTTCGCCACGATCGGGCTGCTCGATTCCTTGCACTACCGCGAGCGTCTCGCCGACAGCCCTGCAGACACGCCC
CACTATGCGGTCGACGTGAAGTCGGCATTCGACGTGCTGCTCGGCGACCTGCCGAAGCGTCAGGAAAAGACCTATTCGGC
GCCTCTCGCGACGCGGCTTTATGCCAAGGAATTCGTCGAGCGCAATGGCGAAACCGTGCACGACTACCCGCGCTTGCGCT
ACGGCGGCGCGCATCTGAAGGGTGACGACGCGCGCGCGGGCGACATCGCCCTGCGCGTGCTCGGCGGTCTCGCTGCGGGG
CTCTTCGCCAGCCTCGTTCTGTTCGCCTTGCTCGCCACGTGGCAGGCGAGGCGGTTGCGGCGGCCGCTCGGCGGATGGCT
TGCCGACTGGCGCCGGGGCCGTCTCGGCTGGCCCGCGCGGACGGTGGTCGTGGTCGCCTCGCTGATGCTGATGCTCGCCG
GCGTGATCGTGCAGCTCGCGGCCGGCTACCACGTGCTCGGTACCGACAAGGTCGGCCAGGACGTGCTCTACATCAGCCTC
AAGAGCATACGCACGGGCCTCGTGATCGGCACCTTGACGACGCTCGTCACCTTGCCGCTCGCGATCGGATTCGGCATCGC
CGCCGGCTATTTCCGGGGCTGGGTCGACGACGTGATCCAGTACGTCTACACCGTGCTCAACTCGATTCCGGGCGTATTGC
TGATCGCCGCCGCCGTGCTGATCGTTCAGGTCTACATCGAGTCCAATCCCGAGGCCTTCGACACCGCGGCGGCGCGCGCC
GACGTTCGCCTGCTCGCGCTCTCCCTCATCATGGGCGTGACGAGCTGGACCGGCCTCGCGCGACTGCTGCGCGGCGAATC
GCTCAAGCTCAGGACGCTCGACTACATCGAGGCGGCGCGCGCGTTCGGCGTCAGCCACGTCCGCATCGTCAGCCGCCATA
TCTTTCCGAACGTTTTCCATCTCGTGCTGATCGCGATCGTGCTCGATTTCTCGGGGCTCGTCCTCGCCGAGGCCGTGCTT
TCCTACGTCGGCGTCGGCGTCGACCCGACGATGTACAGCTGGGGCAACATGATCAACGGCGCACGACTCGAACTCGGGCG
CGAGCCCGTCGTCTGGTGGCAGCTCGCGGCCGCGTTCGTCTTCATGTTCACGCTCGTGCTCGCGGCGAACCTCTTCGCCG
ACGGCGTCCGCGACGCCTTCGATCCCCGCCAGGGAGCGCGCCGGTGA

Upstream 100 bases:

>100_bases
TCGTGCGCGCGATGGTCTTCCTCGGTTCCTTCCTCTACATCGTCGGCCTGATTCTTACCGACATCTCCTACTCGTGGGTC
GATCCGAGGGTGCGGCTGCA

Downstream 100 bases:

>100_bases
AGCCGCTGTTGCAGGTCGACCGGCTCGTCACCGCGTTCGGCGAGGGTAAAGACGCCGTGGGCGTCGTCGACGGGGTGTCG
TTCCGCGTCGACGCGGGCGA

Product: oligopeptide ABC transporter permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MTIQPVILWTDALVFLLVAALLGLAWFIRRRPHLRAPWRAVGERPMAVGAALVLAVFATIGLLDSLHYRERLADSPADTP
HYAVDVKSAFDVLLGDLPKRQEKTYSAPLATRLYAKEFVERNGETVHDYPRLRYGGAHLKGDDARAGDIALRVLGGLAAG
LFASLVLFALLATWQARRLRRPLGGWLADWRRGRLGWPARTVVVVASLMLMLAGVIVQLAAGYHVLGTDKVGQDVLYISL
KSIRTGLVIGTLTTLVTLPLAIGFGIAAGYFRGWVDDVIQYVYTVLNSIPGVLLIAAAVLIVQVYIESNPEAFDTAAARA
DVRLLALSLIMGVTSWTGLARLLRGESLKLRTLDYIEAARAFGVSHVRIVSRHIFPNVFHLVLIAIVLDFSGLVLAEAVL
SYVGVGVDPTMYSWGNMINGARLELGREPVVWWQLAAAFVFMFTLVLAANLFADGVRDAFDPRQGARR

Sequences:

>Translated_468_residues
MTIQPVILWTDALVFLLVAALLGLAWFIRRRPHLRAPWRAVGERPMAVGAALVLAVFATIGLLDSLHYRERLADSPADTP
HYAVDVKSAFDVLLGDLPKRQEKTYSAPLATRLYAKEFVERNGETVHDYPRLRYGGAHLKGDDARAGDIALRVLGGLAAG
LFASLVLFALLATWQARRLRRPLGGWLADWRRGRLGWPARTVVVVASLMLMLAGVIVQLAAGYHVLGTDKVGQDVLYISL
KSIRTGLVIGTLTTLVTLPLAIGFGIAAGYFRGWVDDVIQYVYTVLNSIPGVLLIAAAVLIVQVYIESNPEAFDTAAARA
DVRLLALSLIMGVTSWTGLARLLRGESLKLRTLDYIEAARAFGVSHVRIVSRHIFPNVFHLVLIAIVLDFSGLVLAEAVL
SYVGVGVDPTMYSWGNMINGARLELGREPVVWWQLAAAFVFMFTLVLAANLFADGVRDAFDPRQGARR
>Mature_467_residues
TIQPVILWTDALVFLLVAALLGLAWFIRRRPHLRAPWRAVGERPMAVGAALVLAVFATIGLLDSLHYRERLADSPADTPH
YAVDVKSAFDVLLGDLPKRQEKTYSAPLATRLYAKEFVERNGETVHDYPRLRYGGAHLKGDDARAGDIALRVLGGLAAGL
FASLVLFALLATWQARRLRRPLGGWLADWRRGRLGWPARTVVVVASLMLMLAGVIVQLAAGYHVLGTDKVGQDVLYISLK
SIRTGLVIGTLTTLVTLPLAIGFGIAAGYFRGWVDDVIQYVYTVLNSIPGVLLIAAAVLIVQVYIESNPEAFDTAAARAD
VRLLALSLIMGVTSWTGLARLLRGESLKLRTLDYIEAARAFGVSHVRIVSRHIFPNVFHLVLIAIVLDFSGLVLAEAVLS
YVGVGVDPTMYSWGNMINGARLELGREPVVWWQLAAAFVFMFTLVLAANLFADGVRDAFDPRQGARR

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787054, Length=240, Percent_Identity=30, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787760, Length=250, Percent_Identity=29.2, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI1787498, Length=241, Percent_Identity=30.2904564315353, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1789964, Length=240, Percent_Identity=31.6666666666667, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788505, Length=239, Percent_Identity=29.2887029288703, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1789889, Length=240, Percent_Identity=27.5, Blast_Score=75, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 51212; Mature: 51081

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIQPVILWTDALVFLLVAALLGLAWFIRRRPHLRAPWRAVGERPMAVGAALVLAVFATI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHH
GLLDSLHYRERLADSPADTPHYAVDVKSAFDVLLGDLPKRQEKTYSAPLATRLYAKEFVE
HHHHHHHHHHHHCCCCCCCCCEEEEHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHH
RNGETVHDYPRLRYGGAHLKGDDARAGDIALRVLGGLAAGLFASLVLFALLATWQARRLR
CCCCEEHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPLGGWLADWRRGRLGWPARTVVVVASLMLMLAGVIVQLAAGYHVLGTDKVGQDVLYISL
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCHHHHHHH
KSIRTGLVIGTLTTLVTLPLAIGFGIAAGYFRGWVDDVIQYVYTVLNSIPGVLLIAAAVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
IVQVYIESNPEAFDTAAARADVRLLALSLIMGVTSWTGLARLLRGESLKLRTLDYIEAAR
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHH
AFGVSHVRIVSRHIFPNVFHLVLIAIVLDFSGLVLAEAVLSYVGVGVDPTMYSWGNMING
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHCCCCC
ARLELGREPVVWWQLAAAFVFMFTLVLAANLFADGVRDAFDPRQGARR
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TIQPVILWTDALVFLLVAALLGLAWFIRRRPHLRAPWRAVGERPMAVGAALVLAVFATI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHH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HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]