Click here to switch to the map view.

The map label for this gene is tmk

Identifier: 74317561

GI number: 74317561

Start: 1627747

End: 1628361

Strand: Reverse

Name: tmk

Synonym: Tbd_1543

Alternate gene names: 74317561

Gene position: 1628361-1627747 (Counterclockwise)

Preceding gene: 74317562

Following gene: 74317560

Centisome position: 55.96

GC content: 71.06

Gene sequence:

>615_bases
ATGAGCCTTCCCGGAAAATTCATCACCCTCGAGGGCGTCGACGGCGCCGGCAAGAGCACCCACGTGGGCTTCGTCGCCGA
GTGGTTGCGCGGGCAGGGCAGGGAGGTGATCGTGACGCGCGAGCCGGGCGGAACCGCGCTCGGCGAGACGCTGCGCGAAC
TGCTGCTGCATCGCGAGATGGCGGCCGACACCGAGCTGCTGCTGATGTTCGCGGCGCGGCAGCAGCACTTGGCCGAACTG
ATCCTGCCTGCGTTGGCGCGCGGCGCCTGGGTCGTCTCCGACCGCTTCACCGATGCGAGCTACGCCTACCAGTGCGGCGG
GCGGCGCATCGCGGCCGAACGCATCGCGGCGCTCGAAGACTGGGTGCAGCGCGGCTTCGCGCCCGACCTCACGCTGCTCT
TCGACGTGCCCCCCGCGGTCGCCGAGGAACGACGCTCGAGCGTGCGCGCGGCCGACCGCTTCGAGCAGGAGGCCGGCAGC
TTCTTCGCGCGCGTGCGCGACGCCTATCTCGTGCGTGCGCGTGCGGAGCCGCATCGCATCCACGTGCTCGACGCGCGGCA
GACGATCGACGCCGTGCAGGCCGAAATCGCGCGGCTGCTGCAGGACTTGACGTGA

Upstream 100 bases:

>100_bases
CGCAGACCGATGCGCTCTATTTCGTCTCGCGCGGCGACGGCACCCACGTCTTTTCGAGCGACCTCGCGGCACACAACCGC
GCCGTCCGCCGCTACCAGAA

Downstream 100 bases:

>100_bases
GCGTGGCCTATCCCTGGCTCGAACCGGTCTGGCAGCGCCTGCTCGCGACGCGGTCCCGCCCTGCGCAAGCGCTGCTTCTC
GCCGGTCCGCGCGGCGTCGG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MSLPGKFITLEGVDGAGKSTHVGFVAEWLRGQGREVIVTREPGGTALGETLRELLLHREMAADTELLLMFAARQQHLAEL
ILPALARGAWVVSDRFTDASYAYQCGGRRIAAERIAALEDWVQRGFAPDLTLLFDVPPAVAEERRSSVRAADRFEQEAGS
FFARVRDAYLVRARAEPHRIHVLDARQTIDAVQAEIARLLQDLT

Sequences:

>Translated_204_residues
MSLPGKFITLEGVDGAGKSTHVGFVAEWLRGQGREVIVTREPGGTALGETLRELLLHREMAADTELLLMFAARQQHLAEL
ILPALARGAWVVSDRFTDASYAYQCGGRRIAAERIAALEDWVQRGFAPDLTLLFDVPPAVAEERRSSVRAADRFEQEAGS
FFARVRDAYLVRARAEPHRIHVLDARQTIDAVQAEIARLLQDLT
>Mature_203_residues
SLPGKFITLEGVDGAGKSTHVGFVAEWLRGQGREVIVTREPGGTALGETLRELLLHREMAADTELLLMFAARQQHLAELI
LPALARGAWVVSDRFTDASYAYQCGGRRIAAERIAALEDWVQRGFAPDLTLLFDVPPAVAEERRSSVRAADRFEQEAGSF
FARVRDAYLVRARAEPHRIHVLDARQTIDAVQAEIARLLQDLT

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=198, Percent_Identity=43.9393939393939, Blast_Score=141, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_THIDA (Q3SIM9)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315301.1
- HSSP:   P65248
- ProteinModelPortal:   Q3SIM9
- SMR:   Q3SIM9
- STRING:   Q3SIM9
- GeneID:   3672023
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1543
- NMPDR:   fig|292415.3.peg.1543
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- PhylomeDB:   Q3SIM9
- BioCyc:   TDEN292415:TBD_1543-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 22619; Mature: 22488

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPGKFITLEGVDGAGKSTHVGFVAEWLRGQGREVIVTREPGGTALGETLRELLLHREM
CCCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
AADTELLLMFAARQQHLAELILPALARGAWVVSDRFTDASYAYQCGGRRIAAERIAALED
HCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHCCCCHHHHHHHHHHHH
WVQRGFAPDLTLLFDVPPAVAEERRSSVRAADRFEQEAGSFFARVRDAYLVRARAEPHRI
HHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
HVLDARQTIDAVQAEIARLLQDLT
EEECHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLPGKFITLEGVDGAGKSTHVGFVAEWLRGQGREVIVTREPGGTALGETLRELLLHREM
CCCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
AADTELLLMFAARQQHLAELILPALARGAWVVSDRFTDASYAYQCGGRRIAAERIAALED
HCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHCCCCHHHHHHHHHHHH
WVQRGFAPDLTLLFDVPPAVAEERRSSVRAADRFEQEAGSFFARVRDAYLVRARAEPHRI
HHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEE
HVLDARQTIDAVQAEIARLLQDLT
EEECHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA