Click here to switch to the map view.

The map label for this gene is hdrA [H]

Identifier: 74317665

GI number: 74317665

Start: 1730050

End: 1732308

Strand: Reverse

Name: hdrA [H]

Synonym: Tbd_1647

Alternate gene names: 74317665

Gene position: 1732308-1730050 (Counterclockwise)

Preceding gene: 74317666

Following gene: 74317664

Centisome position: 59.53

GC content: 65.52

Gene sequence:

>2259_bases
ATGGCTGACATCAAAGTCGCAGCGTACATCTGCAAGGGCTGCGGACTCGGCGAGCGCCTCGACACCGACGCGCTCGTGAA
GATCGCGCAGAAGGACGGCAAGGTCCCTCTCGCCAAGTCGCACGATTTCCTGTGCAACGCCGACGGCGTCGCGATGATCA
AGAACGACATCGCCAACGAGGGCGTGACCCACATCATGATCGGCGCGTGCTCGCGGCGCGCCAAGACCGAGGCGTTCTAT
TTTCCCGAAAACGCCGTCGCACGCGCCAACCTGCGCGAGGGCGTGATCTGGATCCGCCCCGACACCGACGAGGCGCGCGA
GACGACGCAGGAGATGGCCGAGGACTACGTCCGCATGGGCTGTGCCGAAGTCAAGGCGATGGCCGCGCCGGCGGGCAACC
CCAACACCGGGAGCAGCAAGACGCTGCTCGTCGTCGGCGGCGGCGTGACCGGCATGACGACCGCGATCGAGGCGTCCAAG
ACCGGCTACCCGGTCGTGCTCGTCGAAAAATCCGGCGCGCTGGGCGGCTGGGGCGGCAAGCTTTACAAGCGCGTGCCTGT
GCACGAGCCCTACAAAACGCCGATGGACACGGGCGTCGCCGACCTCGTCTCGCAGGTCCTCGGCGACAGCAACATCAAGC
TGTATCTGAACGCGAGCATCGCGAAGACCGACGGCGCGCCCGGACGCTTCGTCGTCGAGATCGCGACCGAGTCCGGCGCG
ACGCACACCGAGGACATCGGCGCGATCGTGCAGGCGACCGGCTTCACGCTGTACGACATGAACAAGCTGCCCGAGCTCGG
CGCGGGCAAGTCGCCGAACGTCGTCGACCAGGCGGGGCTCGAGGCCCTGGCGAATGCTGCGGCCGCGGGCGACGGCGTGA
TTCGCCGGCCTTCCGACGGTCAGCCCGTCAAGTCGGTCGTGTTCGTGCAGTGTGCCGGTCAGCGCGATCCGACGGGTCAG
CACCTGTCCTACTGTTCGGGCTTCTGCTGCAACGCCAGCATCAAGCAGGCGATGTACTTCAAGGACGCCAACCCGGCGGT
CGACACGACGATCATCTATACCGACCTGCGCACGCCCGGCAACGGCGAAGACTTCTACCGCAGCGCGCAGGAGAAGGGCG
TCATCTTCACCAAGGGCAAGGTCTCGGAAGTCGTCCCCGGCGGCGACAGCCTCACCGTGACCTTCCACGATCTGATCCTC
GACGACAGCAAGGCGACAATGGGCGACGTCGACCTCGTCGTGCTGGCAACCGGCCAGGTCGCGAACTCGGGCGTCAACAT
CGACGCCCTGACCAAACCGCAGGTCGAGGGCCAGGAAGGTGGACAGCAGTCCGGCGCGACGGTCGAAGTCAAGCCGATCT
CGATCCTCAACCTGACCTATCGTCAGGGCCCGGACGTGCCGCAGCTGAAGCAGGGCTTCACCGACTCGCACTTCATCTGC
TTCCCTTACGAAACGCGCCGCACGGGCATCTACACGGCCGGCCCGGTGCGTCGTCCGATGGACATGACGCAGGCCCGCGA
GGACGCGACCGGCGCCGCGCTGAAGGCGATCCAGGCGCTGGAAAATGCCGAACTGGGCCGCGCGGCGCATCCGCGCTCGG
GCGATCTTTCCTTCCCGAAGGTGCGTCTCGAAGGCTGCACGCAGTGCAAGCGCTGTACGGTCGAATGTCCGTTCGGTGCG
ATCGACGAGGACGAGAAGCGCTTCCCGGTCTTCAACGAATCGCGCTGCCGCCGGTGCGGTACCTGCATGGGCGCGTGCCC
GGTGCGCGTGATTTCGTTCGAGAACTACTCGGTCAACACGGTCGGCGCGCAGATCAAGGCCGTCGACATTCCCGACGAAT
TCAGCGAGAAGCCGCGCATCCTGATCCTCGCCTGCGAGAACGACGCCTACCCCGCGCTCGACATGGCCGGCATGAACCGC
AACGAGTACTCGGCCTTCGTGCGCATCATCCCGATCCGCTGTCTCGGTTCGGTCAACACGATCTGGGTGACCGACGCGCT
CAACGCGGGCTACGACGGCGTCATGATGATGGGCTGCAAGTCCGGCGACGAGTACCAGTGCCACTTCGTCAAAGGCTCGG
AGCTGGGCCGCGTGCGCATGTCCAAGATCGACGACACGCTGAAGACGCTCAACCTGGAGTCGGAGCGCGTGCGCGATCTC
GAGGTGGCGATCACCGACATCGAACGCGTGCCCGAGATGATCAACAAGTACGCGGAAGAGCTGGTTGCCGTCGGCCCCAG
CCCGTTCAAGGGATTCTAA

Upstream 100 bases:

>100_bases
GAACGCGCTCGACGTCAACCGGGCGGTGCAGTCGGCGACGGCCGCGGCATTGCGCGCCATCCAGGTGGTCAACAAAGTAG
CAAAGGCGGAGGCTTAAGAA

Downstream 100 bases:

>100_bases
AATGCATCGGCCATTTTTGACGAGGCATCAGACCGGAGTGAATGCATGAGCGCGAACACCGCAATGGCGGAGAGGTACCG
CAACAATTTCCTCAAGGAAA

Product: heterodisulfide reductase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 752; Mature: 751

Protein sequence:

>752_residues
MADIKVAAYICKGCGLGERLDTDALVKIAQKDGKVPLAKSHDFLCNADGVAMIKNDIANEGVTHIMIGACSRRAKTEAFY
FPENAVARANLREGVIWIRPDTDEARETTQEMAEDYVRMGCAEVKAMAAPAGNPNTGSSKTLLVVGGGVTGMTTAIEASK
TGYPVVLVEKSGALGGWGGKLYKRVPVHEPYKTPMDTGVADLVSQVLGDSNIKLYLNASIAKTDGAPGRFVVEIATESGA
THTEDIGAIVQATGFTLYDMNKLPELGAGKSPNVVDQAGLEALANAAAAGDGVIRRPSDGQPVKSVVFVQCAGQRDPTGQ
HLSYCSGFCCNASIKQAMYFKDANPAVDTTIIYTDLRTPGNGEDFYRSAQEKGVIFTKGKVSEVVPGGDSLTVTFHDLIL
DDSKATMGDVDLVVLATGQVANSGVNIDALTKPQVEGQEGGQQSGATVEVKPISILNLTYRQGPDVPQLKQGFTDSHFIC
FPYETRRTGIYTAGPVRRPMDMTQAREDATGAALKAIQALENAELGRAAHPRSGDLSFPKVRLEGCTQCKRCTVECPFGA
IDEDEKRFPVFNESRCRRCGTCMGACPVRVISFENYSVNTVGAQIKAVDIPDEFSEKPRILILACENDAYPALDMAGMNR
NEYSAFVRIIPIRCLGSVNTIWVTDALNAGYDGVMMMGCKSGDEYQCHFVKGSELGRVRMSKIDDTLKTLNLESERVRDL
EVAITDIERVPEMINKYAEELVAVGPSPFKGF

Sequences:

>Translated_752_residues
MADIKVAAYICKGCGLGERLDTDALVKIAQKDGKVPLAKSHDFLCNADGVAMIKNDIANEGVTHIMIGACSRRAKTEAFY
FPENAVARANLREGVIWIRPDTDEARETTQEMAEDYVRMGCAEVKAMAAPAGNPNTGSSKTLLVVGGGVTGMTTAIEASK
TGYPVVLVEKSGALGGWGGKLYKRVPVHEPYKTPMDTGVADLVSQVLGDSNIKLYLNASIAKTDGAPGRFVVEIATESGA
THTEDIGAIVQATGFTLYDMNKLPELGAGKSPNVVDQAGLEALANAAAAGDGVIRRPSDGQPVKSVVFVQCAGQRDPTGQ
HLSYCSGFCCNASIKQAMYFKDANPAVDTTIIYTDLRTPGNGEDFYRSAQEKGVIFTKGKVSEVVPGGDSLTVTFHDLIL
DDSKATMGDVDLVVLATGQVANSGVNIDALTKPQVEGQEGGQQSGATVEVKPISILNLTYRQGPDVPQLKQGFTDSHFIC
FPYETRRTGIYTAGPVRRPMDMTQAREDATGAALKAIQALENAELGRAAHPRSGDLSFPKVRLEGCTQCKRCTVECPFGA
IDEDEKRFPVFNESRCRRCGTCMGACPVRVISFENYSVNTVGAQIKAVDIPDEFSEKPRILILACENDAYPALDMAGMNR
NEYSAFVRIIPIRCLGSVNTIWVTDALNAGYDGVMMMGCKSGDEYQCHFVKGSELGRVRMSKIDDTLKTLNLESERVRDL
EVAITDIERVPEMINKYAEELVAVGPSPFKGF
>Mature_751_residues
ADIKVAAYICKGCGLGERLDTDALVKIAQKDGKVPLAKSHDFLCNADGVAMIKNDIANEGVTHIMIGACSRRAKTEAFYF
PENAVARANLREGVIWIRPDTDEARETTQEMAEDYVRMGCAEVKAMAAPAGNPNTGSSKTLLVVGGGVTGMTTAIEASKT
GYPVVLVEKSGALGGWGGKLYKRVPVHEPYKTPMDTGVADLVSQVLGDSNIKLYLNASIAKTDGAPGRFVVEIATESGAT
HTEDIGAIVQATGFTLYDMNKLPELGAGKSPNVVDQAGLEALANAAAAGDGVIRRPSDGQPVKSVVFVQCAGQRDPTGQH
LSYCSGFCCNASIKQAMYFKDANPAVDTTIIYTDLRTPGNGEDFYRSAQEKGVIFTKGKVSEVVPGGDSLTVTFHDLILD
DSKATMGDVDLVVLATGQVANSGVNIDALTKPQVEGQEGGQQSGATVEVKPISILNLTYRQGPDVPQLKQGFTDSHFICF
PYETRRTGIYTAGPVRRPMDMTQAREDATGAALKAIQALENAELGRAAHPRSGDLSFPKVRLEGCTQCKRCTVECPFGAI
DEDEKRFPVFNESRCRRCGTCMGACPVRVISFENYSVNTVGAQIKAVDIPDEFSEKPRILILACENDAYPALDMAGMNRN
EYSAFVRIIPIRCLGSVNTIWVTDALNAGYDGVMMMGCKSGDEYQCHFVKGSELGRVRMSKIDDTLKTLNLESERVRDLE
VAITDIERVPEMINKYAEELVAVGPSPFKGF

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953
- InterPro:   IPR003813
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4; PF02662 FlpD [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 80813; Mature: 80682

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIKVAAYICKGCGLGERLDTDALVKIAQKDGKVPLAKSHDFLCNADGVAMIKNDIANE
CCCCEEEHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEECCCCCEEHHHHHCCC
GVTHIMIGACSRRAKTEAFYFPENAVARANLREGVIWIRPDTDEARETTQEMAEDYVRMG
CCEEEEEEHHCCCCCCCEEECCCCHHHHCHHHCCEEEEECCCHHHHHHHHHHHHHHHHHC
CAEVKAMAAPAGNPNTGSSKTLLVVGGGVTGMTTAIEASKTGYPVVLVEKSGALGGWGGK
HHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCEEEEECCCCCCCCCCH
LYKRVPVHEPYKTPMDTGVADLVSQVLGDSNIKLYLNASIAKTDGAPGRFVVEIATESGA
HHEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEEECCCCCCEEEEEEECCCCC
THTEDIGAIVQATGFTLYDMNKLPELGAGKSPNVVDQAGLEALANAAAAGDGVIRRPSDG
CCHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCC
QPVKSVVFVQCAGQRDPTGQHLSYCSGFCCNASIKQAMYFKDANPAVDTTIIYTDLRTPG
CCCCEEEEEEECCCCCCCCCHHHHHCCCCCCCHHHHHEEECCCCCCCCEEEEEEECCCCC
NGEDFYRSAQEKGVIFTKGKVSEVVPGGDSLTVTFHDLILDDSKATMGDVDLVVLATGQV
CCHHHHHHHHHCCEEEECCCCCEECCCCCEEEEEEEEEEEECCCCCCCCEEEEEEEECCC
ANSGVNIDALTKPQVEGQEGGQQSGATVEVKPISILNLTYRQGPDVPQLKQGFTDSHFIC
CCCCCCEEEECCCCCCCCCCCCCCCCEEEEECEEEEEEEECCCCCCHHHHHCCCCCCEEE
FPYETRRTGIYTAGPVRRPMDMTQAREDATGAALKAIQALENAELGRAAHPRSGDLSFPK
EECCCCCCCEEECCCCCCCCHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
VRLEGCTQCKRCTVECPFGAIDEDEKRFPVFNESRCRRCGTCMGACPVRVISFENYSVNT
EHHHHCCCHHHEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEECCCEEEE
VGAQIKAVDIPDEFSEKPRILILACENDAYPALDMAGMNRNEYSAFVRIIPIRCLGSVNT
ECCEEEEEECCHHHCCCCCEEEEEECCCCCCCEECCCCCCHHHEEEEEEEEEEECCCCCE
IWVTDALNAGYDGVMMMGCKSGDEYQCHFVKGSELGRVRMSKIDDTLKTLNLESERVRDL
EEEEECCCCCCCCEEEEECCCCCCEEEEEECCCCCCCEEHHHHHHHHHHCCCCHHHHHHH
EVAITDIERVPEMINKYAEELVAVGPSPFKGF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ADIKVAAYICKGCGLGERLDTDALVKIAQKDGKVPLAKSHDFLCNADGVAMIKNDIANE
CCCEEEHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEECCCCCEEHHHHHCCC
GVTHIMIGACSRRAKTEAFYFPENAVARANLREGVIWIRPDTDEARETTQEMAEDYVRMG
CCEEEEEEHHCCCCCCCEEECCCCHHHHCHHHCCEEEEECCCHHHHHHHHHHHHHHHHHC
CAEVKAMAAPAGNPNTGSSKTLLVVGGGVTGMTTAIEASKTGYPVVLVEKSGALGGWGGK
HHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCEEEEECCCCCCCCCCH
LYKRVPVHEPYKTPMDTGVADLVSQVLGDSNIKLYLNASIAKTDGAPGRFVVEIATESGA
HHEECCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEEEEEECCCCCCEEEEEEECCCCC
THTEDIGAIVQATGFTLYDMNKLPELGAGKSPNVVDQAGLEALANAAAAGDGVIRRPSDG
CCHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCC
QPVKSVVFVQCAGQRDPTGQHLSYCSGFCCNASIKQAMYFKDANPAVDTTIIYTDLRTPG
CCCCEEEEEEECCCCCCCCCHHHHHCCCCCCCHHHHHEEECCCCCCCCEEEEEEECCCCC
NGEDFYRSAQEKGVIFTKGKVSEVVPGGDSLTVTFHDLILDDSKATMGDVDLVVLATGQV
CCHHHHHHHHHCCEEEECCCCCEECCCCCEEEEEEEEEEEECCCCCCCCEEEEEEEECCC
ANSGVNIDALTKPQVEGQEGGQQSGATVEVKPISILNLTYRQGPDVPQLKQGFTDSHFIC
CCCCCCEEEECCCCCCCCCCCCCCCCEEEEECEEEEEEEECCCCCCHHHHHCCCCCCEEE
FPYETRRTGIYTAGPVRRPMDMTQAREDATGAALKAIQALENAELGRAAHPRSGDLSFPK
EECCCCCCCEEECCCCCCCCHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
VRLEGCTQCKRCTVECPFGAIDEDEKRFPVFNESRCRRCGTCMGACPVRVISFENYSVNT
EHHHHCCCHHHEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEECCCEEEE
VGAQIKAVDIPDEFSEKPRILILACENDAYPALDMAGMNRNEYSAFVRIIPIRCLGSVNT
ECCEEEEEECCHHHCCCCCEEEEEECCCCCCCEECCCCCCHHHEEEEEEEEEEECCCCCE
IWVTDALNAGYDGVMMMGCKSGDEYQCHFVKGSELGRVRMSKIDDTLKTLNLESERVRDL
EEEEECCCCCCCCEEEEECCCCCCEEEEEECCCCCCCEEHHHHHHHHHHCCCCHHHHHHH
EVAITDIERVPEMINKYAEELVAVGPSPFKGF
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]