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The map label for this gene is nodT [H]

Identifier: 74317433

GI number: 74317433

Start: 1502245

End: 1503807

Strand: Reverse

Name: nodT [H]

Synonym: Tbd_1415

Alternate gene names: 74317433

Gene position: 1503807-1502245 (Counterclockwise)

Preceding gene: 74317434

Following gene: 74317432

Centisome position: 51.68

GC content: 71.08

Gene sequence:

>1563_bases
GTGCGCGGTCGTGAAGGGCAGCCGCGCAGACGCTATACAATTTCGAGGCTTACTTTCGAACCATCGGGCAGCTCCTTGAA
TAAGCAGCCATTTCGCACCGACGGCCGACGCCGCGAGACGATGAAGACGCGGTCTTTCGTCGCGCCCGCGCTGTTCGCGT
TCGTCGTGCTGGCGCTCACGGGCTGCGTCACGGTCGGCCCCGGTCACGTCGCGCCCGAGCCTTCGCTTCCCGCGCACTGG
GCGACACCCGACGCGCAGCCGCACGCGGGATACGTCGCCCGGCAATCCGATCTCGGTCAGTGGTGGCGCAGCCTCGGCGA
TCCGCTCCTTGTCACGCTGGTCGACGAGGCGTTGCGCACCGGGCCCGATGTCCGCAGTGCAGAGGCGCGCCTGCGTGCTG
CGCGCGCACGCCGCGCCGTCGCCGGGGCCGACCGCTTTCCGAGCGTGAACGCATCGGGCAGCGCCCGCCACAGCGACTCG
AACGCGCAGGTCGGCAGCGGCTCGATGCAGGATCTCTACAGCGTCGGCTTCGATGCCTCGTGGGAACTCGATGTCTTCGG
CCGCGTGCGCCGCAGCGTCGAGGCGGCAGGTGCCGACCATGAATCGTCGCAGGCCGAGCTTGCGAACGCGCGCGTCTCGC
TCGCCGCCGAGGTGGCGCTGACCTACGTCGAAGTGCGCGTGTTGCAGATCCGCCTCGGCATCGCGCGCGCCAATCTCGCG
AGCCAGACCGAAACGCTGCAGTTGACCGACTGGCGCGCGCAGGCGGGGCTCGTCAGCAGCCAGGATTCGGAGCAGGCGCG
CGCCAACCTTGAGCAGACGCGGGCGCAGATTCCGAGCCTCGAAACGAGTCTCGCCGAGGCGGCGTACCGGCTCGATCTGC
TGCTCGGCGTGCCGCCCGGCACGCTCACGCCGCGCCTCGCAACAGGCGGCGAACTGCCGGCGCTTCCCGCGGAGGTCGCC
GTCGGCATCCCTGCCGACACGCTGCGCCAGCGACCCGACGTGCGCGCCGCCGAGCGGATGCTGGCGGCAGAAACCGCGCG
CGTCGGCGTCGCCCAGGCGGCACGCTTTCCGTCGTTCAGTCTTTCGGGCTCGATCGGCCTCGAGGCGCTGACGCTCGGCG
GGCTGAGCGACAGCGGCGCGACGCGTTCGCTGCTCGCCGGGATTACCGCGCCGATCTTCGACGCCGGGCGCTTGCGCGCG
CAGGTCGACGTTCAGGACGCCGTGCGGGAACAGGCGCGGGTCGCGTACGAGCGCACGGTGCTGACGGCGTTGCAGGAGGT
CGAAAGCGCGCTGGTCGCGCTCGCGCGCAACCGCGAACGCAGCGAGGCGCTGGCCAAGGGCGCGGCCGCGGCGCGCAACG
CGGCGGATTTCGCGCGGCAGCGCTACAGCACCGGACTGATCGATTTCCAGTCGGTGCTCGACACGGAACGCAGCGTGCTC
GCGCTCGAAGACAGCCTCGCGAGCACCCGCGCGGACGGCGTTCTGGCGCTGATCCGGCTATACAAGGCACTCGGCGGCGG
ATGGTCGCCGGCCGCATCCGCTTCGCAAGAGGGCCCCGCATGA

Upstream 100 bases:

>100_bases
GCCTCTATGCGGCCGAGCAGGCGCTGATCGCCGAGCGGCTCGTCGACGCGACCAATCGCGTGACGCTCTATCGCACGCTC
GGCGGAGGCTGGCGCTGACA

Downstream 100 bases:

>100_bases
CCCACCCCAACACCGCGCCGGGCGAGCGCAGCACCGCCGTGAAGGCGCTCGTCGACGCGCGCTCGACTCCCTGGACGCGC
CGGCTCATCGGCGCGGCGCT

Product: RND efflux system outer membrane lipoprotein NodT

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MRGREGQPRRRYTISRLTFEPSGSSLNKQPFRTDGRRRETMKTRSFVAPALFAFVVLALTGCVTVGPGHVAPEPSLPAHW
ATPDAQPHAGYVARQSDLGQWWRSLGDPLLVTLVDEALRTGPDVRSAEARLRAARARRAVAGADRFPSVNASGSARHSDS
NAQVGSGSMQDLYSVGFDASWELDVFGRVRRSVEAAGADHESSQAELANARVSLAAEVALTYVEVRVLQIRLGIARANLA
SQTETLQLTDWRAQAGLVSSQDSEQARANLEQTRAQIPSLETSLAEAAYRLDLLLGVPPGTLTPRLATGGELPALPAEVA
VGIPADTLRQRPDVRAAERMLAAETARVGVAQAARFPSFSLSGSIGLEALTLGGLSDSGATRSLLAGITAPIFDAGRLRA
QVDVQDAVREQARVAYERTVLTALQEVESALVALARNRERSEALAKGAAAARNAADFARQRYSTGLIDFQSVLDTERSVL
ALEDSLASTRADGVLALIRLYKALGGGWSPAASASQEGPA

Sequences:

>Translated_520_residues
MRGREGQPRRRYTISRLTFEPSGSSLNKQPFRTDGRRRETMKTRSFVAPALFAFVVLALTGCVTVGPGHVAPEPSLPAHW
ATPDAQPHAGYVARQSDLGQWWRSLGDPLLVTLVDEALRTGPDVRSAEARLRAARARRAVAGADRFPSVNASGSARHSDS
NAQVGSGSMQDLYSVGFDASWELDVFGRVRRSVEAAGADHESSQAELANARVSLAAEVALTYVEVRVLQIRLGIARANLA
SQTETLQLTDWRAQAGLVSSQDSEQARANLEQTRAQIPSLETSLAEAAYRLDLLLGVPPGTLTPRLATGGELPALPAEVA
VGIPADTLRQRPDVRAAERMLAAETARVGVAQAARFPSFSLSGSIGLEALTLGGLSDSGATRSLLAGITAPIFDAGRLRA
QVDVQDAVREQARVAYERTVLTALQEVESALVALARNRERSEALAKGAAAARNAADFARQRYSTGLIDFQSVLDTERSVL
ALEDSLASTRADGVLALIRLYKALGGGWSPAASASQEGPA
>Mature_520_residues
MRGREGQPRRRYTISRLTFEPSGSSLNKQPFRTDGRRRETMKTRSFVAPALFAFVVLALTGCVTVGPGHVAPEPSLPAHW
ATPDAQPHAGYVARQSDLGQWWRSLGDPLLVTLVDEALRTGPDVRSAEARLRAARARRAVAGADRFPSVNASGSARHSDS
NAQVGSGSMQDLYSVGFDASWELDVFGRVRRSVEAAGADHESSQAELANARVSLAAEVALTYVEVRVLQIRLGIARANLA
SQTETLQLTDWRAQAGLVSSQDSEQARANLEQTRAQIPSLETSLAEAAYRLDLLLGVPPGTLTPRLATGGELPALPAEVA
VGIPADTLRQRPDVRAAERMLAAETARVGVAQAARFPSFSLSGSIGLEALTLGGLSDSGATRSLLAGITAPIFDAGRLRA
QVDVQDAVREQARVAYERTVLTALQEVESALVALARNRERSEALAKGAAAARNAADFARQRYSTGLIDFQSVLDTERSVL
ALEDSLASTRADGVLALIRLYKALGGGWSPAASASQEGPA

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=463, Percent_Identity=30.2375809935205, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI2367348, Length=441, Percent_Identity=27.891156462585, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 55301; Mature: 55301

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGREGQPRRRYTISRLTFEPSGSSLNKQPFRTDGRRRETMKTRSFVAPALFAFVVLALT
CCCCCCCCHHHEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GCVTVGPGHVAPEPSLPAHWATPDAQPHAGYVARQSDLGQWWRSLGDPLLVTLVDEALRT
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
GPDVRSAEARLRAARARRAVAGADRFPSVNASGSARHSDSNAQVGSGSMQDLYSVGFDAS
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
WELDVFGRVRRSVEAAGADHESSQAELANARVSLAAEVALTYVEVRVLQIRLGIARANLA
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQTETLQLTDWRAQAGLVSSQDSEQARANLEQTRAQIPSLETSLAEAAYRLDLLLGVPPG
CCCCEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCC
TLTPRLATGGELPALPAEVAVGIPADTLRQRPDVRAAERMLAAETARVGVAQAARFPSFS
CCCCCCCCCCCCCCCCHHHEECCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
LSGSIGLEALTLGGLSDSGATRSLLAGITAPIFDAGRLRAQVDVQDAVREQARVAYERTV
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHH
LTALQEVESALVALARNRERSEALAKGAAAARNAADFARQRYSTGLIDFQSVLDTERSVL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHH
ALEDSLASTRADGVLALIRLYKALGGGWSPAASASQEGPA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRGREGQPRRRYTISRLTFEPSGSSLNKQPFRTDGRRRETMKTRSFVAPALFAFVVLALT
CCCCCCCCHHHEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GCVTVGPGHVAPEPSLPAHWATPDAQPHAGYVARQSDLGQWWRSLGDPLLVTLVDEALRT
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHC
GPDVRSAEARLRAARARRAVAGADRFPSVNASGSARHSDSNAQVGSGSMQDLYSVGFDAS
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
WELDVFGRVRRSVEAAGADHESSQAELANARVSLAAEVALTYVEVRVLQIRLGIARANLA
CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SQTETLQLTDWRAQAGLVSSQDSEQARANLEQTRAQIPSLETSLAEAAYRLDLLLGVPPG
CCCCEEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEECCCC
TLTPRLATGGELPALPAEVAVGIPADTLRQRPDVRAAERMLAAETARVGVAQAARFPSFS
CCCCCCCCCCCCCCCCHHHEECCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
LSGSIGLEALTLGGLSDSGATRSLLAGITAPIFDAGRLRAQVDVQDAVREQARVAYERTV
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHH
LTALQEVESALVALARNRERSEALAKGAAAARNAADFARQRYSTGLIDFQSVLDTERSVL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHH
ALEDSLASTRADGVLALIRLYKALGGGWSPAASASQEGPA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]