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The map label for this gene is kdsB

Identifier: 74317523

GI number: 74317523

Start: 1594649

End: 1595407

Strand: Reverse

Name: kdsB

Synonym: Tbd_1505

Alternate gene names: 74317523

Gene position: 1595407-1594649 (Counterclockwise)

Preceding gene: 74317524

Following gene: 74317522

Centisome position: 54.83

GC content: 69.57

Gene sequence:

>759_bases
ATGCACTTTCGCGTCGTCATTCCCGCGCGCTACGGGTCGAGCCGCCTGCCGGGCAAGCCGCTCGCCGACATCGGCGGCAG
GCCGATGGTGCTGCACGTGCTCGACCGCGCCCTGCAGGCCGGCGCCGAGTCGGTCGTCGTCGCGACCGACGACGCCCGGG
TGCAGGCGGCGGTCGAAGCGGCTGGCCATCAGGCGCTGCTGACCTCGCCCGATCATCAGTCGGGCACCGAACGTCTGGTC
GAAGTCGCCGAAACGCTCGGCTGGCCGGATGACACGCTCGTGGTCAATGTGCAGGGCGACGAGCCGCTGATCGATCCGGC
GCTGATACGCGAGGCCGCGCGCCAGCTTGTCGTGCACACCGACGCCGTGATGGCGACCCTGGCACACCCGATCCACGACC
ACGCCGACTTCGTCAATCCGAACGTCGTCAAGGTCGTCGCCGACGAAGCCGGCTACGCGGTCTACTTCAGCCGCGCGCCG
ATCCCCTGGCCACGCGACGCCTTCGCGGCCGAGCAGCCGATGCCGCACGAAATCGGCGCGCTACGTCACATCGGTCTCTA
TGCCTATCGCGCGGGTTTTCTGCGCACCTACGCGAGCCTCGCGAGTTCGCCGCTCGAACGCTGCGAGATGCTCGAGCAAT
TGCGCGTGCTGTGGCACGGCTACCGCATCAGTCTCGGCGTCACGCCGACCGCGCCGGCCCCCGGCGTCGACACGGCGGAC
GACCTGGCGCGCGTCAGGGCGCTGTTCGCGGCTGTTTAA

Upstream 100 bases:

>100_bases
CGCCTCGCCTATCCCGTGCGTGACGACATTCCGGTGATGCTGCCTGAGGAGGCGCGCGCCGTCGGCCCCGACGAAGTTCA
CGGTCAGGCCTAAGGCGGCC

Downstream 100 bases:

>100_bases
CAGCCTCTTGAATCCGGCAATAAAATTTTTTAAGTGTTGCTCCCCGCGCGCTTGCCTTAGGCTAGCGCGCTTTGGGACAT
TCATATCAATTTAGGGGAGA

Product: 3-deoxy-manno-octulosonate cytidylyltransferase

Products: NA

Alternate protein names: CMP-2-keto-3-deoxyoctulosonic acid synthase; CKS; CMP-KDO synthase

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MHFRVVIPARYGSSRLPGKPLADIGGRPMVLHVLDRALQAGAESVVVATDDARVQAAVEAAGHQALLTSPDHQSGTERLV
EVAETLGWPDDTLVVNVQGDEPLIDPALIREAARQLVVHTDAVMATLAHPIHDHADFVNPNVVKVVADEAGYAVYFSRAP
IPWPRDAFAAEQPMPHEIGALRHIGLYAYRAGFLRTYASLASSPLERCEMLEQLRVLWHGYRISLGVTPTAPAPGVDTAD
DLARVRALFAAV

Sequences:

>Translated_252_residues
MHFRVVIPARYGSSRLPGKPLADIGGRPMVLHVLDRALQAGAESVVVATDDARVQAAVEAAGHQALLTSPDHQSGTERLV
EVAETLGWPDDTLVVNVQGDEPLIDPALIREAARQLVVHTDAVMATLAHPIHDHADFVNPNVVKVVADEAGYAVYFSRAP
IPWPRDAFAAEQPMPHEIGALRHIGLYAYRAGFLRTYASLASSPLERCEMLEQLRVLWHGYRISLGVTPTAPAPGVDTAD
DLARVRALFAAV
>Mature_252_residues
MHFRVVIPARYGSSRLPGKPLADIGGRPMVLHVLDRALQAGAESVVVATDDARVQAAVEAAGHQALLTSPDHQSGTERLV
EVAETLGWPDDTLVVNVQGDEPLIDPALIREAARQLVVHTDAVMATLAHPIHDHADFVNPNVVKVVADEAGYAVYFSRAP
IPWPRDAFAAEQPMPHEIGALRHIGLYAYRAGFLRTYASLASSPLERCEMLEQLRVLWHGYRISLGVTPTAPAPGVDTAD
DLARVRALFAAV

Specific function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria

COG id: COG1212

COG function: function code M; CMP-2-keto-3-deoxyoctulosonic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsB family

Homologues:

Organism=Escherichia coli, GI1787147, Length=247, Percent_Identity=56.6801619433198, Blast_Score=274, Evalue=5e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDSB_THIDA (Q3SIR7)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_315263.1
- ProteinModelPortal:   Q3SIR7
- SMR:   Q3SIR7
- STRING:   Q3SIR7
- GeneID:   3672918
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1505
- NMPDR:   fig|292415.3.peg.1505
- eggNOG:   COG1212
- HOGENOM:   HBG637773
- OMA:   FSRAPLP
- PhylomeDB:   Q3SIR7
- ProtClustDB:   PRK05450
- BioCyc:   TDEN292415:TBD_1505-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00057
- InterPro:   IPR003329
- InterPro:   IPR004528
- TIGRFAMs:   TIGR00466

Pfam domain/function: PF02348 CTP_transf_3

EC number: =2.7.7.38

Molecular weight: Translated: 27232; Mature: 27232

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFRVVIPARYGSSRLPGKPLADIGGRPMVLHVLDRALQAGAESVVVATDDARVQAAVEA
CCEEEEEECCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHH
AGHQALLTSPDHQSGTERLVEVAETLGWPDDTLVVNVQGDEPLIDPALIREAARQLVVHT
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHH
DAVMATLAHPIHDHADFVNPNVVKVVADEAGYAVYFSRAPIPWPRDAFAAEQPMPHEIGA
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHH
LRHIGLYAYRAGFLRTYASLASSPLERCEMLEQLRVLWHGYRISLGVTPTAPAPGVDTAD
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHH
DLARVRALFAAV
HHHHHHHHHHCC
>Mature Secondary Structure
MHFRVVIPARYGSSRLPGKPLADIGGRPMVLHVLDRALQAGAESVVVATDDARVQAAVEA
CCEEEEEECCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHH
AGHQALLTSPDHQSGTERLVEVAETLGWPDDTLVVNVQGDEPLIDPALIREAARQLVVHT
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHH
DAVMATLAHPIHDHADFVNPNVVKVVADEAGYAVYFSRAPIPWPRDAFAAEQPMPHEIGA
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHH
LRHIGLYAYRAGFLRTYASLASSPLERCEMLEQLRVLWHGYRISLGVTPTAPAPGVDTAD
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHH
DLARVRALFAAV
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA