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The map label for this gene is hdrA [H]

Identifier: 74317666

GI number: 74317666

Start: 1732312

End: 1733595

Strand: Reverse

Name: hdrA [H]

Synonym: Tbd_1648

Alternate gene names: 74317666

Gene position: 1733595-1732312 (Counterclockwise)

Preceding gene: 74317669

Following gene: 74317665

Centisome position: 59.58

GC content: 62.46

Gene sequence:

>1284_bases
ATGACGGAGCATGTTGCGACCAACGAGACGATCCTCGTGGTGGGCGGCGGGATTTCCGGCATGACCGCCGCGCTCGAAGC
GGCCGAAACCGGCAAAAACGTTGTGCTGATTGAGAAAAACCCTGCGTTGGGCGGACGGACGTCCCAGTTGTATCGCTACT
TTCCCAAGCTTTGCCATCCCGTGTGCGGCCTGGAAATCAATACGCGCCGCCTGAAGAACAATCCGCGCGTGCGTGTCATG
ACGCTCGCCGAGGTAACCGGCATCGAGGGCAGCACCGGCAACTACACCGTCTCGGTCAAGGTCAAGCCGCGCTACGTCAA
CGAAAATTGCACCGCCTGCGGCGAATGCGGCCGCGCCGTCGAAACCCTGGTCGACGATCCGTTCAACTACAACCTCGGCC
AGCACAAGGCGGCATATCTGCCGAACGCGATGGCCTATCCGCAACGCTACGTGATCGATCCGGCGATCATCGGCACGGCC
GACGCCGAGCGTGCCAAGGCGGCCTGCAAATACGGCGCGGTCGACCTCGACATGAAGGAAGAGACGATCCAGGTCAAGGC
CGGCGCGGTGGTCTGGGCGACCGGTTGGCAGCCCTACGACGCGGCGAAGATCCAGCCTTACGGCTACGACCGCTTCAAGA
ACGTCATCACCAGTGTCGAGTTCGAGCGCCTCGCCGACATCCACGGCCCGACCGGCGGCAAGATCCTGCGTCCGTCGGAC
GGCAAGGAAGCGAAGAACATCGCCTTCATCCAGTGCGCCGGGTCGCGCGACGAAAACCATCTCCGGCACTGTTCACGCAT
CTGCTGCATGGCGTCGCTTAAGCAGACGCACTACGTGCGCGAAGCGTATCCCCAGGACGGCAAGTCGACGATCTACTACA
TCGACATCCGGGCGATCGACCGCTTCGAGGATTTCTACCAGAAAGTCCAGGCCGATCCATCGGTCACCTTCGTCAAATCC
AAGGTCGCCAAGATCACCGAGGACGAACAGGGCAATCCGATCTGCTGGGGCGTCAATACCGAAGGCTACAAGCGTTACAC
CACGACCCACGATCTGGTGGTCCTCGCCGTCGGCATGGAGCCGTCGGTCAAAGGCATCAACATTCCGGGCCACATCGTCG
CGGACTCGAGCGGCTTCATCGAGGCGGATCCGGCCAATGGCGCGGTGTTCGGCGCCGGGTGCGCGTCGAACGCGCTCGAC
GTCAACCGGGCGGTGCAGTCGGCGACGGCCGCGGCATTGCGCGCCATCCAGGTGGTCAACAAAGTAGCAAAGGCGGAGGC
TTAA

Upstream 100 bases:

>100_bases
ACACTGAATTCGGCTTAAAAACCGGCTATCTGGGAATGATTCAAAGCCTTGGTCCCAGGTATTTTCGAACGGCTTTGCAT
CCACTGGGTGGGAGAAACCA

Downstream 100 bases:

>100_bases
GAAATGGCTGACATCAAAGTCGCAGCGTACATCTGCAAGGGCTGCGGACTCGGCGAGCGCCTCGACACCGACGCGCTCGT
GAAGATCGCGCAGAAGGACG

Product: heterodisulfide reductase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MTEHVATNETILVVGGGISGMTAALEAAETGKNVVLIEKNPALGGRTSQLYRYFPKLCHPVCGLEINTRRLKNNPRVRVM
TLAEVTGIEGSTGNYTVSVKVKPRYVNENCTACGECGRAVETLVDDPFNYNLGQHKAAYLPNAMAYPQRYVIDPAIIGTA
DAERAKAACKYGAVDLDMKEETIQVKAGAVVWATGWQPYDAAKIQPYGYDRFKNVITSVEFERLADIHGPTGGKILRPSD
GKEAKNIAFIQCAGSRDENHLRHCSRICCMASLKQTHYVREAYPQDGKSTIYYIDIRAIDRFEDFYQKVQADPSVTFVKS
KVAKITEDEQGNPICWGVNTEGYKRYTTTHDLVVLAVGMEPSVKGINIPGHIVADSSGFIEADPANGAVFGAGCASNALD
VNRAVQSATAAALRAIQVVNKVAKAEA

Sequences:

>Translated_427_residues
MTEHVATNETILVVGGGISGMTAALEAAETGKNVVLIEKNPALGGRTSQLYRYFPKLCHPVCGLEINTRRLKNNPRVRVM
TLAEVTGIEGSTGNYTVSVKVKPRYVNENCTACGECGRAVETLVDDPFNYNLGQHKAAYLPNAMAYPQRYVIDPAIIGTA
DAERAKAACKYGAVDLDMKEETIQVKAGAVVWATGWQPYDAAKIQPYGYDRFKNVITSVEFERLADIHGPTGGKILRPSD
GKEAKNIAFIQCAGSRDENHLRHCSRICCMASLKQTHYVREAYPQDGKSTIYYIDIRAIDRFEDFYQKVQADPSVTFVKS
KVAKITEDEQGNPICWGVNTEGYKRYTTTHDLVVLAVGMEPSVKGINIPGHIVADSSGFIEADPANGAVFGAGCASNALD
VNRAVQSATAAALRAIQVVNKVAKAEA
>Mature_426_residues
TEHVATNETILVVGGGISGMTAALEAAETGKNVVLIEKNPALGGRTSQLYRYFPKLCHPVCGLEINTRRLKNNPRVRVMT
LAEVTGIEGSTGNYTVSVKVKPRYVNENCTACGECGRAVETLVDDPFNYNLGQHKAAYLPNAMAYPQRYVIDPAIIGTAD
AERAKAACKYGAVDLDMKEETIQVKAGAVVWATGWQPYDAAKIQPYGYDRFKNVITSVEFERLADIHGPTGGKILRPSDG
KEAKNIAFIQCAGSRDENHLRHCSRICCMASLKQTHYVREAYPQDGKSTIYYIDIRAIDRFEDFYQKVQADPSVTFVKSK
VAKITEDEQGNPICWGVNTEGYKRYTTTHDLVVLAVGMEPSVKGINIPGHIVADSSGFIEADPANGAVFGAGCASNALDV
NRAVQSATAAALRAIQVVNKVAKAEA

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953
- InterPro:   IPR003813
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4; PF02662 FlpD [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 46361; Mature: 46230

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHVATNETILVVGGGISGMTAALEAAETGKNVVLIEKNPALGGRTSQLYRYFPKLCHP
CCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCH
VCGLEINTRRLKNNPRVRVMTLAEVTGIEGSTGNYTVSVKVKPRYVNENCTACGECGRAV
HCCCEEEHHHHCCCCCEEEEEEEEECCCCCCCCCEEEEEEEEEEEECCCCCHHHHHHHHH
ETLVDDPFNYNLGQHKAAYLPNAMAYPQRYVIDPAIIGTADAERAKAACKYGAVDLDMKE
HHHHCCCCCCCCCCCHHHHCCCHHCCCCEEEECCCEEECCCHHHHHHHHHCCCEECCCCC
ETIQVKAGAVVWATGWQPYDAAKIQPYGYDRFKNVITSVEFERLADIHGPTGGKILRPSD
CEEEEECCEEEEECCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCC
GKEAKNIAFIQCAGSRDENHLRHCSRICCMASLKQTHYVREAYPQDGKSTIYYIDIRAID
CCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEHH
RFEDFYQKVQADPSVTFVKSKVAKITEDEQGNPICWGVNTEGYKRYTTTHDLVVLAVGME
HHHHHHHHHCCCCCEEHHHHHHHHCCCCCCCCCEEEECCCCCCEEEECCCCEEEEEECCC
PSVKGINIPGHIVADSSGFIEADPANGAVFGAGCASNALDVNRAVQSATAAALRAIQVVN
CCCCCCCCCCEEEECCCCCEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KVAKAEA
HHHHCCC
>Mature Secondary Structure 
TEHVATNETILVVGGGISGMTAALEAAETGKNVVLIEKNPALGGRTSQLYRYFPKLCHP
CCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHCCH
VCGLEINTRRLKNNPRVRVMTLAEVTGIEGSTGNYTVSVKVKPRYVNENCTACGECGRAV
HCCCEEEHHHHCCCCCEEEEEEEEECCCCCCCCCEEEEEEEEEEEECCCCCHHHHHHHHH
ETLVDDPFNYNLGQHKAAYLPNAMAYPQRYVIDPAIIGTADAERAKAACKYGAVDLDMKE
HHHHCCCCCCCCCCCHHHHCCCHHCCCCEEEECCCEEECCCHHHHHHHHHCCCEECCCCC
ETIQVKAGAVVWATGWQPYDAAKIQPYGYDRFKNVITSVEFERLADIHGPTGGKILRPSD
CEEEEECCEEEEECCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCC
GKEAKNIAFIQCAGSRDENHLRHCSRICCMASLKQTHYVREAYPQDGKSTIYYIDIRAID
CCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEHH
RFEDFYQKVQADPSVTFVKSKVAKITEDEQGNPICWGVNTEGYKRYTTTHDLVVLAVGME
HHHHHHHHHCCCCCEEHHHHHHHHCCCCCCCCCEEEECCCCCCEEEECCCCEEEEEECCC
PSVKGINIPGHIVADSSGFIEADPANGAVFGAGCASNALDVNRAVQSATAAALRAIQVVN
CCCCCCCCCCEEEECCCCCEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KVAKAEA
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]